This package provides methods to integrate functions over m-dimensional simplices in n-dimensional Euclidean space. There are exact methods for polynomials and adaptive methods for integrating an arbitrary function.

Computerized Adaptive Testing simulations with dichotomous and polytomous items. Selects items with Maximum Fisher Information method or randomly, with or without constraints (content balancing and item exposure control). Evaluates the simulation results in terms of precision, item exposure, and test length. Inspired on Magis & Barrada (2017) <doi:10.18637/jss.v076.c01>.

PAM (Partitioning Around Medoids) algorithm application to samples of single cell sequencing techniques with a high number of cells (as many as the computer memory allows). The package uses a binary format to store matrices (either full, sparse or symmetric) in files written in the disk that can contain any data type (not just double) which allows its manipulation when memory is sufficient to load them as int or float, but not as double. The PAM implementation is done in parallel, using several/all the cores of the machine, if it has them. This package shares a great part of its code with packages jmatrix and parallelpam but their functionality is included here so there is no need to install them.

Analysis tools to investigate changes in intercellular communication from scRNA-seq data. Using a Seurat object as input, the package infers which cell-cell interactions are present in the dataset and how these interactions change between two conditions of interest (e.g. young vs old). It relies on an internal database of ligand-receptor interactions (available for human, mouse and rat) that have been gathered from several published studies. Detection and differential analyses rely on permutation tests. The package also contains several tools to perform over-representation analysis and visualize the results. See Lagger, C. et al. (2023) <doi:10.1038/s43587-023-00514-x> for a full description of the methodology.

This package provides a test for the existence of a subgroup with enhanced treatment effect. And, a sample size calculation procedure for the subgroup detection test.

Runs SQL statements on in-memory data frames within a temporary in-memory duckdb data base.

This package provides a port of the Scarabee toolkit originally written as a Matlab-based application. scaRabee provides a framework for simulation and optimization of pharmacokinetic-pharmacodynamic models at the individual and population level. It is built on top of the neldermead package, which provides the direct search algorithm proposed by Nelder and Mead for model optimization.

This package provides functions to create and manage research compendiums for data analysis. Research compendiums are a standard and intuitive folder structure for organizing the digital materials of a research project, which can significantly improve reproducibility. The package offers several compendium structure options that fit different research project as well as the ability of duplicating the folder structure of existing projects or implementing custom structures. It also simplifies the use of version control.

Building predictive models with stacking which is a type of ensemble learning. Learners can be specified from those implemented in caret'. For more information of the package, see Nukui and Onogi (2023) <doi:10.1101/2023.06.06.543970>.

This package provides tools for analysing the agreement of two or more rankings of the same items. Examples are importance rankings of predictor variables and risk predictions of subjects. Benchmarks for agreement are computed based on random permutation and bootstrap. See Ekstrøm CT, Gerds TA, Jensen, AK (2018). "Sequential rank agreement methods for comparison of ranked lists." _Biostatistics_, *20*(4), 582-598 <doi:10.1093/biostatistics/kxy017> for more information.

This package implements the algorithm described in Guo, H., and Li, J., "scSorter: assigning cells to known cell types according to known marker genes". Cluster cells to known cell types based on marker genes specified for each cell type.

Calculates a degree of spatial association between regionalizations or categorical maps using the information-theoretical V-measure (Nowosad and Stepinski (2018) <doi:10.1080/13658816.2018.1511794>). It also offers an R implementation of the MapCurve method (Hargrove et al. (2006) <doi:10.1007/s10109-006-0025-x>).

This package provides a facility to generate balanced semi-Latin rectangles with any cell size (preferably up to ten) with given number of treatments, see Uto, N.P. and Bailey, R.A. (2020). "Balanced Semi-Latin rectangles: properties, existence and constructions for block size two". Journal of Statistical Theory and Practice, 14(3), 1-11, <doi:10.1007/s42519-020-00118-3>. It also provides facility to generate partially balanced semi-Latin rectangles for cell size 2, 3 and 4 for any number of treatments.

An extension to the individual claim simulator called SynthETIC (on CRAN), to simulate the evolution of case estimates of incurred losses through the lifetime of an insurance claim. The transactional simulation output now comprises key dates, and both claim payments and revisions of estimated incurred losses. An initial set of test parameters, designed to mirror the experience of a real insurance portfolio, were set up and applied by default to generate a realistic test data set of incurred histories (see vignette). However, the distributional assumptions used to generate this data set can be easily modified by users to match their experiences. Reference: Avanzi B, Taylor G, Wang M (2021) "SPLICE: A Synthetic Paid Loss and Incurred Cost Experience Simulator" <arXiv:2109.04058>.

This package provides robust estimation for spatial error model to presence of outliers in the residuals. The classical estimation methods can be influenced by the presence of outliers in the data. We proposed a robust estimation approach based on the robustified likelihood equations for spatial error model (Vural Yildirim & Yeliz Mert Kantar (2020): Robust estimation approach for spatial error model, Journal of Statistical Computation and Simulation, <doi:10.1080/00949655.2020.1740223>).

Utilizes the Reliability-Adjusted Product Indicator (RAPI) method to estimate effects among latent variables, thus allowing for more precise definition and analysis of mediation and moderation models. Our simulation studies reveal that while silp may exhibit instability with smaller sample sizes and lower reliability scores (e.g., N = 100, omega = 0.7), implementing nearest positive definite matrix correction and bootstrap confidence interval estimation can significantly ameliorate this volatility. When these adjustments are applied, silp achieves estimations akin in quality to those derived from LMS. In conclusion, the silp package is a valuable tool for researchers seeking to explore complex relational structures between variables without resorting to commercial software. Cheung et al.(2021)<doi:10.1007/s10869-020-09717-0> Hsiao et al.(2018)<doi:10.1177/0013164416679877>.

This package provides tools for the optimization of stratified sampling design. It determines a stratification of a sampling frame that minimizes sample cost while satisfying precision constraints in a multivariate and multidomain context. The approach relies on a genetic algorithm; each candidate partition of the frame is an individual whose fitness is evaluated via the Bethel-Chromy allocation to meet target precisions. Functions support analysis of optimization results, labeling of the frame with new strata, and drawing a sample according to the optimal allocation. Algorithmic components adapt code from the genalg package. See M. Ballin and G. Barcaroli (2020) "R package SamplingStrata: new developments and extension to Spatial Sampling" <doi:10.48550/arXiv.2004.09366>.

This package provides kernel weighting methods for estimation of proportional hazards models with intermittently observed longitudinal covariates. Cao H., Churpek M. M., Zeng D., and Fine J. P. (2015) <doi:10.1080/01621459.2014.957289>.

This package provides a collection of functions for estimating spatial regimes, aggregations of neighboring spatial units that are homogeneous in functional terms. The term spatial regime, therefore, should not be understood as a synonym for cluster. More precisely, the term cluster does not presuppose any functional relationship between the variables considered, while the term regime is linked to a regressive relationship underlying the spatial process.

Identifies individuals in a social network who should be the intervention subjects for a network intervention in which you have a group of targets, a group of avoiders, and a group that is neither.

Manipulating input and output files of the STICS crop model. Files are either JavaSTICS XML files or text files used by the model fortran executable. Most basic functionalities are reading or writing parameter names and values in both XML or text input files, and getting data from output files. Advanced functionalities include XML files generation from XML templates and/or spreadsheets, or text files generation from XML files by using xslt transformation.

This package provides comprehensive analytics, reporting, and testing capabilities for systematic review search strategies. The package focuses on validating search performance, generating standardized PRISMA'-compliant reports, and ensuring reproducibility in evidence synthesis. Features include precision-recall analysis, cross-database performance comparison, benchmark validation against gold standards, sensitivity analysis, temporal coverage assessment, automated report generation, and statistical comparison of search strategies. Supports multiple export formats including CSV', Excel', RIS', BibTeX', and EndNote'. Includes tools for duplicate detection, search strategy optimization, cross-validation frameworks, meta-analysis of benchmark results, power analysis for study design, and reproducibility package creation. Optionally connects to PubMed for direct database searching and real-time strategy comparison using the E-utilities API'. Enhanced with bootstrap comparison methods, McNemar test for strategy evaluation, and comprehensive visualization tools for performance assessment. Methods based on Manning et al. (2008) for information retrieval metrics, Moher et al. (2009) for PRISMA guidelines, and Sampson et al. (2006) for systematic review search methodology.

Simplifies the process of generating samples from a variety of probability distributions, allowing users to quickly create data frames for demonstrations, troubleshooting, or teaching purposes. Data is available in multiple sizesâ small, medium, and large. For more information, refer to the package documentation.

Fast and efficient sampling from general univariate probability density functions. Implements a rejection sampling approach designed to take advantage of modern CPU caches and minimise evaluation of the target density for most samples. Many standard densities are internally implemented in C for high performance, with general user defined densities also supported. A paper describing the methodology will be released soon.