Creation and selection of N-way Partial Least Squares (NPLS) models. Selection of the optimal number of components can be done using ncrossreg(). NPLS was originally described by Rasmus Bro, see <doi:10.1002/%28SICI%291099-128X%28199601%2910%3A1%3C47%3A%3AAID-CEM400%3E3.0.CO%3B2-C>.

Calculate NOS (node overlap and segregation) and the associated metrics described in Strona and Veech (2015) <doi:10.1111/2041-210X.12395> and Strona et al. (2018) <doi:10.1111/ecog.03447>. The functions provided in the package enable assessment of structural patterns ranging from complete node segregation to perfect nestedness in a variety of network types. In addition, they provide a measure of network modularity.

This package provides functions to flash your hue lights, or text yourself, from R. Designed to be used with long running scripts.

In the working paper titled "Why You Should Never Use the Hodrick-Prescott Filter", James D. Hamilton proposes a new alternative to economic time series filtering. The neverhpfilter package provides functions and data for reproducing his work. Hamilton (2017) <doi:10.3386/w23429>.

This package provides a functional programming based implementation of the super learner algorithm with an emphasis on supporting the use of formulas to specify learners. This approach offers several improvements compared to past implementations including the ability to easily use random-effects specified in formulas (like y ~ (age | strata) + ...) and construction of new learners is as simple as writing and passing a new function. The super learner algorithm was originally described in van der Laan et al. (2007) <https://biostats.bepress.com/ucbbiostat/paper222/>.

Access the New Zealand Freshwater Fish Database from R and a few functions to clean the data once in R.

There are three distinct approaches for phase error correction, they are: a single linear model with a choice of optimization functions, multiple linear models with optimization function choices and a shrinkage-based method. The methodology is based on our new algorithms and various references (Binczyk et al. (2015) <doi:10.1186/1475-925X-14-S2-S5>,Chen et al. (2002) <doi:10.1016/S1090-7807(02)00069-1>, de Brouwer (2009) <doi:10.1016/j.jmr.2009.09.017>, Džakula (2000) <doi:10.1006/jmre.2000.2123>, Ernst (1969) <doi:10.1016/0022-2364(69)90003-1>, Liland et al. (2010) <doi:10.1366/000370210792434350>).

This package provides functions for specifying and fitting nested dichotomy logistic regression models for a multi-category response and methods for summarising and plotting those models. Nested dichotomies are statistically independent, and hence provide an additive decomposition of tests for the overall polytomous response. When the dichotomies make sense substantively, this method can be a simpler alternative to the standard multinomial logistic model which compares response categories to a reference level. See: J. Fox (2016), "Applied Regression Analysis and Generalized Linear Models", 3rd Ed., ISBN 1452205663.

This package performs a Necessary Condition Analysis (NCA). (Dul, J. 2016. Necessary Condition Analysis (NCA). Logic and Methodology of Necessary but not Sufficient causality." Organizational Research Methods 19(1), 10-52) <doi:10.1177/1094428115584005>. NCA identifies necessary (but not sufficient) conditions in datasets, where x causes (e.g. precedes) y. Instead of drawing a regression line through the middle of the data in an xy-plot, NCA draws the ceiling line. The ceiling line y = f(x) separates the area with observations from the area without observations. (Nearly) all observations are below the ceiling line: y <= f(x). The empty zone is in the upper left hand corner of the xy-plot (with the convention that the x-axis is horizontal and the y-axis is vertical and that values increase upwards and to the right''). The ceiling line is a (piecewise) linear non-decreasing line: a linear step function or a straight line. It indicates which level of x (e.g. an effort or input) is necessary but not sufficient for a (desired) level of y (e.g. good performance or output). A quick start guide for using this package can be found here: <https://repub.eur.nl/pub/78323/> or <https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2624981>.

NONMEM has been a tool for running nonlinear mixed effects models since the 80s and is still used today (Bauer 2019 <doi:10.1002/psp4.12404>). This tool allows you to convert NONMEM models to rxode2 (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>) and with simple models nlmixr2 syntax (Fidler et al (2019) <doi:10.1002/psp4.12445>). The nlmixr2 syntax requires the residual specification to be included and it is not always translated. If available, the rxode2 model will read in the NONMEM data and compare the simulation for the population model ('PRED') individual model ('IPRED') and residual model ('IWRES') to immediately show how well the translation is performing. This saves the model development time for people who are creating an rxode2 model manually. Additionally, this package reads in all the information to allow simulation with uncertainty (that is the number of observations, the number of subjects, and the covariance matrix) with a rxode2 model. This is complementary to the babelmixr2 package that translates nlmixr2 models to NONMEM and can convert the objects converted from nonmem2rx to a full nlmixr2 fit.

This package provides a reproducible workflow for binning and visualizing NMR (nuclear magnetic resonance) spectra from environmental samples. The nmrrr package is intended for post-processing of NMR data, including importing, merging and, cleaning data from multiple files, visualizing NMR spectra, performing binning/integrations for compound classes, and relative abundance calculations. This package can be easily inserted into existing analysis workflows by users to help with analyzing and interpreting NMR data.

This package provides functions for the normal Laplace distribution. Currently, it provides limited functionality. Density, distribution and quantile functions, random number generation, and moments are provided.

Replacement for nls() tools for working with nonlinear least squares problems. The calling structure is similar to, but much simpler than, that of the nls() function. Moreover, where nls() specifically does NOT deal with small or zero residual problems, nlmrt is quite happy to solve them. It also attempts to be more robust in finding solutions, thereby avoiding singular gradient messages that arise in the Gauss-Newton method within nls(). The Marquardt-Nash approach in nlmrt generally works more reliably to get a solution, though this may be one of a set of possibilities, and may also be statistically unsatisfactory. Added print and summary as of August 28, 2012.

Illustrate graphically the most common Null Hypothesis Significance Testing procedures. More specifically, this package provides functions to plot Chi-Squared, F, t (one- and two-tailed) and z (one- and two-tailed) tests, by plotting the probability density under the null hypothesis as a function of the different test statistic values. Although highly flexible (color theme, fonts, etc.), only the minimal number of arguments (observed test statistic, degrees of freedom) are necessary for a clear and useful graph to be plotted, with the observed test statistic and the p value, as well as their corresponding value labels. The axes are automatically scaled to present the relevant part and the overall shape of the probability density function. This package is especially intended for education purposes, as it provides a helpful support to help explain the Null Hypothesis Significance Testing process, its use and/or shortcomings.

Designed to create interactive and visually compelling network maps using R Shiny. It allows users to quickly analyze CSV files and visualize complex relationships, structures, and connections within data by leveraging powerful network analysis libraries and dynamic web interfaces.

In shotgun proteomics, shared peptides (i.e., peptides that might originate from different proteins sharing homology, from different proteoforms due to alternative mRNA splicing, post-translational modifications, proteolytic cleavages, and/or allelic variants) represent a major source of ambiguity in protein identifications. The net4pg package allows to assess and handle ambiguity of protein identifications. It implements methods for two main applications. First, it allows to represent and quantify ambiguity of protein identifications by means of graph connected components (CCs). In graph theory, CCs are defined as the largest subgraphs in which any two vertices are connected to each other by a path and not connected to any other of the vertices in the supergraph. Here, proteins sharing one or more peptides are thus gathered in the same CC (multi-protein CC), while unambiguous protein identifications constitute CCs with a single protein vertex (single-protein CCs). Therefore, the proportion of single-protein CCs and the size of multi-protein CCs can be used to measure the level of ambiguity of protein identifications. The package implements a strategy to efficiently calculate graph connected components on large datasets and allows to visually inspect them. Secondly, the net4pg package allows to exploit the increasing availability of matched transcriptomic and proteomic datasets to reduce ambiguity of protein identifications. More precisely, it implement a transcriptome-based filtering strategy fundamentally consisting in the removal of those proteins whose corresponding transcript is not expressed in the sample-matched transcriptome. The underlying assumption is that, according to the central dogma of biology, there can be no proteins without the corresponding transcript. Most importantly, the package allows to visually inspect the effect of the filtering on protein identifications and quantify ambiguity before and after filtering by means of graph connected components. As such, it constitutes a reproducible and transparent method to exploit transcriptome information to enhance protein identifications. All methods implemented in the net4pg package are fully described in Fancello and Burger (2022) <doi:10.1186/s13059-022-02701-2>.

Similarity measures for hierarchical clustering of objects characterized by nominal (categorical) variables. Evaluation criteria for nominal data clustering.

This package provides a fast negative binomial mixed model for conducting association analysis of multi-subject single-cell data. It can be used for identifying marker genes, differential expression and co-expression analyses. The model includes subject-level random effects to account for the hierarchical structure in multi-subject single-cell data. See He et al. (2021) <doi:10.1038/s42003-021-02146-6>.

This package provides a graphical display of results from network meta-analysis (NMA). It is suitable for outcomes like odds ratio (OR), risk ratio (RR), risk difference (RD) and standardized mean difference (SMD). It also has an option to visually display and compare the surface under the cumulative ranking (SUCRA) of different treatments.

The Negative Binomial regression with mean and shape modeling and mean and variance modeling and Beta Binomial regression with mean and dispersion modeling.

Estimate the correlation between two NIfTI images across random parcellations of the images (Fortea et al., under review). This approach overcomes the problems of both voxel-based correlations (neighbor voxels may be spatially dependent) and atlas-based correlations (the correlation may depend on the atlas used).

This package provides methods to estimate finite-population parameters under nonresponse that is not missing at random (NMAR, nonignorable). Incorporates auxiliary information and user-specified response models, and supports independent samples and complex survey designs via objects from the survey package. Provides diagnostics and optional variance estimates. For methodological background see Qin, Leung and Shao (2002) <doi:10.1198/016214502753479338> and Riddles, Kim and Im (2016) <doi:10.1093/jssam/smv047>.

This package provides methods and tools for forecasting univariate time series using the NARFIMA (Neural AutoRegressive Fractionally Integrated Moving Average) model. It combines neural networks with fractional differencing to capture both nonlinear patterns and long-term dependencies. The NARFIMA model supports seasonal adjustment, Box-Cox transformations, optional exogenous variables, and the computation of prediction intervals. In addition to the NARFIMA model, this package provides alternative forecasting models including NARIMA (Neural ARIMA), NBSTS (Neural Bayesian Structural Time Series), and NNaive (Neural Naive) for performance comparison across different modeling approaches. The methods are based on algorithms introduced by Chakraborty et al. (2025) <doi:10.48550/arXiv.2509.06697>.

This package implements the framework presented in Cucci, D. A., Voirol, L., Khaghani, M. and Guerrier, S. (2023) <doi:10.1109/TIM.2023.3267360> which allows to analyze the impact of sensor error modeling on the performance of integrated navigation (sensor fusion) based on inertial measurement unit (IMU), Global Positioning System (GPS), and barometer data. The framework relies on Monte Carlo simulations in which a Vanilla Extended Kalman filter is coupled with realistic and user-configurable noise generation mechanisms to recover a reference trajectory from noisy measurements. The evaluation of several statistical metrics of the solution, aggregated over hundreds of simulated realizations, provides reasonable estimates of the expected performances of the system in real-world conditions.