According to the order of the loci on the chromosome, the loci can be connected according to the interrelationship between them and classified according to different locus types.

Biologically relevant, yet mathematically sound constraints are used to compute the propensity and thence infer the dominant direction of reactions of a generic biochemical network. The reactions must be unique and their number must exceed that of the reactants,i.e., reactions >= reactants + 2. ReDirection', computes the null space of a user-defined stoichiometry matrix. The spanning non-zero and unique reaction vectors (RVs) are combinatorially summed to generate one or more subspaces recursively. Every reaction is represented as a sequence of identical components across all RVs of a particular subspace. The terms are evaluated with (biologically relevant bounds, linear maps, tests of convergence, descriptive statistics, vector norms) and the terms are classified into forward-, reverse- and equivalent-subsets. Since, these are mutually exclusive the probability of occurrence is binary (all, 1; none, 0). The combined propensity of a reaction is the p1-norm of the sub-propensities, i.e., sum of the products of the probability and maximum numeric value of a subset (least upper bound, greatest lower bound). This, if strictly positive is the probable rate constant, is used to infer dominant direction and annotate a reaction as "Forward (f)", "Reverse (b)" or "Equivalent (e)". The inherent computational complexity (NP-hard) per iteration suggests that a suitable value for the number of reactions is around 20. Three functions comprise ReDirection. These are check_matrix() and reaction_vector() which are internal, and calculate_reaction_vector() which is external.

This package provides an easy way to report the results of ROC analysis, including: 1. an ROC curve. 2. the value of Cutoff, AUC (Area Under Curve), ACC (accuracy), SEN (sensitivity), SPE (specificity), PLR (positive likelihood ratio), NLR (negative likelihood ratio), PPV (positive predictive value), NPV (negative predictive value), PPA (percentage of positive accordance), NPA (percentage of negative accordance), TPA (percentage of total accordance), KAPPA (kappa value).

This package provides access to the xylib C library for to import xy data from powder diffraction, spectroscopy and other experimental methods.

Interface to access data via the United States Department of Agriculture's National Agricultural Statistical Service (NASS) Quick Stats web API <https://quickstats.nass.usda.gov/api/>. Convenience functions facilitate building queries based on available parameters and valid parameter values. This product uses the NASS API but is not endorsed or certified by NASS.

Exploit controlled vocabularies organized on tematres servers.

This package implements simple Hamiltonian Monte Carlo routines in R for sampling from any desired target distribution which is continuous and smooth. See Neal (2017) <arXiv:1701.02434> for further details on Hamiltonian Monte Carlo. Automatic parameter selection is not supported.

Computing singular value decomposition with robustness is a challenging task. This package provides an implementation of computing robust SVD using density power divergence (<doi:10.48550/arXiv.2109.10680>). It combines the idea of robustness and efficiency in estimation based on a tuning parameter. It also provides utility functions to simulate various scenarios to compare performances of different algorithms.

MCMC based sampling of binary matrices with fixed margins as used in exact Rasch model tests.

Package to Handle R Requests from R Service Bus Applications with JSON Payloads in a generic way. The incoming request is encoded as a string (character vector of length one) containing the JSON file passed through by the client.

Loads Axon Binary Files (both ABF and ABF2') created by Axon Instruments/Molecular Devices software such as pClamp'.

R Commander plugin for teaching statistical methods. It adds a new menu for making easier the teaching of the main concepts about the main statistical methods.

Handle climate data from the DWD ('Deutscher Wetterdienst', see <https://www.dwd.de/EN/climate_environment/cdc/cdc_node_en.html> for more information). Choose observational time series from meteorological stations with selectDWD()'. Find raster data from radar and interpolation according to <https://brry.github.io/rdwd/raster-data.html>. Download (multiple) data sets with progress bars and no re-downloads through dataDWD()'. Read both tabular observational data and binary gridded datasets with readDWD()'.

Enhances the R Optimization Infrastructure ('ROI') package by registering the quadprog solver. It allows for solving quadratic programming (QP) problems.

This package provides a collection of tools for extracting structured data from <https://www.reddit.com/>.

Rank-based (R) estimation and inference for linear models. Estimation is for general scores and a library of commonly used score functions is included.

This package provides methods and tools for implementing functional singular spectrum analysis and related techniques.

Interface to use and access Wilensky's NetLogo (Wilensky 1999) from R using either headless (no GUI) or interactive GUI mode. Provides functions to load models, execute commands, and get values from reporters. Mostly analogous to the NetLogo Mathematica Link <https://github.com/NetLogo/Mathematica-Link>.

An implementation of the radviz projection in R. It enables the visualization of multidimensional data while maintaining the relation to the original dimensions. This package provides functions to create and plot radviz projections, and a number of summary plots that enable comparison and analysis. For reference see Hoffman *et al.* (1999) (<doi:10.1145/331770.331775>) for original implementation, see Di Caro *et al* (2012) (<doi:10.1007/978-3-642-13672-6_13>), for the original method for dimensional anchor arrangements, see Demsar *et al.* (2007) (<doi:10.1016/j.jbi.2007.03.010>) for the original Freeviz implementation.

Blaze is an open-source, high-performance C++ math library for dense and sparse arithmetic. With its state-of-the-art Smart Expression Template implementation Blaze combines the elegance and ease of use of a domain-specific language with HPC-grade performance, making it one of the most intuitive and fastest C++ math libraries available. The RcppBlaze package includes the header files from the Blaze library with disabling some functionalities related to link to the thread and system libraries which make RcppBlaze be a header-only library. Therefore, users do not need to install Blaze'.

This package creates the radar-boxplot, a plot that was created by the author during his Ph.D. in forest resources. The radar-boxplot is a visualization feature suited for multivariate classification/clustering. It provides an intuitive deep understanding of the data.

We implement causal mediation analysis using the methods proposed by Hong (2010) and Hong, Deutsch & Hill (2015) <doi:10.3102/1076998615583902>. It allows the estimation and hypothesis testing of causal mediation effects through ratio of mediator probability weights (RMPW). This strategy conveniently relaxes the assumption of no treatment-by-mediator interaction while greatly simplifying the outcome model specification without invoking strong distributional assumptions. We also implement a sensitivity analysis by extending the RMPW method to assess potential bias in the presence of omitted pretreatment or posttreatment covariates. The sensitivity analysis strategy was proposed by Hong, Qin, and Yang (2018) <doi:10.3102/1076998617749561>.

Inverse normal transformation (INT) based genetic association testing. These tests are recommend for continuous traits with non-normally distributed residuals. INT-based tests robustly control the type I error in settings where standard linear regression does not, as when the residual distribution exhibits excess skew or kurtosis. Moreover, INT-based tests outperform standard linear regression in terms of power. These tests may be classified into two types. In direct INT (D-INT), the phenotype is itself transformed. In indirect INT (I-INT), phenotypic residuals are transformed. The omnibus test (O-INT) adaptively combines D-INT and I-INT into a single robust and statistically powerful approach. See McCaw ZR, Lane JM, Saxena R, Redline S, Lin X. "Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies" <doi:10.1111/biom.13214>.

In data science, it is a common practice to compute a series of columns (e.g. features) against a common response vector. Various metrics are provided with efficient computation implemented with Rcpp'.