DNA methylation is essential for human, and environment can change the DNA methylation and affect body status. Epigenome-Wide Mediation Analysis Study (EMAS) can find potential mediator CpG sites between exposure (x) and outcome (y) in epigenome-wide. For more information on the methods we used, please see the following references: Tingley, D. (2014) <doi:10.18637/jss.v059.i05>, Turner, S. D. (2018) <doi:10.21105/joss.00731>, Rosseel, D. (2012) <doi:10.18637/jss.v048.i02>.

This package implements the conditional estimation procedure of Lee, Sun, Sun and Taylor (2016) <doi:10.1214/15-AOS1371>. This procedure allows hypothesis testing on the mean of a normal random vector subject to linear constraints. Also supports computation of the MLE of the mean subject to the same constraints.

Fitting and testing multi-attribute probabilistic choice models, especially the Bradley-Terry-Luce (BTL) model (Bradley & Terry, 1952 <doi:10.1093/biomet/39.3-4.324>; Luce, 1959), elimination-by-aspects (EBA) models (Tversky, 1972 <doi:10.1037/h0032955>), and preference tree (Pretree) models (Tversky & Sattath, 1979 <doi:10.1037/0033-295X.86.6.542>).

Various Expectation-Maximization (EM) algorithms are implemented for item response theory (IRT) models. The package includes IRT models for binary and ordinal responses, along with dynamic and hierarchical IRT models with binary responses. The latter two models are fitted using variational EM. The package also includes variational network and text scaling models. The algorithms are described in Imai, Lo, and Olmsted (2016) <DOI:10.1017/S000305541600037X>.

Automatically performs exploratory data analysis (EDA) for tabular datasets, including data summaries, missing value analysis, descriptive statistics, visualizations, correlation analysis, outlier detection, and automated report generation. The package provides a streamlined workflow for rapid data exploration and produces publication-ready tables and graphics. For methodological details see Tukey (1977, ISBN:9780201076165), Pearson (1895) <doi:10.1098/rspl.1895.0041>, and Wickham (2014) <doi:10.18637/jss.v059.i10>.

Capture code evaluations and script executions by expressions, outputs, and condition calls for logging.

Provide the EMU Speech Database Management System (EMU-SDMS) with database management, data extraction, data preparation and data visualization facilities. See <https://ips-lmu.github.io/The-EMU-SDMS-Manual/> for more details.

This package provides a lightweight implementation of functions and methods for fast and fully automatic time series modeling and forecasting using Echo State Networks (ESNs).

Implementation of the Edge Selection Algorithm for undirected graph selection. The least angle regression-based algorithm selects edges of an undirected graph based on the projection of the current residuals on the two dimensional edge-planes. The algorithm selects symmetric adjacency matrix, which many other regression-based undirected graph selection procedures cannot do.

Exploring time series for signal detection. It is specifically designed to detect possible outbreaks using infectious disease surveillance data at the European Union / European Economic Area or country level. Automatic detection tools used are presented in the paper "Monitoring count time series in R: aberration detection in public health surveillance", by Salmon (2016) <doi:10.18637/jss.v070.i10>. The package includes: - Signal Detection tool, an interactive shiny application in which the user can import external data and perform basic signal detection analyses; - An automated report in HTML format, presenting the results of the time series analysis in tables and graphs. This report can also be stratified by population characteristics (see Population variable). This project was funded by the European Centre for Disease Prevention and Control.

This package provides functions that help with analysis of prognostic study data. This allows users with little experience of developing models to develop models and assess the performance of the prognostic models. This also summarises the information, so the performance of multiple models can be displayed simultaneously. This minor update fixes issues related to memory requirements with large number of simulations and deals with situations when there is overfitting of data. Gurusamy, K (2026)<https://github.com/kurinchi2k/EQUALPrognosis>.

This package provides functions for the computation of functional elastic shape means over sets of open planar curves. The package is particularly suitable for settings where these curves are only sparsely and irregularly observed. It uses a novel approach for elastic shape mean estimation, where planar curves are treated as complex functions and a full Procrustes mean is estimated from the corresponding smoothed Hermitian covariance surface. This is combined with the methods for elastic mean estimation proposed in Steyer, Stöcker, Greven (2022) <doi:10.1111/biom.13706>. See Stöcker et. al. (2022) <arXiv:2203.10522> for details.

Ensemble Model Output Statistics to create probabilistic forecasts from ensemble forecasts and weather observations.

Testing for parallel trends is crucial in the Difference-in-Differences framework. To this end, this package performs equivalence testing in the context of Difference-in-Differences estimation. It allows users to test if pre-treatment trends in the treated group are â equivalentâ to those in the control group. Here, â equivalenceâ means that rejection of the null hypothesis implies that a function of the pre-treatment placebo effects (maximum absolute, average or root mean squared value) does not exceed a pre-specified threshold below which trend differences are considered negligible. The package is based on the theory developed in Dette & Schumann (2024) <doi:10.1080/07350015.2024.2308121>.

This package provides a collection of small functions useful for epidemics analysis and infectious disease modelling. This includes computation of basic reproduction numbers from growth rates, generation of hashed labels to anonymize data, and fitting discretized Gamma distributions.

Models integrate environmental DNA (eDNA) detection data and traditional survey data to jointly estimate species catch rate (see package vignette: <https://ednajoint.netlify.app/>). Models can be used with count data via traditional survey methods (i.e., trapping, electrofishing, visual) and replicated eDNA detection/nondetection data via polymerase chain reaction (i.e., PCR or qPCR) from multiple survey locations. Estimated parameters include probability of a false positive eDNA detection, a site-level covariates that scale the sensitivity of eDNA surveys relative to traditional surveys, and gear scaling coefficients for traditional gear types. Models are implemented with a Bayesian framework (Markov chain Monte Carlo) using the Stan probabilistic programming language.

Build entity relationship diagrams (ERD) to specify the nature of the relationship between tables in a database.

Simulates cyclic voltammetry, linear-sweep voltammetry (both with and without stirring of the solution), and single-pulse and double-pulse chronoamperometry and chronocoulometry experiments using the implicit finite difference method outlined in Gosser (1993, ISBN: 9781560810261) and in Brown (2015) <doi:10.1021/acs.jchemed.5b00225>. Additional functions provide ways to display and to examine the results of these simulations. The primary purpose of this package is to provide tools for use in courses in analytical chemistry.

This package provides tools to download and manipulate the Permanent Household Survey from Argentina (EPH is the Spanish acronym for Permanent Household Survey). e.g: get_microdata() for downloading the datasets, get_poverty_lines() for downloading the official poverty baskets, calculate_poverty() for the calculation of stating if a household is in poverty or not, following the official methodology. organize_panels() is used to concatenate observations from different periods, and organize_labels() adds the official labels to the data. The implemented methods are based on INDEC (2016) <http://www.estadistica.ec.gba.gov.ar/dpe/images/SOCIEDAD/EPH_metodologia_22_pobreza.pdf>. As this package works with the argentinian Permanent Household Survey and its main audience is from this country, the documentation was written in Spanish.

This package provides a simple interface to search and retrieve scientific articles from the SciELO (Scientific Electronic Library Online) database <https://scielo.org>. It allows querying, filtering, and visualizing results in an interactive table.

This package provides a high-level R6 interface for creating complex Office Open XML (OOXML) charts. Allows users to build multi-series combo charts with secondary axes and granular styling options, designed to integrate seamlessly with openxlsx2'.

Because fungicide resistance is an important phenotypic trait for fungi and oomycetes, it is necessary to have a standardized method of statistically analyzing the Effective Concentration (EC) values. This package is designed for those who are not terribly familiar with R to be able to analyze and plot an entire set of isolates using the drc package.

Forecasting univariate time series with ensemble empirical mode decomposition (EEMD) with long short-term memory (LSTM). For method details see Jaiswal, R. et al. (2022). <doi:10.1007/s00521-021-06621-3>.

This package contains tools for formatting inline code, renaming redundant columns, aggregating age categories, adding survey weights, finding the earliest date of an event, plotting z-curves, generating population counts and formatting proportions with confidence intervals. This is part of the R4Epis project <https://r4epi.github.io/sitrep/>.