Simulate Mediterranean forest functioning and dynamics using cohort-based description of vegetation [De Caceres et al. (2015) <doi:10.1016/j.agrformet.2015.06.012>; De Caceres et al. (2021) <doi:10.1016/j.agrformet.2020.108233>].

An aggressive dimensionality reduction and network estimation technique for a high-dimensional Gaussian graphical model (GGM). Please refer to: Efficient Dimensionality Reduction for High-Dimensional Network Estimation, Safiye Celik, Benjamin A. Logsdon, Su-In Lee, Proceedings of The 31st International Conference on Machine Learning, 2014, p. 1953--1961.

Multivariate functional principal component analysis via fast covariance estimation for multivariate sparse functional data or longitudinal data proposed by Li, Xiao, and Luo (2020) <doi: 10.1002/sta4.245>.

This package provides a method for the multiresolution analysis of spatial fields and images to capture scale-dependent features. mrbsizeR is based on scale space smoothing and uses differences of smooths at neighbouring scales for finding features on different scales. To infer which of the captured features are credible, Bayesian analysis is used. The scale space multiresolution analysis has three steps: (1) Bayesian signal reconstruction. (2) Using differences of smooths, scale-dependent features of the reconstructed signal can be found. (3) Posterior credibility analysis of the differences of smooths created. The method has first been proposed by Holmstrom, Pasanen, Furrer, Sain (2011) <DOI:10.1016/j.csda.2011.04.011> and extended in Flury, Gerber, Schmid and Furrer (2021) <DOI:10.1016/j.spasta.2020.100483>.

This package provides a variety of association tests for microbiome data analysis including Quasi-Conditional Association Tests (QCAT) described in Tang Z.-Z. et al.(2017) <doi:10.1093/bioinformatics/btw804> and Zero-Inflated Generalized Dirichlet Multinomial (ZIGDM) tests described in Tang Z.-Z. & Chen G. (2017, submitted).

This package implements a generalization of the Cochran-Armitage trend test to multinomial data. In addition to an overall test, multiple testing adjusted p-values for trend in individual outcomes and power calculation is available.

Multilevel models (mixed effects models) are the statistical tool of choice for analyzing multilevel data (Searle et al, 2009). These models account for the correlated nature of observations within higher level units by adding group-level error terms that augment the singular residual error of a standard OLS regression. Multilevel and mixed effects models often require specialized data pre-processing and further post-estimation derivations and graphics to gain insight into model results. The package presented here, mlmtools', is a suite of pre- and post-estimation tools for multilevel models in R'. Package implements post-estimation tools designed to work with models estimated using lme4''s (Bates et al., 2014) lmer() function, which fits linear mixed effects regression models. Searle, S. R., Casella, G., & McCulloch, C. E. (2009, ISBN:978-0470009598). Bates, D., Mächler, M., Bolker, B., & Walker, S. (2014) <doi:10.18637/jss.v067.i01>.

This package provides functions, which make matrix creation conciser (such as the core package's function m() for rowwise matrix definition or runifm() for random value matrices). Allows to set multiple matrix values at once, by using list of formulae. Provides additional matrix operators and dedicated plotting function.

This package provides functions for carrying out nonparametric hypothesis tests of the MCAR hypothesis based on the theory of Frechet classes and compatibility. Also gives functions for computing halfspace representations of the marginal polytope and related geometric objects.

This package provides a causal mediation approach under the counterfactual framework to test the significance of total, direct and indirect effects. In this approach, a group of methylated sites from a predefined region are utilized as the mediator, and the functional transformation is used to reduce the possible high dimension in the region-based methylated sites and account for their location information.

This package provides functions to enhance the available statistical analysis procedures in R by providing simple functions to analysis and visualize the 16S rRNA data.Here we present a tutorial with minimum working examples to demonstrate usage and dependencies.

Software to aid in modeling and analyzing mass-spectrometry-based proteome melting data. Quantitative data is imported and normalized and thermal behavior is modeled at the protein level. Methods exist for normalization, modeling, visualization, and export of results. For a general introduction to MS-based thermal profiling, see Savitski et al. (2014) <doi:10.1126/science.1255784>.

Computes the Nelson-Aalen estimator of the cumulative transition hazard for arbitrary Markov multistate models <ISBN:978-0-387-68560-1>.

This package provides tools to conduct Bayesian multivariate network meta-analysis providing - the single correlation coefficient model by Efthimiou et al. (2015) <doi:10.1093/biostatistics/kxu030>; - per-outcome treatment hierarchies using the surface under the cumulative ranking curve (SUCRA), the probability of best value, or median (or mean) ranks (Salanti et al., 2011) <doi:10.1016/j.jclinepi.2010.03.016>; - across-outcomes benefit-risk assessment using the ViÅ¡eKriterijumska Optimizacija I Kompromisno ReÅ¡enje (VIKOR) method (Opricovic & Tzeng, 2004) <doi:10.1016/S0377-2217(03)00020-1>; - convergence checks using trace plots, density plots, or the R-hat statistic; - forest plots of treatment estimates, scatter plots of per-outcome rankings, Hasse diagrams (Carlsen & Bruggemann, 2014) <doi:10.1002/cem.2569> to visualize the partial order of the treatments across all outcomes.

Utilizing a combination of machine learning models (Random Forest, Naive Bayes, K-Nearest Neighbor, Support Vector Machines, Extreme Gradient Boosting, and Linear Discriminant Analysis) and a deep Artificial Neural Network model, MBMethPred can predict medulloblastoma subgroups, including wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4 from DNA methylation beta values. See Sharif Rahmani E, Lawarde A, Lingasamy P, Moreno SV, Salumets A and Modhukur V (2023), MBMethPred: a computational framework for the accurate classification of childhood medulloblastoma subgroups using data integration and AI-based approaches. Front. Genet. 14:1233657. <doi: 10.3389/fgene.2023.1233657> for more details.

The MARSS package provides maximum-likelihood parameter estimation for constrained and unconstrained linear multivariate autoregressive state-space (MARSS) models, including partially deterministic models. MARSS models are a class of dynamic linear model (DLM) and vector autoregressive model (VAR) model. Fitting available via Expectation-Maximization (EM), BFGS (using optim), and TMB (using the marssTMB companion package). Functions are provided for parametric and innovations bootstrapping, Kalman filtering and smoothing, model selection criteria including bootstrap AICb, confidences intervals via the Hessian approximation or bootstrapping, and all conditional residual types. See the user guide for examples of dynamic factor analysis, dynamic linear models, outlier and shock detection, and multivariate AR-p models. Online workshops (lectures, eBook, and computer labs) at <https://atsa-es.github.io/>.

Matrix eQTL is designed for fast eQTL analysis on large datasets. Matrix eQTL can test for association between genotype and gene expression using linear regression with either additive or ANOVA genotype effects. The models can include covariates to account for factors as population stratification, gender, and clinical variables. It also supports models with heteroscedastic and/or correlated errors, false discovery rate estimation and separate treatment of local (cis) and distant (trans) eQTLs. For more details see Shabalin (2012) <doi:10.1093/bioinformatics/bts163>.

Maximum likelihood estimates are obtained via an EM algorithm with either a first-order or a fully exponential Laplace approximation as documented by Broatch and Karl (2018) <doi:10.48550/arXiv.1710.05284>, Karl, Yang, and Lohr (2014) <doi:10.1016/j.csda.2013.11.019>, and by Karl (2012) <doi:10.1515/1559-0410.1471>. Karl and Zimmerman <doi:10.1016/j.jspi.2020.06.004> use this package to illustrate how the home field effect estimator from a mixed model can be biased under nonrandom scheduling.

The goal of midr is to provide a model-agnostic method for interpreting and explaining black-box predictive models by creating a globally interpretable surrogate model. The package implements Maximum Interpretation Decomposition (MID), a functional decomposition technique that finds an optimal additive approximation of the original model. This approximation is achieved by minimizing the squared error between the predictions of the black-box model and the surrogate model. The theoretical foundations of MID are described in Iwasawa & Matsumori (2025) [Forthcoming], and the package itself is detailed in Asashiba et al. (2025) <doi:10.48550/arXiv.2506.08338>.

BEAST2 (<https://www.beast2.org>) is a widely used Bayesian phylogenetic tool, that uses DNA/RNA/protein data and many model priors to create a posterior of jointly estimated phylogenies and parameters. mcbette allows to do a Bayesian model comparison over some site and clock models, using babette (<https://github.com/ropensci/babette/>).

Work with Microsoft Access .mdb and .accdb files using the open source MDB Tools library <https://github.com/mdbtools/mdbtools/>. The library is compiled and bundled with the package, so no external installation is required. Provides high-level helpers for reading tables, exporting to CSV or JSON, inspecting table definitions, and running SQL queries. Also exposes a full read-only DBI interface for use with standard database workflows.

Producing high-quality documents suitable for publication directly from R is made possible by the R Markdown ecosystem. memoiR makes it easy. It provides templates to knit memoirs, articles and slideshows with helpers to publish the documents on GitHub Pages and activate continuous integration.

The number of biological databases is growing rapidly, but different databases use different IDs to refer to the same biological entity. The inconsistency in IDs impedes the integration of various types of biological data. To resolve the problem, we developed MantaID', a data-driven, machine-learning based approach that automates identifying IDs on a large scale. The MantaID model's prediction accuracy was proven to be 99%, and it correctly and effectively predicted 100,000 ID entries within two minutes. MantaID supports the discovery and exploitation of ID patterns from large quantities of databases. (e.g., up to 542 biological databases). An easy-to-use freely available open-source software R package, a user-friendly web application, and API were also developed for MantaID to improve applicability. To our knowledge, MantaID is the first tool that enables an automatic, quick, accurate, and comprehensive identification of large quantities of IDs, and can therefore be used as a starting point to facilitate the complex assimilation and aggregation of biological data across diverse databases.

Conjoint measurement is a psychophysical procedure in which stimulus pairs are presented that vary along 2 or more dimensions and the observer is required to compare the stimuli along one of them. This package contains functions to estimate the contribution of the n scales to the judgment by a maximum likelihood method under several hypotheses of how the perceptual dimensions interact. Reference: Knoblauch & Maloney (2012) "Modeling Psychophysical Data in R". <doi:10.1007/978-1-4614-4475-6>.