The level-dependent cross-validation method is implemented for the selection of thresholding value in wavelet shrinkage. This procedure is implemented by coupling a conventional cross validation with an imputation method due to a limitation of data length, a power of 2. It can be easily applied to classical leave-one-out and k-fold cross validation. Since the procedure is computationally fast, a level-dependent cross validation can be performed for wavelet shrinkage of various data such as a data with correlated errors.

Access chemical, hazard, bioactivity, and exposure data from the Computational Toxicology and Exposure ('CTX') APIs <https://api-ccte.epa.gov/docs/>. ccdR was developed to streamline the process of accessing the information available through the CTX APIs without requiring prior knowledge of how to use APIs. Most data is also available on the CompTox Chemical Dashboard ('CCD') <https://comptox.epa.gov/dashboard/> and other resources found at the EPA Computational Toxicology and Exposure Online Resources <https://www.epa.gov/comptox-tools>.

Enables simultaneous statistical inference for the accuracy of multiple classifiers in multiple subgroups (strata). For instance, allows to perform multiple comparisons in diagnostic accuracy studies with co-primary endpoints sensitivity and specificity (Westphal M, Zapf A. Statistical inference for diagnostic test accuracy studies with multiple comparisons. Statistical Methods in Medical Research. 2024;0(0). <doi:10.1177/09622802241236933>).

Calculate p-values and confidence intervals using cluster-adjusted t-statistics (based on Ibragimov and Muller (2010) <DOI:10.1198/jbes.2009.08046>, pairs cluster bootstrapped t-statistics, and wild cluster bootstrapped t-statistics (the latter two techniques based on Cameron, Gelbach, and Miller (2008) <DOI:10.1162/rest.90.3.414>. Procedures are included for use with GLM, plm (pooling or fixed effects), and mlogit models.

This package implements a methodology for using cell volume distributions to estimate cell growth rates and division times that is described in the paper, "Cell Volume Distributions Reveal Cell Growth Rates and Division Times", by Michael Halter, John T. Elliott, Joseph B. Hubbard, Alessandro Tona and Anne L. Plant, which appeared in the Journal of Theoretical Biology. In order to reproduce the analysis used to obtain Table 1 in the paper, execute the command "example(fitVolDist)".

Implementation of case-control data analysis using likelihood ratio approaches and logistic regression for the classification of variants of uncertain significance (VUS) in breast, ovarian, or custom cancer susceptibility genes.

This package provides a collection of functions that make it easier to understand crime (or other) data, and assist others in understanding it. The package helps you read data from various sources, clean it, fix column names, and graph the data.

Processes survey data and displays estimation results along with the relative standard error in a table, including the number of samples and also uses a t-distribution approach to compute confidence intervals, similar to SPSS (Statistical Package for the Social Sciences) software.

Collective matrix factorization (CMF) finds joint low-rank representations for a collection of matrices with shared row or column entities. This code learns a variational Bayesian approximation for CMF, supporting multiple likelihood potentials and missing data, while identifying both factors shared by multiple matrices and factors private for each matrix. For further details on the method see Klami et al. (2014) <arXiv:1312.5921>. The package can also be used to learn Bayesian canonical correlation analysis (CCA) and group factor analysis (GFA) models, both of which are special cases of CMF. This is likely to be useful for people looking for CCA and GFA solutions supporting missing data and non-Gaussian likelihoods. See Klami et al. (2013) <https://research.cs.aalto.fi/pml/online-papers/klami13a.pdf> and Virtanen et al. (2012) <http://proceedings.mlr.press/v22/virtanen12.html> for details on Bayesian CCA and GFA, respectively.

The CalMaTe method calibrates preprocessed allele-specific copy number estimates (ASCNs) from DNA microarrays by controlling for single-nucleotide polymorphism-specific allelic crosstalk. The resulting ASCNs are on average more accurate, which increases the power of segmentation methods for detecting changes between copy number states in tumor studies including copy neutral loss of heterozygosity. CalMaTe applies to any ASCNs regardless of preprocessing method and microarray technology, e.g. Affymetrix and Illumina.

Fits cumulative link models (CLMs) for ordinal categorical data using CmdStanR'. Supports various link functions including logit, probit, cloglog, loglog, cauchit, and flexible parametric links such as Generalized Extreme Value (GEV), Asymmetric Exponential Power (AEP), and Symmetric Power. Models are pre-compiled using the instantiate package for fast execution without runtime compilation. Methods are described in Agresti (2010, ISBN:978-0-470-08289-8), Wang and Dey (2011) <doi:10.1007/s10651-010-0154-8>, and Naranjo, Perez, and Martin (2015) <doi:10.1007/s11222-014-9449-1>.

This package implements functions for comparing strings, sequences and numeric vectors for clustering and record linkage applications. Supported comparison functions include: generalized edit distances for comparing sequences/strings, Monge-Elkan similarity for fuzzy comparison of token sets, and L-p distances for comparing numeric vectors. Where possible, comparison functions are implemented in C/C++ to ensure good performance.

Biotechnology in spatial omics has advanced rapidly over the past few years, enhancing both throughput and resolution. However, existing annotation pipelines in spatial omics predominantly rely on clustering methods, lacking the flexibility to integrate extensive annotated information from single-cell RNA sequencing (scRNA-seq) due to discrepancies in spatial resolutions, species, or modalities. Here we introduce the CAESAR suite, an open-source software package that provides image-based spatial co-embedding of locations and genomic features. It uniquely transfers labels from scRNA-seq reference, enabling the annotation of spatial omics datasets across different technologies, resolutions, species, and modalities, based on the conserved relationship between signature genes and cells/locations at an appropriate level of granularity. Notably, CAESAR enriches location-level pathways, allowing for the detection of gradual biological pathway activation within spatially defined domain types. More details on the methods related to our paper currently under submission. A full reference to the paper will be provided in future versions once the paper is published.

This package provides R users with direct access to genomic and clinical data from the cBioPortal web resource via user-friendly functions that wrap cBioPortal's existing API endpoints <https://www.cbioportal.org/api/swagger-ui/index.html>. Users can browse and query genomic data on mutations, copy number alterations and fusions, as well as data on tumor mutational burden ('TMB'), microsatellite instability status ('MSI'), FACETS and select clinical data points (depending on the study). See <https://www.cbioportal.org/> and Gao et al., (2013) <doi:10.1126/scisignal.2004088> for more information on the cBioPortal web resource.

Synthesizing joint distributions from marginal densities, focusing on controlling key statistical properties such as correlation for continuous data, mutual information for categorical data, and inducing Simpson's Paradox. Generate datasets with specified correlation structures for continuous variables, adjust mutual information between categorical variables, and manipulate subgroup correlations to intentionally create Simpson's Paradox. Joe (1997) <doi:10.1201/b13150> Sklar (1959) <https://en.wikipedia.org/wiki/Sklar%27s_theorem>.

Offers a diverse collection of datasets focused on cardiovascular and heart disease research, including heart failure, myocardial infarction, aortic dissection, transplant outcomes, cardiovascular risk factors, drug efficacy, and mortality trends. Designed for researchers, clinicians, epidemiologists, and data scientists, the package features clinical, epidemiological, and simulated datasets covering a wide range of conditions and treatments such as statins, anticoagulants, and beta blockers. It supports analyses related to disease progression, treatment effects, rehospitalization, and public health outcomes across various cardiovascular patient populations.

Discover causality for bivariate categorical data. This package aims to enable users to discover causality for bivariate observational categorical data. See Ni, Y. (2022) <arXiv:2209.08579> "Bivariate Causal Discovery for Categorical Data via Classification with Optimal Label Permutation. Advances in Neural Information Processing Systems 35 (in press)".

Fits constrained groupwise additive index models and provides functions for inference and interpretation of these models. The method is described in Masselot, Chebana, Campagna, Lavigne, Ouarda, Gosselin (2022) "Constrained groupwise additive index models" <doi:10.1093/biostatistics/kxac023>.

Core functions for simulating quantities of interest from generalised linear models (GLM). This package will form the backbone of a series of other packages that improve the interpretation of GLM estimates.

Estimation of Markov generator matrices from discrete-time observations. The implemented approaches comprise diagonal and weighted adjustment of matrix logarithm based candidate solutions as in Israel (2001) <doi:10.1111/1467-9965.00114> as well as a quasi-optimization approach. Moreover, the expectation-maximization algorithm and the Gibbs sampling approach of Bladt and Sorensen (2005) <doi:10.1111/j.1467-9868.2005.00508.x> are included.

Composite Kernel Machine Regression based on Likelihood Ratio Test (CKLRT): in this package, we develop a kernel machine regression framework to model the overall genetic effect of a SNP-set, considering the possible GE interaction. Specifically, we use a composite kernel to specify the overall genetic effect via a nonparametric function and we model additional covariates parametrically within the regression framework. The composite kernel is constructed as a weighted average of two kernels, one corresponding to the genetic main effect and one corresponding to the GE interaction effect. We propose a likelihood ratio test (LRT) and a restricted likelihood ratio test (RLRT) for statistical significance. We derive a Monte Carlo approach for the finite sample distributions of LRT and RLRT statistics. (N. Zhao, H. Zhang, J. Clark, A. Maity, M. Wu. Composite Kernel Machine Regression based on Likelihood Ratio Test with Application for Combined Genetic and Gene-environment Interaction Effect (Submitted).).

This package provides an array of statistical models common in causal inference such as standardization, IP weighting, propensity matching, outcome regression, and doubly-robust estimators. Estimates of the average treatment effects from each model are given with the standard error and a 95% Wald confidence interval (Hernan, Robins (2020) <https://miguelhernan.org/whatifbook/>).

Several authors have proposed methods for constructing simultaneous confidence intervals for multinomial proportions. The package implements seven classical approachesâ Wilson, Quesenberry and Hurst, Goodman, Wald (with and without continuity correction), Fitzpatrick and Scott, and Sison and Glazâ along with Bayesian methods based on Dirichlet models. Both equal and unequal Dirichlet priors are supported, providing a broad framework for inference, data analysis, and sensitivity evaluation.

Fork of calendR R package to generate ready to print calendars with ggplot2 (see <https://r-coder.com/calendar-plot-r/>) with additional features (backwards compatible). calendRio provides a calendR() function that serves as a drop-in replacement for the upstream version but allows for additional parameters unlocking extra functionality.