This package provides tools for fitting periodic coefficients regression models to data where periodicity plays a crucial role. It allows users to model and analyze relationships between variables that exhibit cyclical or seasonal patterns, offering functions for estimating parameters and testing the periodicity of coefficients in linear regression models. For simple periodic coefficient regression model see Regui et al. (2024) <doi:10.1080/03610918.2024.2314662>.

The original definition of the two and three dimensional Kolmogorov-Smirnov two-sample test statistics given by Peacock (1983) is implemented. Two R-functions: peacock2 and peacock3, are provided to compute the test statistics in two and three dimensional spaces, respectively. Note the Peacock test is different from the Fasano and Franceschini test (1987). The latter is a variant of the Peacock test.

This package provides classes to pre-process microarray gene expression data as part of the OOMPA collection of packages described at <http://oompa.r-forge.r-project.org/>.

This package provides tools for exploratory process data analysis. Process data refers to the data describing participants problem-solving processes in computer-based assessments. It is often recorded in computer log files. This package provides functions to read, process, and write process data. It also implements two feature extraction methods to compress the information stored in process data into standard numerical vectors. This package also provides recurrent neural network based models that relate response processes with other binary or scale variables of interest. The functions that involve training and evaluating neural networks are wrappers of functions in keras'.

This package provides a versatile R visualization package that empowers researchers with comprehensive visualization tools for seamlessly mapping peptides to protein sequences, identifying distinct domains and regions of interest, accentuating mutations, and highlighting post-translational modifications, all while enabling comparisons across diverse experimental conditions. Potential applications of PepMapViz include the visualization of cross-software mass spectrometry results at the peptide level for specific protein and domain details in a linearized format and post-translational modification coverage across different experimental conditions; unraveling insights into disease mechanisms. It also enables visualization of Major histocompatibility complex-presented peptide clusters in different antibody regions predicting immunogenicity in antibody drug development.

Conduct a priori power analyses via Monte-Carlo style data simulation for linear and generalized linear mixed-effects models (LMMs/GLMMs). Provides a user-friendly workflow with helper functions to easily define fixed and random effects as well as diagnostic functions to evaluate the adequacy of the results of the power analysis.

Fit calibrations curves for clinical prediction models and calculate several associated metrics (Eavg, E50, E90, Emax). Ideally predicted probabilities from a prediction model should align with observed probabilities. Calibration curves relate predicted probabilities (or a transformation thereof) to observed outcomes via a flexible non-linear smoothing function. pmcalibration allows users to choose between several smoothers (regression splines, generalized additive models/GAMs, lowess, loess). Both binary and time-to-event outcomes are supported. See Van Calster et al. (2016) <doi:10.1016/j.jclinepi.2015.12.005>; Austin and Steyerberg (2019) <doi:10.1002/sim.8281>; Austin et al. (2020) <doi:10.1002/sim.8570>.

This package contains the core methods for the evaluation of principal surrogates in a single clinical trial. Provides a flexible interface for defining models for the risk given treatment and the surrogate, the models for integration over the missing counterfactual surrogate responses, and the estimation methods. Estimated maximum likelihood and pseudo-score can be used for estimation, and the bootstrap for inference. A variety of post-estimation summary methods are provided, including print, summary, plot, and testing.

Easy and efficient access to the API provided by Prevedere', an industry insights and predictive analytics company. Query and download indicators, models and workbenches built with Prevedere for further analysis and reporting <https://www.prevedere.com/>.

This package provides data set and function for exploration of Multiple Indicator Cluster Survey (MICS) 2017-18 Household questionnaire data for Punjab, Pakistan. The results of the present survey are critically important for the purposes of SDG monitoring, as the survey produces information on 32 global SDG indicators. The data was collected from 53,840 households selected at the second stage with systematic random sampling out of a sample of 2,692 clusters selected using Probability Proportional to size sampling. Six questionnaires were used in the survey: (1) a household questionnaire to collect basic demographic information on all de jure household members (usual residents), the household, and the dwelling; (2) a water quality testing questionnaire administered in three households in each cluster of the sample; (3) a questionnaire for individual women administered in each household to all women age 15-49 years; (4) a questionnaire for individual men administered in every second household to all men age 15-49 years; (5) an under-5 questionnaire, administered to mothers (or caretakers) of all children under 5 living in the household; and (6) a questionnaire for children age 5-17 years, administered to the mother (or caretaker) of one randomly selected child age 5-17 years living in the household (<http://www.mics.unicef.org/surveys>).

Estimates two-level multilevel linear model and two-level multivariate linear multilevel model with weights following Probability Weighted Iterative Generalised Least Squares approach. For details see Veiga et al.(2014) <doi:10.1111/rssc.12020>.

Projection pursuit (PP) with 17 methods and grand tour with 3 methods. Being that projection pursuit searches for low-dimensional linear projections in high-dimensional data structures, while grand tour is a technique used to explore multivariate statistical data through animation.

Permutation (randomisation) test for single-case phase design data with two phases (e.g., pre- and post-treatment). Correction for dependency of observations is done through stepwise resampling the time series while varying the distance between observations. The required distance 0,1,2,3.. is determined based on repeated dependency testing while stepwise increasing the distance. In preparation: Vroegindeweij et al. "A Permutation distancing test for single-case observational AB phase design data: A Monte Carlo simulation study".

An implementation of a non-parametric statistical model using a parallelised Monte Carlo sampling scheme. The method implemented in this package allows non-parametric inference to be regularized for small sample sizes, while also being more accurate than approximations such as variational Bayes. The concentration parameter is an effective sample size parameter, determining the faith we have in the model versus the data. When the concentration is low, the samples are close to the exact Bayesian logistic regression method; when the concentration is high, the samples are close to the simplified variational Bayes logistic regression. The method is described in full in the paper Lyddon, Walker, and Holmes (2018), "Nonparametric learning from Bayesian models with randomized objective functions" <arXiv:1806.11544>.

This package provides functions for bootstrapping the power of ANOVA designs based on estimated means and standard deviations of the conditions. Please refer to the documentation of the boot.power.anova() function for further details.

Simulate the dynamic of lion populations using a specific Individual-Based Model (IBM) compiled in C.

Reads/write binary genotype file compatible with PLINK <https://www.cog-genomics.org/plink/1.9/input#bed> into/from a R matrix; traverse genotype data one windows of variants at a time, like apply() or a for loop; reads/writes genotype relatedness/kinship matrices created by PLINK <https://www.cog-genomics.org/plink/1.9/distance#make_rel> or GCTA <https://cnsgenomics.com/software/gcta/#MakingaGRM> into/from a R square matrix. It is best used for bringing data produced by PLINK and GCTA into R workflow.

This package provides a figure region is prepared, creating a plot region with suitable background color, grid lines or shadings, and providing axes and labeling if not suppressed. Subsequently, information carrying graphics elements can be added (points, lines, barplot with add=TRUE and so forth).

An interface to compute poverty and inequality indicators for more than 160 countries and regions from the World Bank's database of household surveys, through the Poverty and Inequality Portal (PIP).

Generic code for estimating treatment effects with panel data. The idea is to break into separate steps organizing the data, looping over groups and time periods, computing group-time average treatment effects, and aggregating group-time average treatment effects. Often, one is able to implement a new identification/estimation procedure by simply replacing the step on estimating group-time average treatment effects. See several different examples of this approach in the package documentation.

Calibrate p-values under a robust perspective using the methods developed by Sellke, Bayarri, and Berger (2001) <doi:10.1198/000313001300339950> and obtain measures of the evidence provided by the data in favor of point null hypotheses which are safer and more straightforward to interpret.

This package contains functions to fit proportional hazards (PH) model to partly interval-censored (PIC) data (Pan et al. (2020) <doi:10.1177/0962280220921552>), PH model with spatial frailty to spatially dependent PIC data (Pan and Cai (2021) <doi:10.1080/03610918.2020.1839497>), and mixed effects PH model to clustered PIC data. Each random intercept/random effect can follow both a normal prior and a Dirichlet process mixture prior. It also includes the corresponding functions for general interval-censored data.

This package provides a collection of functions for modelling mutations in pedigrees with marker data, as used e.g. in likelihood computations with microsatellite data. Implemented models include equal, proportional and stepwise models, as well as random models for experimental work, and custom models allowing the user to apply any valid mutation matrix. Allele lumping is done following the lumpability criteria of Kemeny and Snell (1976), ISBN:0387901922.

This package provides tools to import, clean, and visualize movement data, particularly from motion capture systems such as Optitrack's Motive', the Straw Lab's Flydra', or from other sources. We provide functions to remove artifacts, standardize tunnel position and tunnel axes, select a region of interest, isolate specific trajectories, fill gaps in trajectory data, and calculate 3D and per-axis velocity. For experiments of visual guidance, we also provide functions that use subject position to estimate perception of visual stimuli.