Implementation of the MarkerPen algorithm, short for marker gene detection via penalized principal component analysis, described in the paper by Qiu, Wang, Lei, and Roeder (2021, <doi:10.1093/bioinformatics/btab257>). MarkerPen is a semi-supervised algorithm for detecting marker genes by combining prior marker information with bulk transcriptome data.

Uses memory-mapping to enable the random access of elements of a text file of characters separated by characters as if it were a simple R(cpp) matrix.

It provides functions to compute the values of different modifications of the Rand and Wallace indices. The indices are used to measure the stability or similarity of two partitions obtained on two different sets of units with a non-empty intercept. Splitting and merging of clusters can (depends on the selected index) have a different effect on the value of the indices. The indices are proposed in Cugmas and Ferligoj (2018) <http://ibmi.mf.uni-lj.si/mz/2018/no-1/Cugmas2018.pdf>.

This package provides a graphical user interface (GUI) for performing Multidimensional Scaling applications and interactively analysing the results all within the GUI environment. The MDS-GUI provides means of performing Classical Scaling, Least Squares Scaling, Metric SMACOF, Non-Metric SMACOF, Kruskal's Analysis and Sammon Mapping with animated optimisation.

This package provides tools to perform interrupted-time series through a generalised least squares (GLS) framework on linear outcomes. Allows for multiple interventions and a control with ARMA (autoregressive and moving-average) correction. For more details see Lopez Bernal, Cummins, and Gasparrini (2017) <doi:10.1093/ije/dyw098>.

This package provides R6 objects to perform parallelized hyperparameter optimization and cross-validation. Hyperparameter optimization can be performed with Bayesian optimization (via rBayesianOptimization <https://cran.r-project.org/package=rBayesianOptimization>) and grid search. The optimized hyperparameters can be validated using k-fold cross-validation. Alternatively, hyperparameter optimization and validation can be performed with nested cross-validation. While mlexperiments focuses on core wrappers for machine learning experiments, additional learner algorithms can be supplemented by inheriting from the provided learner base class.

The tools for MicroRNA Set Enrichment Analysis can identify risk pathways(or prior gene sets) regulated by microRNA set in the context of microRNA expression data. (1) This package constructs a correlation profile of microRNA and pathways by the hypergeometric statistic test. The gene sets of pathways derived from the three public databases (Kyoto Encyclopedia of Genes and Genomes ('KEGG'); Reactome'; Biocarta') and the target gene sets of microRNA are provided by four databases('TarBaseV6.0'; mir2Disease'; miRecords'; miRTarBase';). (2) This package can quantify the change of correlation between microRNA for each pathway(or prior gene set) based on a microRNA expression data with cases and controls. (3) This package uses the weighted Kolmogorov-Smirnov statistic to calculate an enrichment score (ES) of a microRNA set that co-regulate to a pathway , which reflects the degree to which a given pathway is associated with the specific phenotype. (4) This package can provide the visualization of the results.

Pipeline for Genome-Wide Association Study using Multi-Locus Mixed Model from Segura V, Vilhjálmsson BJ et al. (2012) <doi:10.1038/ng.2314>. The pipeline include detection of associated SNPs with MLMM, model selection by lowest eBIC and p-value threshold, estimation of the effects of the SNPs in the selected model and graphical functions.

Get map data frames for the Indian subcontinent with different region levels (e.g., district, state). The package also offers convenience functions for plotting choropleths, visualizing spatial data, and handling state/district codes.

Multivariate Surrogate Synchrony ('mvSUSY') estimates the synchrony within datasets that contain more than two time series. mvSUSY was developed from Surrogate Synchrony ('SUSY') with respect to implementing surrogate controls, and extends synchrony estimation to multivariate data. mvSUSY works as described in Meier & Tschacher (2021).

This package provides functions to perform sensitivity analysis on a model with multivariate output.

Calculate morphine milligram equivalents (MME) for opioid dose comparison using standardized methods. Can directly call the NIH HEAL MME Online Calculator <https://research-mme.wakehealth.edu/api> API or replicate API calculations on the user's local machine from the comfort of R'. Creation of the NIH HEAL MME Online Calculator and the MME calculations implemented in this package are described in Adams MCB, Sward KA, Perkins ML, Hurley RW (2025) <doi:10.1097/j.pain.0000000000003529>.

An ensemble classifier for multiclass classification. This is a novel classifier that natively works as an ensemble. It projects data on a large number of matrices, and uses very simple classifiers on each of these projections. The results are then combined, ideally via Dempster-Shafer Calculus.

This package provides a function to perform bias diagnostics on linear mixed models fitted with lmer() from the lme4 package. Implements permutation tests for assessing the bias of fixed effects, as described in Karl and Zimmerman (2021) <doi:10.1016/j.jspi.2020.06.004>. Karl and Zimmerman (2020) <doi:10.17632/tmynggddfm.1> provide R code for implementing the test using mvglmmRank output. Development of this package was assisted by GPT o1-preview for code structure and documentation.

Read, process, and analyse data from muscle near-infrared spectroscopy (mNIRS) devices. Import raw data from .csv or .xls(x) files and return time-series data and metadata. Includes standardised methods for cleaning, filtering, and pre-processing mNIRS data for subsequent analysis. Also includes a custom plot theme and colour palette. Intended for mNIRS researchers and practitioners in exercise physiology, sports science, and clinical rehabilitation with minimal coding experience required.

This package provides functions to access data from public RESTful APIs including REST Countries API', World Bank API', and Nager.Date API', covering Mexico's economic indicators, population statistics, literacy rates, international geopolitical information and official public holidays. The package also includes curated datasets related to Mexico such as air quality monitoring stations, pollution zones, income surveys, postal abbreviations, election studies, forest productivity and demographic data by state. It supports research and analysis focused on Mexico by integrating reliable global APIs with structured national datasets drawn from open and academic sources. For more information on the APIs, see: REST Countries API <https://restcountries.com/>, World Bank API <https://datahelpdesk.worldbank.org/knowledgebase/articles/889392>, and Nager.Date API <https://date.nager.at/Api>.

An efficient implementation of the MCPMod (Multiple Comparisons and Modeling) method to support a simulation-based design and analysis of dose-finding trials with normally distributed, binary and count endpoints (Bretz et al. (2005) <doi:10.1111/j.1541-0420.2005.00344.x>).

This package provides functions and datasets to support Smilde, Næs and Liland (2021, ISBN: 978-1-119-60096-1) "Multiblock Data Fusion in Statistics and Machine Learning - Applications in the Natural and Life Sciences". This implements and imports a large collection of methods for multiblock data analysis with common interfaces, result- and plotting functions, several real data sets and six vignettes covering a range different applications.

The Iterative Proportional Fitting (IPF) algorithm operates on count data. This package offers implementations for several algorithms that extend this to nested structures: parent and child items for both of which constraints can be provided. The fitting algorithms include Iterative Proportional Updating <https://trid.trb.org/view/881554>, Hierarchical IPF <doi:10.3929/ethz-a-006620748>, Entropy Optimization <https://trid.trb.org/view/881144>, and Generalized Raking <doi:10.2307/2290793>. Additionally, a number of replication methods is also provided such as Truncate, replicate, sample <doi:10.1016/j.compenvurbsys.2013.03.004>.

This package provides methods for high-dimensional multi-view learning based on the multi-view stacking (MVS) framework. For technical details on the MVS and stacked penalized logistic regression (StaPLR) methods see Van Loon, Fokkema, Szabo, & De Rooij (2020) <doi:10.1016/j.inffus.2020.03.007> and Van Loon et al. (2022) <doi:10.3389/fnins.2022.830630>.

This package provides a unified framework for fitting, predicting, and interpreting nonlinear relationships in single-level, multilevel, and longitudinal regression models. Flexible functional forms are supported using natural cubic splines ('splines'), B-splines ('splines'), and GAM smooths ('mgcv'). Supports two-way and nested clustering via lme4', automatic knot selection by AIC or BIC, multilevel R-squared decomposition (Nakagawa-Schielzeth marginal and conditional R-squared with level-specific variance partitioning), a postestimation suite returning first and second derivatives with confidence bands, turning points and inflection regions, and a model comparison workflow contrasting linear, polynomial, and spline fits by AIC, BIC, and likelihood-ratio tests. Cluster heterogeneity in nonlinear effects is supported via random-slope spline terms.

An RStudio Addin wrapper for the mergen package. This package employs artificial intelligence to convert data analysis questions into executable code, explanations, and algorithms. This package makes it easier to use Large Language Models in your development environment by providing a chat-like interface, while also allowing you to inspect and execute the returned code.

This package provides routines for multivariate measurement error correction. Includes procedures for linear, logistic and Cox regression models. Bootstrapped standard errors and confidence intervals can be obtained for corrected estimates.

This package provides a framework to perform soft clustering using simplex-structured matrix factorisation (SSMF). The package contains a set of functions for determining the optimal number of prototypes, the optimal algorithmic parameters, the estimation confidence intervals and the diversity of clusters. Abdolali, Maryam & Gillis, Nicolas (2020) <doi:10.1137/20M1354982>.