This package provides a comprehensive suite for assessing multivariate normality using six statistical tests (Mardia, Henzeâ Zirkler, Henzeâ Wagner, Royston, Doornikâ Hansen, Energy). Also includes univariate diagnostics, bivariate density visualization, robust outlier detection, power transformations (e.g., Boxâ Cox, Yeoâ Johnson), and imputation strategies ("mean", "median", "mice") for handling missing data. Bootstrap resampling is supported for selected tests to improve p-value accuracy in small samples. Diagnostic plots are available via both ggplot2 and interactive plotly visualizations. See Korkmaz et al. (2014) <https://journal.r-project.org/archive/2014-2/korkmaz-goksuluk-zararsiz.pdf>.

Multi-criteria design of experiments algorithm that simultaneously optimizes up to six different criteria ('I', Id', D', Ds', A and As'). The algorithm finds the optimal Pareto front and, if requested, selects a possible symmetrical design on it. The symmetrical design is selected based on two techniques: minimum distance with the Utopia point or the TOPSIS approach.

Mass-balance-adjusted Regression algorithm for streamflow reconstruction at sub-annual resolution (e.g., seasonal or monthly). The algorithm implements a penalty term to minimize the differences between the total sub-annual flows and the annual flow. The method is described in Nguyen et al (2020) <DOI:10.1002/essoar.10504791.1>.

Perform multivariate modeling of evolved traits, with special attention to understanding the interplay of the multi-factorial determinants of their origins in complex ecological settings (Stephens, 2007 <doi:10.1016/j.tree.2006.12.003>). This software primarily concentrates on phylogenetic regression analysis, enabling implementation of tree transformation averaging and visualization functionality. Functions additionally support information theoretic approaches (Grueber, 2011 <doi:10.1111/j.1420-9101.2010.02210.x>; Garamszegi, 2011 <doi:10.1007/s00265-010-1028-7>) such as model averaging and selection of phylogenetic models. Accessory functions are also implemented for coef standardization (Cade 2015), selection uncertainty, and variable importance (Burnham & Anderson 2000). There are other numerous functions for visualizing confounded variables, plotting phylogenetic trees, as well as reporting and exporting modeling results. Lastly, as challenges to ecology are inherently multifarious, and therefore often multi-dataset, this package features several functions to support the identification, interpolation, merging, and updating of missing data and outdated nomenclature.

Implementing various things including functions for LaTeX tables, the Kalman filter, QQ-plots with simulation-based confidence intervals, linear regression diagnostics, web scraping, development tools, relative risk and odds rati, GARCH(1,1) Forecasting.

This package implements the generalization of the Shapiro-Wilk test for multivariate normality proposed by Villasenor-Alva and Gonzalez-Estrada (2009).

This package provides tools for the integration, visualisation, and modelling of spatial epidemiological data using the method described in Azeez, A., & Noel, C. (2025). Predictive Modelling and Spatial Distribution of Pancreatic Cancer in Africa Using Machine Learning-Based Spatial Model <doi:10.5281/zenodo.16529986> and <doi:10.5281/zenodo.16529016>. It facilitates the analysis of geographic health data by combining modern spatial mapping tools with advanced machine learning (ML) algorithms. mlspatial enables users to import and pre-process shapefile and associated demographic or disease incidence data, generate richly annotated thematic maps, and apply predictive models, including Random Forest, XGBoost', and Support Vector Regression, to identify spatial patterns and risk factors. It is suited for spatial epidemiologists, public health researchers, and GIS analysts aiming to uncover hidden geographic patterns in health-related outcomes and inform evidence-based interventions.

Makes it possible to create an internally consistent repository consisting of selected packages from CRAN-like repositories. The user specifies a set of desired packages, and miniCRAN recursively reads the dependency tree for these packages, then downloads only this subset. The user can then install packages from this repository directly, rather than from CRAN. This is useful in production settings, e.g. server behind a firewall, or remote locations with slow (or zero) Internet access.

Animal abundance estimation via conventional, multiple covariate and mark-recapture distance sampling (CDS/MCDS/MRDS). Detection function fitting is performed via maximum likelihood. Also included are diagnostics and plotting for fitted detection functions. Abundance estimation is via a Horvitz-Thompson-like estimator.

Detection of multivariate outliers using robust estimates of location and scale. The Minimum Covariance Determinant (MCD) estimator is used to calculate robust estimates of the mean vector and covariance matrix. Outliers are determined based on robust Mahalanobis distances using either an unstructured covariance matrix, a principal components structured covariance matrix, or a factor analysis structured covariance matrix. Includes options for specifying the direction of interest for outlier detection for each variable.

Implementation of the mid-n algorithms presented in Wellek S (2015) <DOI:10.1111/stan.12063> Statistica Neerlandica 69, 358-373 for exact sample size calculation for superiority trials with binary outcome.

This package provides functions and examples based on the m-out-of-n bootstrap suggested by Politis, D.N. and Romano, J.P. (1994) <doi:10.1214/aos/1176325770>. Additionally there are functions to estimate the scaling factor tau and the subsampling size m. For a detailed description and a full list of references, see Dalitz, C. and Lögler, F. (2024) <doi:10.48550/arXiv.2412.05032>.

Simultaneously estimates sparse regression coefficients and response network structure in multivariate models with missing data. Unlike traditional approaches requiring imputation, handles missingness natively through unbiased estimating equations (MCAR/MAR compatible). Employs dual L1 regularization with automated selection via cross-validation or information criteria. Includes parallel computation, warm starts, adaptive grids, publication-ready visualizations, and prediction methods. Ideal for genomics, neuroimaging, and multi-trait studies with incomplete high-dimensional outcomes. See Zeng et al. (2025) <doi:10.48550/arXiv.2507.05990>.

This package provides a Comprehensive tool for almost all existing multiple testing methods for multiple families. The package summarizes the existing methods for multiple families multiple testing procedures (MTPs) such as double FDR, group Benjamini-Hochberg (GBH) procedure and average FDR controlling procedure. The package also provides some novel multiple testing procedures using selective inference idea.

Modelling interacting microbial populations - example applications include human gut microbiota, rumen microbiota and phytoplankton. Solves a system of ordinary differential equations to simulate microbial growth and resource uptake over time. This version contains network visualisation functions.

Fits Bayesian time-course models for model-based network meta-analysis (MBNMA) that allows inclusion of multiple time-points from studies. Repeated measures over time are accounted for within studies by applying different time-course functions, following the method of Pedder et al. (2019) <doi:10.1002/jrsm.1351>. The method allows synthesis of studies with multiple follow-up measurements that can account for time-course for a single or multiple treatment comparisons. Several general time-course functions are provided; others may be added by the user. Various characteristics can be flexibly added to the models, such as correlation between time points and shared class effects. The consistency of direct and indirect evidence in the network can be assessed using unrelated mean effects models and/or by node-splitting.

Summarize multiple biomarker responses of aquatic organisms to contaminants using Cliffâ s delta, as described in Pham & Sokolova (2023) <doi:10.1002/ieam.4676>.

The purpose of this package is to share a collection of functions the author wrote during weekends for managing kitchen and garden tasks, e.g. making plant growth charts or Thanksgiving kitchen schedule charts, etc. Functions might include but not limited to: (1) aiding summarizing time related data; (2) generating axis transformation from data; and (3) aiding Markdown (with html output) and Shiny file editing.

Estimation, inference and diagnostics for Univariate Autoregressive Markov Switching Models for Linear and Generalized Models. Distributions for the series include gaussian, Poisson, binomial and gamma cases. The EM algorithm is used for estimation (see Perlin (2012) <doi:10.2139/ssrn.1714016>).

Generates derived parameter(s) from Monte Carlo Markov Chain (MCMC) samples using R code. This allows Bayesian models to be fitted without the inclusion of derived parameters which add unnecessary clutter and slow model fitting. For more information on MCMC samples see Brooks et al. (2011) <isbn:978-1-4200-7941-8>.

Cancer cells accumulate DNA mutations as result of DNA damage and DNA repair processes. This computational framework is aimed at deciphering DNA mutational signatures operating in cancer. The framework includes modules that support raw data import and processing, mutational signature extraction, and results interpretation and visualization. The framework accepts widely used file formats storing information about DNA variants, such as Variant Call Format files. The framework performs Non-Negative Matrix Factorization to extract mutational signatures explaining the observed set of DNA mutations. Bootstrapping is performed as part of the analysis. The framework supports parallelization and is optimized for use on multi-core systems. The software was described by Fantini D et al (2020) <doi:10.1038/s41598-020-75062-0> and is based on a custom R-based implementation of the original MATLAB WTSI framework by Alexandrov LB et al (2013) <doi:10.1016/j.celrep.2012.12.008>.

Generate central composite designs (CCD)with full as well as fractional factorial points (half replicate) and Box Behnken designs (BBD) with minimally changed run sequence.

Stand-alone HTTP capable R-package repository, that fully supports R's install.packages() and available.packages(). It also contains API endpoints for end-users to add/update packages. This package can supplement miniCRAN', which has functions for maintaining a local (partial) copy of CRAN'. Current version is bare-minimum without any access-control or much security.

Implement multiverse style analyses (Steegen S., Tuerlinckx F, Gelman A., Vanpaemal, W., 2016) <doi:10.1177/1745691616658637> to show the robustness of statistical inference. Multiverse analysis is a philosophy of statistical reporting where paper authors report the outcomes of many different statistical analyses in order to show how fragile or robust their findings are. The multiverse package (Sarma A., Kale A., Moon M., Taback N., Chevalier F., Hullman J., Kay M., 2021) <doi:10.31219/osf.io/yfbwm> allows users to concisely and flexibly implement multiverse-style analysis, which involve declaring alternate ways of performing an analysis step, in R and R Notebooks.