Computation of stopping boundaries for a single-arm trial using a Bayesian criterion; i.e., for each m<=n (n= total patient number of the trial) the smallest number of observed toxicities is calculated leading to the termination of the trial/accrual according to the specified criteria. The probabilities of stopping the trial/accrual at and up until (resp.) the m-th patient (m<=n) is also calculated. This design is more conservative than the frequentist approach (using Clopper Pearson CIs) which might be preferred as it concerns safety.See also Aamot et.al.(2010) "Continuous monitoring of toxicity in clinical trials - simulating the risk of stopping prematurely" <doi:10.5414/cpp48476>.

This package provides tools to download data series from Banco de España ('BdE') on tibble format. Banco de España is the national central bank and, within the framework of the Single Supervisory Mechanism ('SSM'), the supervisor of the Spanish banking system along with the European Central Bank. This package is in no way sponsored endorsed or administered by Banco de España'.

Create highly customized tables with this simple and dependency-free package. Data frames can be converted to HTML', LaTeX', Markdown', Word', PNG', PDF', or Typst tables. The user interface is minimalist and easy to learn. The syntax is concise. HTML tables can be customized using the flexible Bootstrap framework, and LaTeX code with the tabularray package.

This package provides functions such as str_crush(), add_missing_column(), coalesce_data() and drop_na_all() that complement tidyverse functionality or functions that provide alternative behaviors such as if_else2() and str_detect2().

This package provides a set of functions to implement Time Series Cointegrated System (TSCS) spatial interpolation and relevant data visualization.

Integrates several popular high-dimensional methods based on Linear Discriminant Analysis (LDA) and provides a comprehensive and user-friendly toolbox for linear, semi-parametric and tensor-variate classification as mentioned in Yuqing Pan, Qing Mai and Xin Zhang (2019) <arXiv:1904.03469>. Functions are included for covariate adjustment, model fitting, cross validation and prediction.

To handle higher-order tensor data. See Kolda and Bader (2009) <doi:10.1137/07070111X> for details on tensor. While existing packages on tensor data extend the base array class to some data classes, this package serves as an alternative resort to handle tensor only as array class. Some functionalities related to missingness are also supported.

Create HTML tables of descriptive statistics, as one would expect to see as the first table (i.e. "Table 1") in a medical/epidemiological journal article.

Simple trustworthy utility functions to use TauDEM (Terrain Analysis Using Digital Elevation Models <https://hydrology.usu.edu/taudem/taudem5/>) command-line interface. This package provides a guide to installation of TauDEM and its dependencies GDAL (Geopatial Data Abstraction Library) and MPI (Message Passing Interface) for different operating systems. Moreover, it checks that TauDEM and its dependencies are correctly installed and included to the PATH, and it provides wrapper commands for calling TauDEM methods from R.

This package implements rank preserving structural failure time model (RPSFTM), iterative parameter estimation (IPE), inverse probability of censoring weights (IPCW), marginal structural model (MSM), simple two-stage estimation (TSEsimp), and improved two-stage estimation with g-estimation (TSEgest) methods for treatment switching in randomized clinical trials.

This package provides functions and example files to calculate the tRNA adaptation index, a measure of the level of co-adaptation between the set of tRNA genes and the codon usage bias of protein-coding genes in a given genome. The methodology is described in dos Reis, Wernisch and Savva (2003) <doi:10.1093/nar/gkg897>, and dos Reis, Savva and Wernisch (2004) <doi:10.1093/nar/gkh834>.

The trapezoid package provides dtrapezoid', ptrapezoid', qtrapezoid', and rtrapezoid functions for the trapezoidal distribution.

This package provides a coherent interface to multiple modelling tools for fitting trends along with a standardised approach for generating confidence and prediction intervals.

Utilities for text analysis.

Statistical interpretation of forensic glass transfer (Simulation of the probability distribution of recovered glass fragments).

When plotting treated-minus-control differences, after-minus-before changes, or difference-in-differences, the ttrans() function symmetrically transforms the positive and negative tails to aid plotting. The package includes an observational study with three control groups and an unaffected outcome; see Rosenbaum (2022) <doi:10.1080/00031305.2022.2063944>.

This package provides ggplot2 geoms for drawing treemaps.

Cluster data without specifying the number of clusters using the Table Invitation Prior (TIP) introduced in the paper "Clustering Gene Expression Using the Table Invitation Prior" by Charles W. Harrison, Qing He, and Hsin-Hsiung Huang (2022) <doi:10.3390/genes13112036>. TIP is a Bayesian prior that uses pairwise distance and similarity information to cluster vectors, matrices, or tensors.

This package provides a collection of clinical trial designs and methods, implemented in rstan and R, including: the Continual Reassessment Method by O'Quigley et al. (1990) <doi:10.2307/2531628>; EffTox by Thall & Cook (2004) <doi:10.1111/j.0006-341X.2004.00218.x>; the two-parameter logistic method of Neuenschwander, Branson & Sponer (2008) <doi:10.1002/sim.3230>; and the Augmented Binary method by Wason & Seaman (2013) <doi:10.1002/sim.5867>; and more. We provide functions to aid model-fitting and analysis. The rstan implementations may also serve as a cookbook to anyone looking to extend or embellish these models. We hope that this package encourages the use of Bayesian methods in clinical trials. There is a preponderance of early phase trial designs because this is where Bayesian methods are used most. If there is a method you would like implemented, please get in touch.

This package provides functions to produce, fit and predict from bipartite networks with abundance, trait and phylogenetic information. Its methods are described in detail in Benadi, G., Dormann, C.F., Fruend, J., Stephan, R. & Vazquez, D.P. (2021) Quantitative prediction of interactions in bipartite networks based on traits, abundances, and phylogeny. The American Naturalist, in press.

This package provides two classes extending data.table class. Simple tableList class wraps data.table and any additional structures together. More complex tableMatrix class combines data.table and matrix'. See <http://github.com/InferenceTechnologies/tableMatrix> for more information and examples.

Analysis and visualization of data from temporal sensory methods, including for temporal check-all-that-apply (TCATA) and temporal dominance of sensations (TDS). Methods are mainly from manuscripts by Castura, J.C., Antúnez, L., Giménez, A., and Ares, G. (2016) <doi:10.1016/j.foodqual.2015.06.017>, Castura, Baker, and Ross (2016) <doi:10.1016/j.foodqual.2016.06.011>, and Pineau et al. (2009) <doi:10.1016/j.foodqual.2009.04.005>.

Calculate optimal Zhong's two-/three-stage Phase II designs (see Zhong (2012) <doi:10.1016/j.cct.2012.07.006>). Generate Target Toxicity decision table for Phase I dose-finding (two-/three-stage). This package also allows users to run dose-finding simulations based on customized decision table.

GUI for entering test items and obtaining raw and transformed scores. The results are shown on the console and can be saved to a tabular text file for further statistical analysis. The user can define his own tests and scoring procedures through a GUI.