This package implements different inventory models, the bullwhip effect and other supply chain performance variables. Marchena Marlene (2010) <arXiv:1009.3977>.

Finds causal connections in precision data, finds lags and embeddings in time series, guides training of neural networks and other smooth models, evaluates their performance, gives a mathematically grounded answer to the over-training problem. Smooth regression is based on the Gamma test, which measures smoothness in a multivariate relationship. Causal relations are smooth, noise is not. sr includes the Gamma test and search techniques that use it. References: Evans & Jones (2002) <doi:10.1098/rspa.2002.1010>, AJ Jones (2004) <doi:10.1007/s10287-003-0006-1>.

This package creates superpixels based on input spatial data. This package works on spatial data with one variable (e.g., continuous raster), many variables (e.g., RGB rasters), and spatial patterns (e.g., areas in categorical rasters). It is based on the SLIC algorithm (Achanta et al. (2012) <doi:10.1109/TPAMI.2012.120>), and readapts it to work with arbitrary dissimilarity measures.

Seamless and standardized interaction with data exported from the clinical data management system (CDMS) secuTrial'<https://www.secutrial.com>. The primary data export the package works with is a standard non-rectangular export.

Identifying cell types based on expression profiles is a pillar of single cell analysis. scROSHI identifies cell types based on expression profiles of single cell analysis by utilizing previously obtained cell type specific gene sets. It takes into account the hierarchical nature of cell type relationship and does not require training or annotated data. A detailed description of the method can be found at: Prummer, Bertolini, Bosshard, Barkmann, Yates, Boeva, The Tumor Profiler Consortium, Stekhoven, and Singer (2022) <doi:10.1101/2022.04.05.487176>.

This package performs a dual-parameter sensitivity analysis of treatment effect to unmeasured confounding in observational studies with either survival or competing risks outcomes. Huang, R., Xu, R. and Dulai, P.S.(2020) <doi:10.1002/sim.8672>.

Single cell resolution data has been valuable in learning about tissue microenvironments and interactions between cells or spots. This package allows for the simulation of this level of data, be it single cell or â spotsâ , in both a univariate (single metric or cell type) and bivariate (2 or more metrics or cell types) ways. As more technologies come to marker, more methods will be developed to derive spatial metrics from the data which will require a way to benchmark methods against each other. Additionally, as the field currently stands, there is not a gold standard method to be compared against. We set out to develop an R package that will allow users to simulate point patterns that can be biologically informed from different tissue domains, holes, and varying degrees of clustering/colocalization. The data can be exported as spatial files and a summary file (like HALO'). <https://github.com/FridleyLab/scSpatialSIM/>.

Estimating the force of infection from time varying, age varying, or constant serocatalytic models from population based seroprevalence studies using a Bayesian framework, including data simulation functions enabling the generation of serological surveys based on this models. This tool also provides a flexible prior specification syntax for the force of infection and the seroreversion rate, as well as methods to assess model convergence and comparison criteria along with useful visualisation functions.

This package contains tests for association between a set of genetic variants and multiple correlated outcomes that are interval censored. Interval-censored data arises when the exact time of the onset of an outcome of interest is unknown but known to fall between two time points.

The stratification of univariate populations under stratified sampling designs is implemented according to Khan et al. (2002) <doi:10.1177/0008068320020518> and Khan et al. (2015) <doi:10.1080/02664763.2015.1018674> in this library. It determines the Optimum Strata Boundaries (OSB) and Optimum Sample Sizes (OSS) for the study variable, y, using the best-fit frequency distribution of a survey variable (if data is available) or a hypothetical distribution (if data is not available). The method formulates the problem of determining the OSB as mathematical programming problem which is solved by using a dynamic programming technique. If a dataset of the population is available to the surveyor, the method estimates its best-fit distribution and determines the OSB and OSS under Neyman allocation directly. When the dataset is not available, stratification is made based on the assumption that the values of the study variable, y, are available as hypothetical realizations of proxy values of y from recent surveys. Thus, it requires certain distributional assumptions about the study variable. At present, it handles stratification for the populations where the study variable follows a continuous distribution, namely, Pareto, Triangular, Right-triangular, Weibull, Gamma, Exponential, Uniform, Normal, Log-normal and Cauchy distributions.

SEM Trees and SEM Forests -- an extension of model-based decision trees and forests to Structural Equation Models (SEM). SEM trees hierarchically split empirical data into homogeneous groups each sharing similar data patterns with respect to a SEM by recursively selecting optimal predictors of these differences. SEM forests are an extension of SEM trees. They are ensembles of SEM trees each built on a random sample of the original data. By aggregating over a forest, we obtain measures of variable importance that are more robust than measures from single trees. A description of the method was published by Brandmaier, von Oertzen, McArdle, & Lindenberger (2013) <doi:10.1037/a0030001> and Arnold, Voelkle, & Brandmaier (2020) <doi:10.3389/fpsyg.2020.564403>.

We propose a procedure for sample size calculation while controlling false discovery rate for RNA-seq experimental design. Our procedure depends on the Voom method proposed for RNA-seq data analysis by Law et al. (2014) <DOI:10.1186/gb-2014-15-2-r29> and the sample size calculation method proposed for microarray experiments by Liu and Hwang (2007) <DOI:10.1093/bioinformatics/btl664>. We develop a set of functions that calculates appropriate sample sizes for two-sample t-test for RNA-seq experiments with fixed or varied set of parameters. The outputs also contain a plot of power versus sample size, a table of power at different sample sizes, and a table of critical test values at different sample sizes. To install this package, please use source("http://bioconductor.org/biocLite.R"); biocLite("ssizeRNA")'. For R version 3.5 or greater, please use if(!requireNamespace("BiocManager", quietly = TRUE))install.packages("BiocManager"); BiocManager::install("ssizeRNA")'.

This package provides deep learning models for right-censored survival data using the torch backend. Supports multiple loss functions, including Cox partial likelihood, L2-penalized Cox, time-dependent Cox, and accelerated failure time (AFT) loss. Offers a formula-based interface, built-in support for cross-validation, hyperparameter tuning, survival curve plotting, and evaluation metrics such as the C-index, Brier score, and integrated Brier score. For methodological details, see Kvamme et al. (2019) <https://www.jmlr.org/papers/v20/18-424.html>.

This package provides a workflow based on machine learning methods to construct and compare single-cell gene regulatory networks (scGRN) using single-cell RNA-seq (scRNA-seq) data collected from different conditions. Uses principal component regression, tensor decomposition, and manifold alignment, to accurately identify even subtly shifted gene expression programs. See <doi:10.1016/j.patter.2020.100139> for more details.

This package provides tools for estimating empirical sample complexity bounds for supervised learning tasks. The package supports simulation-based estimates of generalization curves, parametric extrapolation of empirical sample complexity bounds, theoretical bounds based on Vapnik-Chervonenkis dimension, and optional monotone Gaussian process extrapolation for users who install the external cmdstanr workflow. For more details, see Carter and Choi (2024) <doi:10.31219/osf.io/evrcj>.

Perform association test within linear mixed model framework using score test integrated with Empirical Bayes for genome-wide association study. Firstly, score test was conducted for each marker under linear mixed model framework, taking into account the genetic relatedness and population structure. And then all the potentially associated markers were selected with a less stringent criterion. Finally, all the selected markers were placed into a multi-locus model to identify the true quantitative trait nucleotide.

Implementation of the Conditional Least Square (CLS) estimates and its covariance matrix for the first-order spatial integer-valued autoregressive model (SINAR(1,1)) proposed by Ghodsi (2012) <doi:10.1080/03610926.2011.560739>.

This package provides a customizable timer widget for shiny applications. Key features include countdown and count-up mode, multiple display formats (including simple seconds, minutes-seconds, hours-minutes-seconds, and minutes-seconds-centiseconds), ability to pause, resume, and reset the timer. shinytimer widget can be particularly useful for creating interactive and time-sensitive applications, tracking session times, setting time limits for tasks or quizzes, and more.

Bayesian clustering of spatial regions with similar functional shapes using spanning trees and latent Gaussian models. The method enforces spatial contiguity within clusters and supports a wide range of latent Gaussian models, including non-Gaussian likelihoods, via the R-INLA framework. The algorithm is based on Zhong, R., Chacón-Montalván, E. A., and Moraga, P. (2024) <doi:10.48550/arXiv.2407.12633>, extending the approach of Zhang, B., Sang, H., Luo, Z. T., and Huang, H. (2023) <doi:10.1214/22-AOAS1643>. The package includes tools for model fitting, convergence diagnostics, visualization, and summarization of clustering results.

This package contains fast functions to calculate the exact Bayes posterior for the Sparse Normal Sequence Model, implementing the algorithms described in Van Erven and Szabo (2021, <doi:10.1214/20-BA1227>). For general hierarchical priors, sample sizes up to 10,000 are feasible within half an hour on a standard laptop. For beta-binomial spike-and-slab priors, a faster algorithm is provided, which can handle sample sizes of 100,000 in half an hour. In the implementation, special care has been taken to assure numerical stability of the methods even for such large sample sizes.

Affords researchers the ability to draw stratified samples from the U.S. Department of Veteran's Affairs/Department of Defense Identity Repository (VADIR) database according to a variety of population characteristics. The VADIR database contains information for all veterans who were separated from the military after 1980. The central utility of the present package is to integrate data cleaning and formatting for the VADIR database with the stratification methods described by Mahto (2019) <https://CRAN.R-project.org/package=splitstackshape>. Data from VADIR are not provided as part of this package.

This package provides a set of tools inspired by Stata to explore data.frames ('summarize', tabulate', xtile', pctile', binscatter', elapsed quarters/month, lead/lag).

Identifies single nucleotide variants in next-generation sequencing data by estimating their local false discovery rates. For more details, see Karimnezhad, A. and Perkins, T. J. (2024) <doi:10.1038/s41598-024-51958-z>.

Automates the creation of Dockerfiles for deploying Shiny applications. By integrating with renv for dependency management and leveraging Docker-based solutions, it simplifies the process of containerizing Shiny apps, ensuring reproducibility and consistency across different environments. Additionally, it facilitates the setup of CI/CD pipelines for building Docker images on both GitLab and GitHub.