An Electronic Data Capture system (EDC) and Data Standard agnostic solution that enables the pharmaceutical programming community to develop Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM) datasets in R. The reusable algorithms concept in sdtm.oak provides a framework for modular programming and can potentially automate the conversion of raw clinical data to SDTM through standardized SDTM specifications. SDTM is one of the required standards for data submission to the Food and Drug Administration (FDA) in the United States and Pharmaceuticals and Medical Devices Agency (PMDA) in Japan. SDTM standards are implemented following the SDTM Implementation Guide as defined by CDISC <https://www.cdisc.org/standards/foundational/sdtmig>.

We propose a procedure for sample size calculation while controlling false discovery rate for RNA-seq experimental design. Our procedure depends on the Voom method proposed for RNA-seq data analysis by Law et al. (2014) <DOI:10.1186/gb-2014-15-2-r29> and the sample size calculation method proposed for microarray experiments by Liu and Hwang (2007) <DOI:10.1093/bioinformatics/btl664>. We develop a set of functions that calculates appropriate sample sizes for two-sample t-test for RNA-seq experiments with fixed or varied set of parameters. The outputs also contain a plot of power versus sample size, a table of power at different sample sizes, and a table of critical test values at different sample sizes. To install this package, please use source("http://bioconductor.org/biocLite.R"); biocLite("ssizeRNA")'. For R version 3.5 or greater, please use if(!requireNamespace("BiocManager", quietly = TRUE))install.packages("BiocManager"); BiocManager::install("ssizeRNA")'.

An overall test for seasonality of a given time series in addition to a set of individual seasonality tests as described by Ollech and Webel (forthcoming): An overall seasonality test. Bundesbank Discussion Paper.

Discovery of spatial patterns with Hidden Markov Random Field. This package is designed for spatial transcriptomic data and single molecule fluorescent in situ hybridization (FISH) data such as sequential fluorescence in situ hybridization (seqFISH) and multiplexed error-robust fluorescence in situ hybridization (MERFISH). The methods implemented in this package are described in Zhu et al. (2018) <doi:10.1038/nbt.4260>.

Implementation of hybrid STL decomposition based time delay neural network model for univariate time series forecasting. For method details see Jha G K, Sinha, K (2014). <doi:10.1007/s00521-012-1264-z>, Xiong T, Li C, Bao Y (2018). <doi:10.1016/j.neucom.2017.11.053>.

Programs to find the sample size or power of studies using the Sequential Parallel Comparison Design (SPCD) and programs to analyze such studies. This is a clinical trial design where patients initially on placebo who did not respond are re-randomized between placebo and active drug in a second phase and the results of the two phases are pooled. The method of analyzing binary data with this design is described in Fava,Evins, Dorer and Schoenfeld(2003) <doi:10.1159/000069738>, and the method of analyzing continuous data is described in Chen, Yang, Hung and Wang (2011) <doi:10.1016/j.cct.2011.04.006>.

Implementation of all possible forms of 2x2 and 3x3 space-filling curves, i.e., the generalized forms of the Hilbert curve <https://en.wikipedia.org/wiki/Hilbert_curve>, the Peano curve <https://en.wikipedia.org/wiki/Peano_curve> and the Peano curve in the meander type (Figure 5 in <https://eudml.org/doc/141086>). It can generates nxn curves expanded from any specific level-1 units. It also implements the H-curve and the three-dimensional Hilbert curve.

Algorithm to estimate the Sobol indices using a non-parametric fit of the regression curve. The bandwidth is estimated using bootstrap to reduce the finite-sample bias. The package is based on the paper Solà s, M. (2018) <arXiv:1803.03333>.

Simultaneously infers state-dependent diversification across two or more states of a single or multiple traits while accounting for the role of a possible concealed trait. See Herrera-Alsina et al. (2019) <doi:10.1093/sysbio/syy057>.

This package provides a simple progress bar to use for basic and advanced users that suits all those who prefer procedural programming. It is especially useful for integration into markdown files thanks to the progress bar's customisable appearance.

Generate common data forms for complex data suitable for conversions and transmission by decomposition as paths or primitives. Paths are sequentially-linked records, primitives are basic atomic elements and both can model many forms and be grouped into hierarchical structures. The universal models SC0 (structural) and SC (labelled, relational) are composed of edges and can represent any hierarchical form. Specialist models PATH', ARC and TRI provide the most common intermediate forms used for converting from one form to another. The methods are inspired by the simplicial complex <https://en.wikipedia.org/wiki/Simplicial_complex> and provide intermediate forms that relate spatial data structures to this mathematical construct.

This package provides functions to generate K-fold cross validation (CV) folds and CV test error estimates that take into account how a survey dataset's sampling design was constructed (SRS, clustering, stratification, and/or unequal sampling weights). You can input linear and logistic regression models, along with data and a type of survey design in order to get an output that can help you determine which model best fits the data using K-fold cross validation. Our paper on "K-Fold Cross-Validation for Complex Sample Surveys" by Wieczorek, Guerin, and McMahon (2022) <doi:10.1002/sta4.454> explains why differing how we take folds based on survey design is useful.

Routines for a collection of screen-and-clean type variable selection procedures, including UPS and GS.

Supervised and unsupervised multivariate methods, supplemented by GUI and some visualizations, to perform various analyses in the field of computational stylistics, authorship attribution, etc. For further reference, see Eder et al. (2016), <https://journal.r-project.org/archive/2016/RJ-2016-007/index.html>. You are also encouraged to visit the Computational Stylistics Group's website <https://computationalstylistics.github.io/>, where a reasonable amount of information about the package and related projects are provided.

This package provides functions for creating, displaying, and evaluating stopping rules for safety monitoring in clinical studies.

This package provides functions and data sets inspired by data sharpening - data perturbation to achieve improved performance in nonparametric estimation, as described in Choi, E., Hall, P. and Rousson, V. (2000). Capabilities for enhanced local linear regression function and derivative estimation are included, as well as an asymptotically correct iterated data sharpening estimator for any degree of local polynomial regression estimation. A cross-validation-based bandwidth selector is included which, in concert with the iterated sharpener, will often provide superior performance, according to a median integrated squared error criterion. Sample data sets are provided to illustrate function usage.

This package provides a consistent interface to use various methods to calculate the periodogram and estimate the period of a rhythmic time-course. Methods include Lomb-Scargle, fast Fourier transform, and three versions of the chi-square periodogram. See Tackenberg and Hughey (2021) <doi:10.1371/journal.pcbi.1008567>.

Adds support for the English language to the sylly package. Due to some restrictions on CRAN, the full package sources are only available from the project homepage. To ask for help, report bugs, suggest feature improvements, or discuss the global development of the package, please consider subscribing to the koRpus-dev mailing list (<http://korpusml.reaktanz.de>).

Settings and functions to extend the knitr SAS engine.

We provide a suite of tools for estimating the sample complexity of a chosen model through theoretical bounds and simulation. The package incorporates methods for estimating the Vapnik-Chervonenkis dimension (VCD) of a chosen algorithm, which can be used to estimate its sample complexity. Alternatively, we provide simulation methods to estimate sample complexity directly. For more details, see Carter, P & Choi, D (2024). "Learning from Noise: Applying Sample Complexity for Political Science Research" <doi:10.31219/osf.io/evrcj>.

Given a likelihood provided by the user, this package applies it to a given matrix dataset in order to find change points in the data that maximize the sum of the likelihoods of all the segments. This package provides a handful of algorithms with different time complexities and assumption compromises so the user is able to choose the best one for the problem at hand. The implementation of the segmentation algorithms in this package are based on the paper by Bruno M. de Castro, Florencia Leonardi (2018) <arXiv:1501.01756>. The Berlin weather sample dataset was provided by Deutscher Wetterdienst <https://dwd.de/>. You can find all the references in the Acknowledgments section of this package's repository via the URL below.

Identifying cell types based on expression profiles is a pillar of single cell analysis. scROSHI identifies cell types based on expression profiles of single cell analysis by utilizing previously obtained cell type specific gene sets. It takes into account the hierarchical nature of cell type relationship and does not require training or annotated data. A detailed description of the method can be found at: Prummer, Bertolini, Bosshard, Barkmann, Yates, Boeva, The Tumor Profiler Consortium, Stekhoven, and Singer (2022) <doi:10.1101/2022.04.05.487176>.

In forensics, it is common and effective practice to analyse glass fragments from the scene and suspects to gain evidence of placing a suspect at the crime scene. This kind of analysis involves comparing the physical and chemical attributes of glass fragments that exist on both the person and at the crime scene, and assessing the significance in a likeness that they share. The package implements the Scott-Knott Modification 2 algorithm (SKM2) (Christopher M. Triggs and James M. Curran and John S. Buckleton and Kevan A.J. Walsh (1997) <doi:10.1016/S0379-0738(96)02037-3> "The grouping problem in forensic glass analysis: a divisive approach", Forensic Science International, 85(1), 1--14) for small sample glass fragment analysis using the refractive index (ri) of a set of glass samples. It also includes an experimental multivariate analog to the Scott-Knott algorithm for similar analysis on glass samples with multiple chemical concentration variables and multiple samples of the same item; testing against the Hotellings T^2 distribution (J.M. Curran and C.M. Triggs and J.R. Almirall and J.S. Buckleton and K.A.J. Walsh (1997) <doi:10.1016/S1355-0306(97)72197-X> "The interpretation of elemental composition measurements from forensic glass evidence", Science & Justice, 37(4), 241--244).

Programmatic interface to the SNOTEL snow data (<https://www.nrcs.usda.gov/programs-initiatives/sswsf-snow-survey-and-water-supply-forecasting-program>). Provides easy downloads of snow data into your R work space or a local directory. Additional post-processing routines to extract snow season indexes are provided.