Offers meta programming style tools to generate configurable R functions that produce HTML forms based on table input and SQL meta data. Also generates functions for collecting the parameters of those HTML forms after they are submitted. Useful for quickly generating HTML forms based on existing SQL tables. To use the resultant functions, the output files containing those functions must be read into the R environment (perhaps using base::source()).

This package provides a common interface for applying dimensionality reduction methods, such as Principal Component Analysis ('PCA'), Independent Component Analysis ('ICA'), diffusion maps, Locally-Linear Embedding ('LLE'), t-distributed Stochastic Neighbor Embedding ('t-SNE'), and Uniform Manifold Approximation and Projection ('UMAP'). Has built-in support for sparse matrices.

Dynamic model averaging for binary and continuous outcomes.

This package provides a Bayesian clustering method for replicated time series or replicated measurements from multiple experimental conditions, e.g., time-course gene expression data. It estimates the number of clusters directly from the data using a Dirichlet-process prior. See Fu, A. Q., Russell, S., Bray, S. and Tavare, S. (2013) Bayesian clustering of replicated time-course gene expression data with weak signals. The Annals of Applied Statistics. 7(3) 1334-1361. <doi:10.1214/13-AOAS650>.

Using a Gaussian copula approach, this package generates simulated data mimicking a target real dataset. It supports normal, Poisson, empirical, and DESeq2 (negative binomial with size factors) marginal distributions. It uses an low-rank plus diagonal covariance matrix to efficiently generate omics-scale data. Methods are described in: Yang, Grant, and Brooks (2025) <doi:10.1101/2025.01.31.634335>.

Loads behavioural data from the widely used Drosophila Activity Monitor System (DAMS, TriKinetics <https://trikinetics.com/>) into the rethomics framework.

This package provides a comprehensive framework for early epidemic detection through school absenteeism surveillance. The package offers three core functionalities: (1) simulation of population structures, epidemic spread, and resulting school absenteeism patterns; (2) implementation of surveillance models that generate alerts for impending epidemics based on absenteeism data and (3) evaluation of alert timeliness and accuracy through alert time quality metrics to optimize model parameters. These tools enable public health officials and researchers to develop and assess early warning systems before implementation. Methods are based on research published in Vanderkruk et al. (2023) <doi:10.1186/s12889-023-15747-z> and Ward et al. (2019) <doi:10.1186/s12889-019-7521-7>.

This package provides a collection of widely used univariate data sets of various applied domains on applications of distribution theory. The functions allow researchers and practitioners to quickly, easily, and efficiently access and use these data sets. The data are related to different applied domains and as follows: Bio-medical, survival analysis, medicine, reliability analysis, hydrology, actuarial science, operational research, meteorology, extreme values, quality control, engineering, finance, sports and economics. The total 100 data sets are documented along with associated references for further details and uses.

R codes for distance based cell lineage reconstruction. Our methods won both sub-challenges 2 and 3 of the Allen Institute Cell Lineage Reconstruction DREAM Challenge in 2020. References: Gong et al. (2021) <doi:10.1016/j.cels.2021.05.008>, Gong et al. (2022) <doi:10.1186/s12859-022-04633-x>.

Solves quadratic programming problems using Richard L. Dykstra's cyclic projection algorithm. Routine allows for a combination of equality and inequality constraints. See Dykstra (1983) <doi:10.1080/01621459.1983.10477029> for details.

Differential Analysis of short RNA transcripts that can be modeled by either Poisson or Negative binomial distribution. The statistical methodology implemented in this package is based on the random selection of references genes (Desaulle et al. (2021) <arXiv:2103.09872>).

This package provides a penalized/non-penalized implementation for dynamic regression in the presence of autocorrelated residuals (DREGAR) using iterative penalized/ordinary least squares. It applies Mallows CP, AIC, BIC and GCV to select the tuning parameters.

This package provides functions to download and treat data regarding the Brazilian Amazon region from a variety of official sources.

This package contains functions for the MCMC simulation of dyadic network models j2 (Zijlstra, 2017, <doi:10.1080/0022250X.2017.1387858>) and p2 (Van Duijn, Snijders & Zijlstra, 2004, <doi: 10.1046/j.0039-0402.2003.00258.x>), the multilevel p2 model (Zijlstra, Van Duijn & Snijders (2009) <doi: 10.1348/000711007X255336>), and the bidirectional (multilevel) counterpart of the the multilevel p2 model as described in Zijlstra, Van Duijn & Snijders (2009) <doi: 10.1348/000711007X255336>, the (multilevel) b2 model.

Designed to create a basic data dictionary and append to the original dataset's attributes list. The package makes use of a tidy dataset and creates a data frame that will serve as a linker that will aid in building the dictionary. The dictionary is then appended to the list of the original dataset's attributes. The user will have the option of entering variable and item descriptions by writing code or use alternate functions that will prompt the user to add these.

Statistical hypothesis testing of pattern heterogeneity via differences in underlying distributions across multiple contingency tables. Five tests are included: the comparative chi-squared test (Song et al. 2014) <doi:10.1093/nar/gku086> (Zhang et al. 2015) <doi:10.1093/nar/gkv358>, the Sharma-Song test (Sharma et al. 2021) <doi:10.1093/bioinformatics/btab240>, the heterogeneity test, the marginal-change test (Sharma et al. 2020) <doi:10.1145/3388440.3412485>, and the strength test (Sharma et al. 2020) <doi:10.1145/3388440.3412485>. Under the null hypothesis that row and column variables are statistically independent and joint distributions are equal, their test statistics all follow an asymptotically chi-squared distribution. A comprehensive type analysis categorizes the relation among the contingency tables into type null, 0, 1, and 2 (Sharma et al. 2020) <doi:10.1145/3388440.3412485>. They can identify heterogeneous patterns that differ in either the first order (marginal) or the second order (differential departure from independence). Second-order differences reveal more fundamental changes than first-order differences across heterogeneous patterns.

This package provides density, distribution function, quantile function and random generation for the split normal and split-t distributions, and computes their mean, variance, skewness and kurtosis for the two distributions (Li, F, Villani, M. and Kohn, R. (2010) <doi:10.1016/j.jspi.2010.04.031>).

Reaction rate dynamics can be retrieved from metabolite concentration time courses. User has to provide corresponding stoichiometric matrix but not a regulation model (Michaelis-Menten or similar). Instead of solving an ordinary differential equation (ODE) system describing the evolution of concentrations, we use B-splines to catch the concentration and rate dynamics then solve a least square problem on their coefficients with non-negativity (and optionally monotonicity) constraints. Constraints can be also set on initial values of concentration. The package dynafluxr can be used as a library but also as an application with command line interface dynafluxr::cli("-h") or graphical user interface dynafluxr::gui().

Diagnostics for linear L1 regression (also known as LAD - Least Absolute Deviations), including: estimation, confidence intervals, tests of hypotheses, measures of leverage, methods of diagnostics for L1 regression, special diagnostics graphs and measures of leverage. The algorithms are based in Dielman (2005) <doi:10.1080/0094965042000223680>, Elian et al. (2000) <doi:10.1080/03610920008832518> and Dodge (1997) <doi:10.1006/jmva.1997.1666>. This package builds on the quantreg package, which is a well-established package for tuning quantile regression models. There are also tests to verify if the errors have a Laplace distribution based on the work of Puig and Stephens (2000) <doi:10.2307/1270952>.

Generate point data for representing people within spatial data. This collects a suite of tools for creating simple dot density maps. Several functions from different spatial packages are standardized to take the same arguments so that they can be easily substituted for each other.

Estimates dose-response relations from summarized dose-response data and to combines them according to principles of (multivariate) random-effects models.

This package provides methods to estimate the optimal treatment regime among all linear regimes via smoothed estimation methods, and construct element-wise confidence intervals for the optimal linear treatment regime vector, as well as the confidence interval for the optimal value via wild bootstrap procedures, if the population follows treatments recommended by the optimal linear regime. See more details in: Wu, Y. and Wang, L. (2021), "Resampling-based Confidence Intervals for Model-free Robust Inference on Optimal Treatment Regimes", Biometrics, 77: 465â 476, <doi:10.1111/biom.13337>.

Generate descriptive statistics such as measures of location, dispersion, frequency tables, cross tables, group summaries and multiple one/two way tables.

Apache licensed alternative to Highcharter which provides functions for both fast and beautiful interactive visualization for Markdown and Shiny'.