To assist biological researchers in assembling taxonomically and marker focused molecular sequence data sets. MACER accepts a list of genera as a user input and uses NCBI-GenBank and BOLD as resources to download and assemble molecular sequence datasets. These datasets are then assembled by marker, aligned, trimmed, and cleaned. The use of this package allows the publication of specific parameters to ensure reproducibility. The MACER package has four core functions and an example run through using all of these functions can be found in the associated repository <https://github.com/rgyoung6/MACER_example>.

This package provides a method to impute the missingness in categorical data. Details see the paper <doi:10.4310/SII.2020.v13.n1.a2>.

There are two functions-meta2d and meta3d for detecting rhythmic signals from time-series datasets. For analyzing time-series datasets without individual information, meta2d is suggested, which could incorporates multiple methods from ARSER, JTK_CYCLE and Lomb-Scargle in the detection of interested rhythms. For analyzing time-series datasets with individual information, meta3d is suggested, which takes use of any one of these three methods to analyze time-series data individual by individual and gives out integrated values based on analysis result of each individual.

An extended version of the nonparametric Bayesian monotonic regression procedure described in Saarela & Arjas (2011) <DOI:10.1111/j.1467-9469.2010.00716.x>, allowing for multiple additive monotonic components in the linear predictor, and time-to-event outcomes through case-base sampling. The extension and its applications, including estimation of absolute risks, are described in Saarela & Arjas (2015) <DOI:10.1111/sjos.12125>. The package also implements the nonparametric ordinal regression model described in Saarela, Rohrbeck & Arjas <DOI:10.1214/22-BA1310>.

Generates multivariate subgaussian stable probabilities using the QRSVN algorithm as detailed in Genz and Bretz (2002) <DOI:10.1198/106186002394> but by sampling positive stable variates not chi/sqrt(nu).

This package provides a toolkit containing statistical analysis models motivated by multivariate forms of the Conway-Maxwell-Poisson (COM-Poisson) distribution for flexible modeling of multivariate count data, especially in the presence of data dispersion. Currently the package only supports bivariate data, via the bivariate COM-Poisson distribution described in Sellers et al. (2016) <doi:10.1016/j.jmva.2016.04.007>. Future development will extend the package to higher-dimensional data.

Extends multiverse package (Sarma A., Kale A., Moon M., Taback N., Chevalier F., Hullman J., Kay M., 2021) <doi:10.31219/osf.io/yfbwm>, which allows users perform to create explorable multiverse analysis in R. This extension provides an additional level of abstraction to the multiverse package with the aim of creating user friendly syntax to researchers, educators, and students in statistics. The mverse syntax is designed to allow piping and takes hints from the tidyverse grammar. The package allows users to define and inspect multiverse analysis using familiar syntax in R.

This package performs (simultaneous) inferences for ratios of linear combinations of coefficients in the general linear model, linear mixed model, and for quantiles in a one-way layout. Multiple comparisons and simultaneous confidence interval estimations can be performed for ratios of treatment means in the normal one-way layout with homogeneous and heterogeneous treatment variances, according to Dilba et al. (2007) <https://cran.r-project.org/doc/Rnews/Rnews_2007-1.pdf> and Hasler and Hothorn (2008) <doi:10.1002/bimj.200710466>. Confidence interval estimations for ratios of linear combinations of linear model parameters like in (multiple) slope ratio and parallel line assays can be carried out. Moreover, it is possible to calculate the sample sizes required in comparisons with a control based on relative margins. For the simple two-sample problem, functions for a t-test for ratio-formatted hypotheses and the corresponding confidence interval are provided assuming homogeneous or heterogeneous group variances.

This package provides methods for Geographically Weighted Regression with spatial autocorrelation (Geniaux and Martinetti 2017) <doi:10.1016/j.regsciurbeco.2017.04.001>. Implements Multiscale Geographically Weighted Regression with Top-Down Scale approaches (Geniaux 2026) <doi:10.1007/s10109-025-00481-4>.

This package provides a procedure for comparing multivariate samples associated with different groups. It uses principal component analysis to convert multivariate observations into a set of linearly uncorrelated statistical measures, which are then compared using a number of statistical methods. The procedure is independent of the distributional properties of samples and automatically selects features that best explain their differences, avoiding manual selection of specific points or summary statistics. It is appropriate for comparing samples of time series, images, spectrometric measures or similar multivariate observations. This package is described in Fachada et al. (2016) <doi:10.32614/RJ-2016-055>.

Give access to MUI X Tree View components, which lets users navigate hierarchical lists of data with nested levels that can be expanded and collapsed.

This package provides a tool for computing probabilities and other quantities that are relevant in selecting performance criteria for discrete trial training. The main function, miebl(), computes Bayesian and frequentist probabilities and bounds for each of n possible performance criterion choices when attempting to determine a student's true mastery level by counting their number of successful attempts at displaying learning among n trials. The reporting function miebl_re() takes output from miebl() and prepares it into a brief report for a specific criterion. miebl_cp() combines 2 to 5 distributions of true mastery level given performance criterion in one plot for comparison. Ramos (2025) <doi:10.1007/s40617-025-01058-9>.

Build CPMs (cumulative probability models, also known as cumulative link models) to account for detection limits (both single and multiple detection limits) in response variables. Conditional quantiles and conditional CDFs can be calculated based on fitted models. The package implements methods described in Tian, Y., Li, C., Tu, S., James, N. T., Harrell, F. E., & Shepherd, B. E. (2022). "Addressing Detection Limits with Semiparametric Cumulative Probability Models". <arXiv:2207.02815>.

Fast approximate methods for mixed logistic regression in genome-wide analysis studies (GWAS). Two computationnally efficient methods are proposed for obtaining effect size estimates (beta) in Mixed Logistic Regression in GWAS: the Approximate Maximum Likelihood Estimate (AMLE), and the Offset method. The wald test obtained with AMLE is identical to the score test. Data can be genotype matrices in plink format, or dosage (VCF files). The methods are described in details in Milet et al (2020) <doi:10.1101/2020.01.17.910109>.

Create interactive d3.js visualizations from R with built-in statistical transforms. Computes confidence intervals, regression fits, LOESS smoothing, moving averages, error bars, and uncertainty visualizations (quantile dot plots and fan charts) in R and renders them as composable chart layers via htmlwidgets'. Supports 36 chart types including boxplots, violin plots, Q-Q diagnostic plots, calendar heatmaps, survival curves, and group comparisons with pairwise significance testing. Also provides a machine-readable chart specification schema with validators so that large language model agents can author and verify charts. Works in RStudio', Shiny', and R Markdown'.

Similarity plots based on correlation and median absolute deviation (MAD); adjusting colors for heatmaps; aggregate technical replicates; calculate pairwise fold-changes and log fold-changes; compute one- and two-way ANOVA; simplified interface to package limma (Ritchie et al. (2015), <doi:10.1093/nar/gkv007> ) for moderated t-test and one-way ANOVA; Hamming and Levenshtein (edit) distance of strings as well as optimal alignment scores for global (Needleman-Wunsch) and local (Smith-Waterman) alignments with constant gap penalties (Merkl and Waack (2009), ISBN:978-3-527-32594-8).

This package provides essential tools for the pre-processing techniques of matching and weighting multiply imputed datasets. The package includes functions for matching within and across multiply imputed datasets using various methods, estimating weights for units in the imputed datasets using multiple weighting methods, calculating causal effect estimates in each matched or weighted dataset using parametric or non-parametric statistical models, and pooling the resulting estimates according to Rubin's rules (please see <https://journal.r-project.org/archive/2021/RJ-2021-073/> for more details).

This package provides programmatic access to the Meetup GraphQL API (<https://www.meetup.com/graphql/>), enabling users to retrieve information about groups, events, and members from Meetup (<https://www.meetup.com/>). Supports authentication via OAuth2 and includes functions for common queries and data manipulation tasks.

The mFilter package implements several time series filters useful for smoothing and extracting trend and cyclical components of a time series. The routines are commonly used in economics and finance, however they should also be interest to other areas. Currently, Christiano-Fitzgerald, Baxter-King, Hodrick-Prescott, Butterworth, and trigonometric regression filters are included in the package.

In many agricultural, engineering, industrial, post-harvest and processing experiments, the number of factor level changes and hence the total number of changes is of serious concern as such experiments may consists of hard-to-change factors where it is physically very difficult to change levels of some factors or sometime such experiments may require normalization time to obtain adequate operating condition. For this reason, run orders that offer the minimum number of factor level changes and at the same time minimize the possible influence of systematic trend effects on the experimentation have been sought. Factorial designs with minimum changes in factors level may be preferred for such situations as these minimally changed run orders will minimize the cost of the experiments. For method details see, Bhowmik, A.,Varghese, E., Jaggi, S. and Varghese, C. (2017)<doi:10.1080/03610926.2016.1152490>.This package used to construct all possible minimally changed factorial run orders for different experimental set ups along with different statistical criteria to measure the performance of these designs. It consist of the function minFactDesign().

This package provides a computationally efficient solution for generating optimal experimental designs in Accelerated Life Testing (ALT). Leveraging a Particle Swarm Optimization (PSO)-based hybrid algorithm, the package identifies optimal test plans that minimize estimation variance under specified failure models and stress profiles. For more detailed, see Lee et al. (2025), Optimal Robust Strategies for Accelerated Life Tests and Fatigue Testing of Polymer Composite Materials <doi:10.1214/25-AOAS2075>, and Hoang (2025), Model-Robust Minimax Design of Accelerated Life Tests via PSO-based Hybrid Algorithm, Master Thesis, Unpublished.

An interface to build machine learning models for classification and regression problems. mikropml implements the ML pipeline described by TopçuoÄ lu et al. (2020) <doi:10.1128/mBio.00434-20> with reasonable default options for data preprocessing, hyperparameter tuning, cross-validation, testing, model evaluation, and interpretation steps. See the website <https://www.schlosslab.org/mikropml/> for more information, documentation, and examples.

Fast simulation from ordinary differential equation (ODE) based models typically employed in quantitative pharmacology and systems biology.

Fits mixed Poisson regression models (Poisson-Inverse Gaussian or Negative-Binomial) on data sets with response variables being count data. The models can have varying precision parameter, where a linear regression structure (through a link function) is assumed to hold on the precision parameter. The Expectation-Maximization algorithm for both these models (Poisson Inverse Gaussian and Negative Binomial) is an important contribution of this package. Another important feature of this package is the set of functions to perform global and local influence analysis. See Barreto-Souza and Simas (2016) <doi:10.1007/s11222-015-9601-6> for further details.