DNA methylation signatures are usually based on multivariate approaches that require hundreds of sites for predictions. CimpleG is a method for the detection of small CpG methylation signatures used for cell-type classification and deconvolution. CimpleG is time efficient and performs as well as top performing methods for cell-type classification of blood cells and other somatic cells, while basing its prediction on a single DNA methylation site per cell type (but users can also select more sites if they so wish). Users can train cell type classifiers ('CimpleG based, and others) and directly apply these in a deconvolution of cell mixes context. Altogether, CimpleG provides a complete computational framework for the delineation of DNAm signatures and cellular deconvolution. For more details see Maié et al. (2023) <doi:10.1186/s13059-023-03000-0>.

This software package provides Cox survival analysis for high-dimensional and multiblock datasets. It encompasses a suite of functions dedicated from the classical Cox regression to newest analysis, including Cox proportional hazards model, Stepwise Cox regression, and Elastic-Net Cox regression, Sparse Partial Least Squares Cox regression (sPLS-COX) incorporating three distinct strategies, and two Multiblock-PLS Cox regression (MB-sPLS-COX) methods. This tool is designed to adeptly handle high-dimensional data, and provides tools for cross-validation, plot generation, and additional resources for interpreting results. While references are available within the corresponding functions, key literature is mentioned below. Terry M Therneau (2024) <https://CRAN.R-project.org/package=survival>, Noah Simon et al. (2011) <doi:10.18637/jss.v039.i05>, Philippe Bastien et al. (2005) <doi:10.1016/j.csda.2004.02.005>, Philippe Bastien (2008) <doi:10.1016/j.chemolab.2007.09.009>, Philippe Bastien et al. (2014) <doi:10.1093/bioinformatics/btu660>, Kassu Mehari Beyene and Anouar El Ghouch (2020) <doi:10.1002/sim.8671>, Florian Rohart et al. (2017) <doi:10.1371/journal.pcbi.1005752>.

Parallel coordinate plotting with resolutions for large data sets and missing values.

This package contains Coverage Adjusted Standardized Mutual Information ('CASMI')-based functions. CASMI is a fundamental concept of a series of methods. For more information about CASMI and CASMI'-related methods, please refer to the corresponding publications (e.g., a feature selection method, Shi, J., Zhang, J., & Ge, Y. (2019) <doi:10.3390/e21121179>, and a dataset quality measurement method, Shi, J., Zhang, J., & Ge, Y. (2019) <doi:10.1109/ICHI.2019.8904553>) or contact the package author for the latest updates.

Accelerate Bayesian analytics workflows in R through interactive modelling, visualization, and inference. Define probabilistic graphical models using directed acyclic graphs (DAGs) as a unifying language for business stakeholders, statisticians, and programmers. This package relies on interfacing with the numpyro python package.

Package contains functions for analyzing check-all-that-apply (CATA) data from consumer and sensory tests. Cochran's Q test, McNemar's test, and Penalty-Lift analysis are provided; for details, see Meyners, Castura & Carr (2013) <doi:10.1016/j.foodqual.2013.06.010>. Cluster analysis can be performed using b-cluster analysis, then evaluated using various measures; for details, see Castura, Meyners, Varela & Næs (2022) <doi:10.1016/j.foodqual.2022.104564>. Consumers can also be clustered on their product-related hedonic responses; see Castura, Meyners, Pohjanheimo, Varela & Næs (2023) <doi:10.1111/joss.12860>. Permutation tests based on the L1-norm methods are provided; for details, see Chaya, Castura & Greenacre (2025) <doi:10.1016/j.foodqual.2025.105639>.

Typical morphological profiling datasets have millions of cells and hundreds of features per cell. When working with this data, you must clean the data, normalize the features to make them comparable across experiments, transform the features, select features based on their quality, and aggregate the single-cell data, if needed. cytominer makes these steps fast and easy. Methods used in practice in the field are discussed in Caicedo (2017) <doi:10.1038/nmeth.4397>. An overview of the field is presented in Caicedo (2016) <doi:10.1016/j.copbio.2016.04.003>.

This package provides the ability to create interaction maps, discover CNV map domains (edges), gene annotate interactions, and create interactive visualizations of these CNV interaction maps.

This package contains functions for estimating generalized parametric mixture and non-mixture cure models <doi:10.1016/j.cmpb.2022.107125>, loss of lifetime, mean residual lifetime, and crude event probabilities.

This k-means algorithm is able to cluster data with missing values and as a by-product completes the data set. The implementation can deal with missing values in multiple variables and is computationally efficient since it iteratively uses the current cluster assignment to define a plausible distribution for missing value imputation. Weights are used to shrink early random draws for missing values (i.e., draws based on the cluster assignments after few iterations) towards the global mean of each feature. This shrinkage slowly fades out after a fixed number of iterations to reflect the increasing credibility of cluster assignments. See the vignette for details.

Implementations of recent complex-valued wavelet spectral procedures for analysis of irregularly sampled signals, see Hamilton et al (2018) <doi:10.1080/00401706.2017.1281846>.

Calculate the predictive discrete Fourier transform, complete discrete Fourier transform, complete periodogram, and tapered complete periodogram. This algorithm is based on the preprint "Spectral methods for small sample time series: A complete periodogram approach" (2020) by Sourav Das, Suhasini Subba Rao, and Junho Yang.

Merging data from multiple sources is a relevant approach for comprehensively evaluating complex systems. However, the inherent problems encountered when analyzing single tables are amplified with the generation of multi-block datasets, and finding the relationships between data layers of increasing complexity constitutes a challenging task. For that purpose, a generic methodology is proposed by combining the strength of established data analysis strategies, i.e. multi-block approaches and the Orthogonal Partial Least Squares (OPLS) framework to provide an efficient tool for the fusion of data obtained from multiple sources. The package enables quick and efficient implementation of the consensus OPLS model for any horizontal multi-block data structures (observation-based matching). Moreover, it offers an interesting range of metrics and graphics to help to determine the optimal number of components and check the validity of the model through permutation tests. Interpretation tools include score and loading plots, Variable Importance in Projection (VIP), functionality predict for SHAP computing, and performance coefficients such as R2, Q2, and DQ2 coefficients. J. Boccard and D.N. Rutledge (2013) <doi:10.1016/j.aca.2013.01.022>.

Confirms if the number is Luhn compliant. Can check if credit card, IMEI number or any other Luhn based number is correct. For more info see: <https://en.wikipedia.org/wiki/Luhn_algorithm>.

Finds a low-dimensional embedding of high-dimensional data, conditioning on available manifold information. The current version supports conditional MDS (based on either conditional SMACOF in Bui (2021) <arXiv:2111.13646> or closed-form solution in Bui (2022) <doi:10.1016/j.patrec.2022.11.007>) and conditional ISOMAP in Bui (2021) <arXiv:2111.13646>.

This package provides functions for fitting univariate linear regression models under Scale Mixtures of Skew-Normal (SMSN) distributions, considering left, right or interval censoring and missing responses. Estimation is performed via an EM-type algorithm. Includes selection criteria, sample generation and envelope. For details, see Gil, Y.A., Garay, A.M., and Lachos, V.H. (2025) <doi:10.1007/s10260-025-00797-x>.

This package provides a spatially-aware cell clustering algorithm is provided with cluster significance assessment. It comprises four key modules: spatially-aware cell-gene co-embedding, cell clustering, signature gene identification, and cluster significant assessment. More details can be referred to Peng Xie, et al. (2025) <doi:10.1016/j.cell.2025.05.035>.

This package provides a tool that imports, subsets, visualizes, and exports the Correlates of State Policy Project dataset assembled by Marty P. Jordan and Matt Grossmann (2020) <http://ippsr.msu.edu/public-policy/correlates-state-policy>. The Correlates data contains over 2000 variables across more than 100 years that pertain to state politics and policy in the United States. Users with only a basic understanding of R can subset this data across multiple dimensions, export their search results, create map visualizations, export the citations associated with their searches, and more.

This package provides methods for difference-in-differences with a continuous treatment and staggered treatment adoption. Includes estimation of treatment effects and causal responses as a function of the dose, event studies indexed by length of exposure to the treatment, and aggregation into overall average effects. Uniform inference procedures are included, along with both parametric and nonparametric models for treatment effects. The methods are based on Callaway, Goodman-Bacon, and Sant'Anna (2025) <doi:10.48550/arXiv.2107.02637>.

To re-calculate the coefficients and the standard deviation when changing the reference group.

Estimation of average treatment effects (ATE) of point interventions on time-to-event outcomes with K competing risks (K can be 1). The method uses propensity scores and inverse probability weighting for emulation of baseline randomization, which is described in Charpignon et al. (2022) <doi:10.1038/s41467-022-35157-w>.

Enable seamless interaction with Consibio Cloud <https://consibio.cloud> API <https://api.v2.consibio.com/api-docs/>. This package provides tools to query data from resources like projects, elements, devices, and datalogs.

This package provides various tools of for clustering multivariate angular data on the torus. The package provides angular adaptations of usual clustering methods such as the k-means clustering, pairwise angular distances, which can be used as an input for distance-based clustering algorithms, and implements clustering based on the conformal prediction framework. Options for the conformal scores include scores based on a kernel density estimate, multivariate von Mises mixtures, and naive k-means clusters. Moreover, the package provides some basic data handling tools for angular data.

Quantify and visualise various measures of chemical diversity and dissimilarity, for phytochemical compounds and other sets of chemical composition data. Importantly, these measures can incorporate biosynthetic and/or structural properties of the chemical compounds, resulting in a more comprehensive quantification of diversity and dissimilarity. For details, see Petrén, Köllner and Junker (2023) <doi:10.1111/nph.18685>.