This package provides a dynamic programming solution to segmentation based on maximization of arbitrary similarity measures within segments. The general idea, theory and this implementation are described in Machne, Murray & Stadler (2017) <doi:10.1038/s41598-017-12401-8>. In addition to the core algorithm, the package provides time-series processing and clustering functions as described in the publication. These are generally applicable where a `k-means` clustering yields meaningful results, and have been specifically developed for clustering of the Discrete Fourier Transform of periodic gene expression data (`circadian or `yeast metabolic oscillations'). This clustering approach is outlined in the supplemental material of Machne & Murray (2012) <doi:10.1371/journal.pone.0037906>), and here is used as a basis of segment similarity measures. Notably, the time-series processing and clustering functions can also be used as stand-alone tools, independent of segmentation, e.g., for transcriptome data already mapped to genes.

Simulate multivariate correlated data given nonparametric marginals and their joint structure characterized by a Pearson or Spearman correlation matrix. The simulator engages the problem from a purely computational perspective. It assumes no statistical models such as copulas or parametric distributions, and can approximate the target correlations regardless of theoretical feasibility. The algorithm integrates and advances the Iman-Conover (1982) approach <doi:10.1080/03610918208812265> and the Ruscio-Kaczetow iteration (2008) <doi:10.1080/00273170802285693>. Package functions are carefully implemented in C++ for squeezing computing speed, suitable for large input in a manycore environment. Precision of the approximation and computing speed both substantially outperform various CRAN packages to date. Benchmarks are detailed in function examples. A simple heuristic algorithm is additionally designed to optimize the joint distribution in the post-simulation stage. The heuristic demonstrated good potential of achieving the same level of precision of approximation without the enhanced Iman-Conover-Ruscio-Kaczetow. The package contains a copy of Permuted Congruential Generator.

Corrects the spelling of a given word in English using a modification of Peter Norvig's spell correct algorithm (see <http://norvig.com/spell-correct.html>) which handles up to three edits. The algorithm tries to find the spelling with maximum probability of intended correction out of all possible candidate corrections from the original word.

Symbolic data analysis methods: importing/exporting data from ASSO XML Files, distance calculation for symbolic data (Ichino-Yaguchi, de Carvalho measure), zoom star plot, 3d interval plot, multidimensional scaling for symbolic interval data, dynamic clustering based on distance matrix, HINoV method for symbolic data, Ichino's feature selection method, principal component analysis for symbolic interval data, decision trees for symbolic data based on optimal split with bagging, boosting and random forest approach (+visualization), kernel discriminant analysis for symbolic data, Kohonen's self-organizing maps for symbolic data, replication and profiling, artificial symbolic data generation. (Milligan, G.W., Cooper, M.C. (1985) <doi:10.1007/BF02294245>, Breiman, L. (1996), <doi:10.1007/BF00058655>, Hubert, L., Arabie, P. (1985), <doi:10.1007%2FBF01908075>, Ichino, M., & Yaguchi, H. (1994), <doi:10.1109/21.286391>, Rand, W.M. (1971) <doi:10.1080/01621459.1971.10482356>, Breckenridge, J.N. (2000) <doi:10.1207/S15327906MBR3502_5>, Groenen, P.J.F, Winsberg, S., Rodriguez, O., Diday, E. (2006) <doi:10.1016/j.csda.2006.04.003>, Dudek, A. (2007), <doi:10.1007/978-3-540-70981-7_4>).

Simulates and plots quantities of interest (relative hazards, first differences, and hazard ratios) for linear coefficients, multiplicative interactions, polynomials, penalised splines, and non-proportional hazards, as well as stratified survival curves from Cox Proportional Hazard models. It also simulates and plots marginal effects for multiplicative interactions. Methods described in Gandrud (2015) <doi:10.18637/jss.v065.i03>.

Extension to the spatstat package, containing interactive graphics capabilities.

This package provides kernel weighting methods for estimation of proportional hazards models with intermittently observed longitudinal covariates. Cao H., Churpek M. M., Zeng D., and Fine J. P. (2015) <doi:10.1080/01621459.2014.957289>.

This package provides a flexible framework combining variable screening and random projection techniques for fitting ensembles of predictive generalized linear models to high-dimensional data. Designed for extensibility, the package implements key techniques as S3 classes with user-friendly constructors, enabling easy integration and development of new procedures for high-dimensional applications. For more details see Parzer et al (2024a) <doi:10.48550/arXiv.2312.00130> and Parzer et al (2024b) <doi:10.48550/arXiv.2410.00971>.

Add significance marks to any R Boxplot, including a given significance niveau.

This package provides a set of plotting methods for simmer trajectories and simulations.

Selection index is one of the efficient and acurrate method for selection of animals. This package is useful for construction of selection indices. It uses mixed and random model least squares analysis to estimate the heritability of traits and genetic correlation between traits. The package uses the sire model as it is considered as random effect. The genetic and phenotypic (co)variances along with the relative economic values are used to construct the selection index for any number of traits. It also estimates the accuracy of the index and the genetic gain expected for different traits. Fisher (1936) <doi:10.1111/j.1469-1809.1936.tb02137.x>.

This package provides a ggplot2 theme and colour palettes to create accessible data visualisations in the Scottish Government.

Implementation of Stepwise Clustered Ensemble (SCE) and Stepwise Cluster Analysis (SCA) for multivariate data analysis. The package provides comprehensive tools for feature selection, model training, prediction, and evaluation in hydrological and environmental modeling applications. Key functionalities include recursive feature elimination (RFE), Wilks feature importance analysis, model validation through out-of-bag (OOB) validation, and ensemble prediction capabilities. The package supports both single and multivariate response variables, making it suitable for complex environmental modeling scenarios. For more details see Li et al. (2021) <doi:10.5194/hess-25-4947-2021>.

Constructs cell-typeâ specific gene regulatory networks from single-cell RNA-sequencing data. The method implements the SCORPION algorithm, which first aggregates individual cells into supercells and then applies PANDA (Passing Attributes between Networks for Data Assimilation) to infer transcription factorâ target regulatory relationships. It also provides statistical methods for differential edge analysis.

Mappings for estimated one rep max from commonly used formulas. Convenience functions for turning mass/rep/set data into useful derived quantities.

Visualization and analysis of Vectra Immunoflourescent data. Options for calculating both the univariate and bivariate Ripley's K are included. Calculations are performed using a permutation-based approach presented by Wilson et al. <doi:10.1101/2021.04.27.21256104>.

This package provides functions for the evaluation of surrogate endpoints when both the surrogate and the true endpoint are failure time variables. The approaches implemented are: (1) the two-step approach (Burzykowski et al, 2001) <DOI:10.1111/1467-9876.00244> with a copula model (Clayton, Plackett, Hougaard) at the first step and either a linear regression of log-hazard ratios at the second step (either adjusted or not for measurement error); (2) mixed proportional hazard models estimated via mixed Poisson GLM (Rotolo et al, 2017 <DOI:10.1177/0962280217718582>).

Compiles and displays the available data sets regarding the Italian school system, with a focus on the infrastructural aspects. Input datasets are downloaded from the web, with the aim of updating everything to real time. The functions are divided in four main modules, namely Get', to scrape raw data from the web Util', various utilities needed to process raw data Group', to aggregate data at the municipality or province level Map', to visualize the output datasets.

This package provides a collection of tools and functions to adjust a variety of stochastic blockmodels (SBM). Supports at the moment Simple, Bipartite, Multipartite and Multiplex SBM (undirected or directed with Bernoulli, Poisson or Gaussian emission laws on the edges, and possibly covariate for Simple and Bipartite SBM). See Léger (2016) <doi:10.48550/arXiv.1602.07587>, Barbillon et al. (2020) <doi:10.1111/rssa.12193> and Bar-Hen et al. (2020) <doi:10.48550/arXiv.1807.10138>.

Set of tools to find coherent patterns in gene expression (microarray) data using a Bayesian Sparse Latent Factor Model (SLFM) <DOI:10.1007/978-3-319-12454-4_15>. Considerable effort has been put to build a fast and memory efficient package, which makes this proposal an interesting and computationally convenient alternative to study patterns of gene expressions exhibited in matrices. The package contains the implementation of two versions of the model based on different mixture priors for the loadings: one relies on a degenerate component at zero and the other uses a small variance normal distribution for the spike part of the mixture.

The aim of the spatial downscaling is to increase the spatial resolution of the gridded geospatial input data. This package contains two deep learning based spatial downscaling methods, super-resolution deep residual network (SRDRN) (Wang et al., 2021 <doi:10.1029/2020WR029308>) and UNet (Ronneberger et al., 2015 <doi:10.1007/978-3-319-24574-4_28>), along with a statistical baseline method bias correction and spatial disaggregation (Wood et al., 2004 <doi:10.1023/B:CLIM.0000013685.99609.9e>). The SRDRN and UNet methods are implemented to optionally account for cyclical temporal patterns in case of spatio-temporal data. For more details of the methods, see Sipilä et al. (2025) <doi:10.48550/arXiv.2512.13753>.

This package provides a pipeline to perform small area estimation and prevalence mapping of binary indicators using health and demographic survey data, described in Fuglstad et al. (2022) <doi:10.48550/arXiv.2110.09576> and Wakefield et al. (2020) <doi:10.1111/insr.12400>.

Processes amino acid alignments produced by the IPD-IMGT/HLA (Immuno Polymorphism-ImMunoGeneTics/Human Leukocyte Antigen) Database to identify user-defined amino acid residue motifs shared across HLA alleles, HLA alleles, or HLA haplotypes, and calculates frequencies based on HLA allele frequency data. SSHAARP (Searching Shared HLA Amino Acid Residue Prevalence) uses Generic Mapping Tools (GMT) software and the GMT R package to generate global frequency heat maps that illustrate the distribution of each user-defined map around the globe. SSHAARP analyzes the allele frequency data described by Solberg et al. (2008) <doi:10.1016/j.humimm.2008.05.001>, a global set of 497 population samples from 185 published datasets, representing 66,800 individuals total. Users may also specify their own datasets, but file conventions must follow the prebundled Solberg dataset, or the mock haplotype dataset.

This package provides functions to generate K-fold cross validation (CV) folds and CV test error estimates that take into account how a survey dataset's sampling design was constructed (SRS, clustering, stratification, and/or unequal sampling weights). You can input linear and logistic regression models, along with data and a type of survey design in order to get an output that can help you determine which model best fits the data using K-fold cross validation. Our paper on "K-Fold Cross-Validation for Complex Sample Surveys" by Wieczorek, Guerin, and McMahon (2022) <doi:10.1002/sta4.454> explains why differing how we take folds based on survey design is useful.