This package provides a series of checks to identify common issues in Study Data Tabulation Model (SDTM) datasets. These checks are intended to be generalizable, actionable, and meaningful for analysis.

Adds Progressive Web App support for Shiny apps, including desktop and mobile installations.

Stepwise regression is a statistical technique used for model selection. This package streamlines stepwise regression analysis by supporting multiple regression types(linear, Cox, logistic, Poisson, Gamma, and negative binomial), incorporating popular selection strategies(forward, backward, bidirectional, and subset), and offering essential metrics. It enables users to apply multiple selection strategies and metrics in a single function call, visualize variable selection processes, and export results in various formats. StepReg offers a data-splitting option to address potential issues with invalid statistical inference and a randomized forward selection option to avoid overfitting. We validated StepReg's accuracy using public datasets within the SAS software environment. For an interactive web interface, users can install the companion StepRegShiny package.

This package provides SPSS- and SAS-like output for least squares multiple regression, logistic regression, and count variable regressions. Detailed output is also provided for OLS moderated regression, interaction plots, and Johnson-Neyman regions of significance. The output includes standardized coefficients, partial and semi-partial correlations, collinearity diagnostics, plots of residuals, and detailed information about simple slopes for interactions. The output for some functions includes Bayes Factors and, if requested, regression coefficients from Bayesian Markov Chain Monte Carlo analyses. There are numerous options for model plots. The REGIONS_OF_SIGNIFICANCE function also provides Johnson-Neyman regions of significance and plots of interactions for both lm and lme models. There is also a function for partial and semipartial correlations and a function for conducting Cohen's set correlation analyses.

This package provides flexible hazard ratio curves allowing non-linear relationships between continuous predictors and survival. To better understand the effects that each continuous covariate has on the outcome, results are expressed in terms of hazard ratio curves, taking a specific covariate value as reference. Confidence bands for these curves are also derived.

Processes amino acid alignments produced by the IPD-IMGT/HLA (Immuno Polymorphism-ImMunoGeneTics/Human Leukocyte Antigen) Database to identify user-defined amino acid residue motifs shared across HLA alleles, HLA alleles, or HLA haplotypes, and calculates frequencies based on HLA allele frequency data. SSHAARP (Searching Shared HLA Amino Acid Residue Prevalence) uses Generic Mapping Tools (GMT) software and the GMT R package to generate global frequency heat maps that illustrate the distribution of each user-defined map around the globe. SSHAARP analyzes the allele frequency data described by Solberg et al. (2008) <doi:10.1016/j.humimm.2008.05.001>, a global set of 497 population samples from 185 published datasets, representing 66,800 individuals total. Users may also specify their own datasets, but file conventions must follow the prebundled Solberg dataset, or the mock haplotype dataset.

An implementation of the full-likelihood Bayes factor (FLB) for evaluating segregation evidence in clinical medical genetics. The method was introduced by Thompson et al. (2003) <doi:10.1086/378100>. This implementation supports custom penetrance values and liability classes, and allows visualisations and robustness analysis as presented in Ratajska et al. (2023) <doi:10.1002/mgg3.2107>. See also the online app shinyseg', <https://chrcarrizosa.shinyapps.io/shinyseg>, which offers interactive segregation analysis with many additional features (Carrizosa et al. (2024) <doi:10.1093/bioinformatics/btae201>).

This package creates a numeric guide for writing the formula for the determinant of a square matrix (a detguide) as a function of the elements of the matrix and writes out that formula, the symbolic representation.

Some R functions, such as optim(), require a function its gradient passed as separate arguments. When these are expensive to calculate it may be much faster to calculate the function (fn) and gradient (gr) together since they often share many calculations (chain rule). This package allows the user to pass in a single function that returns both the function and gradient, then splits (hence splitfngr') them so the results can be accessed separately. The functions provided allow this to be done with any number of functions/values, not just for functions and gradients.

Generate and translate standard Universally Unique Identifiers (UUIDs) into shorter - or just different - formats and back. Also implements base58 encoders and decoders.

This package provides a subgroup identification method for precision medicine based on quantitative objectives. This method can handle continuous, binary and survival endpoint for both prognostic and predictive case. For the predictive case, the method aims at identifying a subgroup for which treatment is better than control by at least a pre-specified or auto-selected constant. For the prognostic case, the method aims at identifying a subgroup that is at least better than a pre-specified/auto-selected constant. The derived signature is a linear combination of predictors, and the selected subgroup are subjects with the signature > 0. The false discover rate when no true subgroup exists is controlled at a user-specified level.

Set of tools aimed at wrapping some of the functionalities of the packages tools, utils and codetools into a nicer format so that an IDE can use them.

Highest posterior model is widely accepted as a good model among available models. In terms of variable selection highest posterior model is often the true model. Our stochastic search process SAHPM based on simulated annealing maximization method tries to find the highest posterior model by maximizing the model space with respect to the posterior probabilities of the models. This package currently contains the SAHPM method only for linear models. The codes for GLM will be added in future.

Nonparametric and semiparametric estimations of the time-dependent ROC curve for an incomplete failure time data with surrogate failure time endpoints.

Visualization and analysis of Vectra Immunoflourescent data. Options for calculating both the univariate and bivariate Ripley's K are included. Calculations are performed using a permutation-based approach presented by Wilson et al. <doi:10.1101/2021.04.27.21256104>.

Finds causal connections in precision data, finds lags and embeddings in time series, guides training of neural networks and other smooth models, evaluates their performance, gives a mathematically grounded answer to the over-training problem. Smooth regression is based on the Gamma test, which measures smoothness in a multivariate relationship. Causal relations are smooth, noise is not. sr includes the Gamma test and search techniques that use it. References: Evans & Jones (2002) <doi:10.1098/rspa.2002.1010>, AJ Jones (2004) <doi:10.1007/s10287-003-0006-1>.

This package provides a set of functions to quantify and visualise social autocorrelation.

Converts the floor speeches of Uruguayan legislators, extracted from the parliamentary minutes, to tidy data.frame where each observation is the intervention of a single legislator.

The developed package can be used to generate a spatial population for different levels of relationships among the dependent and auxiliary variables along with spatially varying model parameters. A spatial layout is designed as a [0,k-1]x[0,k-1] square region on which observations are collected at (k x k) lattice points with a unit distance between any two neighbouring points along the horizontal and vertical axes. For method details see Chao, Liu., Chuanhua, Wei. and Yunan, Su. (2018).<doi:10.1080/10485252.2018.1499907>. The generated spatial population can be utilized in Geographically Weighted Regression model based analysis for studying the spatially varying relationships among the variables. Furthermore, various statistical analysis can be performed on this spatially generated data.

Generate Stochastic Branching Networks ('SBNs'). Used to model the branching structure of rivers.

The past decade has demonstrated an increased need to better understand risks leading to systemic crises. This framework offers scholars, practitioners and policymakers a useful toolbox to explore such risks in financial systems. Specifically, this framework provides popular econometric and network measures to monitor systemic risk and to measure the consequences of regulatory decisions. These systemic risk measures are based on the frameworks of Adrian and Brunnermeier (2016) <doi:10.1257/aer.20120555> and Billio, Getmansky, Lo and Pelizzon (2012) <doi:10.1016/j.jfineco.2011.12.010>.

Simple class to hold contents of a SMET file as specified in Bavay (2021) <https://code.wsl.ch/snow-models/meteoio/-/blob/master/doc/SMET_specifications.pdf>. There numerical meteorological measurements are all based on MKS (SI) units and timestamp is standardized to UTC time.

Generate syntax for use with the sparklines package for LaTeX.

This package provides a multidimensional dataset of students performance assessment in high school physics. The SPHERE dataset was collected from 497 students in four public high schools specifically measuring their conceptual understanding, scientific ability, and attitude toward physics [see Santoso et al. (2024) <doi:10.17632/88d7m2fv7p.1>]. The data collection was conducted using some research based assessments established by the physics education research community. They include the Force Concept Inventory, the Force and Motion Conceptual Evaluation, the Rotational and Rolling Motion Conceptual Survey, the Fluid Mechanics Concept Inventory, the Mechanical Waves Conceptual Survey, the Thermal Concept Evaluation, the Survey of Thermodynamic Processes and First and Second Laws, the Scientific Abilities Assessment Rubrics, and the Colorado Learning Attitudes about Science Survey. Students attributes related to gender, age, socioeconomic status, domicile, literacy, physics identity, and test results administered using teachers developed items are also reported in this dataset.