This package aims to identify candidate genes that are differentially methylated between cases and controls. It applies Student's t-test and delta beta analysis to identify candidate genes containing multiple CpG sites.

This package implements two methods for performing a constrained principal component analysis (PCA), where non-negativity and/or sparsity constraints are enforced on the principal axes (PAs). The function nsprcomp computes one principal component (PC) after the other. Each PA is optimized such that the corresponding PC has maximum additional variance not explained by the previous components. In contrast, the function nscumcomp jointly computes all PCs such that the cumulative variance is maximal. Both functions have the same interface as the prcomp function from the stats package (plus some extra parameters).

This package provides R bindings for Google's s2 library for geometric calculations on the sphere. High-performance constructors and exporters provide high compatibility with existing spatial packages, transformers construct new geometries from existing geometries, predicates provide a means to select geometries based on spatial relationships, and accessors extract information about geometries.

This package estimates optimal cutpoints for binary classification metrics. It also validates performance using bootstrapping. Some methods for more robust cutpoint estimation are supported, e.g. a parametric method assuming normal distributions, bootstrapped cutpoints, and smoothing of the metric values per cutpoint using Generalized Additive Models. Various plotting functions are included.

This package implements a successive halving and hyperband optimization algorithm for the mlr3 ecosystem. The implementation in mlr3hyperband features improved scheduling and parallelizes the evaluation of configurations. The package includes tuners for hyperparameter optimization in mlr3tuning and optimizers for black-box optimization in bbotk.

Inference based on models with or without spatially-correlated random effects, multivariate responses, or non-Gaussian random effects (e.g., Beta). Variation in residual variance (heteroscedasticity) can itself be represented by a mixed-effect model. Both classical geostatistical models (Rousset and Ferdy 2014 <doi:10.1111/ecog.00566>), and Markov random field models on irregular grids (as considered in the INLA package, <https://www.r-inla.org>), can be fitted, with distinct computational procedures exploiting the sparse matrix representations for the latter case and other autoregressive models. Laplace approximations are used for likelihood or restricted likelihood. Penalized quasi-likelihood and other variants discussed in the h-likelihood literature (Lee and Nelder 2001 <doi:10.1093/biomet/88.4.987>) are also implemented.

This package provides an interface to Amazon Web Services end user computing services, including collaborative document editing, mobile intranet, and more.

This package provides methods for cluster analysis. It is a much extended version of the original from Peter Rousseeuw, Anja Struyf and Mia Hubert, based on Kaufman and Rousseeuw (1990) "Finding Groups in Data".

The first day of any MMWR week is Sunday. MMWR week numbering is sequential beginning with 1 and incrementing with each week to a maximum of 52 or 53. MMWR week #1 of an MMWR year is the first week of the year that has at least four days in the calendar year. This package provides functionality to convert dates to MMWR day, week, and year and the reverse.

This package provides high level functions for parallel programming with Rcpp. For example, the parallelFor() function can be used to convert the work of a standard serial for loop into a parallel one and the parallelReduce() function can be used for accumulating aggregates or other values.

This package simulates continuous distributions of random vectors using Markov chain Monte Carlo (MCMC). Users specify the distribution by an R function that evaluates the log unnormalized density. Algorithms are random walk Metropolis algorithm (function metrop), simulated tempering (function temper), and morphometric random walk Metropolis (function morph.metrop), which achieves geometric ergodicity by change of variable.

This package provides an implementation of scatter plots for plotting. a three dimensional point cloud.

This package fits models for genotypic disequilibria, as described in Huttley and Wilson (2000), Weir (1996) and Weir and Wilson (1986). Contrast terms are available that account for first order interactions between loci. It also implements, for a single locus in a single population, a conditional exact test for Hardy-Weinberg equilibrium.

This package provides functions that simplify submitting R scripts to a Slurm workload manager, in part by automating the division of embarrassingly parallel calculations across cluster nodes.

This package provides a set of tools to extract bibliographic content from the National Center for Biotechnology Information (NCBI) databases, including PubMed. The name RISmed is a portmanteau of RIS (for Research Information Systems, a common tag format for bibliographic data) and PubMed.

This package includes functions for processing GeoJson objects relying on RFC 7946. The geojson encoding is based on json11, a tiny JSON library for C++11. Furthermore, the source code is exported in R through the Rcpp and RcppArmadillo packages.

This package performs score test using saddlepoint approximation to estimate the null distribution. It also prepares summary statistics for meta-analysis and performs meta-analysis to combine multiple association results.

This package creates alluvial diagrams (also known as parallel sets plots) for multivariate and time series-like data.

This package provides a suite of functions to help ease the use of the d3.js visualization library in R. These helpers include htmltools::htmlDependency functions, hierarchy builders, and conversion tools for partykit, igraph, table, and data.frame R objects into the JSON format that the d3.js library expects.

This package is for genomic regions processing using command line tools such as BEDTools, BEDOPS and Tabix. These tools offer scalable and efficient utilities to perform genome arithmetic e.g indexing, formatting and merging. The bedr package's API enhances access to these tools as well as offers additional utilities for genomic regions processing.

This package provides extra themes and scales for ggplot2 that replicate the look of plots by Edward Tufte and Stephen Few in Fivethirtyeight, The Economist, Stata, Excel, and The Wall Street Journal, among others. This package also provides geoms for Tufte's box plot and range frame.

This package implements shadowtextGrob() for grid and geom_shadowtext() layer for ggplot2. These functions draw text grob with background shadow.

Gtable is a collection of tools to make it easier to work with "tables" of grobs.

This is a package that allows conversion to and from data in JavaScript Object Notation (JSON) format. This allows R objects to be inserted into Javascript/ECMAScript/ActionScript code and allows R programmers to read and convert JSON content to R objects. This is an alternative to the rjson package.