Genotyping assays for bi-allelic markers (e.g. SNPs) produce signal intensities for the two alleles. fitPoly assigns genotypes (allele dosages) to a collection of polyploid samples based on these signal intensities. fitPoly replaces the older package fitTetra that was limited (a.o.) to only tetraploid populations whereas fitPoly accepts any ploidy level. Reference: Voorrips RE, Gort G, Vosman B (2011) <doi:10.1186/1471-2105-12-172>. New functions added on conversion of data from SNP array software formats, drawing of XY-scatterplots with or without genotype colors, checking against expected F1 segregation patterns, comparing results from two different assays (probes) for the same SNP, recovery from a saveMarkerModels() crash.

The fastai <https://docs.fast.ai/index.html> library simplifies training fast and accurate neural networks using modern best practices. It is based on research in to deep learning best practices undertaken at fast.ai', including out of the box support for vision, text, tabular, audio, time series, and collaborative filtering models.

FASTQC is the most widely used tool for evaluating the quality of high throughput sequencing data. It produces, for each sample, an html report and a compressed file containing the raw data. If you have hundreds of samples, you are not going to open up each HTML page. You need some way of looking at these data in aggregate. fastqcr Provides helper functions to easily parse, aggregate and analyze FastQC reports for large numbers of samples. It provides a convenient solution for building a Multi-QC report, as well as, a one-sample report with result interpretations.

Lightweight utilities to estimate autoregressive (AR) and autoregressive moving average (ARMA) noise models from residuals and apply matched generalized least squares to whiten functional magnetic resonance imaging (fMRI) design and data matrices. The ARMA estimator follows a classic 1982 approach <doi:10.1093/biomet/69.1.81>, and a restricted AR family mirrors workflows described by Cox (2012) <doi:10.1016/j.neuroimage.2011.08.056>.

This package provides a toolbox for estimating vector fields from intensive longitudinal data, and construct potential landscapes thereafter. The vector fields can be estimated with two nonparametric methods: the Multivariate Vector Field Kernel Estimator (MVKE) by Bandi & Moloche (2018) <doi:10.1017/S0266466617000305> and the Sparse Vector Field Consensus (SparseVFC) algorithm by Ma et al. (2013) <doi:10.1016/j.patcog.2013.05.017>. The potential landscapes can be constructed with a simulation-based approach with the simlandr package (Cui et al., 2021) <doi:10.31234/osf.io/pzva3>, or the Bhattacharya et al. (2011) method for path integration <doi:10.1186/1752-0509-5-85>.

The heterogeneous treatment effect estimation procedure proposed by Imai and Ratkovic (2013)<DOI: 10.1214/12-AOAS593>. The proposed method is applicable, for example, when selecting a small number of most (or least) efficacious treatments from a large number of alternative treatments as well as when identifying subsets of the population who benefit (or are harmed by) a treatment of interest. The method adapts the Support Vector Machine classifier by placing separate LASSO constraints over the pre-treatment parameters and causal heterogeneity parameters of interest. This allows for the qualitative distinction between causal and other parameters, thereby making the variable selection suitable for the exploration of causal heterogeneity. The package also contains a class of functions, CausalANOVA, which estimates the average marginal interaction effects (AMIEs) by a regularized ANOVA as proposed by Egami and Imai (2019). It contains a variety of regularization techniques to facilitate analysis of large factorial experiments.

Generate decision tables and simulate operating characteristics for phase I dose-finding designs to enable objective comparison across methods. Supported designs include the traditional 3+3, Bayesian Optimal Interval (BOIN) (Liu and Yuan (2015) <doi:10.1158/1078-0432.CCR-14-1526>), modified Toxicity Probability Interval-2 (mTPI-2) (Guo et al. (2017) <doi:10.1002/sim.7185>), interval 3+3 (i3+3) (Liu et al. (2020) <doi:10.1177/0962280220939123>), and Generalized 3+3 (G3). Provides visualization tools for comparing decision rules and operating characteristics across multiple designs simultaneously.

Estimates the conditional error distributions of random forest predictions and common parameters of those distributions, including conditional misclassification rates, conditional mean squared prediction errors, conditional biases, and conditional quantiles, by out-of-bag weighting of out-of-bag prediction errors as proposed by Lu and Hardin (2021). This package is compatible with several existing packages that implement random forests in R.

Interface to Palantir Foundry', including reading and writing structured or unstructured datasets, and more <https://www.palantir.com/platforms/foundry/>.

This package provides a set of helper functions for constructing file paths relative to the root of various types of projects, such as R packages, Git repositories, and more. File paths are specified with function arguments, or `$` to navigate into folders to specific files supported by auto-completion.

Toolbox to process raw data from closed loop flux chamber (or tent) setups into ecosystem gas fluxes usable for analysis. It goes from a data frame of gas concentration over time (which can contain several measurements) and a meta data file indicating which measurement was done when, to a data frame of ecosystem gas fluxes including quality diagnostics. Organized with one function per step, maximizing user flexibility and backwards compatibility. Different models to estimate the fluxes from the raw data are available: exponential as described in Zhao et al (2018) <doi:10.1016/j.agrformet.2018.08.022>, exponential as described in Hutchinson and Mosier (1981) <doi:10.2136/sssaj1981.03615995004500020017x>, quadratic, and linear. Other functions include quality assessment, plotting for visual check, calculation of fluxes based on the setup specific parameters (chamber size, plot area, ...), gross primary production and transpiration rate calculation, and light response curves.

Over sixty clustering algorithms are provided in this package with consistent input and output, which enables the user to try out algorithms swiftly. Additionally, 26 statistical approaches for the estimation of the number of clusters as well as the mirrored density plot (MD-plot) of clusterability are implemented. The packages is published in Thrun, M.C., Stier Q.: "Fundamental Clustering Algorithms Suite" (2021), SoftwareX, <DOI:10.1016/j.softx.2020.100642>. Moreover, the fundamental clustering problems suite (FCPS) offers a variety of clustering challenges any algorithm should handle when facing real world data, see Thrun, M.C., Ultsch A.: "Clustering Benchmark Datasets Exploiting the Fundamental Clustering Problems" (2020), Data in Brief, <DOI:10.1016/j.dib.2020.105501>.

Three methods are implemented in R to facilitate the aggregations of flags in official statistics. From the underlying flags the highest in the hierarchy, the most frequent, or with the highest total weight is propagated to the flag(s) for EU or other aggregates. Below there are some reference documents for the topic: <https://sdmx.org/wp-content/uploads/CL_OBS_STATUS_v2_1.docx>, <https://sdmx.org/wp-content/uploads/CL_CONF_STATUS_1_2_2018.docx>, <http://ec.europa.eu/eurostat/data/database/information>, <http://www.oecd.org/sdd/33869551.pdf>, <https://sdmx.org/wp-content/uploads/CL_OBS_STATUS_implementation_20-10-2014.pdf>.

For cleaning and analysis of graphs, such as animal closing force measurements. forceR was initially written and optimized to deal with insect bite force measurements, but can be used for any time series. Includes a full workflow to load, plot and crop data, correct amplifier and baseline drifts, identify individual peak shapes (bites), rescale (normalize) peak curves, and find best polynomial fits to describe and analyze force curve shapes.

Provide functions for forest inventory calculations. Common volumetric equations (Smalian, Newton and Huber) as well stacking factor and form.

This package provides a lightweight suite of functions for retrieving information about 5-digit or 2-digit US FIPS codes.

Useful functions to standardize software outputs from ProteomeDiscoverer, Spectronaut, DIA-NN and MaxQuant on precursor, modified peptide and proteingroup level and to trace software differences for identifications such as varying proteingroup denotations for common precursor.

Standard generalized additive models assume a response function, which induces an assumption on the shape of the distribution of the response. However, miss-specifying the response function results in biased estimates. Therefore in Spiegel et al. (2017) <doi:10.1007/s11222-017-9799-6> we propose to estimate the response function jointly with the covariate effects. This package provides the underlying functions to estimate these generalized additive models with flexible response functions. The estimation is based on an iterative algorithm. In the outer loop the response function is estimated, while in the inner loop the covariate effects are determined. For the response function a strictly monotone P-spline is used while the covariate effects are estimated based on a modified Fisher-Scoring algorithm. Overall the estimation relies on the mgcv'-package.

Build display tables easily by extending the functionality of the flextable package. Features include spanning header, grouping rows, parsing markdown and so on.

This package implements the Fixed Effect Jackknife Instrumental Variables ('FEJIV') estimator of Chao, Swanson, and Woutersen (2023) <doi:10.1016/j.jeconom.2022.12.011>, allowing consistent IV estimation with many (possibly weak) instruments, cluster fixed effects, heteroskedastic errors, and many exogenous covariates. The estimator is recommended by SÅ oczyÅ ski (2024) <doi:10.48550/arXiv.2011.06695> as an alternative to two-stage least squares when estimating the interacted specification of Angrist and Imbens (1995) <doi:10.1080/01621459.1995.10476535>.

Implementation to perform forecasting of locally stationary wavelet processes by examining the local second order structure of the time series.

Aim: Supports the most frequently used methods to combine forecasts. Among others: Simple average, Ordinary Least Squares, Least Absolute Deviation, Constrained Least Squares, Variance-based, Best Individual model, Complete subset regressions and Information-theoretic (information criteria based).

An interface to the fastText <https://github.com/facebookresearch/fastText> library for efficient learning of word representations and sentence classification. The fastText algorithm is explained in detail in (i) "Enriching Word Vectors with subword Information", Piotr Bojanowski, Edouard Grave, Armand Joulin, Tomas Mikolov, 2017, <doi:10.1162/tacl_a_00051>; (ii) "Bag of Tricks for Efficient Text Classification", Armand Joulin, Edouard Grave, Piotr Bojanowski, Tomas Mikolov, 2017, <doi:10.18653/v1/e17-2068>; (iii) "FastText.zip: Compressing text classification models", Armand Joulin, Edouard Grave, Piotr Bojanowski, Matthijs Douze, Herve Jegou, Tomas Mikolov, 2016, <arXiv:1612.03651>.

For ordinal rating data, consider the accelerated EM algorithm to estimate and test models within the family of CUB models (where CUB stands for Combination of a discrete Uniform and a shifted Binomial distributions). The procedure is built upon Louis identity for the observed information matrix. Best-subset variable selection is then implemented since it becomes more feasible from the computational point of view.