Sequential Kalman filter for scalable online changepoint detection by temporally correlated data. It enables fast single and multiple change points with missing values. See the reference: Hanmo Li, Yuedong Wang, Mengyang Gu (2023), <arXiv:2310.18611>.

Spatial coverage sampling and random sampling from compact geographical strata created by k-means. See Walvoort et al. (2010) <doi:10.1016/j.cageo.2010.04.005> for details.

SMAHP (pronounced as SOO-MAP) is a novel multi-omics framework for causal mediation analysis of high-dimensional proteogenomic data with survival outcomes. The full methodological details can be found in our recent preprint by Ahn S et al. (2025) <doi:10.48550/arXiv.2503.08606>.

Fitting the full likelihood proportional hazards model and extracting the residuals.

This package creates and fits staged event tree probability models, which are probabilistic graphical models capable of representing asymmetric conditional independence statements for categorical variables. Includes functions to create, plot and fit staged event trees from data, as well as many efficient structure learning algorithms. References: Carli F, Leonelli M, Riccomagno E, Varando G (2022). <doi: 10.18637/jss.v102.i06>. Collazo R. A., Görgen C. and Smith J. Q. (2018, ISBN:9781498729604). Görgen C., Bigatti A., Riccomagno E. and Smith J. Q. (2018) <arXiv:1705.09457>. Thwaites P. A., Smith, J. Q. (2017) <arXiv:1510.00186>. Barclay L. M., Hutton J. L. and Smith J. Q. (2013) <doi:10.1016/j.ijar.2013.05.006>. Smith J. Q. and Anderson P. E. (2008) <doi:10.1016/j.artint.2007.05.004>.

Represent biomedical dataset structure as typed dependency graphs so that sample provenance, repeated-measure structure, study design, batch effects, and temporal relationships are explicit and inspectable. Validates dataset structure, detects sample-level overlap, derives deterministic split constraints, and produces a tool-agnostic split specification for leakage-aware evaluation workflows.

This package provides a set of tools to assist statistical programmers in validating Study Data Tabulation Model (SDTM) domain data sets. Statistical programmers are required to validate that a SDTM data set domain has been programmed correctly, per the SDTM Implementation Guide (SDTMIG) by CDISC (<https://www.cdisc.org/standards/foundational/sdtmig>), study specification, and study protocol using a process called double programming. Double programming involves two different programmers independently converting the raw electronic data cut (EDC) data into a SDTM domain data table and comparing their results to ensure accurate standardization of the data. One of these attempts is termed production and the other validation'. Generally, production runs are the official programs for submittals and these are written in SAS'. Validation runs can be programmed in another language, in this case R'.

This package provides the SELF criteria to learn causal structure. Please cite "Ruichu Cai, Jie Qiao, Zhenjie Zhang, Zhifeng Hao. SELF: Structural Equational Embedded Likelihood Framework for Causal Discovery. AAAI. 2018.".

This package implements the Seinhorst model to analyze the relationship between initial nematode densities and plant growth response using nonlinear least squares estimation. The package provides tools for model fitting, prediction, and visualization, facilitating the study of plant-nematode interactions. Model parameters can be estimated or set to predefined values based on Seinhorst (1986) <doi:10.1007/978-1-4613-2251-1_11>.

The spork syntax describes label formatting concisely, supporting mixed nesting of subscripts and superscripts to arbitrary depth. It intends to be easy to read and write in plain text, and easy to convert to equivalent presentations in plotmath', latex', and html'. Greek symbols and a multiplication symbol are explicitly supported. See ?as_spork and ?as_previews.

Computes sequential A-, MV-, D- and E-optimal or near-optimal block and row-column designs for two-colour cDNA microarray experiments using the linear fixed effects and mixed effects models where the interest is in a comparison of all possible elementary treatment contrasts. The package also provides an optional method of using the graphical user interface (GUI) R package tcltk to ensure that it is user friendly.

Sensitivity analysis in unmatched observational studies, with or without strata. The main functions are sen2sample() and senstrat(). See Rosenbaum, P. R. and Krieger, A. M. (1990), JASA, 85, 493-498, <doi:10.1080/01621459.1990.10476226> and Gastwirth, Krieger and Rosenbaum (2000), JRSS-B, 62, 545â 555 <doi:10.1111/1467-9868.00249> .

Automatic generation and selection of spatial predictors for Random Forest models fitted to spatially structured data. Spatial predictors are constructed from a distance matrix among training samples using Moran's Eigenvector Maps (MEMs; Dray, Legendre, and Peres-Neto 2006 <DOI:10.1016/j.ecolmodel.2006.02.015>) or the RFsp approach (Hengl et al. <DOI:10.7717/peerj.5518>). These predictors are used alongside user-supplied explanatory variables in Random Forest models. The package provides functions for model fitting, multicollinearity reduction, interaction identification, hyperparameter tuning, evaluation via spatial cross-validation, and result visualization using partial dependence and interaction plots. Model fitting relies on the ranger package (Wright and Ziegler 2017 <DOI:10.18637/jss.v077.i01>).

Shapley Value Regression for calculating the relative importance of independent variables in linear regression with avoiding the collinearity.

The sparseMatEst package provides functions for estimating sparse covariance and precision matrices with error control. A false positive rate is fixed corresponding to the probability of falsely including a matrix entry in the support of the estimator. It uses the binary search method outlined in Kashlak and Kong (2019) <arXiv:1705.02679> and in Kashlak (2019) <arXiv:1903.10988>.

Recently, regularized variable selection has emerged as a powerful tool to identify and dissect gene-environment interactions. Nevertheless, in longitudinal studies with high dimensional genetic factors, regularization methods for GÃ E interactions have not been systematically developed. In this package, we provide the implementation of sparse group variable selection, based on both the quadratic inference function (QIF) and generalized estimating equation (GEE), to accommodate the bi-level selection for longitudinal GÃ E studies with high dimensional genomic features. Alternative methods conducting only the group or individual level selection have also been included. The core modules of the package have been developed in C++.

In stability selection (N Meinshausen, P Bühlmann (2010) <doi:10.1111/j.1467-9868.2010.00740.x>) and consensus clustering (S Monti et al (2003) <doi:10.1023/A:1023949509487>), resampling techniques are used to enhance the reliability of the results. In this package (B Bodinier et al (2025) <doi:10.18637/jss.v112.i05>), hyper-parameters are calibrated by maximising model stability, which is measured under the null hypothesis that all selection (or co-membership) probabilities are identical (B Bodinier et al (2023a) <doi:10.1093/jrsssc/qlad058> and B Bodinier et al (2023b) <doi:10.1093/bioinformatics/btad635>). Functions are readily implemented for the use of LASSO regression, sparse PCA, sparse (group) PLS or graphical LASSO in stability selection, and hierarchical clustering, partitioning around medoids, K means or Gaussian mixture models in consensus clustering.

This package provides tools to conduct interpretable sensitivity analyses for weighted estimators, introduced in Huang (2024) <doi:10.1093/jrsssa/qnae012> and Hartman and Huang (2024) <doi:10.1017/pan.2023.12>. The package allows researchers to generate the set of recommended sensitivity summaries to evaluate the sensitivity in their underlying weighting estimators to omitted moderators or confounders. The tools can be flexibly applied in causal inference settings (i.e., in external and internal validity contexts) or survey contexts.

This package provides a fast, consistent tool for plotting and facilitating the analysis of stratigraphic and sedimentological data. Taking advantage of the flexible plotting tools available in R, SDAR uses stratigraphic and sedimentological data to produce detailed graphic logs for outcrop sections and borehole logs. These logs can include multiple features (e.g., bed thickness, lithology, samples, sedimentary structures, colors, fossil content, bioturbation index, gamma ray logs) (Johnson, 1992, <ISSN 0037-0738>).

Spatial forecast verification refers to verifying weather forecasts when the verification set (forecast and observations) is on a spatial field, usually a high-resolution gridded spatial field. Most of the functions here require the forecast and observed fields to be gridded and on the same grid. For a thorough review of most of the methods in this package, please see Gilleland et al. (2009) <doi: 10.1175/2009WAF2222269.1> and for a tutorial on some of the main functions available here, see Gilleland (2022) <doi: 10.5065/4px3-5a05>.

This package creates SEER (Surveillance, Epidemiology and End Results) and A-bomb data binaries from ASCII sources and provides tools for estimating SEER second cancer risks. Methods are described in <doi:10.1038/leu.2015.258>.

Useful to visualize the Poissoneity (an independent Poisson statistical framework, where each RNA measurement for each cell comes from its own independent Poisson distribution) of Unique Molecular Identifier (UMI) based single cell RNA sequencing (scRNA-seq) data, and explore cell clustering based on model departure as a novel data representation.

This package implements stress-strength reliability models under a dependent framework, where both stress and strength variables follow modified Weibull distributions and their dependence is modeled using a Clayton copula (Kizilaslan (2026) <doi:10.48550/arXiv.2604.12130>). The package provides several estimation procedures for model parameters and the stress-strength reliability R, including two-step maximum likelihood estimation (MLE), least squares estimation (LSE), weighted least squares estimation (WLSE), and maximum product of spacings (MPS). It also provides interval estimation using asymptotic confidence intervals based on MLE and bootstrap confidence intervals for all methods. In addition, functions are included for parameter estimation of the modified Weibull distribution (Lai et al. (2003) <doi:10.1109/TR.2002.805788>) and the two-parameter Weibull distribution, along with utilities to compute their probability density function, cumulative distribution function, quantile function, and to generate random samples.

This package provides functions to design and apply tests that are anytime valid. The functions can be used to design hypothesis tests in the prospective/randomised control trial setting or in the observational/retrospective setting. The resulting tests remain valid under both optional stopping and optional continuation. The current version includes safe t-tests and safe tests of two proportions. For details on the theory of safe tests, see Grunwald, de Heide and Koolen (2019) "Safe Testing" <arXiv:1906.07801>, for details on safe logrank tests see ter Schure, Perez-Ortiz, Ly and Grunwald (2020) "The Safe Logrank Test: Error Control under Continuous Monitoring with Unlimited Horizon" <arXiv:2011.06931v3> and Turner, Ly and Grunwald (2021) "Safe Tests and Always-Valid Confidence Intervals for contingency tables and beyond" <arXiv:2106.02693> for details on safe contingency table tests.