In a clinical trial, it frequently occurs that the most credible outcome to evaluate the effectiveness of a new therapy (the true endpoint) is difficult to measure. In such a situation, it can be an effective strategy to replace the true endpoint by a (bio)marker that is easier to measure and that allows for a prediction of the treatment effect on the true endpoint (a surrogate endpoint). The package Surrogate allows for an evaluation of the appropriateness of a candidate surrogate endpoint based on the meta-analytic, information-theoretic, and causal-inference frameworks. Part of this software has been developed using funding provided from the European Union's Seventh Framework Programme for research, technological development and demonstration (Grant Agreement no 602552), the Special Research Fund (BOF) of Hasselt University (BOF-number: BOF2OCPO3), GlaxoSmithKline Biologicals, Baekeland Mandaat (HBC.2022.0145), and Johnson & Johnson Innovative Medicine.

Estimation of an S-shaped function and its corresponding inflection point via a least squares approach. A sequential mixed primal-dual based algorithm is implemented for the fast computation. Details can be found in Feng et al. (2022) <doi:10.1111/rssb.12481>.

Affords researchers the ability to draw stratified samples from the U.S. Department of Veteran's Affairs/Department of Defense Identity Repository (VADIR) database according to a variety of population characteristics. The VADIR database contains information for all veterans who were separated from the military after 1980. The central utility of the present package is to integrate data cleaning and formatting for the VADIR database with the stratification methods described by Mahto (2019) <https://CRAN.R-project.org/package=splitstackshape>. Data from VADIR are not provided as part of this package.

This package provides movies to help students to understand statistical concepts. The rpanel package <https://cran.r-project.org/package=rpanel> is used to create interactive plots that move to illustrate key statistical ideas and methods. There are movies to: visualise probability distributions (including user-supplied ones); illustrate sampling distributions of the sample mean (central limit theorem), the median, the sample maximum (extremal types theorem) and (the Fisher transformation of the) product moment correlation coefficient; examine the influence of an individual observation in simple linear regression; illustrate key concepts in statistical hypothesis testing. Also provided are dpqr functions for the distribution of the Fisher transformation of the correlation coefficient under sampling from a bivariate normal distribution.

Wrapping and supplementing commonly used functions in the R ecosystem related to spatial data science, while serving as a basis for other packages maintained by Wenbo Lv.

This package provides a graphical and automated pipeline for the analysis of short time-series in R ('santaR'). This approach is designed to accommodate asynchronous time sampling (i.e. different time points for different individuals), inter-individual variability, noisy measurements and large numbers of variables. Based on a smoothing splines functional model, santaR is able to detect variables highlighting significantly different temporal trajectories between study groups. Designed initially for metabolic phenotyping, santaR is also suited for other Systems Biology disciplines. Command line and graphical analysis (via a shiny application) enable fast and parallel automated analysis and reporting, intuitive visualisation and comprehensive plotting options for non-specialist users.

Pleiotropy-informed significance analysis of genome-wide association studies with surrogate functional false discovery rates (sfFDR). The sfFDR framework adapts the fFDR to leverage informative data from multiple sets of GWAS summary statistics to increase power in study while accommodating for linkage disequilibrium. sfFDR provides estimates of key FDR quantities in a significance analysis such as the functional local FDR and $q$-value, and uses these estimates to derive a functional $p$-value for type I error rate control and a functional local Bayes factor for post-GWAS analyses (e.g., fine mapping and colocalization).

Estimation for longitudinal data following outcome dependent sampling using the sequential offsetted regression technique. Includes support for binary, count, and continuous data. The first regression is a logistic regression, which uses a known ratio (the probability of being sampled given that the subject/observation was referred divided by the probability of being sampled given that the subject/observation was no referred) as an offset to estimate the probability of being referred given outcome and covariates. The second regression uses this estimated probability to calculate the mean population response given covariates.

Stationary subspace analysis (SSA) is a blind source separation (BSS) variant where stationary components are separated from non-stationary components. Several SSA methods for multivariate time series are provided here (Flumian et al. (2021); Hara et al. (2010) <doi:10.1007/978-3-642-17537-4_52>) along with functions to simulate time series with time-varying variance and autocovariance (Patilea and Raissi(2014) <doi:10.1080/01621459.2014.884504>).

This package provides a lightweight tool that provides a reproducible workflow for selecting and executing appropriate statistical analysis in one-way or two-way experimental designs. The package automatically checks for data normality, conducts parametric (ANOVA) or non-parametric (Kruskal-Wallis) tests, performs post-hoc comparisons with Compact Letter Displays (CLD), and generates publication-ready boxplots, faceted plots, and heatmaps. It is designed for researchers seeking fast, automated statistical summaries and visualization. Based on established statistical methods including Shapiro and Wilk (1965) <doi:10.2307/2333709>, Kruskal and Wallis (1952) <doi:10.1080/01621459.1952.10483441>, Tukey (1949) <doi:10.2307/3001913>, Fisher (1925) <ISBN:0050021702>, and Wickham (2016) <ISBN:978-3-319-24277-4>.

The statistical tools in this package do one of four things: 1) Enhance basic statistical functions with more flexible inputs, smarter defaults, and richer, clearer, and ready-to-use output (e.g., t.test2()) 2) Produce publication-ready commonly needed figures with one line of code (e.g., plot_cdf()) 3) Implement novel analytical tools developed by the authors (e.g., twolines()) 4) Deliver niche functions of high value to the authors that are not easily available elsewhere (e.g., clear(), convert_to_sql(), resize_images()).

An English language syllable counter, plus readability score measure-er. For readability, we support Flesch Reading Ease and Flesch-Kincaid Grade Level ('Kincaid et al'. 1975) <https://stars.library.ucf.edu/cgi/viewcontent.cgi?article=1055&context=istlibrary>, Automated Readability Index ('Senter and Smith 1967) <https://apps.dtic.mil/sti/citations/AD0667273>, Simple Measure of Gobbledygook (McLaughlin 1969), and Coleman-Liau (Coleman and Liau 1975) <doi:10.1037/h0076540>. The package has been carefully optimized and should be very efficient, both in terms of run time performance and memory consumption. The main methods are vectorized by document, and scores for multiple documents are computed in parallel via OpenMP'.

Construct various types of space-filling designs, including Latin hypercube designs, clustering-based designs, maximin designs, maximum projection designs, and uniform designs (Joseph 2016 <doi:10.1080/08982112.2015.1100447>). It also offers the option to optimize designs based on user-defined criteria. This work is supported by U.S. National Science Foundation grant DMS-2310637.

This package contains human behaviour datasets collected by the SAMPLING project (<https://sampling.warwick.ac.uk>).

This package provides a pipeline for estimating the stellar age, mass, and radius given observational effective temperature, [Fe/H], and astroseismic parameters. The results are obtained adopting a maximum likelihood technique over a grid of pre-computed stellar models, as described in Valle et al. (2014) <doi:10.1051/0004-6361/201322210>.

Estimate average treatment effects (ATEs) in stratified randomized experiments. `sreg` supports a wide range of stratification designs, including matched pairs, n-tuple designs, and larger strata with many units â possibly of unequal size across strata. sreg is designed to accommodate scenarios with multiple treatments and cluster-level treatment assignments, and accommodates optimal linear covariate adjustment based on baseline observable characteristics. sreg computes estimators and standard errors based on Bugni, Canay, Shaikh (2018) <doi:10.1080/01621459.2017.1375934>; Bugni, Canay, Shaikh, Tabord-Meehan (2024+) <doi:10.48550/arXiv.2204.08356>; Jiang, Linton, Tang, Zhang (2023+) <doi:10.48550/arXiv.2201.13004>; Bai, Jiang, Romano, Shaikh, and Zhang (2024) <doi:10.1016/j.jeconom.2024.105740>; Bai (2022) <doi:10.1257/aer.20201856>; Bai, Romano, and Shaikh (2022) <doi:10.1080/01621459.2021.1883437>; Liu (2024+) <doi:10.48550/arXiv.2301.09016>; and Cytrynbaum (2024) <doi:10.3982/QE2475>.

Computes confidence intervals for variance using the Chi-Square distribution, without requiring raw data. Wikipedia (2025) <https://en.wikipedia.org/wiki/Chi-squared_distribution>. All-in-One Chi Distribution CI provides functions to calculate confidence intervals for the population variance based on a chi-squared distribution, utilizing a sample variance and sample size. It offers only a simple all-in-one method for quick calculations to find the CI for Chi Distribution.

This package provides methods for regression with high-dimensional predictors and univariate or maltivariate response variables. It considers the decomposition of the coefficient matrix that leads to the best approximation to the signal part in the response given any rank, and estimates the decomposition by solving a penalized generalized eigenvalue problem followed by a least squares procedure. Ruiyan Luo and Xin Qi (2017) <doi:10.1016/j.jmva.2016.09.005>.

Many packages use htmlwidgets <https://CRAN.R-project.org/package=htmlwidgets> for interactive plotting of spatial data. This package provides functions for converting R objects, such as simple features, into structures suitable for use in htmlwidgets mapping libraries.

S4 class wrappers for the ODBC and Pool DBI connection, also provides some utilities to paste small datasets to clipboard, rename columns. It is used by the package stacomiR for connections to the database. Development versions of stacomiR are available in R-forge.

The HJ-Biplot is a multivariate method that represents high-dimensional data in a low-dimensional subspace, capturing most of the informationâ s variability in just a few dimensions. This package implements three new regularized versions of the HJ-Biplot: Ridge, LASSO, and Elastic Net. These versions introduce restrictions that shrink or zero-out variable weights to improve interpretability based on regularization theory. All methods provide graphical representations using ggplot2'.

This package implements the smooth LASSO estimator for the function-on-function linear regression model described in Centofanti et al. (2022) <doi:10.1016/j.csda.2022.107556>.

This package provides a collection of functions for estimating spatial regimes, aggregations of neighboring spatial units that are homogeneous in functional terms. The term spatial regime, therefore, should not be understood as a synonym for cluster. More precisely, the term cluster does not presuppose any functional relationship between the variables considered, while the term regime is linked to a regressive relationship underlying the spatial process.

Calculating home ranges and movements of animals in complex stream environments is often challenging, and standard home range estimators do not apply. This package provides a series of tools for assessing movements in a stream network, such as calculating the total length of stream used, distances between points, and movement patterns over time. See Vignette for additional details. This package was originally released on GitHub under the name SNM'. SNMA was developed for analyses in McKnight et al. (2025) <doi:10.3354/esr01442> which contains additional examples and information.