Targeted Maximum Likelihood Estimation ('TMLE') of treatment/censoring specific mean outcome or marginal structural model for point-treatment and longitudinal data.

Lights Out is a puzzle game consisting of a grid of lights that are either on or off. Pressing any light will toggle it and its adjacent lights. The goal of the game is to switch all the lights off. This package provides an interface to play the game on different board sizes, both through the command line or with a visual application. Puzzles can also be solved using the automatic solver included. View a demo online at <https://daattali.com/shiny/lightsout/>.

Implementation of LT-FH++, an extension of the liability threshold family history (LT-FH) model. LT-FH++ uses a Gibbs sampler for sampling from the truncated multivariate normal distribution and allows for flexible family structures. LT-FH++ was first described in Pedersen, Emil M., et al. (2022) <doi:10.1016/j.ajhg.2022.01.009> as an extension to LT-FH with more flexible family structures, and again as the age-dependent liability threshold (ADuLT) model Pedersen, Emil M., et al. (2023) <https://www.nature.com/articles/s41467-023-41210-z> as an alternative to traditional time-to-event genome-wide association studies, where family history was not considered.

Combines Latent Dirichlet Allocation (LDA) and Bayesian multinomial time series methods in a two-stage analysis to quantify dynamics in high-dimensional temporal data. LDA decomposes multivariate data into lower-dimension latent groupings, whose relative proportions are modeled using generalized Bayesian time series models that include abrupt changepoints and smooth dynamics. The methods are described in Blei et al. (2003) <doi:10.1162/jmlr.2003.3.4-5.993>, Western and Kleykamp (2004) <doi:10.1093/pan/mph023>, Venables and Ripley (2002, ISBN-13:978-0387954578), and Christensen et al. (2018) <doi:10.1002/ecy.2373>.

This package provides functions for computing the r and r* statistics for inference on an arbitrary scalar function of model parameters, plus some code for the (modified) profile likelihood.

Cellular cooperation compromises the established method of calculating clonogenic activity from limiting dilution assay (LDA) data. This tool provides functions that enable robust analysis in presence or absence of cellular cooperation. The implemented method incorporates the same cooperativity module to model the non-linearity associated with cellular cooperation as known from the colony formation assay (Brix et al. (2021) <doi:10.1038/s41596-021-00615-0>: "Analysis of clonogenic growth in vitro." Nature protocols).

This package provides a Low Rank Correction Variational Bayesian algorithm for high-dimensional multi-source heterogeneous quantile linear models. More details have been written up in a paper submitted to the journal Statistics in Medicine, and the details of variational Bayesian methods can be found in Ray and Szabo (2021) <doi:10.1080/01621459.2020.1847121>. It simultaneously performs parameter estimation and variable selection. The algorithm supports two model settings: (1) local models, where variable selection is only applied to homogeneous coefficients, and (2) global models, where variable selection is also performed on heterogeneous coefficients. Two forms of parameter estimation are output: one is the standard variational Bayesian estimation, and the other is the variational Bayesian estimation corrected with low-rank adjustment.

Locally sparse estimator of generalized varying coefficient model for asynchronous longitudinal data by kernel-weighted estimating equation.

Use of this package is deprecated. It has been renamed to LifeInsureR'.

This package provides classes and methods for spatially explicit land use change modelling in R.

The primary purpose of lavaan.mi is to extend the functionality of the R package lavaan', which implements structural equation modeling (SEM). When incomplete data have been multiply imputed, the imputed data sets can be analyzed by lavaan using complete-data estimation methods, but results must be pooled across imputations (Rubin, 1987, <doi:10.1002/9780470316696>). The lavaan.mi package automates the pooling of point and standard-error estimates, as well as a variety of test statistics, using a familiar interface that allows users to fit an SEM to multiple imputations as they would to a single data set using the lavaan package.

This package provides a set of functions to locate some programs available on the user machine. It can locate Node.js', npm', LibreOffice', Microsoft Word', Microsoft PowerPoint', Microsoft Excel', Python', pip', Mozilla Firefox', Google Chrome', Air and Pandoc'. The user can test the availability of a program, optionally with a required version, and call it with the functions system2() or system(). This allows the use of a single function to retrieve the path to a program regardless of the operating system and its configuration.

Data files and a few functions used in the book Linear Models and Regression with R: An Integrated Approach by Debasis Sengupta and Sreenivas Rao Jammalamadaka (2019).

An implementation of a computational framework for performing robust structured regression with the L2 criterion from Chi and Chi (2021+). Improvements using the majorization-minimization (MM) principle from Liu, Chi, and Lange (2022+) added in Version 2.0.

Download and read data on lobbying in the United States Congress. Data is queried from the Senate's Application Programming Interface (<https://lda.senate.gov/api/>). This supports filings since 2008. Functions exist for all primary data endpoints, including queries by filings, contributions, registrations, clients, and lobbyists.

This package provides methods for assessing agreement between repeated measurements obtained by two or more methods using the longitudinal concordance correlation coefficient (LCC). Polynomial mixed-effects models (via nlme') describe how concordance, Pearson correlation and accuracy evolve over time. Functions are provided for model fitting, diagnostic plots, extraction of summaries, and non-parametric bootstrap confidence intervals (including parallel computation), following Oliveira et al. (2018) <doi:10.1007/s13253-018-0321-1>.

This package provides functions to fit log-multiplicative models using gnm', with support for convenient printing, plots, and jackknife/bootstrap standard errors. For complex survey data, models can be fitted from design objects from the survey package. Currently supported models include UNIDIFF (Erikson & Goldthorpe, 1992), a.k.a. log-multiplicative layer effect model (Xie, 1992) <doi:10.2307/2096242>, and several association models: Goodman (1979) <doi:10.2307/2286971> row-column association models of the RC(M) and RC(M)-L families with one or several dimensions; two skew-symmetric association models proposed by Yamaguchi (1990) <doi:10.2307/271086> and by van der Heijden & Mooijaart (1995) <doi:10.1177/0049124195024001002> Functions allow computing the intrinsic association coefficient (see Bouchet-Valat (2022) <doi:10.1177/0049124119852389>) and the Altham (1970) index <doi:10.1111/j.2517-6161.1970.tb00816.x>, including via the Bayes shrinkage estimator proposed by Zhou (2015) <doi:10.1177/0081175015570097>; and the RAS/IPF/Deming-Stephan algorithm.

Four measures of linkage disequilibrium are provided: the usual r^2 measure, the r^2_S measure (r^2 corrected by the structure sample), the r^2_V (r^2 corrected by the relatedness of genotyped individuals), the r^2_VS measure (r^2 corrected by both the relatedness of genotyped individuals and the structure of the sample).

Kernel regression smoothing with adaptive local or global plug-in bandwidth selection.

Local Mean Decomposition is an iterative and self-adaptive approach for demodulating, processing, and analyzing multi-component amplitude modulated and frequency modulated signals. This R package is based on the approach suggested by Smith (2005) <doi:10.1098/rsif.2005.0058> and the Python library PyLMD'.

Estimation of a multi-group count regression models (i.e., Poisson, negative binomial) with latent covariates. This packages provides two extensions compared to ordinary count regression models based on a generalized linear model: First, measurement models for the predictors can be specified allowing to account for measurement error. Second, the count regression can be simultaneously estimated in multiple groups with stochastic group weights. The marginal maximum likelihood estimation is described in Kiefer & Mayer (2020) <doi:10.1080/00273171.2020.1751027>.

An easy-to-use ndjson (newline-delimited JSON') logger. It provides a set of wrappers for base R's message(), warning(), and stop() functions that maintain identical functionality, but also log the handler message to an ndjson log file. No change in existing code is necessary to use this package, and only a few additional adjustments are needed to fully utilize its potential.

Read and write access to PNG image files using the LodePNG library. The package has no external dependencies.

Computations related to group sequential boundaries. Includes calculation of bounds using the Lan-DeMets alpha spending function approach. Based on FORTRAN program ld98 implemented by Reboussin, et al. (2000) <doi:10.1016/s0197-2456(00)00057-x>.