This package provides a generalization of principal component analysis for integrative analysis. The method finds principal components that describe single matrices or that are common to several matrices. The solutions are sparse. Rank of solutions is automatically selected using cross validation. The method is described in Kallus et al. (2019) <doi:10.48550/arXiv.1911.04927>.

Fits generalized Qini curves for evaluating treatment allocation policies with one or more mutually exclusive treatment arms. Given estimated conditional treatment effects and treatment costs, maq computes the optimal treatment allocation over a range of budget levels and estimates the resulting policy value using doubly robust or inverse-propensity weighted scores. The underlying optimization exploits the linear multiple-choice knapsack structure of the allocation problem to compute the full solution path efficiently. For details see Sverdrup, Wu, Athey, and Wager (2025) <doi:10.1080/10618600.2024.2418820>.

Lightweight utilities for nucleic acid melting curve analysis are important in life sciences and diagnostics. This software can be used for the analysis and presentation of melting curve data from microbead-based assays (surface melting curve analysis) and reactions in solution (e.g., quantitative PCR (qPCR), real-time isothermal Amplification). Further information are described in detail in two publications in The R Journal [ <https://journal.r-project.org/archive/2013-2/roediger-bohm-schimke.pdf>; <https://journal.r-project.org/archive/2015-1/RJ-2015-1.pdf>].

This package provides a set of tools for testing networks. It includes functions for univariate and multivariate conditional uniform graph and quadratic assignment procedure testing, and network regression. The package is a complement to Multimodal Political Networks (2021, ISBN:9781108985000), and includes various datasets used in the book. Built on the manynet package, all functions operate with matrices, edge lists, and igraph', network', and tidygraph objects, and on one-mode and two-mode (bipartite) networks.

Different examples and methods for testing (including different proposals described in Ameijeiras-Alonso et al., 2019 <DOI:10.1007/s11749-018-0611-5>) and exploring (including the mode tree, mode forest and SiZer) the number of modes using nonparametric techniques <DOI:10.18637/jss.v097.i09>.

Computes the Nelson-Aalen estimator of the cumulative transition hazard for arbitrary Markov multistate models <ISBN:978-0-387-68560-1>.

This package implements Mander & Thompson's (2010) <doi:10.1016/j.cct.2010.07.008> methods for two-stage designs optimal under the alternative hypothesis for phase II [cancer] trials. Also provides an implementation of Simon's (1989) <doi:10.1016/0197-2456(89)90015-9> original methodology and allows exploration of the operating characteristics of sub-optimal designs.

Three main functions about analyzing massive data (missing observations are allowed) considered from multiple layers of categories are demonstrated. Flexible and diverse applications of the function parameters make the data analyses powerful.

The penalized inverse-variance weighted (pIVW) estimator is a Mendelian randomization method for estimating the causal effect of an exposure variable on an outcome of interest based on summary-level GWAS data. The pIVW estimator accounts for weak instruments and balanced horizontal pleiotropy simultaneously. See Xu S., Wang P., Fung W.K. and Liu Z. (2022) <doi:10.1111/biom.13732>.

Mobile Motor Activity Research Consortium for Health (mMARCH) is a collaborative network of studies of clinical and community samples that employ common clinical, biological, and digital mobile measures across involved studies. One of the main scientific goals of mMARCH sites is developing a better understanding of the inter-relationships between accelerometry-measured physical activity (PA), sleep (SL), and circadian rhythmicity (CR) and mental and physical health in children, adolescents, and adults. Currently, there is no consensus on a standard procedure for a data processing pipeline of raw accelerometry data, and few open-source tools to facilitate their development. The R package GGIR is the most prominent open-source software package that offers great functionality and tremendous user flexibility to process raw accelerometry data. However, even with GGIR', processing done in a harmonized and reproducible fashion requires a non-trivial amount of expertise combined with a careful implementation. In addition, novel accelerometry-derived features of PA/SL/CR capturing multiscale, time-series, functional, distributional and other complimentary aspects of accelerometry data being constantly proposed and become available via non-GGIR R implementations. To address these issues, mMARCH developed a streamlined harmonized and reproducible pipeline for loading and cleaning raw accelerometry data, extracting features available through GGIR as well as through non-GGIR R packages, implementing several data and feature quality checks, merging all features of PA/SL/CR together, and performing multiple analyses including Joint Individual Variation Explained (JIVE), an unsupervised machine learning dimension reduction technique that identifies latent factors capturing joint across and individual to each of three domains of PA/SL/CR. In detail, the pipeline generates all necessary R/Rmd/shell files for data processing after running GGIR for accelerometer data. In module 1, all csv files in the GGIR output directory were read, transformed and then merged. In module 2, the GGIR output files were checked and summarized in one excel sheet. In module 3, the merged data was cleaned according to the number of valid hours on each night and the number of valid days for each subject. In module 4, the cleaned activity data was imputed by the average Euclidean norm minus one (ENMO) over all the valid days for each subject. Finally, a comprehensive report of data processing was created using Rmarkdown, and the report includes few exploratory plots and multiple commonly used features extracted from minute level actigraphy data. Reference: Guo W, Leroux A, Shou S, Cui L, Kang S, Strippoli MP, Preisig M, Zipunnikov V, Merikangas K (2022) Processing of accelerometry data with GGIR in Motor Activity Research Consortium for Health (mMARCH) Journal for the Measurement of Physical Behaviour, 6(1): 37-44.

Routines to perform estimation and inference under the multivariate t-distribution <doi:10.1007/s10182-022-00468-2>. Currently, the following methodologies are implemented: multivariate mean and covariance estimation, hypothesis testing about equicorrelation and homogeneity of variances, the Wilson-Hilferty transformation, QQ-plots with envelopes and random variate generation.

Data and examples from a multilevel modelling software review as well as other well-known data sets from the multilevel modelling literature.

Stand-alone HTTP capable R-package repository, that fully supports R's install.packages() and available.packages(). It also contains API endpoints for end-users to add/update packages. This package can supplement miniCRAN', which has functions for maintaining a local (partial) copy of CRAN'. Current version is bare-minimum without any access-control or much security.

Function ModEstM() is the only one of this package, it estimates the modes of an empirical univariate distribution. It relies on the stats::density() function, even for input control. Due to very good performance of the density estimation, computation time is not an issue. The multiple modes are handled using dplyr::group_by(). For conditions and rates of convergences, see Eddy (1980) <doi:10.1214/aos/1176345080>.

This package implements the MVOPR (Multi-View Orthogonal Projection Regression) method for robust variable selection and integration of multi-modality data.

Collection of functions to compute within-study covariances for different effect sizes, data visualization, and single and multiple imputations for missing data. Effect sizes include correlation (r), mean difference (MD), standardized mean difference (SMD), log odds ratio (logOR), log risk ratio (logRR), and risk difference (RD).

Plot the daily and cumulative number of downloads of your packages. It is designed to be slightly more convenient than the several similar programs. If you want to run this each morning, you do not need to keep typing in the names of your packages. Also, this combines the daily and cumulative counts in one run, you do not need to run separate programs to get both types of information.

Uses a kernel smoothing approach to calculate Mutual Information for comparisons between all types of variables including continuous vs continuous, continuous vs discrete and discrete vs discrete. Uses a nonparametric bias correction giving Bias Corrected Mutual Information (BCMI). Implemented efficiently in Fortran 95 with OpenMP and suited to large genomic datasets.

This package provides tools for longitudinal meta-analysis where studies contribute effect sizes at multiple follow-up time points. Implements robust variance estimation (RVE) with Tipton small-sample corrections following Hedges, Tipton, and Johnson (2010) <doi:10.1002/jrsm.5> and Tipton (2015) <doi:10.1037/met0000011>, time-varying sensitivity analysis via the Impact Threshold for a Confounding Variable (ITCV) following Frank (2000) <doi:10.1177/0049124100029002003>, benchmark calibration of the ITCV threshold against observed study-level covariates, spline-based nonlinear time-trend modeling with a nonlinearity test, and leave-k-out fragility analysis across the follow-up trajectory. Designed for researchers synthesising evidence from studies with repeated outcome measurement in education, psychology, health, and the social sciences.

Collect your data on digital marketing campaigns from Mailchimp using the Windsor.ai API <https://windsor.ai/api-fields/>.

Deploy file changes across multiple GitHub repositories using the GitHub Web API <https://docs.github.com/en/rest>. Allows synchronizing common files, Continuous Integration ('CI') workflows, or configurations across many repositories with a single command.

Estimation of treatment hierarchies in network meta-analysis using a novel frequentist approach based on treatment choice criteria (TCC) and probabilistic ranking models, as described by Evrenoglou et al. (2024) <DOI:10.48550/arXiv.2406.10612>. The TCC are defined using a rule based on the smallest worthwhile difference (SWD). Using the defined TCC, the NMA estimates (i.e., treatment effects and standard errors) are first transformed into treatment preferences, indicating either a treatment preference (e.g., treatment A > treatment B) or a tie (treatment A = treatment B). These treatment preferences are then synthesized using a probabilistic ranking model, which estimates the latent ability parameter of each treatment and produces the final treatment hierarchy. This parameter represents each treatments ability to outperform all the other competing treatments in the network. Here the terms ability to outperform indicates the propensity of each treatment to yield clinically important and beneficial effects when compared to all the other treatments in the network. Consequently, larger ability estimates indicate higher positions in the ranking list.

We introduce a generalized factor model designed to jointly analyze high-dimensional multi-modality data from multiple studies by extracting study-shared and specified factors. Our factor models account for heterogeneous noises and overdispersion among modality variables with augmented covariates. We propose an efficient and speedy variational estimation procedure for estimating model parameters, along with a novel criterion for selecting the optimal number of factors. More details can be referred to Liu et al. (2025) <doi:10.48550/arXiv.2507.09889>.

Normalize data to minimize the difference between sample plates (batch effects). For given data in a matrix and grouping variable (or plate), the function normn_MA normalizes the data on MA coordinates. More details are in the citation. The primary method is Multi-MA'. Other fitting functions on MA coordinates can also be employed e.g. loess.