This package creates sophisticated models of training data and validates the models with an independent test set, cross validation, or Out Of Bag (OOB) predictions on the training data. Create graphs and tables of the model validation results. Applies these models to GIS .img files of predictors to create detailed prediction surfaces. Handles large predictor files for map making, by reading in the .img files in chunks, and output to the .txt file the prediction for each data chunk, before reading the next chunk of data.

This package implements a computational framework to predict microbial community-based metabolic profiles with O2PLS model. It provides procedures of model training and prediction. Paired microbiome and metabolome data are needed for modeling, and the trained model can be applied to predict metabolites of analogous environments using new microbial feature abundances.

Scalable Bayesian clustering of categorical datasets. The package implements a hierarchical Dirichlet (Process) mixture of multinomial distributions. It is thus a probabilistic latent class model (LCM) and can be used to reduce the dimensionality of hierarchical data and cluster individuals into latent classes. It can automatically infer an appropriate number of latent classes or find k classes, as defined by the user. The model is based on a paper by Dunson and Xing (2009) <doi:10.1198/jasa.2009.tm08439>, but implements a scalable variational inference algorithm so that it is applicable to large datasets. It is described and tested in the accompanying paper by Ahlmann-Eltze and Yau (2018) <doi:10.1109/DSAA.2018.00068>.

Pearson and Spearman correlation coefficients are commonly used to quantify the strength of bivariate associations of genomic variables. For example, correlations of gene-level DNA copy number and gene expression measurements may be used to assess the impact of DNA copy number changes on gene expression in tumor tissue. MVisAGe enables users to quickly compute and visualize the correlations in order to assess the effect of regional genomic events such as changes in DNA copy number or DNA methylation level. Please see Walter V, Du Y, Danilova L, Hayward MC, Hayes DN, 2018. Cancer Research <doi:10.1158/0008-5472.CAN-17-3464>.

This package provides a flexible framework for fitting multivariate ordinal regression models with composite likelihood methods. Methodological details are given in Hirk, Hornik, Vana (2020) <doi:10.18637/jss.v093.i04>.

Create beautiful and customizable tables to summarize several statistical models side-by-side. Draw coefficient plots, multi-level cross-tabs, dataset summaries, balance tables (a.k.a. "Table 1s"), and correlation matrices. This package supports dozens of statistical models, and it can produce tables in HTML, LaTeX, Word, Markdown, PDF, PowerPoint, Excel, RTF, JPG, or PNG. Tables can easily be embedded in Rmarkdown or knitr dynamic documents. Details can be found in Arel-Bundock (2022) <doi:10.18637/jss.v103.i01>.

The provided package implements multiple contrast tests for functional data (Munko et al., 2023, <arXiv:2306.15259>). These procedures enable us to evaluate the overall hypothesis regarding equality, as well as specific hypotheses defined by contrasts. In particular, we can perform post hoc tests to examine particular comparisons of interest. Different experimental designs are supported, e.g., one-way and multi-way analysis of variance for functional data.

This package provides functions to calculate hazard and survival function of Multi-Stage Clonal Expansion Models used in cancer epidemiology. For the Two-Stage Clonal Expansion Model an exact solution is implemented assuming piecewise constant parameters. Numerical solutions are provided for its extensions.

This package performs maximum a posteriori Bayesian estimation of individual pharmacokinetic parameters from a model defined in mrgsolve', typically for model-based therapeutic drug monitoring. Internally computes an objective function value from model and data, performs optimization and returns predictions in a convenient format. The performance of the package was described by Le Louedec et al (2021) <doi:10.1002/psp4.12689>.

Allows the user to generate a friendly user interface for emails sending. The user can choose from the most popular free email services ('Gmail', Outlook', Yahoo') and his default email application. The package is a wrapper for the Mailtoui JavaScript library. See <https://mailtoui.com/#menu> for more information.

Extension of the mgcv package, providing visual tools for Generalized Additive Models that exploit the additive structure of such models, scale to large data sets and can be used in conjunction with a wide range of response distributions. The focus is providing visual methods for better understanding the model output and for aiding model checking and development beyond simple exponential family regression. The graphical framework is based on the layering system provided by ggplot2'.

This package provides functions for analyzing the association between one single response categorical variable (SRCV) and one multiple response categorical variable (MRCV), or between two or three MRCVs. A modified Pearson chi-square statistic can be used to test for marginal independence for the one or two MRCV case, or a more general loglinear modeling approach can be used to examine various other structures of association for the two or three MRCV case. Bootstrap- and asymptotic-based standardized residuals and model-predicted odds ratios are available, in addition to other descriptive information. Statisical methods implemented are described in Bilder et al. (2000) <doi:10.1080/03610910008813665>, Bilder and Loughin (2004) <doi:10.1111/j.0006-341X.2004.00147.x>, Bilder and Loughin (2007) <doi:10.1080/03610920600974419>, and Koziol and Bilder (2014) <https://journal.r-project.org/articles/RJ-2014-014/>.

There is an increasing interest in investigating how the compositions of microbial communities are associated with human health and disease. In this package, we present a novel global testing method called aMiSPU, that is highly adaptive and thus high powered across various scenarios, alleviating the issue with the choice of a phylogenetic distance. Our simulations and real data analysis demonstrated that aMiSPU test was often more powerful than several competing methods while correctly controlling type I error rates.

There are two functions-meta2d and meta3d for detecting rhythmic signals from time-series datasets. For analyzing time-series datasets without individual information, meta2d is suggested, which could incorporates multiple methods from ARSER, JTK_CYCLE and Lomb-Scargle in the detection of interested rhythms. For analyzing time-series datasets with individual information, meta3d is suggested, which takes use of any one of these three methods to analyze time-series data individual by individual and gives out integrated values based on analysis result of each individual.

Fast manipulation of symbolic multivariate polynomials using the Map class of the Standard Template Library. The package uses print and coercion methods from the mpoly package but offers speed improvements. It is comparable in speed to the spray package for sparse arrays, but retains the symbolic benefits of mpoly'. To cite the package in publications, use Hankin 2022 <doi:10.48550/ARXIV.2210.15991>. Uses disordR discipline.

This package provides a method for multivariate ordinal data generation given marginal distributions and correlation matrix based on the methodology proposed by Demirtas (2006) <DOI:10.1080/10629360600569246>.

This package performs monotonic binning of numeric risk factor in credit rating models (PD, LGD, EAD) development. All functions handle both binary and continuous target variable. Functions that use isotonic regression in the first stage of binning process have an additional feature for correction of minimum percentage of observations and minimum target rate per bin. Additionally, monotonic trend can be identified based on raw data or, if known in advance, forced by functions argument. Missing values and other possible special values are treated separately from so-called complete cases.

Package with multivariate analysis methodologies for experiment evaluation. The package estimates dissimilarity measures, builds dendrograms, obtains MANOVA, principal components, canonical variables, etc. (Pacote com metodologias de analise multivariada para avaliação de experimentos. O pacote estima medidas de dissimilaridade, construi de dendogramas, obtem a MANOVA, componentes principais, variaveis canonicas, etc.).

Package to carry out merged block randomization (Van der Pas (2019), <doi:10.1177/1740774519827957>), a restricted randomization method designed for small clinical trials (at most 100 subjects) or trials with small strata, for example in multicentre trials. It can be used for more than two groups or unequal randomization ratios.

Designed for multi- and mixed-precision computations, accommodating 64-bit and 32-bit data structures. This flexibility enables fast execution across various applications. The package enhances performance by optimizing operations in both precision levels, which is achieved by integrating with high-speed BLAS and LAPACK libraries like MKL and OpenBLAS'. Including a 32-bit option caters to applications where high precision is unnecessary, accelerating computational processes whenever feasible. The package also provides support for tile-based algorithms in three linear algebra operations: CHOL(), TRSM(), and GEMM(). The tile-based algorithm splits the matrix into smaller tiles, facilitating parallelization through a predefined Directed Acyclic Graph (DAG) for each operation. Enabling OpenMP enhances the efficiency of these operations, leveraging multi-core parallelism. In this case, MPCR facilitates mixed-precision execution by permitting varying precision levels for different tiles. This approach is advantageous in numerous applications, as it maintains the accuracy of the application while accelerating execution in scenarios where single-precision alone does not significantly affect the accuracy of the application.

The MetAlyzer S4 object provides methods to read and reformat metabolomics data for convenient data handling, statistics and downstream analysis. The resulting format corresponds to input data of the Shiny app MetaboExtract (<https://www.metaboextract.shiny.dkfz.de/MetaboExtract/>).

Frequentist and Bayesian linear regression for large data sets. Useful when the data does not fit into memory (for both frequentist and Bayesian regression), to make running time manageable (mainly for Bayesian regression), and to reduce the total running time because of reduced or less severe memory-spillover into the virtual memory. This is an implementation of Merge & Reduce for linear regression as described in Geppert, L.N., Ickstadt, K., Munteanu, A., & Sohler, C. (2020). Streaming statistical models via Merge & Reduce'. International Journal of Data Science and Analytics, 1-17, <doi:10.1007/s41060-020-00226-0>.

This package provides a collection of miscellaneous helper function for running multilevel/mixed models in lme4'. This package aims to provide functions to compute common tasks when estimating multilevel models such as computing the intraclass correlation and design effect, centering variables, estimating the proportion of variance explained at each level, pseudo-R squared, random intercept and slope reliabilities, tests for homogeneity of variance at level-1, and cluster robust and bootstrap standard errors. The tests and statistics reported in the package are from Raudenbush & Bryk (2002, ISBN:9780761919049), Hox et al. (2018, ISBN:9781138121362), and Snijders & Bosker (2012, ISBN:9781849202015).

Traditional methods typically detect breakpoints from individual signals, which means that when applied separately to multiple signals, the breakpoints are not aligned. However, this package implements a common breakpoint detection approach for multiple piecewise constant signals, resulting in increased detection sensitivity and specificity. By employing various techniques, optimal performance is ensured, and computation is accelerated. We hope that this package will be beneficial for researchers in signal processing, bioinformatics, economy, and other related fields. The segmentation(), lambda_estimator() functions are the main functions of this package.