The typicality and eccentricity data analysis (TEDA) framework was put forward by Angelov (2013) <DOI:10.14313/JAMRIS_2-2014/16>. It has been further developed into multiple different techniques since, and provides a non-parametric way of determining how similar an observation, from a process that is not purely random, is to other observations generated by the process. This package provides code to use the batch and recursive TEDA methods that have been published.

This package provides functions that provide point and interval estimations of optimum thresholds for continuous diagnostic tests. The methodology used is based on minimizing an overall cost function in the two- and three-state settings. We also provide functions for sample size determination and estimation of diagnostic accuracy measures. We also include graphical tools. The statistical methodology used here can be found in Perez-Jaume et al (2017) <doi:10.18637/jss.v082.i04> and in Skaltsa et al (2010, 2012) <doi:10.1002/bimj.200900294>, <doi:10.1002/sim.4369>.

This package provides functions are collected to analyse weather data for agriculture purposes including to read weather records in multiple formats, calculate extreme climate index. Demonstration data are included the SILO daily climate data (licensed under CC BY 4.0, <https://www.longpaddock.qld.gov.au/silo/>).

The TEQR package contains software to calculate the operating characteristics for the TEQR and the ACT designs.The TEQR (toxicity equivalence range) design is a toxicity based cumulative cohort design with added safety rules. The ACT (Activity constrained for toxicity) design is also a cumulative cohort design with additional safety rules. The unique feature of this design is that dose is escalated based on lack of activity rather than on lack of toxicity and is de-escalated only if an unacceptable level of toxicity is experienced.

Visualizes the relationship between allele frequency and effect size in genetic association studies. The input is a data frame containing association results. The output is a plot with the effect size of risk variants in the Y axis, and the allele frequency spectrum in the X axis. Corte et al (2023) <doi:10.1101/2023.04.21.23288923>.

The trapezoid package provides dtrapezoid', ptrapezoid', qtrapezoid', and rtrapezoid functions for the trapezoidal distribution.

This package provides tools to help developers and producers manipulate R objects and outputs. It includes tools for displaying results and objects, and for formatting them in the correct format.

An inverse probability of censoring weighted (IPCW) targeted maximum likelihood estimator (TMLE) for evaluating a marginal point treatment effect from data where some variables were collected on only a subset of participants using a two-stage design (or marginal mean outcome for a single arm study). A TMLE for conditional parameters defined by a marginal structural model (MSM) is also available.

Comprehensive functions to calculate sample size and power for clinical trials with two co-primary endpoints. The package supports five endpoint combinations: two continuous endpoints (Sozu et al. 2011 <doi:10.1080/10543406.2011.551329>), two binary endpoints using asymptotic methods (Sozu et al. 2010 <doi:10.1002/sim.3972>) and exact methods (Homma and Yoshida 2025 <doi:10.1177/09622802251368697>), mixed continuous and binary endpoints (Sozu et al. 2012 <doi:10.1002/bimj.201100221>), and mixed count and continuous endpoints (Homma and Yoshida 2024 <doi:10.1002/pst.2337>). All methods appropriately account for correlation between endpoints and provide both sample size and power calculation capabilities.

This package provides bindings to an R grammar for Tree-sitter', to be used alongside the treesitter package. Tree-sitter builds concrete syntax trees for source files of any language, and can efficiently update those syntax trees as the source file is edited.

An implementation of tidy speaker vowel normalization. This includes generic functions for defining new normalization methods for points, formant tracks, and Discrete Cosine Transform coefficients, as well as convenience functions implementing established normalization methods. References for the implemented methods are: Johnson, Keith (2020) <doi:10.5334/labphon.196> Lobanov, Boris (1971) <doi:10.1121/1.1912396> Nearey, Terrance M. (1978) <https://sites.ualberta.ca/~tnearey/Nearey1978_compressed.pdf> Syrdal, Ann K., and Gopal, H. S. (1986) <doi:10.1121/1.393381> Watt, Dominic, and Fabricius, Anne (2002) <https://www.latl.leeds.ac.uk/article/evaluation-of-a-technique-for-improving-the-mapping-of-multiple-speakers-vowel-spaces-in-the-f1-f2-plane/>.

This package implements methods to fit Virtual Twins models (Foster et al. (2011) <doi:10.1002/sim.4322>) for identifying subgroups with differential effects in the context of clinical trials while controlling the probability of falsely detecting a differential effect when the conditional average treatment effect is uniform across the study population using parameter selection methods proposed in Wolf et al. (2022) <doi:10.1177/17407745221095855>.

This package creates geographic map tiles from geospatial map files or non-geographic map tiles from simple image files. This package provides a tile generator function for creating map tile sets for use with packages such as leaflet'. In addition to generating map tiles based on a common raster layer source, it also handles the non-geographic edge case, producing map tiles from arbitrary images. These map tiles, which have a non-geographic, simple coordinate reference system (CRS), can also be used with leaflet when applying the simple CRS option. Map tiles can be created from an input file with any of the following extensions: tif, grd and nc for spatial maps and png, jpg and bmp for basic images. This package requires Python and the gdal library for Python'. Windows users are recommended to install OSGeo4W (<https://trac.osgeo.org/osgeo4w/>) as an easy way to obtain the required gdal support for Python'.

This is a collection of functions optimized for working with with various kinds of text matrices. Focusing on the text matrix as the primary object - represented either as a base R dense matrix or a Matrix package sparse matrix - allows for a consistent and intuitive interface that stays close to the underlying mathematical foundation of computational text analysis. In particular, the package includes functions for working with word embeddings, text networks, and document-term matrices. Methods developed in Stoltz and Taylor (2019) <doi:10.1007/s42001-019-00048-6>, Taylor and Stoltz (2020) <doi:10.1007/s42001-020-00075-8>, Taylor and Stoltz (2020) <doi:10.15195/v7.a23>, and Stoltz and Taylor (2021) <doi:10.1016/j.poetic.2021.101567>.

Estimation of group-based trajectory models, including finite mixture models for longitudinal data, supporting censored normal, zero-inflated Poisson, logit, and beta distributions, using expectation-maximization and quasi-Newton methods, with tools for model selection, diagnostics, and visualization of latent trajectory groups, <doi:10.4159/9780674041318>, Nagin, D. (2005). Group-Based Modeling of Development. Cambridge, MA: Harvard University Press. and Noel (2022), <https://orbilu.uni.lu/>, thesis.

Cooperative game theory models decision-making situations in which a group of agents, called players, may achieve certain benefits by cooperating to reach an optimal outcome. It has great potential in different fields, since it offers a scenario to analyze and solve problems in which cooperation is essential to achieve a common goal. The TUGLab (Transferable Utility Games Laboratory) R package contains a set of scripts that could serve as a helpful complement to the books and other materials used in courses on cooperative game theory, and also as a practical tool for researchers working in this field. The TUGLab project was born in 2006 trying to highlight the geometrical aspects of the theory of cooperative games for 3 and 4 players. TUGlabWeb is an online platform on which the basic functions of TUGLab are implemented, and it is being used all over the world as a resource in degree, master's and doctoral programs. This package is an extension of the first versions and enables users to work with games in general (computational restrictions aside). The user can check properties of games, compute well-known games and calculate several set-valued and single-valued solutions such as the core, the Shapley value, the nucleolus or the core-center. The package also illustrates how the Shapley value flexibly adapts to various cooperative game settings, including weighted players and coalitions, a priori unions, and restricted communication structures. In keeping with the original philosophy of the first versions, special emphasis is placed on the graphical representation of the solution concepts for 3 and 4 players.

Computation of stopping boundaries for a single-arm trial using a Bayesian criterion. For each m<=n (n=total patient number of the trial) the smallest number of observed toxicities is calculated leading to the termination of the trial/accrual according to the specified criteria. The probabilities of stopping the trial/accrual at and up until (resp.) the m-th patient (m<=n) is also calculated. This design is more conservative than the frequentist approach (using Clopper Pearson CIs) which might be preferred as it concerns safety. See also Aamot et al. (2010) "Continuous monitoring of toxicity in clinical Trials - simulating the risk of stopping prematurely" <doi:10.5414/cpp48476>.

Implementation of Testlet and Item Response Theory. A light-version yet comprehensive and streamlined framework for psychometric analysis using unidimensional Item Response Theory (IRT; Baker & Kim (2004) <doi:10.1201/9781482276725>) and Testlet Response Theory (TRT; Wainer et al., (2007) <doi:10.1017/CBO9780511618765>). Designed for researchers, this package supports the estimation of item and person parameters for a wide variety of models, including binary (i.e., Rasch, 2-Parameter Logistic, 3-Parameter Logistic) and polytomous (Partial Credit Model, Generalized Partial Credit Model, Graded Response Model) formats. It also supports the estimation of Testlet models (Rasch Testlet, 2-Parameter Logistic Testlet, 3-Parameter Logistic Testlet, Bifactor, Partial Credit Model Testlet, Graded Response), allowing users to account for local item dependence in bundled items. A key feature is the specialized support for combination use and joint estimation of item response model and testlet response model in one calibration. Beyond standard estimation via Marginal Maximum Likelihood with Expectation-Maximization (EM) or Joint Maximum Likelihood, the package also offers Bayesian estimation using priors with maximum a posteriori (MAP) method for item response theory models. It also provides functions for scale linking and equating (Mean-Mean, Mean-Sigma, Stocking-Lord) to ensure comparability across mixed-format test forms. It also facilitates fixed-parameter calibration, enabling users to estimate person abilities with known item parameters or vice versa, which is essential for pre-equating studies and item bank maintenance. Comprehensive data simulation functions are included to generate synthetic datasets with complex structures, including mixed-model blocks and specific testlet effects, aiding in methodological research and study design validation. Researchers can try multiple simulation situations.

Estimates heterogeneous treatment effects using tidy semantics on experimental or observational data. Methods are based on the doubly-robust learner of Kennedy (2023) <doi:10.1214/23-EJS2157>. You provide a simple recipe for what machine learning algorithms to use in estimating the nuisance functions and tidyhte will take care of cross-validation, estimation, model selection, diagnostics and construction of relevant quantities of interest about the variability of treatment effects.

Flexible simulation of time series using time series components, including seasonal, calendar and outlier effects. Main algorithm described in Ollech, D. (2021) <doi:10.1515/jtse-2020-0028>.

Higher Criticism (HC) test between two frequency tables. Test is based on an adaptation of the Tukey-Donoho-Jin HC statistic to testing frequency tables described in Kipnis (2019) <arXiv:1911.01208>.

When plotting treated-minus-control differences, after-minus-before changes, or difference-in-differences, the ttrans() function symmetrically transforms the positive and negative tails to aid plotting. The package includes an observational study with three control groups and an unaffected outcome; see Rosenbaum (2022) <doi:10.1080/00031305.2022.2063944>.

Translate double and integer valued data into character values formatted for tabulation in manuscripts or other types of academic reports.

Tensor Composition Analysis (TCA) allows the deconvolution of two-dimensional data (features by observations) coming from a mixture of heterogeneous sources into a three-dimensional matrix of signals (features by observations by sources). The TCA framework further allows to test the features in the data for different statistical relations with an outcome of interest while modeling source-specific effects; particularly, it allows to look for statistical relations between source-specific signals and an outcome. For example, TCA can deconvolve bulk tissue-level DNA methylation data (methylation sites by individuals) into a three-dimensional tensor of cell-type-specific methylation levels for each individual (i.e. methylation sites by individuals by cell types) and it allows to detect cell-type-specific statistical relations (associations) with phenotypes. For more details see Rahmani et al. (2019) <DOI:10.1038/s41467-019-11052-9>.