This package provides a robust approach for omics data integration and disease subtyping. PINSPlus is fast and supports the analysis of large datasets with hundreds of thousands of samples and features. The software automatically determines the optimal number of clusters and then partitions the samples in a way such that the results are robust against noise and data perturbation (Nguyen et al. (2019) <DOI: 10.1093/bioinformatics/bty1049>, Nguyen et al. (2017)<DOI: 10.1101/gr.215129.116>, Nguyen et al. (2021)<DOI: 10.3389/fonc.2021.725133>).

This package provides tools that allow developers to write functions for prediction error estimation with minimal programming effort and assist users with model selection in regression problems.

These are harmonized datasets produced as part of the Clinical Trials Network (CTN) protocol number 0094. This is a US National Institute of Drug Abuse (NIDA) funded project; to learn more go to <https://ctnlibrary.org/protocol/ctn0094/>. These are datasets which have the data harmonized from CTN-0027 (<https://ctnlibrary.org/protocol/ctn0027/>), CTN-0030 (<https://ctnlibrary.org/protocol/ctn0030/>), and CTN-0051 (<https://ctnlibrary.org/protocol/ctn0051/>).

Extract and interact with data from the Scottish Health and Social Care Open Data platform <https://www.opendata.nhs.scot>.

An implementation of the generalized power analysis for the local average treatment effect (LATE), proposed by Bansak (2020) <doi:10.1214/19-STS732>. Power analysis is in the context of estimating the LATE (also known as the complier average causal effect, or CACE), with calculations based on a test of the null hypothesis that the LATE equals 0 with a two-sided alternative. The method uses standardized effect sizes to place a conservative bound on the power under minimal assumptions. Package allows users to recover power, sample size requirements, or minimum detectable effect sizes. Package also allows users to work with absolute effects rather than effect sizes, to specify an additional assumption to narrow the bounds, and to incorporate covariate adjustment.

This package provides a C++ backend for multivariate phylogenetic comparative models implemented in the R-package PCMBase'. Can be used in combination with PCMBase to enable fast and parallel likelihood calculation. Implements the pruning likelihood calculation algorithm described in Mitov et al. (2020) <doi:10.1016/j.tpb.2019.11.005>. Uses the SPLITT C++ library for parallel tree traversal described in Mitov and Stadler (2018) <doi:10.1111/2041-210X.13136>.

This package provides functions for modeling, comparing, and visualizing photosynthetic light response curves using established mechanistic and empirical models like the rectangular hyperbola Michaelis-Menton based models ((eq1 (Baly (1935) <doi:10.1098/rspb.1935.0026>)) (eq2 (Kaipiainenn (2009) <doi:10.1134/S1021443709040025>)) (eq3 (Smith (1936) <doi:10.1073/pnas.22.8.504>))), hyperbolic tangent based models ((eq4 (Jassby & Platt (1976) <doi:10.4319/LO.1976.21.4.0540>)) (eq5 (Abe et al. (2009) <doi:10.1111/j.1444-2906.2008.01619.x>))), the non-rectangular hyperbola model (eq6 (Prioul & Chartier (1977) <doi:10.1093/oxfordjournals.aob.a085354>)), exponential based models ((eq8 (Webb et al. (1974) <doi:10.1007/BF00345747>)), (eq9 (Prado & de Moraes (1997) <doi:10.1007/BF02982542>))), and finally the Ye model (eq11 (Ye (2007) <doi:10.1007/s11099-007-0110-5>)). Each of these nonlinear least squares models are commonly used to express photosynthetic response under changing light conditions and has been well supported in the literature, but distinctions in each mathematical model represent moderately different assumptions about physiology and trait relationships which ultimately produce different calculated functional trait values. These models were all thoughtfully discussed and curated by Lobo et al. (2013) <doi:10.1007/s11099-013-0045-y> to express the importance of selecting an appropriate model for analysis, and methods were established in Davis et al. (in review) to evaluate the impact of analytical choice in phylogenetic analysis of the function-valued traits. Gas exchange data on 28 wild sunflower species from Davis et al.are included as an example data set here.

We extend dplyr and fuzzyjoin join functions with features to preprocess the data, apply various data checks, and deal with conflicting columns.

Data and analysis from an experiment with improving touch typing speed, using the tDCS PlatoWork headset produced by PlatoScience.

This package implements the methodology of Huling, Smith, and Chen (2020) <doi:10.1080/01621459.2020.1801449>, which allows for subgroup identification for semi-continuous outcomes by estimating individualized treatment rules. It uses a two-part modeling framework to handle semi-continuous data by separately modeling the positive part of the outcome and an indicator of whether each outcome is positive, but still results in a single treatment rule. High dimensional data is handled with a cooperative lasso penalty, which encourages the coefficients in the two models to have the same sign.

Extracts features from amplification curve data of quantitative Polymerase Chain Reactions (qPCR) according to Pabinger et al. 2014 <doi:10.1016/j.bdq.2014.08.002> for machine learning purposes. Helper functions prepare the amplification curve data for processing as functional data (e.g., Hausdorff distance) or enable the plotting of amplification curve classes (negative, ambiguous, positive). The hookreg() and hookregNL() functions of Burdukiewicz et al. (2018) <doi:10.1016/j.bdq.2018.08.001> can be used to predict amplification curves with an hook effect-like curvature. The pcrfit_single() function can be used to extract features from an amplification curve.

This package implements projected sparse Gaussian process Kriging ('Ingram et. al.', 2008, <doi:10.1007/s00477-007-0163-9>) as an additional method for the intamap package. More details on implementation ('Barillec et. al.', 2010, <doi:10.1016/j.cageo.2010.05.008>).

This package provides a Shiny input widget, pasteBoxInput, that allows users to paste images directly into a Shiny application. The pasted images are captured as Base64 encoded strings and can be used within the application for various purposes, such as display or further processing. This package is particularly useful for applications that require easy and quick image uploads without the need for traditional file selection dialog boxes.

This package provides a unified method, called M statistic, is provided for detecting phylogenetic signals in continuous traits, discrete traits, and multi-trait combinations. Blomberg and Garland (2002) <doi:10.1046/j.1420-9101.2002.00472.x> provided a widely accepted statistical definition of the phylogenetic signal, which is the "tendency for related species to resemble each other more than they resemble species drawn at random from the tree". The M statistic strictly adheres to the definition of phylogenetic signal, formulating an index and developing a method of testing in strict accordance with the definition, instead of relying on correlation analysis or evolutionary models. The novel method equivalently expressed the textual definition of the phylogenetic signal as an inequality equation of the phylogenetic and trait distances and constructed the M statistic. The M statistic implemented in this package is based on the methodology described in Yao and Yuan (2025) <doi:10.1002/ece3.71106>. If you use this method in your research, please cite the paper.

This package implements a general framework for creating dependency graphs using projection as introduced in Fan, Feng and Xia (2019)<arXiv:1501.01617>. Both lasso and sparse additive model projections are implemented. Both Pearson correlation and distance covariance options are available to generate the graph.

This package provides a modeling tool dedicated to biological network modeling (Bertrand and others 2020, <doi:10.1093/bioinformatics/btaa855>). It allows for single or joint modeling of, for instance, genes and proteins. It starts with the selection of the actors that will be the used in the reverse engineering upcoming step. An actor can be included in that selection based on its differential measurement (for instance gene expression or protein abundance) or on its time course profile. Wrappers for actors clustering functions and cluster analysis are provided. It also allows reverse engineering of biological networks taking into account the observed time course patterns of the actors. Many inference functions are provided and dedicated to get specific features for the inferred network such as sparsity, robust links, high confidence links or stable through resampling links. Some simulation and prediction tools are also available for cascade networks (Jung and others 2014, <doi:10.1093/bioinformatics/btt705>). Example of use with microarray or RNA-Seq data are provided.

An R implementation of the cross-platform, language-independent "port4me" algorithm (<https://github.com/HenrikBengtsson/port4me>), which (1) finds a free Transmission Control Protocol ('TCP') port in [1024,65535] that the user can open, (2) is designed to work in multi-user environments, (3), gives different users, different ports, (4) gives the user the same port over time with high probability, (5) gives different ports for different software tools, and (6) requires no configuration.

This package provides a method for fitting the entire regularization path of the principal components lasso for linear and logistic regression models. The algorithm uses cyclic coordinate descent in a path-wise fashion. See URL below for more information on the algorithm. See Tay, K., Friedman, J. ,Tibshirani, R., (2014) Principal component-guided sparse regression <arXiv:1810.04651>.

Implementation of commonly used penalized functional linear regression models, including the Smooth and Locally Sparse (SLoS) method by Lin et al. (2016) <doi:10.1080/10618600.2016.1195273>, Nested Group bridge Regression (NGR) method by Guan et al. (2020) <doi:10.1080/10618600.2020.1713797>, Functional Linear Regression That's interpretable (FLIRTI) by James et al. (2009) <doi:10.1214/08-AOS641>, and the Penalized B-spline regression method.

This function fits a reversible jump Bayesian piecewise exponential model that also includes the intensity of each event considered along with the rate of events.

This package provides a user friendly way to create patient level prediction models using the Observational Medical Outcomes Partnership Common Data Model. Given a cohort of interest and an outcome of interest, the package can use data in the Common Data Model to build a large set of features. These features can then be used to fit a predictive model with a number of machine learning algorithms. This is further described in Reps (2017) <doi:10.1093/jamia/ocy032>.

Parallelized version of the "segment" function from Bioconductor package "DNAcopy", utilizing multi-core computation on host CPU.

This package provides data set and function for exploration of Multiple Indicator Cluster Survey (MICS) 2017-18 Maternal Mortality questionnaire data for Punjab, Pakistan. The results of the present survey are critically important for the purposes of Sustainable Development Goals (SDGs) monitoring, as the survey produces information on 32 global Sustainable Development Goals (SDGs) indicators. The data was collected from 53,840 households selected at the second stage with systematic random sampling out of a sample of 2,692 clusters selected using probability proportional to size sampling. Six questionnaires were used in the survey: (1) a household questionnaire to collect basic demographic information on all de jure household members (usual residents), the household, and the dwelling; (2) a water quality testing questionnaire administered in three households in each cluster of the sample; (3) a questionnaire for individual women administered in each household to all women age 15-49 years; (4) a questionnaire for individual men administered in every second household to all men age 15-49 years; (5) an under-5 questionnaire, administered to mothers (or caretakers) of all children under 5 living in the household; and (6) a questionnaire for children age 5-17 years, administered to the mother (or caretaker) of one randomly selected child age 5-17 years living in the household (<http://www.mics.unicef.org/surveys>).

Simulating and conducting four phase 12 clinical trials with correlated binary bivariate outcomes described. Uses the Efftox (efficacy and toxicity tradeoff, <https://biostatistics.mdanderson.org/SoftwareDownload/SingleSoftware/Index/2>) and SPSO (Semi-Parametric Stochastic Ordering) models with Utility and Desirability based objective functions for dose finding.