Cellular responses to perturbations are highly heterogeneous and depend largely on the initial state of cells. Connecting post-perturbation cells via cellular trajectories to untreated cells (e.g. by leveraging metabolic labeling information) enables exploitation of intercellular heterogeneity as a combined knock-down and overexpression screen to identify pathway modulators, termed Heterogeneity-seq (see Berg et al <doi:10.1101/2024.10.28.620481>). This package contains functions to generate cellular trajectories based on scSLAM-seq (single-cell, thiol-(SH)-linked alkylation of RNA for metabolic labelling sequencing) time courses, functions to identify pathway modulators and to visualize the results.

Compute house price indexes and series using a variety of different methods and models common through the real estate literature. Evaluate index goodness based on accuracy, volatility and revision statistics. Background on basic model construction for repeat sales models can be found at: Case and Quigley (1991) <https://ideas.repec.org/a/tpr/restat/v73y1991i1p50-58.html> and for hedonic pricing models at: Bourassa et al (2006) <doi:10.1016/j.jhe.2006.03.001>. The package author's working paper on the random forest approach to house price indexes can be found at: <http://www.github.com/andykrause/hpi_research>.

Computes the scores and ranks candidates according to voting rules electing the highest median grade. Based on "Tie-breaking the highest median: alternatives to the majority judgment", A. Fabre, Social Choice & Welfare (forthcoming as of 2020). The paper is available here: <https://github.com/bixiou/highest_median/raw/master/Tie-breaking%20Highest%20Median%20-%20Fabre%202019.pdf>. Functions to plot the voting profiles can be found on github: <https://github.com/bixiou/highest_median/blob/master/packages_functions_data.R>.

This package provides a set of routines to quickly download and import the HUGO Gene Nomenclature Committee (HGNC) data set on mapping of gene symbols to gene entries in other genomic databases or resources.

Develops algorithms for fitting, prediction, simulation and initialization of the following models (1)- hidden hybrid Markov/semi-Markov model, introduced by Guedon (2005) <doi:10.1016/j.csda.2004.05.033>, (2)- nonparametric mixture of B-splines emissions (Langrock et al., 2015 <doi:10.1111/biom.12282>), (3)- regime switching regression model (Kim et al., 2008 <doi:10.1016/j.jeconom.2007.10.002>) and auto-regressive hidden hybrid Markov/semi-Markov model, (4)- spline-based nonparametric estimation of additive state-switching models (Langrock et al., 2018 <doi:10.1111/stan.12133>) (5)- robust emission model proposed by Qin et al, 2024 <doi:10.1007/s10479-024-05989-4> (6)- several emission distributions, including mixture of multivariate normal (which can also handle missing data using EM algorithm) and multi-nomial emission (for modeling polymer or DNA sequences) (7)- tools for prediction of future state sequence, computing the score of a new sequence, splitting the samples and sequences to train and test sets, computing the information measures of the models, computing the residual useful lifetime (reliability) and many other useful tools ... (read for more description: Amini et al., 2022 <doi:10.1007/s00180-022-01248-x> and its arxiv version: <doi:10.48550/arXiv.2109.12489>).

This package performs genetic association analyses of case-parent triad (trio) data with multiple markers. It can also incorporate complete or incomplete control triads, for instance independent control children. Estimation is based on haplotypes, for instance SNP haplotypes, even though phase is not known from the genetic data. Haplin estimates relative risk (RR + conf.int.) and p-value associated with each haplotype. It uses maximum likelihood estimation to make optimal use of data from triads with missing genotypic data, for instance if some SNPs has not been typed for some individuals. Haplin also allows estimation of effects of maternal haplotypes and parent-of-origin effects, particularly appropriate in perinatal epidemiology. Haplin allows special models, like X-inactivation, to be fitted on the X-chromosome. A GxE analysis allows testing interactions between environment and all estimated genetic effects. The models were originally described in "Gjessing HK and Lie RT. Case-parent triads: Estimating single- and double-dose effects of fetal and maternal disease gene haplotypes. Annals of Human Genetics (2006) 70, pp. 382-396".

Given a high-dimensional dataset that typically represents a cytometry dataset, and a subset of the datapoints, this algorithm outputs an hyperrectangle so that datapoints within the hyperrectangle best correspond to the specified subset. In essence, this allows the conversion of clustering algorithms outputs to gating strategies outputs.

This package provides a stand-alone function that generates a user specified number of random datasets and computes eigenvalues using the random datasets (i.e., implements Horn's [1965, Psychometrika] parallel analysis <doi:10.1007/BF02289447>). Users then compare the resulting eigenvalues (the mean or the specified percentile) from the random datasets (i.e., eigenvalues resulting from noise) to the eigenvalues generated with the user's data. Can be used for both principal components analysis (PCA) and common/exploratory factor analysis (EFA). The output table shows how large eigenvalues can be as a result of merely using randomly generated datasets. If the user's own dataset has actual eigenvalues greater than the corresponding eigenvalues, that lends support to retain that factor/component. In other words, if the i(th) eigenvalue from the actual data was larger than the percentile of the (i)th eigenvalue generated using randomly generated data, empirical support is provided to retain that factor/component. Horn, J. (1965). A rationale and test for the number of factors in factor analysis. Psychometrika, 32, 179-185.

This package contains various functions for data analysis, notably helpers and diagnostics for Bayesian modelling using Stan.

In order to improve performance for HTTP API clients, httpcache provides simple tools for caching and invalidating cache. It includes the HTTP verb functions GET, PUT, PATCH, POST, and DELETE, which are drop-in replacements for those in the httr package. These functions are cache-aware and provide default settings for cache invalidation suitable for RESTful APIs; the package also enables custom cache-management strategies. Finally, httpcache includes a basic logging framework to facilitate the measurement of HTTP request time and cache performance.

Makes it easy to download a large number of files such as PDF files and CSV files, while automatically slowing down requests, letting you know where it is up to, and adjusting for files that have already been downloaded.

This package provides methods for closed testing using Simes local tests. In particular, calculates adjusted p-values for Hommel's multiple testing method, and provides lower confidence bounds for true discovery proportions. A robust but more conservative variant of the closed testing procedure that does not require the assumption of Simes inequality is also implemented. The methods have been described in detail in Goeman et al (Biometrika 106, 841-856, 2019).

Translation between experimental null hypotheses, hypothesis matrices, and contrast matrices as used in linear regression models. The package is based on the method described in Schad et al. (2019) <doi:10.1016/j.jml.2019.104038> and Rabe et al. (2020) <doi:10.21105/joss.02134>.

High-dimensional matrix factor models have drawn much attention in view of the fact that observations are usually well structured to be an array such as in macroeconomics and finance. In addition, data often exhibit heavy-tails and thus it is also important to develop robust procedures. We aim to address this issue by replacing the least square loss with Huber loss function. We propose two algorithms to do robust factor analysis by considering the Huber loss. One is based on minimizing the Huber loss of the idiosyncratic error's Frobenius norm, which leads to a weighted iterative projection approach to compute and learn the parameters and thereby named as Robust-Matrix-Factor-Analysis (RMFA), see the details in He et al. (2023)<doi:10.1080/07350015.2023.2191676>. The other one is based on minimizing the element-wise Huber loss, which can be solved by an iterative Huber regression algorithm (IHR), see the details in He et al. (2023) <arXiv:2306.03317>. In this package, we also provide the algorithm for alpha-PCA by Chen & Fan (2021) <doi:10.1080/01621459.2021.1970569>, the Projected estimation (PE) method by Yu et al. (2022)<doi:10.1016/j.jeconom.2021.04.001>. In addition, the methods for determining the pair of factor numbers are also given.

This package provides a user-friendly interface for the Hierarchical Data Format 5 ('HDF5') library designed to "just work." It bundles the necessary system libraries to ensure easy installation on all platforms. Features smart defaults that automatically map R objects (vectors, matrices, data frames) to efficient HDF5 types, removing the need to manage low-level details like dataspaces or property lists. Uses the HDF5 library developed by The HDF Group <https://www.hdfgroup.org/>.

Helper functions designed to make dynamically generating R Markdown documents easier by providing a simple and tidy way to create report pieces, shape them to your data, and combine them for exporting into a single R Markdown document.

Read hierarchical fixed width files like those commonly used by many census data providers. Also allows for reading of data in chunks, and reading gzipped files without storing the full file in memory.

Deprecated.

The book "Semiparametric Regression with R" by J. Harezlak, D. Ruppert & M.P. Wand (2018, Springer; ISBN: 978-1-4939-8851-8) makes use of datasets and scripts to explain semiparametric regression concepts. Each of the book's scripts are contained in this package as well as datasets that are not within other R packages. Functions that aid semiparametric regression analysis are also included.

Generates high-entropy integer synthetic populations from marginal and (optionally) seed data using quasirandom sampling, in arbitrary dimensionality (Smith, Lovelace and Birkin (2017) <doi:10.18564/jasss.3550>). The package also provides an implementation of the Iterative Proportional Fitting (IPF) algorithm (Zaloznik (2011) <doi:10.13140/2.1.2480.9923>).

Import and classify canopy fish-eye images, estimate angular gap fraction and derive canopy attributes like leaf area index and openness. Additional information is provided in the study by Chianucci F., Macek M. (2023) <doi:10.1016/j.agrformet.2023.109470>.

Manipulate data through memory-mapped files, as vectors, matrices or arrays. Basic arithmetic functions are implemented, but currently no matrix arithmetic. Can write and read descriptor files for compatibility with the bigmemory package.

This package provides functions to compute small area estimates based on a basic area or unit-level model. The model is fit using restricted maximum likelihood, or in a hierarchical Bayesian way. In the latter case numerical integration is used to average over the posterior density for the between-area variance. The output includes the model fit, small area estimates and corresponding mean squared errors, as well as some model selection measures. Additional functions provide means to compute aggregate estimates and mean squared errors, to minimally adjust the small area estimates to benchmarks at a higher aggregation level, and to graphically compare different sets of small area estimates.

Estimate parameters of the hysteretic threshold autoregressive (HysTAR) model, using conditional least squares. In addition, you can generate time series data from the HysTAR model. For details, see Li, Guan, Li and Yu (2015) <doi:10.1093/biomet/asv017>.