Accurate classification of breast cancer tumors based on gene expression data is not a trivial task, and it lacks standard practices.The PAM50 classifier, which uses 50 gene centroid correlation distances to classify tumors, faces challenges with balancing estrogen receptor (ER) status and gene centering. The PCAPAM50 package leverages principal component analysis and iterative PAM50 calls to create a gene expression-based ER-balanced subset for gene centering, avoiding the use of protein expression-based ER data resulting into an enhanced Breast Cancer subtyping.

Calculate Plant Stress Response Index (PSRI) from time-series germination data with optional radicle vigor integration. Built on the methodological foundation of the Osmotic Stress Response Index (OSRI) framework developed by Walne et al. (2020) <doi:10.1002/agg2.20087>. Provides clean, direct PSRI calculations suitable for agricultural research and statistical analysis. Note: This package implements methodology currently under peer review. Please contact the author before publication using this approach.

The spatial interpolation of genetic distances between samples is based on a modified kriging method that accepts a genetic distance matrix and generates a map of probability of lineage presence. This package also offers tools to generate a map of potential contact zones between groups with user-defined thresholds in the tree to account for old and recent divergence. Additionally, it has functions for IDW interpolation using genetic data and midpoints.

This package provides functions to calculate power and sample size for testing (1) mediation effects; (2) the slope in a simple linear regression; (3) odds ratio in a simple logistic regression; (4) mean change for longitudinal study with 2 time points; (5) interaction effect in 2-way ANOVA; and (6) the slope in a simple Poisson regression.

This package contains three simulation functions for implementing the entire Phase 123 trial and the separate Eff-Tox and Phase 3 portions of the trial, which may be beneficial for use on clusters. The functions AssignEffTox() and RandomizeEffTox() assign doses to patient cohorts during phase 12 and Reoptimize() determines the optimal dose to continue with during Phase 3. The functions ReturnMeansAgent() and ReturnMeanControl() gives the true mean survival for the agent doses and control and ReturnOCS() gives the operating characteristics of the design.

This package provides a modeling tool dedicated to biological network modeling (Bertrand and others 2020, <doi:10.1093/bioinformatics/btaa855>). It allows for single or joint modeling of, for instance, genes and proteins. It starts with the selection of the actors that will be the used in the reverse engineering upcoming step. An actor can be included in that selection based on its differential measurement (for instance gene expression or protein abundance) or on its time course profile. Wrappers for actors clustering functions and cluster analysis are provided. It also allows reverse engineering of biological networks taking into account the observed time course patterns of the actors. Many inference functions are provided and dedicated to get specific features for the inferred network such as sparsity, robust links, high confidence links or stable through resampling links. Some simulation and prediction tools are also available for cascade networks (Jung and others 2014, <doi:10.1093/bioinformatics/btt705>). Example of use with microarray or RNA-Seq data are provided.

Simulate and run the Gaussian puff forward atmospheric model in sensor (specific sensor coordinates) or grid (across the grid of a full oil and gas operations site) modes, following Jia, M., Fish, R., Daniels, W., Sprinkle, B. and Hammerling, D. (2024) <doi:10.26434/chemrxiv-2023-hc95q-v3>. Numerous visualization options, including static and animated, 2D and 3D, and a site map generator based on sensor and source coordinates.

Assessment for statistically-based PPQ sampling plan, including calculating the passing probability, optimizing the baseline and high performance cutoff points, visualizing the PPQ plan and power dynamically. The analytical idea is based on the simulation methods from the textbook Burdick, R. K., LeBlond, D. J., Pfahler, L. B., Quiroz, J., Sidor, L., Vukovinsky, K., & Zhang, L. (2017). Statistical Methods for CMC Applications. In Statistical Applications for Chemistry, Manufacturing and Controls (CMC) in the Pharmaceutical Industry (pp. 227-250). Springer, Cham.

Check a data frame for personal information, including names, location, disability status, and geo-coordinates.

An interface to the API for Pan-STARRS1', a data archive of the PS1 wide-field astronomical survey. The package allows access to the PS1 catalog and to the PS1 images. (see <https://outerspace.stsci.edu/display/PANSTARRS/> for more information). You can use it to plan astronomical observations, make guidance pictures, find magnitudes in five broadband filters (g, r, i, z, y) and more.

Determine the chlorophyll a (Chl a) concentrations of different phytoplankton groups based on their pigment biomarkers. The method uses non-negative matrix factorisation and simulated annealing to minimise error between the observed and estimated values of pigment concentrations (Hayward et al. (2023) <doi:10.1002/lom3.10541>). The approach is similar to the widely used CHEMTAX program (Mackey et al. 1996) <doi:10.3354/meps144265>, but is more straightforward, accurate, and not reliant on initial guesses for the pigment to Chl a ratios for phytoplankton groups.

Facilitates the performance of several analyses, including simple and sequential path coefficient analysis, correlation estimate, drawing correlogram, Heatmap, and path diagram. When working with raw data, that includes one or more dependent variables along with one or more independent variables are available, the path coefficient analysis can be conducted. It allows for testing direct effects, which can be a vital indicator in path coefficient analysis. The process of preparing the dataset rule is explained in detail in the vignette file "Path.Analysis_manual.Rmd". You can find this in the folders labelled "data" and "~/inst/extdata". Also see: 1)the lavaan', 2)a sample of sequential path analysis in metan suggested by Olivoto and Lúcio (2020) <doi:10.1111/2041-210X.13384>, 3)the simple PATHSAS macro written in SAS by Cramer et al. (1999) <doi:10.1093/jhered/90.1.260>, and 4)the semPlot() function of OpenMx as initial tools for conducting path coefficient analyses and SEM (Structural Equation Modeling). To gain a comprehensive understanding of path coefficient analysis, both in theory and practice, see a Minitab macro developed by Arminian, A. in the paper by Arminian et al. (2008) <doi:10.1080/15427520802043182>.

Search for R packages on CRAN directly from the R console, based on the packages titles, short and long descriptions, or other fields. Combine multiple keywords with logical operators ('and', or'), view detailed information on any package and keep track of the latest package contributions to CRAN. If you don't want to search from the R console, use the comfortable R Studio add-in.

An environment to simulate the development of annual plant populations with regard to population dynamics and genetics, especially herbicide resistance. It combines genetics on the individual level (Renton et al. 2011) with a stochastic development on the population level (Daedlow, 2015). Renton, M, Diggle, A, Manalil, S and Powles, S (2011) <doi:10.1016/j.jtbi.2011.05.010> Daedlow, Daniel (2015, doctoral dissertation: University of Rostock, Faculty of Agriculture and Environmental Sciences.).

This package provides a collection of miscellaneous functions for passive acoustics. Much of the content here is adapted to R from code written by other people. If you have any ideas of functions to add, please contact Taiki Sakai.

This package provides tools for performing disproportionality analysis using the information component, proportional reporting rate and the reporting odds ratio. The anticipated use is passing data to the da() function, which executes the disproportionality analysis. See Norén et al (2011) <doi:10.1177/0962280211403604> and Montastruc et al (2011) <doi:10.1111/j.1365-2125.2011.04037.x> for further details.

Identification of the most appropriate pharmacotherapy for each patient based on genomic alterations is a major challenge in personalized oncology. PANACEA is a collection of personalized anti-cancer drug prioritization approaches utilizing network methods. The methods utilize personalized "driverness" scores from driveR to rank drugs, mapping these onto a protein-protein interaction network. The "distance-based" method scores each drug based on these scores and distances between drugs and genes to rank given drugs. The "RWR" method propagates these scores via a random-walk with restart framework to rank the drugs. The methods are described in detail in Ulgen E, Ozisik O, Sezerman OU. 2023. PANACEA: network-based methods for pharmacotherapy prioritization in personalized oncology. Bioinformatics <doi:10.1093/bioinformatics/btad022>.

Automatic estimation of number of principal components in PCA with PEnalized SEmi-integrated Likelihood (PESEL). See Piotr Sobczyk, Malgorzata Bogdan, Julie Josse "Bayesian dimensionality reduction with PCA using penalized semi-integrated likelihood" (2017) <doi:10.1080/10618600.2017.1340302>.

Runs generalized and multinominal logistic (GLM and MLM) models, as well as random forest (RF), Bagging (BAG), and Boosting (BOOST). This package prints out to predictive outcomes easy for the selected data and data splits.

This package provides functions to get prediction intervals and prediction points of future observations from any continuous distribution.

This package provides a system to increase the efficiency of dynamic web-scraping with RSelenium by leveraging parallel processing. You provide a function wrapper for your RSelenium scraping routine with a set of inputs, and parsel runs it in several browser instances. Chunked input processing as well as error catching and logging ensures seamless execution and minimal data loss, even when unforeseen RSelenium errors occur. You can additionally build safe scraping functions with minimal coding by utilizing constructor functions that act as wrappers around RSelenium methods.

This package provides functions for data normalization and transformation in preprocessing stages. Implements scaling methods (min-max, Z-score, L2 normalization) and power transformations (Box-Cox, Yeo-Johnson). Box-Cox transformation is described in Box and Cox (1964) <doi:10.1111/j.2517-6161.1964.tb00553.x>, Yeo-Johnson transformation in Yeo and Johnson (2000) <doi:10.1093/biomet/87.4.954>.

Use Prime Factorization for simplifying computations, for instance for ratios of large factorials.

PROMETHEE (Preference Ranking Organisation METHod for Enrichment of Evaluations) based method assesses alternatives to obtain partial and complete rankings. The package also provides the GLNF (Global Local Net Flow) sorting algorithm to classify alternatives into ordered categories, as well as an index function to measure the classification quality. Barrera, F., Segura, M., & Maroto, C. (2023) <doi:10.1111/itor.13288>. Brans, J.P.; De Smet, Y., (2016) <doi:10.1007/978-1-4939-3094-4_6>.