Gene-level variant association tests with disease status for pedigree data: kernel and burden association statistics.

Visualizes panel data. It has three main functionalities: (1) it plots the treatment status and missing values in a panel dataset; (2) it visualizes the temporal dynamics of a main variable of interest; (3) it depicts the bivariate relationships between a treatment variable and an outcome variable either by unit or in aggregate. For details, see <doi:10.18637/jss.v107.i07>.

An implementation of the "Design Analysis" proposed by Gelman and Carlin (2014) <doi:10.1177/1745691614551642>. It combines the evaluation of Power-Analysis with other inferential-risks as Type-M error (i.e. Magnitude) and Type-S error (i.e. Sign). See also Altoè et al. (2020) <doi:10.3389/fpsyg.2019.02893> and Bertoldo et al. (2020) <doi:10.31234/osf.io/q9f86>.

The Piece-wise exponential (Additive Mixed) Model (PAMM; Bender and others (2018) <doi: 10.1177/1471082X17748083>) is a powerful model class for the analysis of survival (or time-to-event) data, based on Generalized Additive (Mixed) Models (GA(M)Ms). It offers intuitive specification and robust estimation of complex survival models with stratified baseline hazards, random effects, time-varying effects, time-dependent covariates and cumulative effects (Bender and others (2019)), as well as support for left-truncated data as well as competing risks, recurrent events and multi-state settings. pammtools provides tidy workflow for survival analysis with PAMMs, including data simulation, transformation and other functions for data preprocessing and model post-processing as well as visualization.

Implementation of the Partitioned Local Depth (PaLD) approach which provides a measure of local depth and the cohesion of a point to another which (together with a universal threshold for distinguishing strong and weak ties) may be used to reveal local and global structure in data, based on methods described in Berenhaut, Moore, and Melvin (2022) <doi:10.1073/pnas.2003634119>. No extraneous inputs, distributional assumptions, iterative procedures nor optimization criteria are employed. This package includes functions for computing local depths and cohesion as well as flexible functions for plotting community networks and displays of cohesion against distance.

This package implements the Bayesian hierarchical model described by Wheldon, Raftery, Clark and Gerland (see: <doi:10.1080/01621459.2012.737729>) for simultaneously estimating age-specific population counts, fertility rates, mortality rates and net international migration flows, at the national level.

Designed for prediction error estimation through resampling techniques, possibly accelerated by parallel execution on a compute cluster. Newly developed model fitting routines can be easily incorporated. Methods used in the package are detailed in Porzelius Ch., Binder H. and Schumacher M. (2009) <doi:10.1093/bioinformatics/btp062> and were used, for instance, in Porzelius Ch., Schumacher M. and Binder H. (2011) <doi:10.1007/s00180-011-0236-6>.

This package provides a polycross is the pollination by natural hybridization of a group of genotypes, generally selected, grown in isolation from other compatible genotypes in such a way to promote random open pollination. A particular practical application of the polycross method occurs in the production of a synthetic variety resulting from cross-pollinated plants. Laying out these experiments in appropriate designs, known as polycross designs, would not only save experimental resources but also gather more information from the experiment. Different experimental situations may arise in polycross nurseries which may be requiring different polycross designs (Varghese et. al. (2015) <doi:10.1080/02664763.2015.1043860>. " Experimental designs for open pollination in polycross trials"). This package contains a function named PD() which generates nine types of polycross designs suitable for various experimental situations.

The pharmaverse is a set of packages that compose multiple pathways through clinical data generation and reporting in the pharmaceutical industry. This package is designed to guide users to our work-spaces on GitHub', Slack and LinkedIn as well as our website and examples. Learn more about the pharmaverse at <https://pharmaverse.org>.

Defines functions to describe regression models using only pre-computed summary statistics (i.e. means, variances, and covariances) in place of individual participant data. Possible models include linear models for linear combinations, products, and logical combinations of phenotypes. Implements methods presented in Wolf et al. (2021) <doi:10.3389/fgene.2021.745901> Wolf et al. (2020) <doi:10.1142/9789811215636_0063> and Gasdaska et al. (2019) <doi:10.1142/9789813279827_0036>.

The document converter pandoc <https://pandoc.org/> is widely used in the R community. One feature of pandoc is that it can produce and consume JSON-formatted abstract syntax trees (AST). This allows to transform a given source document into JSON-formatted AST, alter it by so called filters and pass the altered JSON-formatted AST back to pandoc'. This package provides functions which allow to write such filters in native R code. Although this package is inspired by the Python package pandocfilters <https://github.com/jgm/pandocfilters/>, it provides additional convenience functions which make it simple to use the pandocfilters package as a report generator. Since pandocfilters inherits most of it's functionality from pandoc it can create documents in many formats (for more information see <https://pandoc.org/>) but is also bound to the same limitations as pandoc'.

Supports the creation of burndown charts and gantt diagrams.

The prevalence package provides Frequentist and Bayesian methods for prevalence assessment studies. IMPORTANT: the truePrev functions in the prevalence package call on JAGS (Just Another Gibbs Sampler), which therefore has to be available on the user's system. JAGS can be downloaded from <https://mcmc-jags.sourceforge.io/>.

This package provides tools for profiling a user-supplied log-likelihood function to calculate confidence intervals for model parameters. Speed of computation can be improved by adjusting the step sizes in the profiling and/or starting the profiling from limits based on the approximate large sample normal distribution for the maximum likelihood estimator of a parameter. The accuracy of the limits can be set by the user. A plot method visualises the log-likelihood and confidence interval. Cases where the profile log-likelihood flattens above the value at which a confidence limit is defined can be handled, leading to a limit at plus or minus infinity. Disjoint confidence intervals will not be found.

This package implements a range of facilities for post-hoc analysis and summarizing linear models, generalized linear models and generalized linear mixed models, including grouping and clustering via pairwise comparisons using graph representations and efficient algorithms for finding maximal cliques of a graph. Includes also non-parametric toos for post-hoc analysis. It has S3 methods for printing summarizing, and producing plots, line and barplots suitable for post-hoc analyses.

The base R data.frame, like any vector, is copied upon modification. This behavior is at odds with that of GUIs and interactive graphics. To rectify this, plumbr provides a mutable, dynamic tabular data model. Models may be chained together to form the complex plumbing necessary for sophisticated graphical interfaces. Also included is a general framework for linking datasets; an typical use case would be a linked brush.

Automate pharmacokinetic/pharmacodynamic bioanalytical procedures based on best practices and regulatory recommendations. The package impose regulatory constrains and sanity checking for common bioanalytical procedures. Additionally, PKbioanalysis provides a relational infrastructure for plate management and injection sequence.

This package implements the methods proposed by Olley, G.S. and Pakes, A. (1996) <doi:10.2307/2171831>, Levinsohn, J. and Petrin, A. (2003) <doi:10.1111/1467-937X.00246>, Ackerberg, D.A. and Caves, K. and Frazer, G. (2015) <doi:10.3982/ECTA13408> and Wooldridge, J.M. (2009) <doi:10.1016/j.econlet.2009.04.026> for structural productivity estimation .

This package provides functions and data sets for the text Probability and Statistics with R.

Easily visualize and animate tabledap and griddap objects obtained via the rerddap package in a simple one-line command, using either base graphics or ggplot2 graphics. plotdap handles extracting and reshaping the data, map projections and continental outlines. Optionally the data can be animated through time using the gganmiate package.

Projection Pursuit (PP) algorithm for dimension reduction based on Gaussian Mixture Models (GMMs) for density estimation using Genetic Algorithms (GAs) to maximise an approximated negentropy index. For more details see Scrucca and Serafini (2019) <doi:10.1080/10618600.2019.1598871>.

This package provides the tools needed to benchmark the R2 value corresponding to a certain acceptable noise level while also providing a rescaling function based on that noise level yielding a new value of R2 we refer to as R2k which is independent of both the number of degrees of freedom and the noise distribution function.

This package provides a graphical user interface for viewing and designing various types of graphs of the data. The graphs can be saved in different formats of an image.

The main attribute of PopVar is the prediction of genetic variance in bi-parental populations, from which the package derives its name. PopVar contains a set of functions that use phenotypic and genotypic data from a set of candidate parents to 1) predict the mean, genetic variance, and superior progeny value of all, or a defined set of pairwise bi-parental crosses, and 2) perform cross-validation to estimate genome-wide prediction accuracy of multiple statistical models. More details are available in Mohammadi, Tiede, and Smith (2015, <doi:10.2135/cropsci2015.01.0030>). A dataset think_barley.rda is included for reference and examples.