The strength of evidence provided by epidemiological and observational studies is inherently limited by the potential for unmeasured confounding. We focus on three key quantities: the observed bound of the confidence interval closest to the null, the relationship between an unmeasured confounder and the outcome, for example a plausible residual effect size for an unmeasured continuous or binary confounder, and the relationship between an unmeasured confounder and the exposure, for example a realistic mean difference or prevalence difference for this hypothetical confounder between exposure groups. Building on the methods put forth by Cornfield et al. (1959), Bross (1966), Schlesselman (1978), Rosenbaum & Rubin (1983), Lin et al. (1998), Lash et al. (2009), Rosenbaum (1986), Cinelli & Hazlett (2020), VanderWeele & Ding (2017), and Ding & VanderWeele (2016), we can use these quantities to assess how an unmeasured confounder may tip our result to insignificance.

This package contains summary data on gene expression in normal human tissues from the Human Protein Atlas for use with the Tissue-Adjusted Pathway Analysis of cancer (TPAC) method. Frost, H. Robert (2023) "Tissue-adjusted pathway analysis of cancer (TPAC)" <doi:10.1101/2022.03.17.484779>.

Univariate time series operations that follow an opinionated design. The main principle of transx is to keep the number of observations the same. Operations that reduce this number have to fill the observations gap.

This package provides functions for preparing and analyzing animal tracking data, with the intention of identifying areas which are potentially important at the population level and therefore of conservation interest. Areas identified using this package may be checked against global or regionally-defined criteria, such as those set by the Key Biodiversity Area program. The method published herein is described in full in Beal et al. 2021 <doi:10.1111/2041-210X.13713>.

This package provides a slightly-opinionated R interface for the Tremendous API (<https://www.tremendous.com/>). In addition to supporting GET and POST requests, tremendousr has, dare I say, tremendously intuitive functions for sending digital rewards and incentives directly from R.

We provide a toolbox to estimate the time delay between the brightness time series of gravitationally lensed quasar images via Bayesian and profile likelihood approaches. The model is based on a state-space representation for irregularly observed time series data generated from a latent continuous-time Ornstein-Uhlenbeck process. Our Bayesian method adopts scientifically motivated hyper-prior distributions and a Metropolis-Hastings within Gibbs sampler, producing posterior samples of the model parameters that include the time delay. A profile likelihood of the time delay is a simple approximation to the marginal posterior distribution of the time delay. Both Bayesian and profile likelihood approaches complement each other, producing almost identical results; the Bayesian way is more principled but the profile likelihood is easier to implement. A new functionality is added in version 1.0.9 for estimating the time delay between doubly-lensed light curves observed in two bands. See also Tak et al. (2017) <doi:10.1214/17-AOAS1027>, Tak et al. (2018) <doi:10.1080/10618600.2017.1415911>, Hu and Tak (2020) <arXiv:2005.08049>.

Simulation methods for phylogenetic trees where (i) all tips are sampled at one time point or (ii) tips are sampled sequentially through time. (i) For sampling at one time point, simulations are performed under a constant rate birth-death process, conditioned on having a fixed number of final tips (sim.bd.taxa()), or a fixed age (sim.bd.age()), or a fixed age and number of tips (sim.bd.taxa.age()). When conditioning on the number of final tips, the method allows for shifts in rates and mass extinction events during the birth-death process (sim.rateshift.taxa()). The function sim.bd.age() (and sim.rateshift.taxa() without extinction) allow the speciation rate to change in a density-dependent way. The LTT plots of the simulations can be displayed using LTT.plot(), LTT.plot.gen() and LTT.average.root(). TreeSim further samples trees with n final tips from a set of trees generated by the common sampling algorithm stopping when a fixed number m>>n of tips is first reached (sim.gsa.taxa()). This latter method is appropriate for m-tip trees generated under a big class of models (details in the sim.gsa.taxa() man page). For incomplete phylogeny, the missing speciation events can be added through simulations (corsim()). (ii) sim.rateshifts.taxa() is generalized to sim.bdsky.stt() for serially sampled trees, where the trees are conditioned on either the number of sampled tips or the age. Furthermore, for a multitype-branching process with sequential sampling, trees on a fixed number of tips can be simulated using sim.bdtypes.stt.taxa(). This function further allows to simulate under epidemiological models with an exposed class. The function sim.genespeciestree() simulates coalescent gene trees within birth-death species trees, and sim.genetree() simulates coalescent gene trees.

Overall predictive performance is measured by a mean score (or loss), which decomposes into miscalibration, discrimination, and uncertainty components. The main focus is visualization of these distinct and complementary aspects in joint displays. See Dimitriadis, Gneiting, Jordan, Vogel (2024) <doi:10.1016/j.ijforecast.2023.09.007>.

This package provides a lightweight and focused text annotation tool built with shiny'. Provides an interactive graphical user interface for coding text documents, managing code hierarchies, creating memos, and analyzing coding patterns. Features include code co-occurrence analysis, visualization of coding patterns, comparison of multiple coding sets, and export capabilities. Supports collaborative qualitative research through standardized annotation formats and analysis tools.

Time-Temperature Superposition analysis is often applied to frequency modulated data obtained by Dynamic Mechanic Analysis (DMA) and Rheometry in the analytical chemistry and physics areas. These techniques provide estimates of material mechanical properties (such as moduli) at different temperatures in a wider range of time. This package provides the Time-Temperature superposition Master Curve at a referred temperature by the three methods: the two wider used methods, Arrhenius based methods and WLF, and the newer methodology based on derivatives procedure. The Master Curve is smoothed by B-splines basis. The package output is composed of plots of experimental data, horizontal and vertical shifts, TTS data, and TTS data fitted using B-splines with bootstrap confidence intervals.

Multiscale multifractal analysis (MMA) (GieraÅ towski et al., 2012)<DOI:10.1103/PhysRevE.85.021915> is a time series analysis method, designed to describe scaling properties of fluctuations within the signal analyzed. The main result of this procedure is the so called Hurst surface h(q,s) , which is a dependence of the local Hurst exponent h (fluctuation scaling exponent) on the multifractal parameter q and the scale of observation s (data window width).

This package provides a collection of methods to estimate parameters of different tempered stable distributions (TSD). Currently, there are seven different tempered stable distributions to choose from: Tempered stable subordinator distribution, classical TSD, generalized classical TSD, normal TSD, modified TSD, rapid decreasing TSD, and Kim-Rachev TSD. The package also provides functions to compute density and probability functions and tools to run Monte Carlo simulations. This package has already been used for the estimation of tempered stable distributions (Massing (2023) <arXiv:2303.07060>). The following references form the theoretical background for various functions in this package. References for each function are explicitly listed in its documentation: Bianchi et al. (2010) <doi:10.1007/978-88-470-1481-7_4> Bianchi et al. (2011) <doi:10.1137/S0040585X97984632> Carrasco (2017) <doi:10.1017/S0266466616000025> Feuerverger (1981) <doi:10.1111/j.2517-6161.1981.tb01143.x> Hansen et al. (1996) <doi:10.1080/07350015.1996.10524656> Hansen (1982) <doi:10.2307/1912775> Hofert (2011) <doi:10.1145/2043635.2043638> Kawai & Masuda (2011) <doi:10.1016/j.cam.2010.12.014> Kim et al. (2008) <doi:10.1016/j.jbankfin.2007.11.004> Kim et al. (2009) <doi:10.1007/978-3-7908-2050-8_5> Kim et al. (2010) <doi:10.1016/j.jbankfin.2010.01.015> Kuechler & Tappe (2013) <doi:10.1016/j.spa.2013.06.012> Rachev et al. (2011) <doi:10.1002/9781118268070>.

The goal of tidyplate is to help researchers convert different types of microplates into tibbles which can be used in data analysis. It accepts xlsx and csv files formatted in a specific way as input. It supports all types of standard microplate formats such as 6-well, 12-well, 24-well, 48-well, 96-well, 384-well, and, 1536-well plates.

U.S. Department of the Treasury, Alcohol and Tobacco Tax and Trade Bureau (TTB) collects data and reports on monthly beer industry production and operations. This data package includes a collection of 10 years (2006 - 2015) worth of data on materials used at U.S. breweries in pounds reported by the Brewer's Report of Operations and the Quarterly Brewer's Report of Operations forms, ready for data analysis. This package also includes historical tax rates on distilled spirits, wine, beer, champagne, and tobacco products as individual data sets.

This package provides access to the Taxonomic Name Resolution Service <https://github.com/ojalaquellueva/tnrsapi> through R. The user supplies plant taxonomic names and the package returns resolved taxonomic names along with information on decisions. Optionally, the package can also be used to parse taxonomic names.

Implementation of a Bayesian two-way latent structure model for integrative genomic clustering. The model clusters samples in relation to distinct data sources, with each subject-dataset receiving a latent cluster label, though cluster labels have across-dataset meaning because of the model formulation. A common scaling across data sources is unneeded, and inference is obtained by a Gibbs Sampler. The model can fit multivariate Gaussian distributed clusters or a heavier-tailed modification of a Gaussian density. Uniquely among integrative clustering models, the formulation makes no nestedness assumptions of samples across data sources -- the user can still fit the model if a study subject only has information from one data source. The package provides a variety of post-processing functions for model examination including ones for quantifying observed alignment of clusterings across genomic data sources. Run time is optimized so that analyses of datasets on the order of thousands of features on fewer than 5 datasets and hundreds of subjects can converge in 1 or 2 days on a single CPU. See "Swanson DM, Lien T, Bergholtz H, Sorlie T, Frigessi A, Investigating Coordinated Architectures Across Clusters in Integrative Studies: a Bayesian Two-Way Latent Structure Model, 2018, <doi:10.1101/387076>, Cold Spring Harbor Laboratory" at <https://www.biorxiv.org/content/early/2018/08/07/387076.full.pdf> for model details.

Transfer learning for generalized factor models with support for continuous, count (Poisson), and binary data types. The package provides functions for single and multiple source transfer learning, source detection to identify positive and negative transfer sources, factor decomposition using Maximum Likelihood Estimation (MLE), and information criteria ('IC1 and IC2') for rank selection. The methods are particularly useful for high-dimensional data analysis where auxiliary information from related source datasets can improve estimation efficiency in the target domain.

There are some experimental scenarios where each experimental unit receives a sequence of treatments across multiple periods, and treatment effects persist beyond the period of application. It focuses on the construction and calculation of the parametric value of the residual effect designs balanced for carryover effects, also referred to as crossover designs, change-over designs, or repeated measurements designs (Aggarwal and Jha, 2010<doi:10.1080/15598608.2010.10412013>). The primary objective of the package is to generate a new class of Balanced Ternary Residual Effect Designs (BTREDs), balanced for carryover effects tailored explicitly for situations where the number of periods is less than or equal to the number of treatments. In addition, the package provides four new classes of Partially Balanced Ternary Residual Effect Designs (PBTREDs), constructed using incomplete block designs, initial sequences, and rectangular association scheme. In addition, one extra function is included to help study the parametric properties of a given residual effect design.

This package provides tools for the exploration of distributions of phylogenetic trees. This package includes a shiny interface which can be started from R using treespaceServer(). For further details see Jombart et al. (2017) <DOI:10.1111/1755-0998.12676>.

Routines for nonlinear time series analysis based on Threshold Autoregressive Moving Average (TARMA) models. It provides functions and methods for: TARMA model fitting and forecasting, including robust estimators, see Goracci et al. JBES (2025) <doi:10.1080/07350015.2024.2412011>; tests for threshold effects, see Giannerini et al. JoE (2024) <doi:10.1016/j.jeconom.2023.01.004>, Goracci et al. Statistica Sinica (2023) <doi:10.5705/ss.202021.0120>, Angelini et al. (2024) <doi:10.48550/arXiv.2308.00444>; unit-root tests based on TARMA models, see Chan et al. Statistica Sinica (2024) <doi:10.5705/ss.202022.0125>.

This package provides an easy-to-use tind class representing time indices of different types (years, quarters, months, ISO 8601 weeks, dates, time of day, date-time, and arbitrary integer/numeric indices). Includes an extensive collection of functions for calendrical computations (including business applications), index conversions, index parsing, and other operations. Auxiliary classes representing time differences and time intervals (with set operations and index matching functionality) are also provided. All routines have been optimised for speed in order to facilitate computations on large datasets. More details regarding calendars in general and calendrical algorithms can be found in "Calendar FAQ" by Claus Tøndering <https://www.tondering.dk/claus/calendar.html>.

Collect marketing data from TikTok Ads using the Windsor.ai API <https://windsor.ai/api-fields/>.

Computes various entropies of given time series. This is the initial version that includes ApEn() and SampEn() functions for calculating approximate entropy and sample entropy. Approximate entropy was proposed by S.M. Pincus in "Approximate entropy as a measure of system complexity", Proceedings of the National Academy of Sciences of the United States of America, 88, 2297-2301 (March 1991). Sample entropy was proposed by J. S. Richman and J. R. Moorman in "Physiological time-series analysis using approximate entropy and sample entropy", American Journal of Physiology, Heart and Circulatory Physiology, 278, 2039-2049 (June 2000). This package also contains FastApEn() and FastSampEn() functions for calculating fast approximate entropy and fast sample entropy. These are newly designed very fast algorithms, resulting from the modification of the original algorithms. The calculated values of these entropies are not the same as the original ones, but the entropy trend of the analyzed time series determines equally reliably. Their main advantage is their speed, which is up to a thousand times higher. A scientific article describing their properties has been submitted to The Journal of Supercomputing and in present time it is waiting for the acceptance.

This package implements the Maximum Likelihood estimator for baseline, placebo, and treatment groups (three-group) experiments with non-compliance proposed by Gerber, Green, Kaplan, and Kern (2010).