DNA methylation of 5-methylcytosine (5mC) is the result of a multi-step, enzyme-dependent process. Predicting these sites in-vitro is laborious, time consuming as well as costly. This Gb5mC-Pred package is an in-silico pipeline for predicting DNA sequences containing the 5mC sites. It uses a machine learning approach which uses Stochastic Gradient Boosting approach for prediction of the sequences with 5mC sites. This package has been developed by using the concept of Navarez and Roxas (2022) <doi:10.1109/TCBB.2021.3082184>.

Conducts causal inference with interactive fixed-effect models. It imputes counterfactuals for each treated unit using control group information based on a linear interactive fixed effects model that incorporates unit-specific intercepts interacted with time-varying coefficients. This method generalizes the synthetic control method to the case of multiple treated units and variable treatment periods, and improves efficiency and interpretability. See Xu (2017) <doi:10.1017/pan.2016.2> for details.

We propose a fully efficient sieve maximum likelihood method to estimate genotype-specific distribution of time-to-event outcomes under a nonparametric model. We can handle missing genotypes in pedigrees. We estimate the time-dependent hazard ratio between two genetic mutation groups using B-splines, while applying nonparametric maximum likelihood estimation to the reference baseline hazard function. The estimators are calculated via an expectation-maximization algorithm.

Geostatistical analysis including variogram-based, likelihood-based and Bayesian methods. Software companion for Diggle and Ribeiro (2007) <doi:10.1007/978-0-387-48536-2>.

This package provides functions for constructing Transformed and Relative Lorenz curves with survey sampling weights. Given a variable of interest measured in two groups with scaled survey weights so that their hypothetical populations are of equal size, tlorenz() computes the proportion of members of the group with smaller values (ordered from smallest to largest) needed for their sum to match the sum of the top qth percentile of the group with higher values. rlorenz() shows the fraction of the total value of the group with larger values held by the pth percentile of those in the group with smaller values. Fd() is a survey weighted cumulative distribution function and Eps() is a survey weighted inverse cdf used in rlorenz(). Ramos, Graubard, and Gastwirth (2025) <doi:10.1093/jrsssa/qnaf044>.

The gene-set distance analysis of omic data is implemented by generalizing distance correlations to evaluate the association of a gene set with categorical and censored event-time variables.

The geohabnet package is designed to perform a geographically or spatially explicit risk analysis of habitat connectivity. Xing et al (2021) <doi:10.1093/biosci/biaa067> proposed the concept of cropland connectivity as a risk factor for plant pathogen or pest invasions. As the functions in geohabnet were initially developed thinking on cropland connectivity, users are recommended to first be familiar with the concept by looking at the Xing et al paper. In a nutshell, a habitat connectivity analysis combines information from maps of host density, estimates the relative likelihood of pathogen movement between habitat locations in the area of interest, and applies network analysis to calculate the connectivity of habitat locations. The functions of geohabnet are built to conduct a habitat connectivity analysis relying on geographic parameters (spatial resolution and spatial extent), dispersal parameters (in two commonly used dispersal kernels: inverse power law and negative exponential models), and network parameters (link weight thresholds and network metrics). The functionality and main extensions provided by the functions in geohabnet to habitat connectivity analysis are a) Capability to easily calculate the connectivity of locations in a landscape using a single function, such as sensitivity_analysis() or msean(). b) As backbone datasets, the geohabnet package supports the use of two publicly available global datasets to calculate cropland density. The backbone datasets in the geohabnet package include crop distribution maps from Monfreda, C., N. Ramankutty, and J. A. Foley (2008) <doi:10.1029/2007gb002947> "Farming the planet: 2. Geographic distribution of crop areas, yields, physiological types, and net primary production in the year 2000, Global Biogeochem. Cycles, 22, GB1022" and International Food Policy Research Institute (2019) <doi:10.7910/DVN/PRFF8V> "Global Spatially-Disaggregated Crop Production Statistics Data for 2010 Version 2.0, Harvard Dataverse, V4". Users can also provide any other geographic dataset that represents host density. c) Because the geohabnet package allows R users to provide maps of host density (as originally in Xing et al (2021)), host landscape density (representing the geographic distribution of either crops or wild species), or habitat distribution (such as host landscape density adjusted by climate suitability) as inputs, we propose the term habitat connectivity. d) The geohabnet package allows R users to customize parameter values in the habitat connectivity analysis, facilitating context-specific (pathogen- or pest-specific) analyses. e) The geohabnet package allows users to automatically visualize maps of the habitat connectivity of locations resulting from a sensitivity analysis across all customized parameter combinations. The primary functions are msean() and sensitivity analysis(). Most functions in geohabnet provide three main outcomes: i) A map of mean habitat connectivity across parameters selected by the user, ii) a map of variance of habitat connectivity across the selected parameters, and iii) a map of the difference between the ranks of habitat connectivity and habitat density. Each function can be used to generate these maps as final outcomes. Each function can also provide intermediate outcomes, such as the adjacency matrices built to perform the analysis, which can be used in other network analysis. Refer to article at <https://garrettlab.github.io/HabitatConnectivity/articles/analysis.html> to see examples of each function and how to access each of these outcome types. To change parameter values, the file called parameters.yaml stores the parameters and their values, can be accessed using get_parameters() and set new parameter values with set_parameters()'. Users can modify up to ten parameters.

Implementing generalized structured component analysis (GSCA) and its basic extensions, including constrained single and multiple group analysis, and second order latent variable modeling. For a comprehensive overview of GSCA, see Hwang & Takane (2014, ISBN: 9780367738754).

Create plots that combine a phylogeny and frequency dynamics. Phylogenetic input can be a generic adjacency matrix or a tree of class "phylo". Inspired by similar plots in publications of the labs of RE Lenski and JE Barrick. Named for HJ Muller (who popularised such plots) and H Wickham (whose code this package exploits).

Método simples e eficiente de geolocalizar dados no Brasil. O pacote é baseado em conjuntos de dados espaciais abertos de endereços brasileiros, utilizando como fonte principal o Cadastro Nacional de Endereços para Fins Estatà sticos (CNEFE). O CNEFE é publicado pelo Instituto Brasileiro de Geografia e Estatà stica (IBGE), órgão oficial de estatà sticas e geografia do Brasil. (A simple and efficient method for geolocating data in Brazil. The package is based on open spatial datasets of Brazilian addresses, primarily using the Cadastro Nacional de Endereços para Fins Estatà sticos (CNEFE), published by the Instituto Brasileiro de Geografia e Estatà stica (IBGE), Brazil's official statistics and geography agency.).

This package provides methods for model selection, estimation, inference, and simulation for the multilevel factor model, based on the principal component estimation and generalised canonical correlation approach. Details can be found in "Generalised Canonical Correlation Estimation of the Multilevel Factor Model." Lin and Shin (2025) <doi:10.2139/ssrn.4295429>.

This is a wrapper for the command line tool googler', which can be found at the following URL: <https://github.com/jarun/googler>.

Annotation of ggplot2 plots with arbitrary TikZ code, using absolute data or relative plot coordinates.

The Greymodels Shiny app is an interactive interface for statistical modelling and forecasting using grey-based models. It covers several state-of-the-art univariate and multivariate grey models. A user friendly interface allows users to easily compare the performance of different models for prediction and among others, visualize graphical plots of predicted values within user chosen confidence intervals. Chang, C. (2019) <doi:10.24818/18423264/53.1.19.11>, Li, K., Zhang, T. (2019) <doi:10.1007/s12667-019-00344-0>, Ou, S. (2012) <doi:10.1016/j.compag.2012.03.007>, Li, S., Zhou, M., Meng, W., Zhou, W. (2019) <doi:10.1080/23307706.2019.1666310>, Xie, N., Liu, S. (2009) <doi:10.1016/j.apm.2008.01.011>, Shao, Y., Su, H. (2012) <doi:10.1016/j.aasri.2012.06.003>, Xie, N., Liu, S., Yang, Y., Yuan, C. (2013) <doi:10.1016/j.apm.2012.10.037>, Li, S., Miao, Y., Li, G., Ikram, M. (2020) <doi:10.1016/j.matcom.2019.12.020>, Che, X., Luo, Y., He, Z. (2013) <doi:10.4028/www.scientific.net/AMM.364.207>, Zhu, J., Xu, Y., Leng, H., Tang, H., Gong, H., Zhang, Z. (2016) <doi:10.1109/appeec.2016.7779929>, Luo, Y., Liao, D. (2012) <doi:10.4028/www.scientific.net/AMR.507.265>, Bilgil, H. (2020) <doi:10.3934/math.2021091>, Li, D., Chang, C., Chen, W., Chen, C. (2011) <doi:10.1016/j.apm.2011.04.006>, Chen, C. (2008) <doi:10.1016/j.chaos.2006.08.024>, Zhou, W., Pei, L. (2020) <doi:10.1007/s00500-019-04248-0>, Xiao, X., Duan, H. (2020) <doi:10.1016/j.engappai.2019.103350>, Xu, N., Dang, Y. (2015) <doi:10.1155/2015/606707>, Chen, P., Yu, H.(2014) <doi:10.1155/2014/242809>, Zeng, B., Li, S., Meng, W., Zhang, D. (2019) <doi:10.1371/journal.pone.0221333>, Liu, L., Wu, L. (2021) <doi:10.1016/j.apm.2020.08.080>, Hu, Y. (2020) <doi:10.1007/s00500-020-04765-3>, Zhou, P., Ang, B., Poh, K. (2006) <doi:10.1016/j.energy.2005.12.002>, Cheng, M., Li, J., Liu, Y., Liu, B. (2020) <doi:10.3390/su12020698>, Wang, H., Wang, P., Senel, M., Li, T. (2019) <doi:10.1155/2019/9049815>, Ding, S., Li, R. (2020) <doi:10.1155/2020/4564653>, Zeng, B., Li, C. (2018) <doi:10.1016/j.cie.2018.02.042>, Xie, N., Liu, S. (2015) <doi:10.1109/JSEE.2015.00013>, Zeng, X., Yan, S., He, F., Shi, Y. (2019) <doi:10.1016/j.apm.2019.11.032>.

The GB2 package explores the Generalized Beta distribution of the second kind. Density, cumulative distribution function, quantiles and moments of the distribution are given. Functions for the full log-likelihood, the profile log-likelihood and the scores are provided. Formulas for various indicators of inequality and poverty under the GB2 are implemented. The GB2 is fitted by the methods of maximum pseudo-likelihood estimation using the full and profile log-likelihood, and non-linear least squares estimation of the model parameters. Various plots for the visualization and analysis of the results are provided. Variance estimation of the parameters is provided for the method of maximum pseudo-likelihood estimation. A mixture distribution based on the compounding property of the GB2 is presented (denoted as "compound" in the documentation). This mixture distribution is based on the discretization of the distribution of the underlying random scale parameter. The discretization can be left or right tail. Density, cumulative distribution function, moments and quantiles for the mixture distribution are provided. The compound mixture distribution is fitted using the method of maximum pseudo-likelihood estimation. The fit can also incorporate the use of auxiliary information. In this new version of the package, the mixture case is complemented with new functions for variance estimation by linearization and comparative density plots.

The aim of this package is to offer more variability of graphics based on the self-organizing maps.

Reads data collected from wearable acceleratometers as used in sleep and physical activity research. Currently supports file formats: binary data from GENEActiv <https://activinsights.com/>, .bin-format from GENEA devices (not for sale), and .cwa-format from Axivity <https://axivity.com>. Further, it has functions for reading text files with epoch level aggregates from Actical', Fitbit', Actiwatch', ActiGraph', and PhilipsHealthBand'. Primarily designed to complement R package GGIR <https://CRAN.R-project.org/package=GGIR>.

This package performs goodness-of-fit tests for model-based clustering based on the methodology developed in <doi:10.48550/arXiv.2511.04206>. It implements a test statistic derived from empirical likelihood to verify the distribution of clusters in multivariate Gaussian mixtures and other latent class models.

This is a dataset package for GANPA, which implements a network-based gene weighting approach to pathway analysis. This package includes data useful for GANPA, such as a functional association network, pathways, an expression dataset and multi-subunit proteins.

This package provides methods for searching through genealogical data and displaying the results. Plotting algorithms assist with data exploration and publication-quality image generation. Includes interactive genealogy visualization tools. Provides parsing and calculation methods for variables in descendant branches of interest. Uses the Grammar of Graphics.

Design of group sequential trials, including non-binding futility analysis at multiple time points (Gallo, Mao, and Shih, 2014, <doi:10.1080/10543406.2014.932285>).

Quantitative genetics tool supporting the modelling of multivariate genetic variance structures in quantitative data. It allows fitting different models through multivariate genetic-relationship-matrix (GRM) structural equation modelling (SEM) in unrelated individuals, using a maximum likelihood approach. Specifically, it combines genome-wide genotyping information, as captured by GRMs, with twin-research-based SEM techniques, St Pourcain et al. (2017) <doi:10.1016/j.biopsych.2017.09.020>, Shapland et al. (2020) <doi:10.1101/2020.08.14.251199>.

This package provides tools.

Functional denoising and functional ANOVA through wavelet-domain Markov groves. Fore more details see: Ma L. and Soriano J. (2018) Efficient functional ANOVA through wavelet-domain Markov groves. <arXiv:1602.03990v2 [stat.ME]>.