Finite candidate-set approximate optimal designs for group testing and related experiments, using convex optimization and equivalence checks. Implements the information matrix and cost structure for the prevalence / sensitivity / specificity model used in Huang and colleagues (2020), as in Chi-Kuang Yeh, Weng Kee Wong, and Julie Zhou (<doi:10.48550/arXiv.2508.08445>).

This package implements the gene-based segregation test(GESE) and the weighted GESE test for identifying genes with causal variants of large effects for family-based sequencing data. The methods are described in Qiao, D. Lange, C., Laird, N.M., Won, S., Hersh, C.P., et al. (2017). <DOI:10.1002/gepi.22037>. Gene-based segregation method for identifying rare variants for family-based sequencing studies. Genet Epidemiol 41(4):309-319. More details can be found at <http://scholar.harvard.edu/dqiao/gese>.

To aggregate a hyper data frame, defined in the package spatstat.geom', according to a grouping structure. To facilitate downstream analysis based on a "grouped" hyper data frame. The author has retired from academic research. Accordingly, this package should not be considered a validated tool for use in peer-reviewed publications or as the basis for grant applications. Backward compatibility with user-code published in <doi:10.1093/bioinformatics/btaf430> is not maintained in versions >= 0.4.0 of this package. The authors of those publications are the appropriate contacts for reproducibility inquiries.

It provides functions to generate operating characteristics and to calculate Sequential Conditional Probability Ratio Tests(SCPRT) efficacy and futility boundary values along with sample/event size of Multi-Arm Multi-Stage(MAMS) trials for different outcomes. The package is based on Jianrong Wu, Yimei Li, Liang Zhu (2023) <doi:10.1002/sim.9682>, Jianrong Wu, Yimei Li (2023) "Group Sequential Multi-Arm Multi-Stage Survival Trial Design with Treatment Selection"(Manuscript accepted for publication) and Jianrong Wu, Yimei Li, Shengping Yang (2023) "Group Sequential Multi-Arm Multi-Stage Trial Design with Ordinal Endpoints"(In preparation).

This package contains an engine for spatially-explicit eco-evolutionary mechanistic models with a modular implementation and several support functions. It allows exploring the consequences of ecological and macroevolutionary processes across realistic or theoretical spatio-temporal landscapes on biodiversity patterns as a general term. Reference: Oskar Hagen, Benjamin Flueck, Fabian Fopp, Juliano S. Cabral, Florian Hartig, Mikael Pontarp, Thiago F. Rangel, Loic Pellissier (2021) "gen3sis: A general engine for eco-evolutionary simulations of the processes that shape Earth's biodiversity" <doi:10.1371/journal.pbio.3001340>.

This package provides R functions to access the API of the project and repository management web application GitLab'. For many common tasks (repository file access, issue assignment and status, commenting) convenience wrappers are provided, and in addition the full API can be used by specifying request locations. GitLab is open-source software and can be self-hosted or used on <https://about.gitlab.com>.

Reconstruction of muscle fibers from image stacks using textural analysis. Includes functions for tracking, smoothing, cleaning, plotting and exporting muscle fibers. Also calculates basic fiber properties (e.g., length, angle and curvature).

This package implements the generalized integration model, which integrates individual-level data and summary statistics under a generalized linear model framework. It supports continuous and binary outcomes to be modeled by the linear and logistic regression models. For binary outcome, data can be sampled in prospective cohort studies or case-control studies. Described in Zhang et al. (2020)<doi:10.1093/biomet/asaa014>.

Extend ggplot2 facets to panel layouts arranged in a grid with ragged edges. facet_ragged_rows() groups panels into rows that can vary in length, facet_ragged_cols() does the same but for columns. These can be useful, for example, to represent nested or partially crossed relationships between faceting variables.

This package provides a Gibbs sampler corresponding to a Group Inverse-Gamma Gamma (GIGG) regression model with adjustment covariates. Hyperparameters in the GIGG prior specification can either be fixed by the user or can be estimated via Marginal Maximum Likelihood Estimation. Jonathan Boss, Jyotishka Datta, Xin Wang, Sung Kyun Park, Jian Kang, Bhramar Mukherjee (2021) <arXiv:2102.10670>.

This package provides convenient access to the official spatial datasets of Peru as sf objects in R. This package includes a wide range of geospatial data covering various aspects of Peruvian geography, such as: administrative divisions (Source: INEI <https://ide.inei.gob.pe/>), protected natural areas (Source: GEO ANP - SERNANP <https://geo.sernanp.gob.pe/visorsernanp/>). All datasets are harmonized in terms of attributes, projection, and topology, ensuring consistency and ease of use for spatial analysis and visualization.

In computationally demanding data analysis pipelines, the targets R package (2021, <doi:10.21105/joss.02959>) maintains an up-to-date set of results while skipping tasks that do not need to rerun. This process increases speed and increases trust in the final end product. However, it also overwrites old output with new output, and past results disappear by default. To preserve historical output, the gittargets package captures version-controlled snapshots of the data store, and each snapshot links to the underlying commit of the source code. That way, when the user rolls back the code to a previous branch or commit, gittargets can recover the data contemporaneous with that commit so that all targets remain up to date.

Simple and user-friendly wrappers to the saemix package for performing linear and non-linear mixed-effects regression modeling for growth data to account for clustering or longitudinal analysis via repeated measurements. The package allows users to fit a variety of growth models, including linear, exponential, logistic, and Gompertz functions. For non-linear models, starting values are automatically calculated using initial least-squares estimates. The package includes functions for summarizing models, visualizing data and results, calculating doubling time and other key statistics, and generating model diagnostic plots and residual summary statistics. It also provides functions for generating publication-ready summary tables for reports. Additionally, users can fit linear and non-linear least-squares regression models if clustering is not applicable. The mixed-effects modeling methods in this package are based on Comets, Lavenu, and Lavielle (2017) <doi:10.18637/jss.v080.i03> as implemented in the saemix package. Please contact us at models@dfci.harvard.edu with any questions.

Analytics to read in and segment raw GENEActiv accelerometer data into epochs and events. For more details on the GENEActiv device, see <https://activinsights.com/resources/geneactiv-support-1-2/>.

Helps find meaningful patterns in complex genetic experiments. First gimap takes data from paired CRISPR (Clustered regularly interspaced short palindromic repeats) screens that has been pre-processed to counts table of paired gRNA (guide Ribonucleic Acid) reads. The input data will have cell counts for how well cells grow (or don't grow) when different genes or pairs of genes are disabled. The output of the gimap package is genetic interaction scores which are the distance between the observed CRISPR score and the expected CRISPR score. The expected CRISPR scores are what we expect for the CRISPR values to be for two unrelated genes. The further away an observed CRISPR score is from its expected score the more we suspect genetic interaction. The work in this package is based off of original research from the Alice Berger lab at Fred Hutchinson Cancer Center (2021) <doi:10.1016/j.celrep.2021.109597>.

An implementation of the generalized graded unfolding model (GGUM) in R, see Roberts, Donoghue, and Laughlin (2000) <doi:10.1177/01466216000241001>). It allows to simulate data sets based on the GGUM. It fits the GGUM and the GUM, and it retrieves item and person parameter estimates. Several plotting functions are available (item and test information functions; item and test characteristic curves; item category response curves). Additionally, there are some functions that facilitate the communication between R and GGUM2004'. Finally, a model-fit checking utility, MODFIT(), is also available.

Statistical functions to fit, validate and describe a Generalized Waring Regression Model (GWRM).

This package provides a fully automated workflow for calibrating and analyzing light-level geolocation ('GLS') data from seabirds and other wildlife. The glscalibrator package auto-discovers birds from directory structures, automatically detects calibration periods from the first days of deployment, processes multiple individuals in batch mode, and generates standardized outputs including position estimates, diagnostic plots, and quality control metrics. Implements the established threshold workflow internally, following the methods described in SGAT (Wotherspoon et al. (2016) <https://github.com/SWotherspoon/SGAT>), GeoLight (Lisovski et al. (2012) <doi:10.1111/j.2041-210X.2012.00185.x>), and TwGeos (Lisovski et al. (2019) <https://github.com/slisovski/TwGeos>).

Simplifies the creation, management, and updating of local databases using data extracted from Google Earth Engine ('GEE'). It integrates with GEE to store, aggregate, and process spatio-temporal data, leveraging SQLite for efficient, serverless storage. The geeLite package provides utilities for data transformation and supports real-time monitoring and analysis of geospatial features, making it suitable for researchers and practitioners in geospatial science. For details, see Kurbucz and Andrée (2025) "Building and Managing Local Databases from Google Earth Engine with the geeLite R Package" <https://hdl.handle.net/10986/43165>.

Focused on extracting important data from track points such as speed, distance, elevation difference and azimuth.(PLAZA, J. et al., 2022) <doi:10.1016/j.applanim.2022.105643>.

Likelihood ratio tests for genome-wide association and genome-wide linkage analysis under heterogeneity.

The philosophy in the package is described in Stasny (1988) <doi:10.2307/1391558> and Guti?rrez, A., Trujillo, L. & Silva, N. (2014), <ISSN:1492-0921> to estimate the gross flows under complex surveys using a Markov chain approach with non response.

This package provides functions and a graphical user interface for graphical described multiple test procedures.

Generalized Turnbull's estimator proposed by Dehghan and Duchesne (2011).