This package provides a collection of dynamic network data sets from various sources and multiple authors represented as networkDynamic'-formatted objects.

Cleans and Normalizes FLUOstar DBF and DAT Files obtained from liposome flux assays. Users should verify extended usage of the package on files from other assay types.

This package provides a JAGS extension module provides neo-normal distributions family including MSNBurr, MSNBurr-IIa, GMSNBurr, Lunetta Exponential Power, Fernandez-Steel Skew t, Fernandez-Steel Skew Normal, Fernandez-Osiewalski-Steel Skew Exponential Power, Jones Skew Exponential Power. References: Choir, A. S. (2020). "The New Neo-Normal Distributions and Their Properties".Unpublished Dissertation. Denwood, M.J. (2016) <doi:10.18637/jss.v071.i09>. Fernandez, C., Osiewalski, J., & Steel, M. F. (1995) <doi:10.1080/01621459.1995.10476637>. Fernandez, C., & Steel, M. F. (1998) <doi:10.1080/01621459.1998.10474117>. Iriawan, N. (2000). "Computationally Intensive Approaches to Inference in NeoNormal Linear Models".Unpublished Dissertation. Mineo, A., & Ruggieri, M. (2005) <doi:10.18637/jss.v012.i04>. Rigby, R. A., & Stasinopoulos, D. M. (2005) <doi:10.1111/j.1467-9876.2005.00510.x>. Lunetta, G. (1963). "Di una Generalizzazione dello Schema della Curva Normale". Rigby, R. A., Stasinopoulos, M. D., Heller, G. Z., & Bastiani, F. D. (2019) <doi:10.1201/9780429298547>.

This package provides a reproducible workflow for binning and visualizing NMR (nuclear magnetic resonance) spectra from environmental samples. The nmrrr package is intended for post-processing of NMR data, including importing, merging and, cleaning data from multiple files, visualizing NMR spectra, performing binning/integrations for compound classes, and relative abundance calculations. This package can be easily inserted into existing analysis workflows by users to help with analyzing and interpreting NMR data.

Estimates micro effects on macro structures (MEMS) and average micro mediated effects (AMME). URL: <https://github.com/sduxbury/netmediate>. BugReports: <https://github.com/sduxbury/netmediate/issues>. Robins, Garry, Phillipa Pattison, and Jodie Woolcock (2005) <doi:10.1086/427322>. Snijders, Tom A. B., and Christian E. G. Steglich (2015) <doi:10.1177/0049124113494573>. Imai, Kosuke, Luke Keele, and Dustin Tingley (2010) <doi:10.1037/a0020761>. Duxbury, Scott (2023) <doi:10.1177/00811750231209040>. Duxbury, Scott (2024) <doi:10.1177/00811750231220950>.

Species Identification using DNA Barcodes Integrated with Environmental Niche Models.

This package contains functions useful for debugging, set operations on vectors, and UTC date and time functionality. It adds a few vector manipulation verbs to purrr and dplyr packages. It can also generate an R file to install and update packages to simplify deployment into production. The functions were developed at the data science firm Numeract LLC and are used in several packages and projects.

NONMEM has been a tool for running nonlinear mixed effects models since the 80s and is still used today (Bauer 2019 <doi:10.1002/psp4.12404>). This tool allows you to convert NONMEM models to rxode2 (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>) and with simple models nlmixr2 syntax (Fidler et al (2019) <doi:10.1002/psp4.12445>). The nlmixr2 syntax requires the residual specification to be included and it is not always translated. If available, the rxode2 model will read in the NONMEM data and compare the simulation for the population model ('PRED') individual model ('IPRED') and residual model ('IWRES') to immediately show how well the translation is performing. This saves the model development time for people who are creating an rxode2 model manually. Additionally, this package reads in all the information to allow simulation with uncertainty (that is the number of observations, the number of subjects, and the covariance matrix) with a rxode2 model. This is complementary to the babelmixr2 package that translates nlmixr2 models to NONMEM and can convert the objects converted from nonmem2rx to a full nlmixr2 fit.

K-nearest neighbor search for projected and non-projected sf spatial layers. Nearest neighbor search uses (1) C code from GeographicLib for lon-lat point layers, (2) function knn() from package nabor for projected point layers, or (3) function st_distance() from package sf for line or polygon layers. The package also includes several other utility functions for spatial analysis.

Functions, examples and data from the first and the second edition of "Numerical Methods and Optimization in Finance" by M. Gilli, D. Maringer and E. Schumann (2019, ISBN:978-0128150658). The package provides implementations of optimisation heuristics (Differential Evolution, Genetic Algorithms, Particle Swarm Optimisation, Simulated Annealing and Threshold Accepting), and other optimisation tools, such as grid search and greedy search. There are also functions for the valuation of financial instruments such as bonds and options, for portfolio selection and functions that help with stochastic simulations.

This package provides tools for data-driven statistical analysis using local polynomial regression and kernel density estimation methods as described in Calonico, Cattaneo and Farrell (2018, <doi:10.1080/01621459.2017.1285776>): lprobust() for local polynomial point estimation and robust bias-corrected inference, lpbwselect() for local polynomial bandwidth selection, kdrobust() for kernel density point estimation and robust bias-corrected inference, kdbwselect() for kernel density bandwidth selection, and nprobust.plot() for plotting results. The main methodological and numerical features of this package are described in Calonico, Cattaneo and Farrell (2019, <doi:10.18637/jss.v091.i08>).

Implementation of network integration approaches comprising unweighted and weighted integration methods. Unweighted integration is performed considering the average, per-edge average, maximum and minimum of networks edges. Weighted integration takes into account a weight for each network during the fusion process, where the weights express the predictiveness strength of each network considering a specific predictive task. Weights can be learned using a machine learning algorithm able to associate the weights to the assessment of the accuracy of the learning algorithm trained on the network itself. The implemented methods can be applied to effectively integrate different biological networks modelling a wide range of problems in bioinformatics (e.g. disease gene prioritization, protein function prediction, drug repurposing, clinical outcome prediction).

NeuroAnatomy Toolbox (nat) enables analysis and visualisation of 3D biological image data, especially traced neurons. Reads and writes 3D images in NRRD and Amira AmiraMesh formats and reads surfaces in Amira hxsurf format. Traced neurons can be imported from and written to SWC and Amira LineSet and SkeletonGraph formats. These data can then be visualised in 3D via rgl', manipulated including applying calculated registrations, e.g. using the CMTK registration suite, and analysed. There is also a simple representation for neurons that have been subjected to 3D skeletonisation but not formally traced; this allows morphological comparison between neurons including searches and clustering (via the nat.nblast extension package).

This package provides a collection of common univariate bounded probability distributions transformed to the unbounded real line, for the purpose of increased MCMC efficiency.

Datasets for nlmixr2 and rxode2'. nlmixr2 is used for fitting and comparing nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the rxode2 package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Create interactive analytic networks. It joins the data analysis power of R to obtain coincidences, co-occurrences and correlations, and the visualization libraries of JavaScript in one package.

This package provides methods and tools for forecasting univariate time series using the NARFIMA (Neural AutoRegressive Fractionally Integrated Moving Average) model. It combines neural networks with fractional differencing to capture both nonlinear patterns and long-term dependencies. The NARFIMA model supports seasonal adjustment, Box-Cox transformations, optional exogenous variables, and the computation of prediction intervals. In addition to the NARFIMA model, this package provides alternative forecasting models including NARIMA (Neural ARIMA), NBSTS (Neural Bayesian Structural Time Series), and NNaive (Neural Naive) for performance comparison across different modeling approaches. The methods are based on algorithms introduced by Chakraborty et al. (2025) <doi:10.48550/arXiv.2509.06697>.

This package provides a software package to perform Wombling, or boundary analysis, using the nimble Bayesian hierarchical modeling environment. Wombling is used widely to track regions of rapid change within the spatial reference domain. Specific functions in the package implement Gaussian process models for point-referenced spatial data followed by predictive inference on rates of change over curves using line integrals. We demonstrate model based Bayesian inference using posterior distributions featuring simple analytic forms while offering uncertainty quantification over curves. For more details on wombling please see, Banerjee and Gelfand (2006) <doi:10.1198/016214506000000041> and Halder, Banerjee and Dey (2024) <doi:10.1080/01621459.2023.2177166>.

Statistical methods for whole-trial and time-domain analysis of single cell neural response to multiple stimuli presented simultaneously. The package is based on the paper by C Glynn, ST Tokdar, A Zaman, VC Caruso, JT Mohl, SM Willett, and JM Groh (2021) "Analyzing second order stochasticity of neural spiking under stimuli-bundle exposure", is in press for publication by the Annals of Applied Statistics. A preprint may be found at <arXiv:1911.04387>.

This package provides quality control (QC), normalization, and batch effect correction operations for NanoString nCounter data, Talhouk et al. (2016) <doi:10.1371/journal.pone.0153844>. Various metrics are used to determine which samples passed or failed QC. Gene expression should first be normalized to housekeeping genes, before a reference-based approach is used to adjust for batch effects. Raw NanoString data can be imported in the form of Reporter Code Count (RCC) files.

This package provides functions to calculate the normalised Lineage-Through- Time (nLTT) statistic, given two phylogenetic trees. The nLTT statistic measures the difference between two Lineage-Through-Time curves, where each curve is normalised both in time and in number of lineages.

This package performs network meta-analysis using integrated nested Laplace approximations ('INLA') which is described in Guenhan, Held, and Friede (2018) <doi:10.1002/jrsm.1285>. Includes methods to assess the heterogeneity and inconsistency in the network. Contains more than ten different network meta-analysis dataset. INLA package can be obtained from <https://www.r-inla.org>.

This package provides a toolkit for medical records data analysis. The naryn package implements an efficient data structure for storing medical records, and provides a set of functions for data extraction, manipulation and analysis.

Three distinct methods are implemented for evaluating the sums of arbitrary negative binomial distributions. These methods are: Furman's exact probability mass function (Furman (2007) <doi:10.1016/j.spl.2006.06.007>), saddlepoint approximation, and a method of moments approximation. Functions are provided to calculate the density function, the distribution function and the quantile function of the convolutions in question given said evaluation methods. Functions for generating random deviates from negative binomial convolutions and for directly calculating the mean, variance, skewness, and excess kurtosis of said convolutions are also provided.