This package provides methods for distance covariance and distance correlation (Szekely, et al. (2007) <doi:10.1214/009053607000000505>), generalized version thereof (Sejdinovic, et al. (2013) <doi:10.1214/13-AOS1140>) and corresponding tests (Berschneider, Bottcher (2018) <doi:10.48550/arXiv.1808.07280>. Distance standard deviation methods (Edelmann, et al. (2020) <doi:10.1214/19-AOS1935>) and distance correlation methods for survival endpoints (Edelmann, et al. (2021) <doi:10.1111/biom.13470>) are also included.

Differential exon usage test for RNA-Seq data via an empirical Bayes shrinkage method for the dispersion parameter the utilizes inclusion-exclusion data to analyze the propensity to skip an exon across groups. The input data consists of two matrices where each row represents an exon and the columns represent the biological samples. The first matrix is the count of the number of reads expressing the exon for each sample. The second matrix is the count of the number of reads that either express the exon or explicitly skip the exon across the samples, a.k.a. the total count matrix. Dividing the two matrices yields proportions representing the propensity to express the exon versus skipping the exon for each sample.

This package provides a toolkit for parsing dice notation, analyzing rolls, calculating success probabilities, and plotting outcome distributions.

Tissue-specific enrichment analysis to assess lists of candidate genes or RNA-Seq expression profiles. Pei G., Dai Y., Zhao Z. Jia P. (2019) deTS: Tissue-Specific Enrichment Analysis to decode tissue specificity. Bioinformatics, In submission.

This package provides a collection of methods for automated data cleaning where all actions are logged.

Direction analysis is a set of tools designed to identify combinatorial effects of multiple treatments/conditions on pathways and kinases profiled by microarray, RNA-seq, proteomics, or phosphoproteomics data. See Yang P et al (2014) <doi:10.1093/bioinformatics/btt616>; and Yang P et al. (2016) <doi:10.1002/pmic.201600068>.

Bayesian inference algorithms based on the population-based "differential evolution" (DE) algorithm. Users can obtain posterior mode (MAP) estimates via DEMAP, posterior samples via DEMCMC, and variational approximations via DEVI.

Phone numbers are often represented as strings because there is no obvious and suitable native representation for them. This leads to high memory use and a lack of standard representation. The package provides integer representation of Australian phone numbers with optional raw vector calling code. The package name is an extension of au and ph'.

Fits disaggregation regression models using TMB ('Template Model Builder'). When the response data are aggregated to polygon level but the predictor variables are at a higher resolution, these models can be useful. Regression models with spatial random fields. The package is described in detail in Nandi et al. (2023) <doi:10.18637/jss.v106.i11>.

Includes functions for the construction of matched samples that are balanced and representative by design. Among others, these functions can be used for matching in observational studies with treated and control units, with cases and controls, in related settings with instrumental variables, and in discontinuity designs. Also, they can be used for the design of randomized experiments, for example, for matching before randomization. By default, designmatch uses the highs optimization solver, but its performance is greatly enhanced by the Gurobi optimization solver and its associated R interface. For their installation, please follow the instructions at <https://www.gurobi.com/getting-started/> and <https://docs.gurobi.com/projects/optimizer/en/current/reference/r/setup.html>. We have also included directions in the gurobi_installation file in the inst folder.

Downloads the public data available from the Brazilian Access to Information Law and and performs a search on information requests and appeals made since 2015.

To create demographic table with simple summary statistics, with optional comparison(s) over one or more groups.

Nonparametric kernel density estimation, bandwidth selection, and other utilities for analyzing directional data. Implements the estimator in Bai, Rao and Zhao (1987) <doi:10.1016/0047-259X(88)90113-3>, the cross-validation bandwidth selectors in Hall, Watson and Cabrera (1987) <doi:10.1093/biomet/74.4.751> and the plug-in bandwidth selectors in Garcà a-Portugués (2013) <doi:10.1214/13-ejs821>.

This package provides functions to run the CRM and TITE-CRM in phase I trials and calibration tools for trial planning purposes.

Discrete factor analysis for dependent Poisson and negative binomial models with truncation, zero inflation, and zero inflated truncation.

Tests for modality of data using its spacing. The main approach evaluates features (peaks, flats) using a combination of parametric models and non-parametric tests, either after smoothing the spacing by a low-pass filter or by looking over larger intervals.

The standard Difference-in-Differences (DID) setup involves two periods and two groups -- a treated group and untreated group. Many applications of DID methods involve more than two periods and have individuals that are treated at different points in time. This package contains tools for computing average treatment effect parameters in Difference in Differences setups with more than two periods and with variation in treatment timing using the methods developed in Callaway and Sant'Anna (2021) <doi:10.1016/j.jeconom.2020.12.001>. The main parameters are group-time average treatment effects which are the average treatment effect for a particular group at a a particular time. These can be aggregated into a fewer number of treatment effect parameters, and the package deals with the cases where there is selective treatment timing, dynamic treatment effects, calendar time effects, or combinations of these. There are also functions for testing the Difference in Differences assumption, and plotting group-time average treatment effects.

To overcome the memory limitations for fitting linear (LM) and Generalized Linear Models (GLMs) to large data sets, this package implements the Divide and Recombine (D&R) strategy. It basically divides the entire large data set into suitable subsets manageable in size and then fits model to each subset. Finally, results from each subset are aggregated to obtain the final estimate. This package also supports fitting GLMs to data sets that cannot fit into memory and provides methods for fitting GLMs under linear regression, binomial regression, Poisson regression, and multinomial logistic regression settings. Respective models are fitted using different D&R strategies as described by: Xi, Lin, and Chen (2009) <doi:10.1109/TKDE.2008.186>, Xi, Lin and Chen (2006) <doi:10.1109/TKDE.2006.196>, Zuo and Li (2018) <doi:10.4236/ojs.2018.81003>, Karim, M.R., Islam, M.A. (2019) <doi:10.1007/978-981-13-9776-9>.

An add-on package to DImodels for the fitting of biodiversity and ecosystem function relationship study data with multiple ecosystem function responses and/or time points. This package uses the multivariate and repeated measures Diversity-Interactions (DI) methods developed by Kirwan et al. (2009) <doi:10.1890/08-1684.1>, Finn et al. (2013) <doi:10.1111/1365-2664.12041>, and Dooley et al. (2015) <doi:10.1111/ele.12504>.

Intensive longitudinal data have become increasingly prevalent in various scientific disciplines. Many such data sets are noisy, multivariate, and multi-subject in nature. The change functions may also be continuous, or continuous but interspersed with periods of discontinuities (i.e., showing regime switches). The package dynr (Dynamic Modeling in R) is an R package that implements a set of computationally efficient algorithms for handling a broad class of linear and nonlinear discrete- and continuous-time models with regime-switching properties under the constraint of linear Gaussian measurement functions. The discrete-time models can generally take on the form of a state-space or difference equation model. The continuous-time models are generally expressed as a set of ordinary or stochastic differential equations. All estimation and computations are performed in C, but users are provided with the option to specify the model of interest via a set of simple and easy-to-learn model specification functions in R. Model fitting can be performed using single-subject time series data or multiple-subject longitudinal data. Ou, Hunter, & Chow (2019) <doi:10.32614%2FRJ-2019-012> provided a detailed introduction to the interface and more information on the algorithms.

This package implements double hierarchical generalized linear models in which the mean, dispersion parameters for variance of random effects, and residual variance (overdispersion) can be further modeled as random-effect models.

This package provides a domain-specific language for specifying translating recursions into dynamic-programming algorithms. See <https://en.wikipedia.org/wiki/Dynamic_programming> for a description of dynamic programming.

Microsoft Word docx files provide an XML structure that is fairly straightforward to navigate, especially when it applies to Word tables and comments. Tools are provided to determine table count/structure, comment count and also to extract/clean tables and comments from Microsoft Word docx documents. There is also nascent support for .doc and .pptx files.

Simplifies and automates the process of exploring and merging data from relational databases. This package allows users to discover table relationships, create a map of all possible joins, and generate executable plans to merge data based on a structured metadata framework.