In many studies across different disciplines, detailed measures of the variables of interest are available. If assumptions can be made regarding the direction of effects between the assessed variables, this has to be considered in the analysis. The functions in this package implement the novel approach CIEE (causal inference using estimating equations; Konigorski et al., 2018, <DOI:10.1002/gepi.22107>) for estimating and testing the direct effect of an exposure variable on a primary outcome, while adjusting for indirect effects of the exposure on the primary outcome through a secondary intermediate outcome and potential factors influencing the secondary outcome. The underlying directed acyclic graph (DAG) of this considered model is described in the vignette. CIEE can be applied to studies in many different fields, and it is implemented here for the analysis of a continuous primary outcome and a time-to-event primary outcome subject to censoring. CIEE uses estimating equations to obtain estimates of the direct effect and robust sandwich standard error estimates. Then, a large-sample Wald-type test statistic is computed for testing the absence of the direct effect. Additionally, standard multiple regression, regression of residuals, and the structural equation modeling approach are implemented for comparison.

Implementation of cross-validation method for testing the forecasting accuracy of several multi-population mortality models. The family of multi-population includes several multi-population mortality models proposed through the actuarial and demography literature. The package includes functions for fitting and forecast the mortality rates of several populations. Additionally, we include functions for testing the forecasting accuracy of different multi-population models. References, <https://journal.r-project.org/articles/RJ-2025-018/>. Atance, D., Debon, A., and Navarro, E. (2020) <doi:10.3390/math8091550>. Bergmeir, C. & Benitez, J.M. (2012) <doi:10.1016/j.ins.2011.12.028>. Debon, A., Montes, F., & Martinez-Ruiz, F. (2011) <doi:10.1007/s13385-011-0043-z>. Lee, R.D. & Carter, L.R. (1992) <doi:10.1080/01621459.1992.10475265>. Russolillo, M., Giordano, G., & Haberman, S. (2011) <doi:10.1080/03461231003611933>. Santolino, M. (2023) <doi:10.3390/risks11100170>.

This package provides function to create, read, write, and work with iCalendar files (which typically have .ics or .ical extensions), and the scheduling data, calendars and timelines of people, organisations and other entities that they represent. iCalendar is an open standard for exchanging calendar and scheduling information between users and computers, described at <https://icalendar.org/>.

Calculate confidence and consistency that measure the goodness-of-fit and transferability of predictive/potential distribution models (including species distribution models) as described by Somodi & Bede-Fazekas et al. (2024) <doi:10.1016/j.ecolmodel.2024.110667>.

This package provides a set of functions for applying a restricted linear algebra to the analysis of count-based data. See the accompanying preprint manuscript: "Normalizing need not be the norm: count-based math for analyzing single-cell data" Church et al (2022) <doi:10.1101/2022.06.01.494334> This tool is specifically designed to analyze count matrices from single cell RNA sequencing assays. The tools implement several count-based approaches for standard steps in single-cell RNA-seq analysis, including scoring genes and cells, comparing cells and clustering, calculating differential gene expression, and several methods for rank reduction. There are many opportunities for further optimization that may prove useful in the analysis of other data. We provide the source code freely available at <https://github.com/shchurch/countland> and encourage users and developers to fork the code for their own purposes.

This package provides functions supporting the common needs of packages ChemoSpec and ChemoSpec2D'.

Encryption wrappers, using low-level support from sodium and openssl'. cyphr tries to smooth over some pain points when using encryption within applications and data analysis by wrapping around differences in function names and arguments in different encryption providing packages. It also provides high-level wrappers for input/output functions for seamlessly adding encryption to existing analyses.

Calculation of sex- and age-standardized growth metrics using the LMS method (lambda-mu-sigma). The package includes functions for the CDC Growth Charts (cdc_z) and the WHO Charts (who_z). Because CDC recommends using the WHO Charts for children under 24 months and the CDC Charts among older children, there can be large differences at age 2.0 years. For example, a girl weighing 9.9 kg would be at the WHO 10th percentile on the day before her second birthday, but at the CDC 2nd percentile the following day. The gradual_z function reduces the differences among 2- to 5-year-olds by taking a weighted average of the CDC and WHO z-scores.

This package provides tools to simulate child-penalty data and estimate DID, TD, and NTD identification frameworks from Leventer (2025), "Identification of Child Penalties" <doi:10.48550/arXiv.2602.07486>.

This package provides analytical methods for analyzing CRISPR screen data at different levels of gene expression. Multi-component normal mixture models and EM algorithms are used for modeling.

When taking online surveys, participants sometimes respond to items without regard to their content. These types of responses, referred to as careless or insufficient effort responding, constitute significant problems for data quality, leading to distortions in data analysis and hypothesis testing, such as spurious correlations. The R package careless provides solutions designed to detect such careless / insufficient effort responses by allowing easy calculation of indices proposed in the literature. It currently supports the calculation of longstring, even-odd consistency, psychometric synonyms/antonyms, Mahalanobis distance, and intra-individual response variability (also termed inter-item standard deviation). For a review of these methods, see Curran (2016) <doi:10.1016/j.jesp.2015.07.006>.

Enables creation of visualizations using the CanvasXpress framework in R. CanvasXpress is a standalone JavaScript library for reproducible research with complete tracking of data and end-user modifications stored in a single PNG image that can be played back. See <https://www.canvasxpress.org> for more information.

Utility functions that provides wrapper to descriptive base functions like cor, mean and table. It makes use of the formula interface to pass variables to functions. It also provides operators to concatenate (%+%), to repeat (%n%) and manage character vectors for nice display.

Obtain, transform and export climate data including reanalyses, (seasonal) forecasts and hindcasts, and weather stations for their use in epidemiological analyses. It is organised in three sequential blocks, input (download and load data), transform (downscaling, verification, spatiotemporal aggregation and threshold-based indicators) and output (visualising and exporting data). Downscaling methods include those described in Duzenli et al. (2026) <doi:10.1038/s41598-026-45067-2> and verification methods are based on those in Manubens et al. (2018) <doi:10.1016/j.envsoft.2018.01.018>.

Explore calcium (Ca) and phosphate (Pi) homeostasis with two novel Shiny apps, building upon on a previously published mathematical model written in C, to ensure efficient computations. The underlying model is accessible here <https://pubmed.ncbi.nlm.nih.gov/28747359/)>. The first application explores the fundamentals of Ca-Pi homeostasis, while the second provides interactive case studies for in-depth exploration of the topic, thereby seeking to foster student engagement and an integrative understanding of Ca-Pi regulation.

Discover causality for bivariate categorical data. This package aims to enable users to discover causality for bivariate observational categorical data. See Ni, Y. (2022) <arXiv:2209.08579> "Bivariate Causal Discovery for Categorical Data via Classification with Optimal Label Permutation. Advances in Neural Information Processing Systems 35 (in press)".

Spatial and non-spatial regression models with compositional responses (and compositional predictors) using the alpha--transformation. Relevant papers include: Tsagris M. and Pantazis Y. (2026), <doi:10.48550/arXiv.2510.12663>, Tsagris M. (2015), <https://soche.cl/chjs/volumes/06/02/Tsagris(2015).pdf>, Tsagris M.T., Preston S. and Wood A.T.A. (2011), <doi:10.48550/arXiv.1106.1451>.

Allows clustering of incomplete observations by addressing missing values using multiple imputation. For achieving this goal, the methodology consists in three steps, following Audigier and Niang 2022 <doi:10.1007/s11634-022-00519-1>. I) Missing data imputation using dedicated models. Four multiple imputation methods are proposed, two are based on joint modelling and two are fully sequential methods, as discussed in Audigier et al. (2021) <doi:10.48550/arXiv.2106.04424>. II) cluster analysis of imputed data sets. Six clustering methods are available (distances-based or model-based), but custom methods can also be easily used. III) Partition pooling. The set of partitions is aggregated using Non-negative Matrix Factorization based method. An associated instability measure is computed by bootstrap (see Fang, Y. and Wang, J., 2012 <doi:10.1016/j.csda.2011.09.003>). Among applications, this instability measure can be used to choose a number of clusters with missing values. The package also proposes several diagnostic tools to tune the number of imputed data sets, to tune the number of iterations in fully sequential imputation, to check the fit of imputation models, etc.

This package contains the adaptation of bubblebath from MATLAB (Danz, 2020: <https://www.mathworks.com/matlabcentral/fileexchange/70348>) and the tools to transform a dataframe of radii and points to plot-able paths.

Copernicus Digital Elevation Model datasets (DEM) of 90 and 30 meters resolution using the awscli command line tool. The Copernicus (DEM) is included in the Registry of Open Data on AWS (Amazon Web Services) and represents the surface of the Earth including buildings, infrastructure and vegetation.

Estimates sugar beet canopy closure with remotely sensed leaf area index and estimates when action might be needed to protect the crop from a Leaf Spot epidemic with a negative prognosis model based on published models.

Is designed to test for association between methylation at CpG sites across the genome and a phenotype of interest, adjusting for any relevant covariates. The package can perform standard analyses of large datasets very quickly with no need to impute the data. It can also handle mixed effects models with chip or batch entering the model as a random intercept. Also includes tools to apply quality control filters, perform permutation tests, and create QQ plots, manhattan plots, and scatterplots for individual CpG sites.

Calculates metrics of proportionality using the logit-normal multinomial model. It can also provide empirical and plugin estimates of these metrics.

Corbae-Ouliaris frequency domain filtering. According to Corbae and Ouliaris (2006) <doi:10.1017/CBO9781139164863.008>, this is a solution for extracting cycles from time series, like business cycles etc. when filtering. This method is valid for both stationary and non-stationary time series.