This package provides a comprehensive analytics framework for building reproducible pipelines on T-cell and B-cell immune receptor repertoire data. Delivers multi-modal immune profiling (bulk, single-cell, CITE-seq/AbSeq, spatial, immunogenicity data), feature engineering (ML-ready feature tables and matrices), and biomarker discovery workflows (cohort comparisons, longitudinal tracking, repertoire similarity, enrichment). Provides a user-friendly interface to widely used AIRR methods â clonality/diversity, V(D)J usage, similarity, annotation, tracking, and many more. Think Scanpy or Seurat, but for AIRR data, a.k.a. Adaptive Immune Receptor Repertoire, VDJ-seq, RepSeq, or VDJ sequencing data. A successor to our previously published "tcR" R package (Nazarov 2015).

We consider the non-parametric maximum likelihood estimation of the underlying distribution function, assuming log-concavity, based on mixed-case interval-censored data. The algorithm implemented is base on Chi Wing Chu, Hok Kan Ling and Chaoyu Yuan (2024, <doi:10.48550/arXiv.2411.19878>).

Download and manage data sets of statistical projects and geographic data created by Instituto Nacional de Estadistica y Geografia (INEGI). See <https://www.inegi.org.mx/>.

Convenient functions to create ggplot2 graphics following the editorial guidelines of the Institute for Applied Economic Research (Ipea).

This package provides a collection of Irucka Embry's miscellaneous USGS functions (processing .exp and .psf files, statistical error functions, "+" dyadic operator for use with NA, creating ADAPS and QW spreadsheet files, calculating saturated enthalpy). Irucka created these functions while a Cherokee Nation Technology Solutions (CNTS) United States Geological Survey (USGS) Contractor and/or USGS employee.

This package provides tools for multivariate nonparametrics, as location tests based on marginal ranks, spatial median and spatial signs computation, Hotelling's T-test, estimates of shape are implemented.

Chi-square tests are computed with corrections.

Computes and decomposes Gini, Bonferroni and Zenga 2007 point and synthetic concentration indexes. Decompositions are intended: by sources, by subpopulations and by sources and subpopulations jointly. References, Zenga M. M.(2007) <doi:10.1400/209575> Zenga M. (2015) <doi:10.1400/246627> Zenga M., Valli I. (2017) <doi:10.26350/999999_000005> Zenga M., Valli I. (2018) <doi:10.26350/999999_000011>.

This package contains functions for evaluating & comparing the performance of Binary classification models. Functions can be called either statically or interactively (as Shiny Apps).

The Interactive Tree Of Life <https://itol.embl.de/> online server can edit and annotate trees interactively. The itol.toolkit package can support all types of annotation templates.

Estimates the intraclass correlation coefficient for trajectory data using a matrix of distances between trajectories. The distances implemented are the extended Hausdorff distances (Min et al. 2007) <doi:10.1080/13658810601073315> and the discrete Fréchet distance (Magdy et al. 2015) <doi:10.1109/IntelCIS.2015.7397286>.

Models, analyzes, and forecasts financial intraday signals. This package currently supports a univariate state-space model for intraday trading volume provided by Chen (2016) <doi:10.2139/ssrn.3101695>.

This package implements the Interval-Censored Sequence Kernel Association (ICSKAT) test for testing the association between interval-censored time-to-event outcomes and groups of single nucleotide polymorphisms (SNPs). Interval-censored time-to-event data occur when the event time is not known exactly but can be deduced to fall within a given interval. For example, some medical conditions like bone mineral density deficiency are generally only diagnosed at clinical visits. If a patient goes for clinical checkups yearly and is diagnosed at, say, age 30, then the onset of the deficiency is only known to fall between the date of their age 29 checkup and the date of the age 30 checkup. Interval-censored data include right- and left-censored data as special cases. This package also implements the interval-censored Burden test and the ICSKATO test, which is the optimal combination of the ICSKAT and Burden tests. Please see the vignette for a quickstart guide. The paper describing these methods is " Inference for Set-Based Effects in Genetic Association Studies with Interval-Censored Outcomes" by Sun R, Zhu L, Li Y, Yasui Y, & Robison L (Biometrics 2023, <doi:10.1111/biom.13636>).

This package provides functions read a dataframe containing one or more International Classification of Diseases Tenth Revision codes per subject. They return original data with injury categorizations and severity scores added.

This package provides functions to estimate the probability to receive the observed treatment, based on individual characteristics. The inverse of these probabilities can be used as weights when estimating causal effects from observational data via marginal structural models. Both point treatment situations and longitudinal studies can be analysed. The same functions can be used to correct for informative censoring.

This minimalist package is designed to quickly score raw data outputted from an Implicit Association Test (IAT; Greenwald, McGhee, & Schwartz, 1998) <doi:10.1037/0022-3514.74.6.1464>. IAT scores are calculated as specified by Greenwald, Nosek, and Banaji (2003) <doi:10.1037/0022-3514.85.2.197>. Outputted values can be interpreted as effect sizes. The input function consists of three arguments. First, indicate the name of the dataset to be analyzed. This is the only required input. Second, indicate the number of trials in your entire IAT (the default is set to 219, which is typical for most IATs). Last, indicate whether congruent trials (e.g., flowers and pleasant) or incongruent trials (e.g., guns and pleasant) were presented first for this participant (the default is set to congruent). The script will tell you how long it took to run the code, the effect size for the participant, and whether that participant should be excluded based on the criteria outlined by Greenwald et al. (2003). Data files should consist of six columns organized in order as follows: Block (0-6), trial (0-19 for training blocks, 0-39 for test blocks), category (dependent on your IAT), the type of item within that category (dependent on your IAT), a dummy variable indicating whether the participant was correct or incorrect on that trial (0=correct, 1=incorrect), and the participantâ s reaction time (in milliseconds). Three sample datasets are included in this package (labeled IAT', TooFastIAT', and BriefIAT') to practice with.

This package provides a pipeline to annotate a number of peaks from the IDSL.IPA peaklists using an exhaustive chemical enumeration-based approach. This package can perform elemental composition calculations using the following 15 elements : C, B, Br, Cl, K, S, Si, N, H, As, F, I, Na, O, and P.

Generates random numbers corresponding to the events on a Poisson point process with changing event rates. This includes the possibility to incorporate additional information such as the number of events occurring or the location of an already known event. It can also generate the probability density functions of specific events in the cases where additional information is available. Based on Hohmann (2019) <arXiv:1901.10754>.

Fit mixed-effects location scale models with spike-and-slab priors on the location random effects to identify units with unusual residual variances. The method is described in detail in Carmo, Williams and Rast (2025) <https://osf.io/sh6ne>.

This package provides a toolkit that allows scientists to work with data from single cell sequencing technologies such as scRNA-seq, scVDJ-seq, scATAC-seq, CITE-Seq and Spatial Transcriptomics (ST). Single (i) Cell R package ('iCellR') provides unprecedented flexibility at every step of the analysis pipeline, including normalization, clustering, dimensionality reduction, imputation, visualization, and so on. Users can design both unsupervised and supervised models to best suit their research. In addition, the toolkit provides 2D and 3D interactive visualizations, differential expression analysis, filters based on cells, genes and clusters, data merging, normalizing for dropouts, data imputation methods, correcting for batch differences, pathway analysis, tools to find marker genes for clusters and conditions, predict cell types and pseudotime analysis. See Khodadadi-Jamayran, et al (2020) <doi:10.1101/2020.05.05.078550> and Khodadadi-Jamayran, et al (2020) <doi:10.1101/2020.03.31.019109> for more details.

This package provides implementation of various correlation coefficients of common use in Information Retrieval. In particular, it includes Kendall (1970, isbn:0852641990) tau coefficient as well as tau_a and tau_b for the treatment of ties. It also includes Yilmaz et al. (2008) <doi:10.1145/1390334.1390435> tauAP correlation coefficient, and versions tauAP_a and tauAP_b developed by Urbano and Marrero (2017) <doi:10.1145/3121050.3121106> to cope with ties.

This package provides user-friendly tools for calibration in survey sampling. The package is production-oriented, and its interface is inspired by the famous popular macro Calmar for SAS, so that Calmar users can quickly get used to icarus'. In addition to calibration (with linear, raking and logit methods), icarus features functions for calibration on tight bounds and penalized calibration.

An R package for inferring cell-type specific gene regulatory network from single-cell RNA-seq data.

The development of ISM was made by Warfield in 1974. ISM is the process of collaborating distinct or related essentials into a simplified and an organized format. Hence, ISM is a methodology that seeks the interrelationships among the various elements considered and endows with a hierarchical and multilevel structure. To run this package user needs to provide a matrix (VAXO) converted into 0's and 1's. Warfield,J.N. (1974) <doi:10.1109/TSMC.1974.5408524> Warfield,J.N. (1974, E-ISSN:2168-2909).