Perform association test within linear mixed model framework using score test integrated with Empirical Bayes for genome-wide association study. Firstly, score test was conducted for each marker under linear mixed model framework, taking into account the genetic relatedness and population structure. And then all the potentially associated markers were selected with a less stringent criterion. Finally, all the selected markers were placed into a multi-locus model to identify the true quantitative trait nucleotide.

During the preparation of data set(s) one usually performs some sanity checks. The idea is that irrespective of where the checks are performed, they are centralized by this package in order to list all at once with examples if a check failed.

This package implements the smooth LASSO estimator for the function-on-function linear regression model described in Centofanti et al. (2022) <doi:10.1016/j.csda.2022.107556>.

This is a core implementation of SAS procedures for linear models - GLM, REG, ANOVA, TTEST, FREQ, and UNIVARIATE. Some R packages provide Type II and Type III SS. However, the results of nested and complex designs are often different from those of SAS'. Different results do not necessarily mean incorrectness. However, many want the same results as SAS'. This package aims to achieve that. Reference: Littell RC, Stroup WW, Freund RJ (2002, ISBN:0-471-22174-0).

Simulation methods for the Fisher Bingham distribution on the unit sphere, the matrix Bingham distribution on a Grassmann manifold, the matrix Fisher distribution on SO(3), and the bivariate von Mises sine model on the torus. The methods use an acceptance/rejection simulation algorithm for the Bingham distribution and are described fully by Kent, Ganeiber and Mardia (2018) <doi:10.1080/10618600.2017.1390468>. These methods supersede earlier MCMC simulation methods and are more general than earlier simulation methods. The methods can be slower in specific situations where there are existing non-MCMC simulation methods (see Section 8 of Kent, Ganeiber and Mardia (2018) <doi:10.1080/10618600.2017.1390468> for further details).

This package provides a spatial covariate-augmented overdispersed Poisson factor model is proposed to perform efficient latent representation learning method for high-dimensional large-scale spatial count data with additional covariates.

Build custom Europe SpatialPolygonsDataFrame, if you don't know what is a SpatialPolygonsDataFrame see SpatialPolygons() in sp', by example for mapLayout() in antaresViz'. Antares is a powerful software developed by RTE to simulate and study electric power systems (more information about Antares here: <https://antares-simulator.org/>).

Estimate the size of a networked population based on respondent-driven sampling data. The package is part of the "RDS Analyst" suite of packages for the analysis of respondent-driven sampling data. See Handcock, Gile and Mar (2014) <doi:10.1214/14-EJS923>, Handcock, Gile and Mar (2015) <doi:10.1111/biom.12255>, Kim and Handcock (2021) <doi:10.1093/jssam/smz055>, and McLaughlin, et. al. (2023) <doi:10.1214/23-AOAS1807>.

Implementation of deep learningâ based changepoint detection algorithm designed for time series with smooth local fluctuations. The method fits localized feedâ forward neural networks to approximate the underlying smooth component and constructs a residualâ based detector that isolates abrupt structural changes. A fully dataâ adaptive empirical cumulative distribution function (ECDF) based thresholding rule and refinement procedures yield accurate changepoint localization without parametric assumptions on noise or trend structure.

This package provides a flexible moving average algorithm for modeling drug exposure in pharmacoepidemiology studies as presented in the article: Ouchi, D., Giner-Soriano, M., Gómez-Lumbreras, A., Vedia Urgell, C.,Torres, F., & Morros, R. (2022). "Automatic Estimation of the Most Likely Drug Combination in Electronic Health Records Using the Smooth Algorithm : Development and Validation Study." JMIR medical informatics, 10(11), e37976. <doi:10.2196/37976>.

An implementation of sample size calculations for external pilot studies that minimize the overall trial sample size for the external pilot and main trial for a continuous endpoint as described in Whitehead et al. (2016) <doi:10.1177/0962280215588241>.

This package provides a programmatic interface to <http://sp2000.org.cn>, re-written based on an accompanying Species 2000 API. Access tables describing catalogue of the Chinese known species of animals, plants, fungi, micro-organisms, and more. This package also supports access to catalogue of life global <http://catalogueoflife.org>, China animal scientific database <http://zoology.especies.cn> and catalogue of life Taiwan <https://taibnet.sinica.edu.tw/home_eng.php>. The development of SP2000 package were supported by Biodiversity Survey and Assessment Project of the Ministry of Ecology and Environment, China <2019HJ2096001006>,Yunnan University's "Double First Class" Project <C176240405> and Yunnan University's Research Innovation Fund for Graduate Students <2019227>.

This package provides an easy-to-use module for adding a chat to a Shiny app. Allows users to send messages and view messages from other users. Messages can be stored in a database or a .rds file.

This package provides a collection of statistical hypothesis tests of functional time series. While it will include more tests when the related literature are enriched, this package contains the following key tests: functional stationarity test, functional trend stationarity test, functional unit root test, to name a few.

Exploratory analysis on any input data describing the structure and the relationships present in the data. The package automatically select the variable and does related descriptive statistics. Analyzing information value, weight of evidence, custom tables, summary statistics, graphical techniques will be performed for both numeric and categorical predictors.

Randomization of presence/absence species distribution raster data with or without including spatial structure for calculating standardized effect sizes and testing null hypothesis. The randomization algorithms are based on classical algorithms for matrices (Gotelli 2000, <doi:10.2307/177478>) implemented for raster data.

Implementation of the original Sequence Globally Unique Identifier (SEGUID) algorithm [Babnigg and Giometti (2006) <doi:10.1002/pmic.200600032>] and SEGUID v2 (<https://www.seguid.org>), which extends SEGUID v1 with support for linear, circular, single- and double-stranded biological sequences, e.g. DNA, RNA, and proteins.

This package provides a classification framework to use expression patterns of pathways as features to identify similarity between biological samples. It provides a new measure for quantifying similarity between expression patterns of pathways.

This package provides tools for simulating, analysing, and fitting mobility-based SEAIR (Susceptible-Exposed-Asymptomatic-Infectious-Recovered) compartmental epidemic models with heterogeneous individual mobility. Each individual carries a fixed mobility trait that scales susceptibility and infectiousness through a rank-one kernel, extending the mobility-based compartmental framework of Jiang et al. (2025) <doi:10.1137/24M1691557> by adding a latent stage and a behavioural split between asymptomatic and symptomatic infectiousness. Provides a numerical solver for the underlying partial differential equation system, closed-form computation of the basic reproduction number R0 and the final epidemic size, and a parametric least-squares routine for recovering the mobility distribution from an observed aggregate symptomatic time series.

This package provides a set of functions is provided for 1) the stratum lengths analysis along a chosen direction, 2) fast estimation of continuous lag spatial Markov chains model parameters and probability computing (also for large data sets), 3) transition probability maps and transiograms drawing, 4) simulation methods for categorical random fields. More details on the methodology are discussed in Sartore (2013) <doi:10.32614/RJ-2013-022> and Sartore et al. (2016) <doi:10.1016/j.cageo.2016.06.001>.

It computes Relative survival, AER and SMR based on French death rates.

Get programmatic access to data from the Czech public budgeting and accounting database, Státnà pokladna <https://monitor.statnipokladna.gov.cz/>.

This package provides functions to perform stepwise split regularized regression. The approach first uses a stepwise algorithm to split the variables into the models with a goodness of fit criterion, and then regularization is applied to each model. The weights of the models in the ensemble are determined based on a criterion selected by the user.

Computes robust p-values for overall fit and nested comparisons of structural equation models fitted with lavaan'. Implements penalized eigenvalue block averaging and penalized regression (Foldnes, Moss, Grønneberg, 2025) <doi:10.1080/10705511.2024.2372028>, including their extension to nested models (Foldnes, Grønneberg, Moss, 2026) <doi:10.3758/s13428-026-02968-4>, alongside familiar corrections such as Satorra-Bentler. Supported settings include complete-data ML, GLS, and ULS, categorical DWLS and ULS, and full-information maximum likelihood with one or several groups.