This package provides an example HiC dataset and two examples of HiCociety outputs from a function named hic2community(). The data are intended for demonstration purposes only and kept small enough to be distributed via CRAN.

Testing homogeneity of k multivariate distributions is a classical and challenging problem in statistics, and this becomes even more challenging when the dimension of the data exceeds the sample size. We construct some tests for this purpose which are exact level (size) alpha tests based on clustering. These tests are easy to implement and distribution-free in finite sample situations. Under appropriate regularity conditions, these tests have the consistency property in HDLSS asymptotic regime, where the dimension of data grows to infinity while the sample size remains fixed. We also consider a multiscale approach, where the results for different number of partitions are aggregated judiciously. Details are in Biplab Paul, Shyamal K De and Anil K Ghosh (2021) <doi:10.1016/j.jmva.2021.104897>; Soham Sarkar and Anil K Ghosh (2019) <doi:10.1109/TPAMI.2019.2912599>; William M Rand (1971) <doi:10.1080/01621459.1971.10482356>; Cyrus R Mehta and Nitin R Patel (1983) <doi:10.2307/2288652>; Joseph C Dunn (1973) <doi:10.1080/01969727308546046>; Sture Holm (1979) <doi:10.2307/4615733>; Yoav Benjamini and Yosef Hochberg (1995) <doi: 10.2307/2346101>.

Estimates frictional constants for hydraulic analysis of rivers. This HYDRaulic ROughness CALculator (HYDROCAL) was previously developed as a spreadsheet tool and accompanying documentation by McKay and Fischenich (2011, <https://erdc-library.erdc.dren.mil/jspui/bitstream/11681/2034/1/CHETN-VII-11.pdf>).

Develops algorithms for fitting, prediction, simulation and initialization of the following models (1)- hidden hybrid Markov/semi-Markov model, introduced by Guedon (2005) <doi:10.1016/j.csda.2004.05.033>, (2)- nonparametric mixture of B-splines emissions (Langrock et al., 2015 <doi:10.1111/biom.12282>), (3)- regime switching regression model (Kim et al., 2008 <doi:10.1016/j.jeconom.2007.10.002>) and auto-regressive hidden hybrid Markov/semi-Markov model, (4)- spline-based nonparametric estimation of additive state-switching models (Langrock et al., 2018 <doi:10.1111/stan.12133>) (5)- robust emission model proposed by Qin et al, 2024 <doi:10.1007/s10479-024-05989-4> (6)- several emission distributions, including mixture of multivariate normal (which can also handle missing data using EM algorithm) and multi-nomial emission (for modeling polymer or DNA sequences) (7)- tools for prediction of future state sequence, computing the score of a new sequence, splitting the samples and sequences to train and test sets, computing the information measures of the models, computing the residual useful lifetime (reliability) and many other useful tools ... (read for more description: Amini et al., 2022 <doi:10.1007/s00180-022-01248-x> and its arxiv version: <doi:10.48550/arXiv.2109.12489>).

Comfortable ways to work with hyperspectral data sets. I.e. spatially or time-resolved spectra, or spectra with any other kind of information associated with each of the spectra. The spectra can be data as obtained in XRF, UV/VIS, Fluorescence, AES, NIR, IR, Raman, NMR, MS, etc. More generally, any data that is recorded over a discretized variable, e.g. absorbance = f(wavelength), stored as a vector of absorbance values for discrete wavelengths is suitable.

This package provides helper functions for analysing patient data in hyperthermic intraperitoneal chemotherapy (HIPEC) workflows. Includes functions to estimate peritoneal surface area (PSA), summarise registry data, and produce reporting graphics. Body surface area calculations are based on Du Bois and Du Bois (1916) <doi:10.1001/archinte.1916.00080130010002>.

This package provides functions for the estimation, plotting, predicting and cross-validation of hierarchical feature regression models as described in Pfitzinger (2024). Cluster Regularization via a Hierarchical Feature Regression. Econometrics and Statistics (in press). <doi:10.1016/j.ecosta.2024.01.003>.

Efficient Bayesian multinomial logistic regression based on heavy-tailed (hyper-LASSO, non-convex) priors. The posterior of coefficients and hyper-parameters is sampled with restricted Gibbs sampling for leveraging the high-dimensionality and Hamiltonian Monte Carlo for handling the high-correlation among coefficients. A detailed description of the method: Li and Yao (2018), Journal of Statistical Computation and Simulation, 88:14, 2827-2851, <doi:10.48550/arXiv.1405.3319>.

Generates HIDECAN plots that summarise and combine the results of genome-wide association studies (GWAS) and transcriptomics differential expression analyses (DE), along with manually curated candidate genes of interest. The HIDECAN plot is presented in Angelin-Bonnet et al. (2023) (currently in review).

Harmony is a tool using AI which allows you to compare items from questionnaires and identify similar content. You can try Harmony at <https://harmonydata.ac.uk/app/> and you can read our blog at <https://harmonydata.ac.uk/blog/> or at <https://fastdatascience.com/how-does-harmony-work/>. Documentation at <https://harmonydata.ac.uk/harmony-r-released/>.

This package provides interpretable high-dimensional mean comparison methods (HMC). For example, users can apply these methods to assess the difference in gene expression between two treatment groups. It is not a gene-by-gene comparison. Instead, the methods focus on the interplay between features and identify those that are predictive of the group label. The tests are valid frequentist procedures and yield sparse estimates indicating which features contribute to the group differences.

Using Dirichlet-Multinomial distribution to provide several functions for formal hypothesis testing, power and sample size calculations for human microbiome experiments.

Pre-made models that can be rapidly tailored to various chemicals and species using chemical-specific in vitro data and physiological information. These tools allow incorporation of chemical toxicokinetics ("TK") and in vitro-in vivo extrapolation ("IVIVE") into bioinformatics, as described by Pearce et al. (2017) (<doi:10.18637/jss.v079.i04>). Chemical-specific in vitro data characterizing toxicokinetics have been obtained from relatively high-throughput experiments. The chemical-independent ("generic") physiologically-based ("PBTK") and empirical (for example, one compartment) "TK" models included here can be parameterized with in vitro data or in silico predictions which are provided for thousands of chemicals, multiple exposure routes, and various species. High throughput toxicokinetics ("HTTK") is the combination of in vitro data and generic models. We establish the expected accuracy of HTTK for chemicals without in vivo data through statistical evaluation of HTTK predictions for chemicals where in vivo data do exist. The models are systems of ordinary differential equations that are developed in MCSim and solved using compiled (C-based) code for speed. A Monte Carlo sampler is included for simulating human biological variability (Ring et al., 2017 <doi:10.1016/j.envint.2017.06.004>) and propagating parameter uncertainty (Wambaugh et al., 2019 <doi:10.1093/toxsci/kfz205>). Empirically calibrated methods are included for predicting tissue:plasma partition coefficients and volume of distribution (Pearce et al., 2017 <doi:10.1007/s10928-017-9548-7>). These functions and data provide a set of tools for using IVIVE to convert concentrations from high-throughput screening experiments (for example, Tox21, ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK") (Wetmore et al., 2015 <doi:10.1093/toxsci/kfv171>).

Monthly median home listing, sale price per square foot, and number of units sold for 2984 counties in the contiguous United States From 2008 to January 2016. Additional data sets containing geographical information and links to Wikipedia are also included.

The haversine is a function used to calculate the distance between a pair of latitude and longitude points while accounting for the assumption that the points are on a spherical globe. This package provides a fast, dataframe compatible, haversine function. For the first publication on the haversine calculation see Joseph de Mendoza y RÃ os (1795) <https://books.google.cat/books?id=030t0OqlX2AC> (In Spanish).

Estimation procedures and goodness-of-fit test for several Markov regime switching models and mixtures of bivariate copula models. The goodness-of-fit test is based on a Cramer-von Mises statistic and uses Rosenblatt's transform and parametric bootstrap to estimate the p-value. The proposed methodologies are described in Nasri, Remillard and Thioub (2020) <doi:10.1002/cjs.11534>.

Calculate and visualize Healthy Eating Index (HEI) scores from National Health and Nutrition Examination Survey 24-hour dietary recall data utilizing three methods recommended by the National Cancer Institute (2024) <https://epi.grants.cancer.gov/hei/hei-methods-and-calculations.html#:~:text=To%20use%20the%20simple%20HEI,the%20total%20scores%20across%20individuals.>. Effortlessly analyze HEI scores across different demographic groups and years.

Hadoop InteractiVE facilitates distributed computing via the MapReduce paradigm through R and Hadoop. An easy to use interface to Hadoop, the Hadoop Distributed File System (HDFS), and Hadoop Streaming is provided.

Processing, analysis and visualization of Hydrogen Deuterium eXchange monitored by Mass Spectrometry experiments (HDX-MS). HaDeX2 introduces a new standardized and reproducible workflow for the analysis of the HDX-MS data, including uncertainty propagation, data aggregation and visualization on 3D structure. Additionally, it covers data exploration, quality control and generation of publication-quality figures. All functionalities are also available in the accompanying shiny app.

Estimating heterogeneous treatment effects with tree-based machine learning algorithms and visualizing estimated results in flexible and presentation-ready ways. For more information, see Brand, Xu, Koch, and Geraldo (2021) <doi:10.1177/0081175021993503>. Our current package first started as a fork of the causalTree package on GitHub and we greatly appreciate the authors for their extremely useful and free package.

The conditional treatment effect for competing risks data in observational studies is estimated. While it is described as a constant difference between the hazard functions given the covariates, we do not assume specific functional forms for the covariates. Rava, D. and Xu, R. (2021) <arXiv:2112.09535>.

This package implements methods developed by Ding, Feller, and Miratrix (2016) <doi:10.1111/rssb.12124> <doi:10.48550/arXiv.1412.5000>, and Ding, Feller, and Miratrix (2018) <doi:10.1080/01621459.2017.1407322> <doi:10.48550/arXiv.1605.06566> for testing whether there is unexplained variation in treatment effects across observations, and for characterizing the extent of the explained and unexplained variation in treatment effects. The package includes wrapper functions implementing the proposed methods, as well as helper functions for analyzing and visualizing the results of the test.

Estimation of high-dimensional multi-response regression with heterogeneous noises under Heterogeneous group square-root Lasso penalty. For details see: Ren, Z., Kang, Y., Fan, Y. and Lv, J. (2018)<arXiv:1606.03803>.

Hospital data analysis workflow tools, modeling, and automations. This library provides many useful tools to review common administrative hospital data. Some of these include average length of stay, readmission rates, average net pay amounts by service lines just to name a few. The aim is to provide a simple and consistent verb framework that takes the guesswork out of everything.