Analysis of relative cell type proportions in bulk gene expression data. Provides a well-validated set of brain cell type-specific marker genes derived from multiple types of experiments, as described in McKenzie (2018) <doi:10.1038/s41598-018-27293-5>. For brain tissue data sets, there are marker genes available for astrocytes, endothelial cells, microglia, neurons, oligodendrocytes, and oligodendrocyte precursor cells, derived from each of human, mice, and combination human/mouse data sets. However, if you have access to your own marker genes, the functions can be applied to bulk gene expression data from any tissue. Also implements multiple options for relative cell type proportion estimation using these marker genes, adapting and expanding on approaches from the CellCODE R package described in Chikina (2015) <doi:10.1093/bioinformatics/btv015>. The number of cell type marker genes used in a given analysis can be increased or decreased based on your preferences and the data set. Finally, provides functions to use the estimates to adjust for variability in the relative proportion of cell types across samples prior to downstream analyses.

Bayesian MCPMod (Fleischer et al. (2022) <doi:10.1002/pst.2193>) is an innovative method that improves the traditional MCPMod by systematically incorporating historical data, such as previous placebo group data. This package offers functions for simulating, analyzing, and evaluating Bayesian MCPMod trials with normally and binary distributed endpoints. It enables the assessment of trial designs incorporating historical data across various true dose-response relationships and sample sizes. Robust mixture prior distributions, such as those derived with the Meta-Analytic-Predictive approach (Schmidli et al. (2014) <doi:10.1111/biom.12242>), can be specified for each dose group. Resulting mixture posterior distributions are used in the Bayesian Multiple Comparison Procedure and modeling steps. The modeling step also includes a weighted model averaging approach (Pinheiro et al. (2014) <doi:10.1002/sim.6052>). Estimated dose-response relationships can be bootstrapped and visualized.

This package provides a Bayesian variable selection approach using continuous spike and slab prior distributions. The prior choices here are motivated by the shrinking and diffusing priors studied in Narisetty & He (2014) <DOI:10.1214/14-AOS1207>.

This package provides a registry of APIs listed on <https://bund.dev> and a core OpenAPI client layer to explore specs and perform requests. Adapter helpers return tidy data frames for supported APIs, with optional response caching and rate limiting guidance.

Fits and simulates multi-optima Ornstein-Uhlenbeck models to phylogenetic comparative data using Bayesian reversible-jump methods. See Uyeda and Harmon (2014) <DOI:10.1093/sysbio/syu057>.

Defines operating characteristics of Bayesian Adaptive Trials considering a generalised linear model response via Monte Carlo simulations of Bayesian GLM fitted via integrated Laplace approximations (INLA).

Simultaneously clusters the Periodontal diseases (PD) patients and their tooth sites after taking the patient- and site-level covariates into consideration. BAREB uses the determinantal point process (DPP) prior to induce diversity among different biclusters to facilitate parsimony and interpretability. Essentially, BAREB is a cluster-wise linear model based on Yuliang (2020) <doi:10.1002/sim.8536>.

For a balanced design of experiments, this package calculates the sample size required to detect a certain standardized effect size, under a significance level. This package also provides three graphs; detectable standardized effect size vs power, sample size vs detectable standardized effect size, and sample size vs power, which show the mutual relationship between the sample size, power and the detectable standardized effect size. The detailed procedure is described in R. V. Lenth (2006-9) <https://homepage.divms.uiowa.edu/~rlenth/Power/>, Y. B. Lim (1998), M. A. Kastenbaum, D. G. Hoel and K. O. Bowman (1970) <doi:10.2307/2334851>, and Douglas C. Montgomery (2013, ISBN: 0849323312).

Calculation of physical (e.g. aerodynamic conductance, surface temperature), and physiological (e.g. canopy conductance, water-use efficiency) ecosystem properties from eddy covariance data and accompanying meteorological measurements. Calculations assume the land surface to behave like a big-leaf and return bulk ecosystem/canopy variables.

The function \codebarcode() produces a histogram-like plot of a distribution that shows granularity in the data.

Perform the Benford's Analysis to a data set in order to evaluate if it contains human fabricated data. For more details on the method see Moreau, 2021, Model Assist. Statist. Appl., 16 (2021) 73â 79. <doi:10.3233/MAS-210517>.

Facilitates the importation of the Boston Blue Bike trip data since 2015. Functions include the computation of trip distances of given trip data. It can also map the location of stations within a given radius and calculate the distance to nearby stations. Data is from <https://www.bluebikes.com/system-data>.

This package provides a set of functions to help clinical trial researchers calculate power and sample size for two-arm Bayesian randomized clinical trials that do or do not incorporate historical control data. At some point during the design process, a clinical trial researcher who is designing a basic two-arm Bayesian randomized clinical trial needs to make decisions about power and sample size within the context of hypothesized treatment effects. Through simulation, the simple_sim() function will estimate power and other user specified clinical trial characteristics at user specified sample sizes given user defined scenarios about treatment effect,control group characteristics, and outcome. If the clinical trial researcher has access to historical control data, then the researcher can design a two-arm Bayesian randomized clinical trial that incorporates the historical data. In such a case, the researcher needs to work through the potential consequences of historical and randomized control differences on trial characteristics, in addition to working through issues regarding power in the context of sample size, treatment effect size, and outcome. If a researcher designs a clinical trial that will incorporate historical control data, the researcher needs the randomized controls to be from the same population as the historical controls. What if this is not the case when the designed trial is implemented? During the design phase, the researcher needs to investigate the negative effects of possible historic/randomized control differences on power, type one error, and other trial characteristics. Using this information, the researcher should design the trial to mitigate these negative effects. Through simulation, the historic_sim() function will estimate power and other user specified clinical trial characteristics at user specified sample sizes given user defined scenarios about historical and randomized control differences as well as treatment effects and outcomes. The results from historic_sim() and simple_sim() can be printed with print_table() and graphed with plot_table() methods. Outcomes considered are Gaussian, Poisson, Bernoulli, Lognormal, Weibull, and Piecewise Exponential. The methods are described in Eggleston et al. (2021) <doi:10.18637/jss.v100.i21>.

Estimate population average treatment effects from a primary data source with borrowing from supplemental sources. Causal estimation is done with either a Bayesian linear model or with Bayesian additive regression trees (BART) to adjust for confounding. Borrowing is done with multisource exchangeability models (MEMs). For information on BART, see Chipman, George, & McCulloch (2010) <doi:10.1214/09-AOAS285>. For information on MEMs, see Kaizer, Koopmeiners, & Hobbs (2018) <doi:10.1093/biostatistics/kxx031>.

This package provides a computational toolbox designed for handling missing values in large datasets with the Multiple Imputation by Chained Equations (MICE) by using Apache Spark'. The methodology is described in Morvan et al. (2026) <doi:10.48550/arXiv.2601.21613>.

Bayesian quantile regression using the asymmetric Laplace distribution, both continuous as well as binary dependent variables are supported. The package consists of implementations of the methods of Yu & Moyeed (2001) <doi:10.1016/S0167-7152(01)00124-9>, Benoit & Van den Poel (2012) <doi:10.1002/jae.1216> and Al-Hamzawi, Yu & Benoit (2012) <doi:10.1177/1471082X1101200304>. To speed up the calculations, the Markov Chain Monte Carlo core of all algorithms is programmed in Fortran and called from R.

Fits finite mixture models of univariate Gaussian distributions using JAGS within a Bayesian framework.

Evaluate, fit, and analyze Hill dose response models (Goutelle et al., 2008 <doi:10.1111/j.1472-8206.2008.00633.x>), also sometimes referred to as four-parameter log-logistic models. Includes tools to invert Hill models, select models based on the Akaike information criterion (Akaike, 1974 <doi:10.1109/TAC.1974.1100705>) or Bayesian information criterion (Schwarz, 1978 <https://www.jstor.org/stable/2958889>), and construct bootstrapped confidence intervals both on the Hill model parameters and values derived from the Hill model parameters.

Simulation and visualization depth-dependent integrated visual fields. Visual fields are measured monocularly at a single depth, yet real-life activities involve predominantly binocular vision at multiple depths. The package provides functions to simulate and visualize binocular visual field impairment in a depth-dependent fashion from monocular visual field results based on Ping Liu, Allison McKendrick, Anna Ma-Wyatt, Andrew Turpin (2019) <doi:10.1167/tvst.9.3.8>. At each location and depth plane, sensitivities are linearly interpolated from corresponding locations in monocular visual field and returned as the higher value of the two. Its utility is demonstrated by evaluating DD-IVF defects associated with 12 glaucomatous archetypes of 24-2 visual field pattern in the included shiny apps.

Bayesian inference on the (discrete) power spectrum of time series.

Multicenter randomized trials involve the collection and analysis of data from numerous study participants across multiple sites. Outliers may be present. To identify outliers, this package examines data at the individual level (univariate and multivariate) and site-level (with and without covariate adjustment). Methods are outlined in further detail in Rigdon et al (to appear).

Fits a Bayesian zero-inflated Bernoulli regression model handling (potentially) different covariates for the zero-inflated and non zero-inflated parts. See Moriña D, Puig P, Navarro A. (2021) <doi:10.1186/s12874-021-01427-2>.

Test the robustness of a user's Qualitative Comparative Analysis solutions to randomness, using the bootstrapped assessment: baQCA(). This package also includes a function that provides recommendations for improving solutions to reach typical significance levels: brQCA(). Data included come from McVeigh et al. (2014) <doi:10.1177/0003122414534065>.

Generic Extraction of main text content from HTML files; removal of ads, sidebars and headers using the boilerpipe <https://github.com/kohlschutter/boilerpipe> Java library. The extraction heuristics from boilerpipe show a robust performance for a wide range of web site templates.