This package implements the DANDELION method for prioritizing candidate disease-related proximal genes by integrating trans-regulatory association p-values and gene-level trait association p-values. The statistical testing framework builds on the divide-aggregate composite-null test described by Liu et al. (2022) <doi:10.1080/01621459.2021.1914634>. The biological application and SNP/gene-based prioritization workflow are motivated by Salamone et al. (under review), "Leveraging trans-gene regulation prioritizes central genes and pathways in asthma". The package provides functions for identifying distal-proximal gene pairs, organizing significant pairs into genomic loci, and visualizing resulting gene networks.

Implementation of three methods based on the diversity forest (DF) algorithm (Hornung, 2022, <doi:10.1007/s42979-021-00920-1>), a split-finding approach that enables complex split procedures in random forests. The package includes: 1. Interaction forests (IFs) (Hornung & Boulesteix, 2022, <doi:10.1016/j.csda.2022.107460>): Model quantitative and qualitative interaction effects using bivariable splitting. Come with the Effect Importance Measure (EIM), which can be used to identify variable pairs that have well-interpretable quantitative and qualitative interaction effects with high predictive relevance. 2. Two random forest-based variable importance measures (VIMs) for multi-class outcomes: the class-focused VIM, which ranks covariates by their ability to distinguish individual outcome classes from the others, and the discriminatory VIM, which measures overall covariate influence irrespective of class-specific relevance. 3. The basic form of diversity forests that uses conventional univariable, binary splitting (Hornung, 2022). Except for the multi-class VIMs, all methods support categorical, metric, and survival outcomes. The package includes visualization tools for interpreting the identified covariate effects. Built as a fork of the ranger R package (main author: Marvin N. Wright), which implements random forests using an efficient C++ implementation.

This package provides functions and example datasets to run a decision-analytic model for prevention and treatment strategies across depression severity states (sub-clinical, mild, moderate, severe, and recurrent). The package supports scenario analyses (base and alternative inputs) and summarises outcomes such as coverage, adherence, effect sizes, and healthcare costs.

Estimate and return the needed parameters for visualizations designed for OpenBudgets.eu <http://openbudgets.eu/> datasets. Calculate descriptive statistical measures in budget data of municipalities across Europe, according to the OpenBudgets.eu data model. There are functions for measuring central tendency and dispersion of amount variables along with their distributions and correlations and the frequencies of categorical variables for a given dataset. Also, can be used generally to other datasets, to extract visualization parameters, convert them to JSON format and use them as input in a different graphical interface.

Uses species occupancy at coarse grain sizes to predict species occupancy at fine grain sizes. Ten models are provided to fit and extrapolate the occupancy-area relationship, as well as methods for preparing atlas data for modelling. See Marsh et. al. (2018) <doi:10.18637/jss.v086.c03>.

Applies dynamic structural equation models to time-series data with generic and simplified specification for simultaneous and lagged effects. Methods are described in Thorson et al. (2024) "Dynamic structural equation models synthesize ecosystem dynamics constrained by ecological mechanisms.".

Individual gene expression patterns are encoded into a series of eigenvector patterns ('WGCNA package). Using the framework of linear model-based differential expression comparisons ('limma package), time-course expression patterns for genes in different conditions are compared and analyzed for significant pattern changes. For reference, see: Greenham K, Sartor RC, Zorich S, Lou P, Mockler TC and McClung CR. eLife. 2020 Sep 30;9(4). <doi:10.7554/eLife.58993>.

Differential Analysis of short RNA transcripts that can be modeled by either Poisson or Negative binomial distribution. The statistical methodology implemented in this package is based on the random selection of references genes (Desaulle et al. (2021) <arXiv:2103.09872>).

Data quality assessments guided by a data quality framework introduced by Schmidt and colleagues, 2021 <doi:10.1186/s12874-021-01252-7> target the data quality dimensions integrity, completeness, consistency, and accuracy. The scope of applicable functions rests on the availability of extensive metadata which can be provided in spreadsheet tables. Either standardized (e.g. as html5 reports) or individually tailored reports can be generated. For an introduction into the specification of corresponding metadata, please refer to the package website <https://dataquality.qihs.uni-greifswald.de/VIN_Annotation_of_Metadata.html>.

Build a Dockerfile straight from your R session. dockerfiler allows you to create step by step a Dockerfile, and provide convenient tools to wrap R code inside this Dockerfile.

Improves the balance of optimal matching with near-fine balance by giving penalties on the unbalanced covariates with the unbalanced directions. Many directional penalties can also be viewed as Lagrange multipliers, pushing a matched sample in the direction of satisfying a linear constraint that would not be satisfied without penalization. Yu and Rosenbaum (2019) <doi:10.1111/biom.13098>.

This package provides methods for analyzing categorical dyadic sequences using transition matrices within the Longitudinal Actor-Partner Interdependence Model and Markov-chain framework. The package supports empirical transition counts, maximum likelihood estimation of transition probabilities, and identification of univariate and bivariate patterns of interaction in dyadic sequences.

Clustered or multilevel data structures are common in the assessment of differential item functioning (DIF), particularly in the context of large-scale assessment programs. This package allows users to implement extensions of the Mantel-Haenszel DIF detection procedures in the presence of multilevel data based on the work of Begg (1999) <doi:10.1111/j.0006-341X.1999.00302.x>, Begg & Paykin (2001) <doi:10.1080/00949650108812115>, and French & Finch (2013) <doi:10.1177/0013164412472341>.

Have you ever been tempted to create roxygen2'-style documentation comments for one of your functions that was not part of one of your packages (yet)? This is exactly what this package is about: running roxygen2 on (chunks of) a single code file.

Given count data from two conditions, it determines which transcripts are differentially expressed across the two conditions using Bayesian inference of the parameters of a bottom-up model for PCR amplification. This model is developed in Ndifon Wilfred, Hilah Gal, Eric Shifrut, Rina Aharoni, Nissan Yissachar, Nir Waysbort, Shlomit Reich Zeliger, Ruth Arnon, and Nir Friedman (2012), <http://www.pnas.org/content/109/39/15865.full>, and results in a distribution for the counts that is a superposition of the binomial and negative binomial distribution.

This package provides a suite of tools are provided here to support authors in making their research more discoverable. check_keywords() - this function checks the keywords to assess whether they are already represented in the title and abstract. check_fields() - this function compares terminology used across the title, abstract and keywords to assess where terminological diversity (i.e. the use of synonyms) could increase the likelihood of the record being identified in a search. The function looks for terms in the title and abstract that also exist in other fields and highlights these as needing attention. suggest_keywords() - this function takes a full text document and produces a list of unigrams, bigrams and trigrams (1-, 2- or 2-word phrases) present in the full text after removing stop words (words with a low utility in natural language processing) that do not occur in the title or abstract that may be suitable candidates for keywords. suggest_title() - this function takes a full text document and produces a list of the most frequently used unigrams, bigrams and trigrams after removing stop words that do not occur in the abstract or keywords that may be suitable candidates for title words. check_title() - this function carries out a number of sub tasks: 1) it compares the length (number of words) of the title with the mean length of titles in major bibliographic databases to assess whether the title is likely to be too short; 2) it assesses the proportion of stop words in the title to highlight titles with low utility in search engines that strip out stop words; 3) it compares the title with a given sample of record titles from an .ris import and calculates a similarity score based on phrase overlap. This highlights the level of uniqueness of the title. This version of the package also contains functions currently in a non-CRAN package called litsearchr <https://github.com/elizagrames/litsearchr>.

Differential Item Functioning (DIF) Analysis with shiny application interfaces. You can run the functions in this package without any arguments and perform your DIF analysis using user-friendly interfaces.

Low level functions for implementing maximum likelihood estimating procedures for complex models using data cloning and Bayesian Markov chain Monte Carlo methods as described in Solymos 2010 <doi:10.32614/RJ-2010-011>. Sequential and parallel MCMC support for JAGS', WinBUGS', OpenBUGS', and Stan'.

Mixed model analysis for quantitative genetics with multi-trait responses and pedigree-based partitioning of individual variation into a range of environmental and genetic variance components for individual and maternal effects. Method documented in dmmOverview.pdf; dmm is an implementation of dispersion mean model described by Searle et al. (1992) "Variance Components", Wiley, NY. Dmm() can do MINQUE', bias-corrected-ML', and REML variance and covariance component estimates.

This package provides functions to import multiple files of multiple data file types ('.xlsx', .xls', .csv', .txt') from a given directory into R data frames.

Preferred methods for common analytical tasks that are undertaken across the Department, including number formatting, project templates and curated reference data.

Perform data quality assessment ('DQA') of electronic health records ('EHR'). Publication: Kapsner et al. (2021) <doi:10.1055/s-0041-1733847>.

Profiles a data frame with minimal input: column type inference, missing-value analysis, distributional summary statistics (including skewness and kurtosis), normality tests, outlier detection, correlation and categorical-association analysis, date-column profiling, grouped comparisons and an overall data-quality score, alongside a set of ggplot2 visualisations. A single entry point, profile_data(), returns a structured S3 object holding metadata, statistics, diagnostics and plots, with print(), summary() and plot() methods, and report() renders the whole profile to a self-contained HTML file. Statistical methods include the Shapiro-Wilk normality test as implemented by Royston (1995) <doi:10.2307/2986146> and the Anderson-Darling test following Stephens (1974) <doi:10.1080/01621459.1974.10480196>, with power comparisons of these tests in Yap and Sim (2011) <doi:10.1080/00949655.2010.520163>, and the categorical association measure of Cramer (1946, ISBN:9780691080048).

This package provides functions to describe sampling and diversity dynamics of fossil occurrence datasets (e.g. from the Paleobiology Database). The package includes methods to calculate range- and occurrence-based metrics of taxonomic richness, extinction and origination rates, along with traditional sampling measures. A powerful subsampling tool is also included that implements frequently used sampling standardization methods in a multiple bin-framework. The plotting of time series and the occurrence data can be simplified by the functions incorporated in the package, as well as other calculations, such as environmental affinities and extinction selectivity testing. Details can be found in: Kocsis, A.T.; Reddin, C.J.; Alroy, J. and Kiessling, W. (2019) <doi:10.1101/423780>.