This package provides an interface to the SuiteSparse UMFPACK LU factorisation routines for sparse matrices stored in compressed column format. Implements the algorithm described in Davis (2004) <doi:10.1145/992200.992206>.

Please see the shinytest to shinytest2 migration guide at <https://rstudio.github.io/shinytest2/articles/z-migration.html>.

This package provides tools for estimating, interpreting, and visualizing Spatial-X (SLX) regression models. Provides a formula-based interface with first-class support for variable-specific weights matrices, higher-order spatial lags, temporally-lagged spatial variables (TSLS), and tidy effects decomposition (direct, indirect, total). Designed to lower the barrier to SLX modeling for applied researchers who already work with sf and lm'-style formulas. Methods follow Wimpy, Whitten, and Williams (2021) <doi:10.1086/710089>.

This package provides the spatial sign correlation and the two-stage spatial sign correlation as well as a one-sample test for the correlation coefficient.

Identifying outcome relevant subgroups has now become as simple as possible! The formerly lengthy and tedious search for the needle in a haystack will be replaced by a single, comprehensive and coherent presentation. The central result of a subgroup screening is a diagram in which each single dot stands for a subgroup. The diagram may show thousands of them. The position of the dot in the diagram is determined by the sample size of the subgroup and the statistical measure of the treatment effect in that subgroup. The sample size is shown on the horizontal axis while the treatment effect is displayed on the vertical axis. Furthermore, the diagram shows the line of no effect and the overall study results. For small subgroups, which are found on the left side of the plot, larger random deviations from the mean study effect are expected, while for larger subgroups only small deviations from the study mean can be expected to be chance findings. So for a study with no conspicuous subgroup effects, the dots in the figure are expected to form a kind of funnel. Any deviations from this funnel shape hint to conspicuous subgroups.

Estimate the regression coefficients and the baseline hazard of proportional hazard Cox models with left, right or interval censored survival data using maximum penalised likelihood. A non-parametric smooth estimate of the baseline hazard function is provided.

Includes bases for litholog generation: graphical functions based on R base graphics, interval management functions and svg importation functions among others. Also include stereographic projection functions, and other functions made to deal with large datasets while keeping options to get into the details of the data. When using for publication please cite Sebastien Wouters, Anne-Christine Da Silva, Frederic Boulvain and Xavier Devleeschouwer, 2021. The R Journal 13:2, 153-178. The palaeomagnetism functions are based on: Tauxe, L., 2010. Essentials of Paleomagnetism. University of California Press. <https://earthref.org/MagIC/books/Tauxe/Essentials/>; Allmendinger, R. W., Cardozo, N. C., and Fisher, D., 2013, Structural Geology Algorithms: Vectors & Tensors: Cambridge, England, Cambridge University Press, 289 pp.; Cardozo, N., and Allmendinger, R. W., 2013, Spherical projections with OSXStereonet: Computers & Geosciences, v. 51, no. 0, p. 193 - 205, <doi: 10.1016/j.cageo.2012.07.021>.

This package provides functions for converting and processing network data from a SpatialLinesDataFrame -Class object to an igraph'-Class object.

In some situations where researchers would like to demonstrate causal effects, it is hard to obtain a sample size that would allow for a well-powered randomized controlled trial. Single case designs are experimental designs that can be used to demonstrate causal effects with only one participant or with only a few participants. The scdtb package provides a suite of tools for analyzing data from studies that use single case designs. The nap() function can be used to compute the nonoverlap of all pairs as outlined by the What Works Clearinghouse (2022) <https://ies.ed.gov/ncee/wwc/Handbooks>. The package also offers the mixed_model_analysis() and cross_lagged() functions which implement mixed effects models and cross lagged analyses as described in Maric & van der Werff (2020) <doi:10.4324/9780429273872-9>. The randomization_test() function implements randomization tests based on methods presented in Onghena (2020) <doi:10.4324/9780429273872-8>. The scdtb() shiny application can be used to upload single case design data and access various scdtb tools for plotting and analysis.

Sensitivity analysis for trials with irregular and informative assessment times, based on a new influence function-based, augmented inverse intensity-weighted estimator.

Add functionality to create drag and drop div elements in shiny.

This package provides tools for reading and writing biological sequences in multiple formats, including FASTA', PHYLIP', CLUSTAL', STOCKHOLM', MEGA and GenBank'. Supports interleaved and sequential layouts where applicable, converts between formats, and manipulates sequence sets (e.g., filtering by patterns and computing consensus sequences from alignments). Also includes functions to download nucleotide records from NCBI by accession.

We analyzed the nucleotide composition of genes with a special emphasis on stability of DNA sequences. Besides, in a variety of different organisms unequal use of synonymous codons, or codon usage bias, occurs which also show variation among genes in the same genome. Seemingly, codon usage bias is affected by both selective constraints and mutation bias which allows and enables us to examine and detect changes in these two evolutionary forces between genomes or along one genome. Therefore, we determined the codon adaptation index (CAI), effective number of codons (ENC) and codon usage analysis with calculation of the relative synonymous codon usage (RSCU), and subsequently predicted the translation efficiency and accuracy through GC-rich codon usages. Furthermore, we estimated the relative stability of the DNA sequence following calculation of the average free energy (Delta G) and Dimer base-stacking energy level.

M-estimators of location and shape following the power family (Frahm, Nordhausen, Oja (2020) <doi:10.1016/j.jmva.2019.104569>) are provided in the case of complete data and also when observations have missing values together with functions aiding their visualization.

This package provides a coherent interface for exploring and transforming multiple related data frames that share a common structure. Complements single-dataset inspection tools by operating across an entire collection at once. Also includes lightweight utilities for related file and folder management tasks.

This package provides a lightweight runtime type system for R that enables developers to declare and enforce variable types during execution. Inspired by TypeScript', the package introduces intuitive syntax for annotating variables and validating data structures, helping catch type-related errors early and making R code more robust and easier to maintain.

This package provides a framework for undertaking space and time varying coefficient models (varying parameter models) using a Generalized Additive Model (GAM) with smooths approach. The framework suggests the need to investigate for the presence and nature of any space-time dependencies in the data. It proposes a workflow that creates and refines an initial space-time GAM and includes tools to create and evaluate multiple model forms. The workflow sequence is to: i) Prepare the data by lengthening it to have a single location and time variables for each observation. ii) Create all possible space and/or time models in which each predictor is specified in different ways in smooths. iii) Evaluate each model via their AIC value and pick the best one. iv) Create the final model. v) Calculate the varying coefficient estimates to quantify how the relationships between the target and predictor variables vary over space, time or space-time. vi) Create maps, time series plots etc. The number of knots used in each smooth can be specified directly or iteratively increased. This is illustrated with a climate point dataset of the dry rain forest in South America. This builds on work in Comber et al (2024) <doi:10.1080/13658816.2023.2270285> and Comber et al (2004) <doi:10.3390/ijgi13120459>.

This package provides a comprehensive Shiny application for analyzing Whole Genome Duplication ('WGD') events. This package provides a user-friendly Shiny web application for non-experienced researchers to prepare input data and execute command lines for several well-known WGD analysis tools, including wgd', ksrates', i-ADHoRe', OrthoFinder', and Whale'. This package also provides the source code for experienced researchers to adjust and install the package to their own server. Key Features 1) Input Data Preparation This package allows users to conveniently upload and format their data, making it compatible with various WGD analysis tools. 2) Command Line Generation This package automatically generates the necessary command lines for selected WGD analysis tools, reducing manual errors and saving time. 3) Visualization This package offers interactive visualizations to explore and interpret WGD results, facilitating in-depth WGD analysis. 4) Comparative Genomics Users can study and compare WGD events across different species, aiding in evolutionary and comparative genomics studies. 5) User-Friendly Interface This Shiny web application provides an intuitive and accessible interface, making WGD analysis accessible to researchers and bioinformaticians of all levels.

This package implements the calibrated sensitivity analysis approach for matched observational studies. Our sensitivity analysis framework views matched sets as drawn from a super-population. The unmeasured confounder is modeled as a random variable. We combine matching and model-based covariate-adjustment methods to estimate the treatment effect. The hypothesized unmeasured confounder enters the picture as a missing covariate. We adopt a state-of-art Expectation Maximization (EM) algorithm to handle this missing covariate problem in generalized linear models (GLMs). As our method also estimates the effect of each observed covariate on the outcome and treatment assignment, we are able to calibrate the unmeasured confounder to observed covariates. Zhang, B., Small, D. S. (2018). <arXiv:1812.00215>.

Provide regularized maximum covariance analysis incorporating smoothness, sparseness and orthogonality of couple patterns by using the alternating direction method of multipliers algorithm. The method can be applied to either regularly or irregularly spaced data, including 1D, 2D, and 3D (Wang and Huang, 2018 <doi:10.1002/env.2481>).

Users may specify what fundamental qualities of a new study have or have not changed in an attempt to reproduce or replicate an original study. A comparison of the differences is visualized. Visualization approach follows Patil', Peng', and Leek (2016) <doi:10.1101/066803>.

For making Trellis-type conditioning plots without strip labels. This is useful for displaying the structure of results from factorial designs and other studies when many conditioning variables would clutter the display with layers of redundant strip labels. Settings of the variables are encoded by layout and spacing in the trellis array and decoded by a separate legend. The functionality is implemented by a single S3 generic strucplot() function that is a wrapper for the Lattice package's xyplot() function. This allows access to all Lattice graphics capabilities in the usual way.

This package implements multiple imputation of missing covariates by Substantive Model Compatible Fully Conditional Specification. This is a modification of the popular FCS/chained equations multiple imputation approach, and allows imputation of missing covariate values from models which are compatible with the user specified substantive model.

This package provides functionality for analytically calculating parameters (via the InteractionPoweR package) useful for simulation of moderated multiple regression, based on the correlations among the predictors and outcome and the reliability of predictors.