Create a hexagon tile map display from spatial polygons. Each polygon is represented by a hexagon tile, placed as close to it's original centroid as possible, with a focus on maintaining spatial relationship to a focal point. Developed to aid visualisation and analysis of spatial distributions across Australia, which can be challenging due to the concentration of the population on the coast and wide open interior.

The complete scripts from the American version of the Office television show in tibble format. Use this package to analyze and have fun with text from the best series of all time.

Implementation of the scregclust algorithm described in Larsson, Held, et al. (2024) <doi:10.1038/s41467-024-53954-3> which reconstructs regulatory programs of target genes in scRNA-seq data. Target genes are clustered into modules and each module is associated with a linear model describing the regulatory program.

This package provides a tool for cutting data into intervals. Allows singleton intervals. Always includes the whole range of data by default. Flexible labelling. Convenience functions for cutting by quantiles etc. Handles dates, times, units and other vectors.

This package provides an interface to the Sensibo Sky API which allows to remotely control non-smart air conditioning units. See <https://sensibo.com> for more informations.

An implementation of the full-likelihood Bayes factor (FLB) for evaluating segregation evidence in clinical medical genetics. The method was introduced by Thompson et al. (2003) <doi:10.1086/378100>. This implementation supports custom penetrance values and liability classes, and allows visualisations and robustness analysis as presented in Ratajska et al. (2023) <doi:10.1002/mgg3.2107>. See also the online app shinyseg', <https://chrcarrizosa.shinyapps.io/shinyseg>, which offers interactive segregation analysis with many additional features (Carrizosa et al. (2024) <doi:10.1093/bioinformatics/btae201>).

Use R to interface with the Charles Schwab Trade API <https://developer.schwab.com/>. Functions include authentication, trading, price requests, account information, and option chains. A user will need a Schwab brokerage account and Schwab Individual Developer app. See README for authentication process and examples.

Visual representations of model fit or predictive success in the form of "separation plots." See Greenhill, Brian, Michael D. Ward, and Audrey Sacks. "The separation plot: A new visual method for evaluating the fit of binary models." American Journal of Political Science 55.4 (2011): 991-1002.

This package provides a workflow based on scTenifoldNet to perform in-silico knockout experiments using single-cell RNA sequencing (scRNA-seq) data from wild-type (WT) control samples as input. First, the package constructs a single-cell gene regulatory network (scGRN) and knocks out a target gene from the adjacency matrix of the WT scGRN by setting the geneâ s outdegree edges to zero. Then, it compares the knocked out scGRN with the WT scGRN to identify differentially regulated genes, called virtual-knockout perturbed genes, which are used to assess the impact of the gene knockout and reveal the geneâ s function in the analyzed cells.

Substitution matrices are important parameters in protein alignment algorithms. These matrices represent the likelihood that an amino acid will be substituted for another during mutation. This tool allows users to apply predefined and custom matrices and then explore the resulting alignments with interactive visualizations. SubVis requires the availability of a web browser.

This package provides a base dependency solution with basic argument parsing for use with Rscript'.

This package implements numerous methods for testing for, modelling, and correcting for heteroskedasticity in the classical linear regression model. The most novel contribution of the package is found in the functions that implement the as-yet-unpublished auxiliary linear variance models and auxiliary nonlinear variance models that are designed to estimate error variances in a heteroskedastic linear regression model. These models follow principles of statistical learning described in Hastie (2009) <doi:10.1007/978-0-387-21606-5>. The nonlinear version of the model is estimated using quasi-likelihood methods as described in Seber and Wild (2003, ISBN: 0-471-47135-6). Bootstrap methods for approximate confidence intervals for error variances are implemented as described in Efron and Tibshirani (1993, ISBN: 978-1-4899-4541-9), including also the expansion technique described in Hesterberg (2014) <doi:10.1080/00031305.2015.1089789>. The wild bootstrap employed here follows the description in Davidson and Flachaire (2008) <doi:10.1016/j.jeconom.2008.08.003>. Tuning of hyper-parameters makes use of a golden section search function that is modelled after the MATLAB function of Zarnowiec (2022) <https://www.mathworks.com/matlabcentral/fileexchange/25919-golden-section-method-algorithm>. A methodological description of the algorithm can be found in Fox (2021, ISBN: 978-1-003-00957-3). There are 25 different functions that implement hypothesis tests for heteroskedasticity. These include a test based on Anscombe (1961) <https://projecteuclid.org/euclid.bsmsp/1200512155>, Ramsey's (1969) BAMSET Test <doi:10.1111/j.2517-6161.1969.tb00796.x>, the tests of Bickel (1978) <doi:10.1214/aos/1176344124>, Breusch and Pagan (1979) <doi:10.2307/1911963> with and without the modification proposed by Koenker (1981) <doi:10.1016/0304-4076(81)90062-2>, Carapeto and Holt (2003) <doi:10.1080/0266476022000018475>, Cook and Weisberg (1983) <doi:10.1093/biomet/70.1.1> (including their graphical methods), Diblasi and Bowman (1997) <doi:10.1016/S0167-7152(96)00115-0>, Dufour, Khalaf, Bernard, and Genest (2004) <doi:10.1016/j.jeconom.2003.10.024>, Evans and King (1985) <doi:10.1016/0304-4076(85)90085-5> and Evans and King (1988) <doi:10.1016/0304-4076(88)90006-1>, Glejser (1969) <doi:10.1080/01621459.1969.10500976> as formulated by Mittelhammer, Judge and Miller (2000, ISBN: 0-521-62394-4), Godfrey and Orme (1999) <doi:10.1080/07474939908800438>, Goldfeld and Quandt (1965) <doi:10.1080/01621459.1965.10480811>, Harrison and McCabe (1979) <doi:10.1080/01621459.1979.10482544>, Harvey (1976) <doi:10.2307/1913974>, Honda (1989) <doi:10.1111/j.2517-6161.1989.tb01749.x>, Horn (1981) <doi:10.1080/03610928108828074>, Li and Yao (2019) <doi:10.1016/j.ecosta.2018.01.001> with and without the modification of Bai, Pan, and Yin (2016) <doi:10.1007/s11749-017-0575-x>, Rackauskas and Zuokas (2007) <doi:10.1007/s10986-007-0018-6>, Simonoff and Tsai (1994) <doi:10.2307/2986026> with and without the modification of Ferrari, Cysneiros, and Cribari-Neto (2004) <doi:10.1016/S0378-3758(03)00210-6>, Szroeter (1978) <doi:10.2307/1913831>, Verbyla (1993) <doi:10.1111/j.2517-6161.1993.tb01918.x>, White (1980) <doi:10.2307/1912934>, Wilcox and Keselman (2006) <doi:10.1080/10629360500107923>, Yuce (2008) <https://dergipark.org.tr/en/pub/iuekois/issue/8989/112070>, and Zhou, Song, and Thompson (2015) <doi:10.1002/cjs.11252>. Besides these heteroskedasticity tests, there are supporting functions that compute the BLUS residuals of Theil (1965) <doi:10.1080/01621459.1965.10480851>, the conditional two-sided p-values of Kulinskaya (2008) <doi:10.48550/arXiv.0810.2124>, and probabilities for the nonparametric trend statistic of Lehmann (1975, ISBN: 0-816-24996-1). For handling heteroskedasticity, in addition to the new auxiliary variance model methods, there is a function to implement various existing Heteroskedasticity-Consistent Covariance Matrix Estimators from the literature, such as those of White (1980) <doi:10.2307/1912934>, MacKinnon and White (1985) <doi:10.1016/0304-4076(85)90158-7>, Cribari-Neto (2004) <doi:10.1016/S0167-9473(02)00366-3>, Cribari-Neto et al. (2007) <doi:10.1080/03610920601126589>, Cribari-Neto and da Silva (2011) <doi:10.1007/s10182-010-0141-2>, Aftab and Chang (2016) <doi:10.18187/pjsor.v12i2.983>, and Li et al. (2017) <doi:10.1080/00949655.2016.1198906>.

Displays the content of a R script into the Cytoscape network-visualization app <https://cytoscape.org/>.

This package provides simple and powerful interfaces that facilitate interaction with ODBC data sources. Each data source gets its own unique and dedicated interface, wrapped around RODBC'. Communication settings are remembered between queries, and are managed silently in the background. The interfaces support multi-statement SQL scripts, which can be parameterised via metaprogramming structures and embedded R expressions.

Simulate multivariate correlated data given nonparametric marginals and their joint structure characterized by a Pearson or Spearman correlation matrix. The simulator engages the problem from a purely computational perspective. It assumes no statistical models such as copulas or parametric distributions, and can approximate the target correlations regardless of theoretical feasibility. The algorithm integrates and advances the Iman-Conover (1982) approach <doi:10.1080/03610918208812265> and the Ruscio-Kaczetow iteration (2008) <doi:10.1080/00273170802285693>. Package functions are carefully implemented in C++ for squeezing computing speed, suitable for large input in a manycore environment. Precision of the approximation and computing speed both substantially outperform various CRAN packages to date. Benchmarks are detailed in function examples. A simple heuristic algorithm is additionally designed to optimize the joint distribution in the post-simulation stage. The heuristic demonstrated good potential of achieving the same level of precision of approximation without the enhanced Iman-Conover-Ruscio-Kaczetow. The package contains a copy of Permuted Congruential Generator.

This package provides a toolkit for simulation studies concerning time-to-event endpoints with non-proportional hazards. SimNPH encompasses functions for simulating time-to-event data in various scenarios, simulating different trial designs like fixed-followup, event-driven, and group sequential designs. The package provides functions to calculate the true values of common summary statistics for the implemented scenarios and offers common analysis methods for time-to-event data. Helper functions for running simulations with the SimDesign package and for aggregating and presenting the results are also included. Results of the conducted simulation study are available in the paper: "A Comparison of Statistical Methods for Time-To-Event Analyses in Randomized Controlled Trials Under Non-Proportional Hazards", Klinglmüller et al. (2025) <doi:10.1002/sim.70019>.

This RStudio addin makes the creation of Shiny and ShinyDashboard apps more efficient. Besides the necessary folder structure, entire apps can be created using a drag and drop interface and customized with respect to a specific use case. The addin allows the export of the required user interface and server code at any time. By allowing the creation of modules, the addin can be used throughout the entire app development process.

Inspired by the art and color research of Sanzo Wada (1883-1967), his "Dictionary Of Color Combinations" (2011, ISBN:978-4861522475), and the interactive site by Dain M. Blodorn Kim <https://github.com/dblodorn/sanzo-wada>, this package brings Wada's color combinations to R for easy use in data visualizations. This package honors 60 of Wada's color combinations: 20 duos, 20 trios, and 20 quads.

The HJ-Biplot is a multivariate method that represents high-dimensional data in a low-dimensional subspace, capturing most of the informationâ s variability in just a few dimensions. This package implements three new regularized versions of the HJ-Biplot: Ridge, LASSO, and Elastic Net. These versions introduce restrictions that shrink or zero-out variable weights to improve interpretability based on regularization theory. All methods provide graphical representations using ggplot2'.

This package performs parametric and non-parametric estimation and simulation for multi-state discrete-time semi-Markov processes. For the parametric estimation, several discrete distributions are considered for the sojourn times: Uniform, Geometric, Poisson, Discrete Weibull and Negative Binomial. The non-parametric estimation concerns the sojourn time distributions, where no assumptions are done on the shape of distributions. Moreover, the estimation can be done on the basis of one or several sample paths, with or without censoring at the beginning or/and at the end of the sample paths. Reliability indicators such as reliability, maintainability, availability, BMP-failure rate, RG-failure rate, mean time to failure and mean time to repair are available as well. The implemented methods are described in Barbu, V.S., Limnios, N. (2008) <doi:10.1007/978-0-387-73173-5>, Barbu, V.S., Limnios, N. (2008) <doi:10.1080/10485250701261913> and Trevezas, S., Limnios, N. (2011) <doi:10.1080/10485252.2011.555543>. Estimation and simulation of discrete-time k-th order Markov chains are also considered.

Three new methods to perform outlier detection in a survival context. In total there are six methods provided, the first three methods are traditional residual-based outlier detection methods, the second three are the concordance-based. Package developed during the work on the two following publications: Pinto J., Carvalho A. and Vinga S. (2015) <doi:10.5220/0005225300750082>; Pinto J.D., Carvalho A.M., Vinga S. (2015) <doi:10.1007/978-3-319-27926-8_22>.

Generate continuous (normal or non-normal), binary, ordinal, and count (Poisson or Negative Binomial) variables with a specified correlation matrix. It can also produce a single continuous variable. This package can be used to simulate data sets that mimic real-world situations (i.e. clinical or genetic data sets, plasmodes). All variables are generated from standard normal variables with an imposed intermediate correlation matrix. Continuous variables are simulated by specifying mean, variance, skewness, standardized kurtosis, and fifth and sixth standardized cumulants using either Fleishman's third-order (<DOI:10.1007/BF02293811>) or Headrick's fifth-order (<DOI:10.1016/S0167-9473(02)00072-5>) polynomial transformation. Binary and ordinal variables are simulated using a modification of the ordsample() function from GenOrd'. Count variables are simulated using the inverse cdf method. There are two simulation pathways which differ primarily according to the calculation of the intermediate correlation matrix. In Correlation Method 1, the intercorrelations involving count variables are determined using a simulation based, logarithmic correlation correction (adapting Yahav and Shmueli's 2012 method, <DOI:10.1002/asmb.901>). In Correlation Method 2, the count variables are treated as ordinal (adapting Barbiero and Ferrari's 2015 modification of GenOrd, <DOI:10.1002/asmb.2072>). There is an optional error loop that corrects the final correlation matrix to be within a user-specified precision value of the target matrix. The package also includes functions to calculate standardized cumulants for theoretical distributions or from real data sets, check if a target correlation matrix is within the possible correlation bounds (given the distributions of the simulated variables), summarize results (numerically or graphically), to verify valid power method pdfs, and to calculate lower standardized kurtosis bounds.

An exploratory and heuristic approach for specification search in Structural Equation Modeling. The basic idea is to subsample the original data and then search for optimal models on each subset. Optimality is defined through two objectives: model fit and parsimony. As these objectives are conflicting, we apply a multi-objective optimization methods, specifically NSGA-II, to obtain optimal models for the whole range of model complexities. From these optimal models, we consider only the relevant model specifications (structures), i.e., those that are both stable (occur frequently) and parsimonious and use those to infer a causal model.

Determines networks of significant synchronization between the discrete states of nodes; see Tumminello et al <doi:10.1371/journal.pone.0017994>.