We provide inference for personalized medicine models. Namely, we answer the questions: (1) how much better does a purported personalized recommendation engine for treatments do over a business-as-usual approach and (2) is that difference statistically significant?

Create a parallel coordinates plot, using `htmlwidgets` package and `d3.js`.

Run simulations to assess the impact of various designs features and the underlying biological behaviour on the outcome of a Patient Derived Xenograft (PDX) population study. This project can either be deployed to a server as a shiny app or installed locally as a package and run the app using the command populationPDXdesignApp()'.

This package implements the Panel Smooth Transition Regression (PSTR) framework for nonlinear panel data modelling. The modelling procedure consists of three stages: Specification, Estimation and Evaluation. The package provides tools for model specification testing, to do PSTR model estimation, and to do model evaluation. The implemented tests allow for cluster dependence and are heteroskedasticity-consistent. The wild bootstrap and wild cluster bootstrap tests are also implemented. Parallel computation (as an option) is implemented in some functions, especially the bootstrap tests. The package supports parallel computation, which is useful for large-scale bootstrap procedures.

To Simplify the time consuming and error prone task of assembling complex data sets for non-linear mixed effects modeling. Users are able to select from different absorption processes such as zero and first order, or a combination of both. Furthermore, data sets containing data from several entities, responses, and covariates can be simultaneously assembled.

Estimating causal effects in the presence of post-treatment confounding using principal stratification. PStrata allows for customized monotonicity assumptions and exclusion restriction assumptions, with automatic full Bayesian inference supported by Stan'. The main function to use in this package is PStrata(), which provides posterior estimates of principal causal effects with uncertainty quantification. Visualization tools are also provided for diagnosis and interpretation. See Liu and Li (2023) <doi:10.48550/arXiv.2304.02740> for details.

Fits penalized generalized estimating equations to longitudinal data with high-dimensional covariates.

This package provides propensity score weighting methods to control for confounding in causal inference with dichotomous treatments and continuous/binary outcomes. It includes the following functional modules: (1) visualization of the propensity score distribution in both treatment groups with mirror histogram, (2) covariate balance diagnosis, (3) propensity score model specification test, (4) weighted estimation of treatment effect, and (5) augmented estimation of treatment effect with outcome regression. The weighting methods include the inverse probability weight (IPW) for estimating the average treatment effect (ATE), the IPW for average treatment effect of the treated (ATT), the IPW for the average treatment effect of the controls (ATC), the matching weight (MW), the overlap weight (OVERLAP), and the trapezoidal weight (TRAPEZOIDAL). Sandwich variance estimation is provided to adjust for the sampling variability of the estimated propensity score. These methods are discussed by Hirano et al (2003) <DOI:10.1111/1468-0262.00442>, Lunceford and Davidian (2004) <DOI:10.1002/sim.1903>, Li and Greene (2013) <DOI:10.1515/ijb-2012-0030>, and Li et al (2016) <DOI:10.1080/01621459.2016.1260466>.

The primary goal of phase I clinical trials is to find the maximum tolerated dose (MTD). To reach this objective, we introduce a new design for phase I clinical trials, the posterior predictive (PoP) design. The PoP design is an innovative model-assisted design that is as simply as the conventional algorithmic designs as its decision rules can be pre-tabulated prior to the onset of trial, but is of more flexibility of selecting diverse target toxicity rates and cohort sizes. The PoP design has desirable properties, such as coherence and consistency. Moreover, the PoP design provides better empirical performance than the BOIN and Keyboard design with respect to high average probabilities of choosing the MTD and slightly lower risk of treating patients at subtherapeutic or overly toxic doses.

This package produces odds ratio analyses with comprehensive reporting tools. Generates plots, summary tables, and diagnostic checks for logistic regression models fitted with glm() using binomial family. Provides visualisation methods, formatted reporting tables via gt', and tools to assess logistic regression model assumptions.

Create a project directory structure, along with typical files for that project. This allows projects to be quickly and easily created, as well as for them to be standardized. Designed specifically with scientists in mind (mainly bio-medical researchers, but likely applies to other fields).

Means to predict process flow, such as process outcome, next activity, next time, remaining time, and remaining trace. Off-the-shelf predictive models based on the concept of Transformers are provided, as well as multiple way to customize the models. This package is partly based on work described in Zaharah A. Bukhsh, Aaqib Saeed, & Remco M. Dijkman. (2021). "ProcessTransformer: Predictive Business Process Monitoring with Transformer Network" <doi:10.48550/arXiv.2104.00721>.

Generate all necessary R/Rmd/shell files for data processing after running GGIR (v2.4.0) for accelerometer data. In part 1, all csv files in the GGIR output directory were read, transformed and then merged. In part 2, the GGIR output files were checked and summarized in one excel sheet. In part 3, the merged data was cleaned according to the number of valid hours on each night and the number of valid days for each subject. In part 4, the cleaned activity data was imputed by the average Euclidean norm minus one (ENMO) over all the valid days for each subject. Finally, a comprehensive report of data processing was created using Rmarkdown, and the report includes few exploratory plots and multiple commonly used features extracted from minute level actigraphy data.

Preparing a scanner data set for price dynamics calculations (data selecting, data classification, data matching, data filtering). Computing bilateral and multilateral indexes. For details on these methods see: Diewert and Fox (2020) <doi:10.1080/07350015.2020.1816176>, BiaÅ ek (2019) <doi:10.2478/jos-2019-0014> or BiaÅ ek (2020) <doi:10.2478/jos-2020-0037>.

Homogeneity tests of the coefficients in panel data. Currently, only the Hsiao test for determining coefficient homogeneity between the panel data individuals is implemented, as described in Hsiao (2022), "Analysis of Panel Data" (<doi:10.1017/9781009057745>).

This package provides functions to read and write APE-compatible phylogenetic trees in NEXUS and Newick formats, while preserving annotations.

This package provides an R interface to the PCATS API <https://pcats.research.cchmc.org/api/__docs__/>, allowing R users to submit tasks and retrieve results.

This package provides essential checklists for R package developers, whether you're creating your first package or beginning a new project. This tool guides you through each step of the development process, including specific considerations for submitting your package to the Comprehensive R Archive Network (CRAN). Simplify your workflow and ensure adherence to best practices with packagepal'.

This package provides a bioinformatics method developed for analyzing the heterogeneity of single-cell populations. Phitest provides an objective and automatic method to evaluate the performance of clustering and quality of cell clusters.

Computes power and level tables for goodness-of-fit tests for the normal, Laplace, and uniform distributions. Generates output in LaTeX format to facilitate reporting and reproducibility. Explanatory graphs help visualize the statistical power of test statistics under various alternatives. For more details, see Lafaye De Micheaux and Tran (2016) <doi:10.18637/jss.v069.i03>.

This package provides convenience functions and pre-programmed Stan models related to the paired comparison factor model. Its purpose is to make fitting paired comparison data using Stan easy. This package is described in Pritikin (2020) <doi:10.1016/j.heliyon.2020.e04821>.

Data sets and functions used in the polish book "Przewodnik po pakiecie R" (The Hitchhiker's Guide to the R). See more at <http://biecek.pl/R>. Among others you will find here data about housing prices, cancer patients, running times and many others.

Package to Percentile estimation of fetal weight for twins by chorionicity (dichorionic-diamniotic or monochorionic-diamniotic).

Automates the process of creating a scale bar and north arrow in any package that uses base graphics to plot in R. Bounding box tools help find and manipulate extents. Finally, there is a function to automate the process of setting margins, plotting the map, scale bar, and north arrow, and resetting graphic parameters upon completion.