Values below the limit of detection (LOD) are a problem in several fields of science, and there are numerous approaches for replacing the missing data. We present a new mathematical solution for maximum likelihood estimation that allows us to estimate the true values of the mean and standard deviation for normal distributions and is significantly faster than previous implementations. The article with the details was submitted to JSS and can be currently seen on <https://www2.arnes.si/~tverbo/LOD/Verbovsek_Sega_2_Manuscript.pdf>.

Stateful helpers for building Matrix (<https://matrix.org>) chat clients in R. Builds on the low-level mx.api Client-Server API bindings, adding local configuration persistence, room resolution, sync cursor handling, sync-event extraction, invite acceptance, a conservative Markdown-to-HTML converter for formatted messages, and Olm'/'Megolm end-to-end encryption orchestration over the optional mx.crypto package.

This package provides a collection of functions for conducting meta-analysis using a structural equation modeling (SEM) approach via the OpenMx and lavaan packages. It also implements various procedures to perform meta-analytic structural equation modeling on the correlation and covariance matrices, see Cheung (2015) <doi:10.3389/fpsyg.2014.01521>.

To create maps from tiles, maptiles downloads, composes and displays tiles from a large number of providers (e.g. OpenStreetMap', Stadia', Esri', CARTO', or Thunderforest').

Enhances mlexperiments <https://CRAN.R-project.org/package=mlexperiments> with additional machine learning ('ML') learners. The package provides R6-based learners for the following algorithms: glmnet <https://CRAN.R-project.org/package=glmnet>, ranger <https://CRAN.R-project.org/package=ranger>, xgboost <https://CRAN.R-project.org/package=xgboost>, and lightgbm <https://CRAN.R-project.org/package=lightgbm>. These can be used directly with the mlexperiments R package.

Multi Calculator of different scores to measure adherence to Mediterranean Diet, to compute them in nutriepidemiological data. Additionally, a sample dataset of this kind of data is provided, and some other minor tools useful in epidemiological studies.

Extension of the mgcv package, providing visual tools for Generalized Additive Models that exploit the additive structure of such models, scale to large data sets and can be used in conjunction with a wide range of response distributions. The focus is providing visual methods for better understanding the model output and for aiding model checking and development beyond simple exponential family regression. The graphical framework is based on the layering system provided by ggplot2'.

Optimization algorithms implemented in R, including conjugate gradient (CG), Broyden-Fletcher-Goldfarb-Shanno (BFGS) and the limited memory BFGS (L-BFGS) methods. Most internal parameters can be set through the call interface. The solvers hold up quite well for higher-dimensional problems.

Metric halfspace depth for object data, generalizing Tukey's depth for Euclidean data. Implementing the method described in Dai and Lopez-Pintado (2022) <doi:10.1080/01621459.2021.2011298>.

Counting process structure is fundamental to model time varying covariates. This package restructures dataframes in the counting process format for one or more variables. F. W. Dekker, et al. (2008) <doi:10.1038/ki.2008.328>.

Estimation and bootstrap utilities for single layer and multilayer Mixed Graphical Models, including functions for centrality, bridge metrics, membership stability, and plotting (De Martino et al. (2026) <doi:10.48550/arXiv.2602.05716>).

Computes Monte Carlo standard errors for summaries of Monte Carlo output. Summaries and their standard errors are based on columns of Monte Carlo simulation output. Dennis D. Boos and Jason A. Osborne (2015) <doi:10.1111/insr.12087>.

Estimates the precision of transdimensional Markov chain Monte Carlo (MCMC) output, which is often used for Bayesian analysis of models with different dimensionality (e.g., model selection). Transdimensional MCMC (e.g., reversible jump MCMC) relies on sampling a discrete model-indicator variable to estimate the posterior model probabilities. If only few switches occur between the models, precision may be low and assessment based on the assumption of independent samples misleading. Based on the observed transition matrix of the indicator variable, the method of Heck, Overstall, Gronau, & Wagenmakers (2019, Statistics & Computing, 29, 631-643) <doi:10.1007/s11222-018-9828-0> draws posterior samples of the stationary distribution to (a) assess the uncertainty in the estimated posterior model probabilities and (b) estimate the effective sample size of the MCMC output.

Summarize multiple biomarker responses of aquatic organisms to contaminants using Cliffâ s delta, as described in Pham & Sokolova (2023) <doi:10.1002/ieam.4676>.

Researchers often need to calculate body-size growth rates for individuals that do not have associated age data. These growth rates are based on mark-recapture data where an individual was captured and measured at time 1 then recaptured and measured at time 2. The sizes at each time and amount of time between captures can be used to calculate growth rates. MRgrowth follows the approach in Edmonds et al. (2021) <doi:10.1371/journal.pone.0259978> and provides functions to calculate growth using three formulas, the Faben's reformulation of the von Bertalanffy formula, the Gompertz formula, and a logistic formula.

An efficient implementation of the MCPMod (Multiple Comparisons and Modeling) method to support a simulation-based design and analysis of dose-finding trials with normally distributed, binary and count endpoints (Bretz et al. (2005) <doi:10.1111/j.1541-0420.2005.00344.x>).

Matching algorithm based on network-flow structure. Users are able to modify the emphasis on three different optimization goals: two different distance measures and the number of treated units left unmatched. The method is proposed by Pimentel and Kelz (2019) <doi:10.1080/01621459.2020.1720693>. The rrelaxiv package, which provides an alternative solver for the underlying network flow problems, carries an academic license and is not available on CRAN, but may be downloaded from Github at <https://github.com/josherrickson/rrelaxiv/>.

This package creates and runs Bayesian mixing models to analyze biological tracer data (i.e. stable isotopes, fatty acids), which estimate the proportions of source (prey) contributions to a mixture (consumer). MixSIAR is not one model, but a framework that allows a user to create a mixing model based on their data structure and research questions, via options for fixed/ random effects, source data types, priors, and error terms. MixSIAR incorporates several years of advances since MixSIR and SIAR'.

This package provides a graphical user interface to apply an advanced method optimization algorithm to various sampling and analysis instruments. This includes generating experimental designs, uploading and viewing data, and performing various analyses to determine the optimal method. Details of the techniques used in this package are published in Gamble, Granger, & Mannion (2024) <doi:10.1021/acs.analchem.3c05763>.

This package provides a collection of moment-matching methods for computing the cumulative distribution function of a positively-weighted sum of chi-squared random variables. Methods include the Satterthwaite-Welch method, Hall-Buckley-Eagleson method, Wood's F method, and the Lindsay-Pilla-Basak method.

Clustering in metagenomics is the process of grouping of microbial contigs in species specific bins. This package contains functions that extract genomic features from metagenome data, find the number of clusters for that given data and find the best clustering algorithm for binning.

MHCnuggets (<https://github.com/KarchinLab/mhcnuggets>) is a Python tool to predict MHC class I and MHC class II epitopes. This package allows one to call MHCnuggets from R.

This package implements the Multi-Objective Clustering Algorithm Guided by a-Priori Biological Knowledge ('MOC-GaPBK') proposed by Parraga-Alava and others (2018) <doi:10.1186/s13040-018-0178-4>. The algorithm performs gene clustering using NSGA-II as the underlying multi-objective evolutionary engine, together with Path-Relinking and Pareto Local Search as intensification and diversification strategies. Two versions of the Xie-Beni validity index are used as objective functions, one per distance matrix, so that prior biological knowledge can be incorporated through the second matrix.

Defines the classes used to explore, cluster and visualize distance matrices, especially those arising from binary data. See Abrams and colleagues, 2021, <doi:10.1093/bioinformatics/btab037>.