Estimation of k-Order time-varying Mixed Graphical Models and mixed VAR(p) models via elastic-net regularized neighborhood regression. For details see Haslbeck & Waldorp (2020) <doi:10.18637/jss.v093.i08>.

Compare microbial co-occurrence networks created from trans_network class of microeco package <https://github.com/ChiLiubio/microeco>. This package is the extension of trans_network class of microeco package and especially useful when different networks are constructed and analyzed simultaneously.

This package provides tools for estimating multivariate probit models, calculating conditional and unconditional expectations, and calculating marginal effects on conditional and unconditional expectations.

Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) is the premier technology for profiling genome-wide localization of chromatin-binding proteins, including transcription factors and histones with various modifications. This package provides a robust method for normalizing ChIP-seq signals across individual samples or groups of samples. It also designs a self-contained system of statistical models for calling differential ChIP-seq signals between two or more biological conditions as well as for calling hypervariable ChIP-seq signals across samples. Refer to Tu et al. (2021) <doi:10.1101/gr.262675.120> and Chen et al. (2022) <doi:10.1186/s13059-022-02627-9> for associated statistical details.

An implementation of MLMC (Multi-Level Monte Carlo), Giles (2008) <doi:10.1287/opre.1070.0496>, Heinrich (1998) <doi:10.1006/jcom.1998.0471>, for R. This package builds on the original Matlab and C++ implementations by Mike Giles to provide a full MLMC driver and example level samplers. Multi-core parallel sampling of levels is provided built-in.

This package provides an interface with the Meteo France Synop data API (see <https://donneespubliques.meteofrance.fr/?fond=produit&id_produit=90&id_rubrique=32> for more information). The Meteo France Synop data are made of meteorological data recorded every three hours on 62 French meteorological stations.

This package provides methods for analyzing and using quartets displayed on a collection of gene trees, primarily to make inferences about the species tree or network under the multi-species coalescent model. These include quartet hypothesis tests for the model, as developed by Mitchell et al. (2019) <doi:10.1214/19-EJS1576>, simplex plots of quartet concordance factors as presented by Allman et al. (2020) <doi:10.1101/2020.02.13.948083>, species tree inference methods based on quartet distances of Rhodes (2019) <doi:10.1109/TCBB.2019.2917204> and Yourdkhani and Rhodes (2019) <doi:10.1007/s11538-020-00773-4>, the NANUQ algorithm for inference of level-1 species networks of Allman et al. (2019) <doi:10.1186/s13015-019-0159-2>, the TINNIK algorithm for inference of the tree of blobs of an arbitrary network of Allman et al.(2022) <doi:10.1007/s00285-022-01838-9>, and NANUQ+ routines for resolving multifurcations in the tree of blobs to cycles as in Allman et al.(2024) (forthcoming). Software announcement by Rhodes et al. (2020) <doi:10.1093/bioinformatics/btaa868>.

Several functions can be used to analyze neuroimaging data using multivariate methods based on the msma package. The functions used in the book entitled "Multivariate Analysis for Neuroimaging Data" (2021, ISBN-13: 978-0367255329) are contained.

Density evaluation and random number generation for the Matrix-Normal Inverse-Wishart (MNIW) distribution, as well as the the Matrix-Normal, Matrix-T, Wishart, and Inverse-Wishart distributions. Core calculations are implemented in a portable (header-only) C++ library, with matrix manipulations using the Eigen library for linear algebra. Also provided is a Gibbs sampler for Bayesian inference on a random-effects model with multivariate normal observations.

Flexible implementation of a structural change point detection algorithm for multivariate time series. It authorizes inclusion of trends, exogenous variables, and break test on the intercept or on the full vector autoregression system. Bai, Lumsdaine, and Stock (1998) <doi:10.1111/1467-937X.00051>.

Apply tests of multiple comparisons based on studentized midrange and range distributions. The tests are: Tukey Midrange ('TM test), Student-Newman-Keuls Midrange ('SNKM test), Means Grouping Midrange ('MGM test) and Means Grouping Range ('MGR test). The first two tests were published by Batista and Ferreira (2020) <doi:10.1590/1413-7054202044008020>. The last two were published by Batista and Ferreira (2023) <doi:10.28951/bjb.v41i4.640>.

Estimate parameters of linear regression and logistic regression with missing covariates with missing data, perform model selection and prediction, using EM-type algorithms. Jiang W., Josse J., Lavielle M., TraumaBase Group (2020) <doi:10.1016/j.csda.2019.106907>.

Calculates multi-scale geomorphometric terrain attributes from regularly gridded digital terrain models using a variable focal windows size (Ilich et al. (2023) <doi:10.1111/tgis.13067>).

This package provides tools for performing mathematical morphology operations, such as erosion and dilation, on data of arbitrary dimensionality. Can also be used for finding connected components, resampling, filtering, smoothing and other image processing-style operations.

Data sets and sample analyses from Pinheiro and Bates, "Mixed-effects Models in S and S-PLUS" (Springer, 2000).

Convenient wrapper functions for the analysis of matrix-assisted laser desorption/ionization-time-of-flight (MALDI-TOF) spectra data in order to select only representative spectra (also called cherry-pick). The package covers the preprocessing and dereplication steps (based on Strejcek, Smrhova, Junkova and Uhlik (2018) <doi:10.3389/fmicb.2018.01294>) needed to cluster MALDI-TOF spectra before the final cherry-picking step. It enables the easy exclusion of spectra and/or clusters to accommodate complex cherry-picking strategies. Alternatively, cherry-picking using taxonomic identification MALDI-TOF data is made easy with functions to import inconsistently formatted reports.

This plot integrates annotation into a manhattan plot. The plot is implemented as a heatmap, which is binned using -log10(p-value) and chromosome position. Annotation currently supported is minor allele frequency and gene function high impact variants.

This package contains model-based treatment of missing data for regression models with missing values in covariates or the dependent variable using maximum likelihood or Bayesian estimation (Ibrahim et al., 2005; <doi:10.1198/016214504000001844>; Luedtke, Robitzsch, & West, 2020a, 2020b; <doi:10.1080/00273171.2019.1640104><doi:10.1037/met0000233>). The regression model can be nonlinear (e.g., interaction effects, quadratic effects or B-spline functions). Multilevel models with missing data in predictors are available for Bayesian estimation. Substantive-model compatible multiple imputation can be also conducted.

Pooling estimates reported in meta-analyses (literature-based, LB) and estimates based on individual participant data (IPD) is not straight-forward as the details of the LB nonlinear function estimate are not usually reported. This package pools the nonlinear IPD dose-response estimates based on a natural cubic spline from lm or glm with the pointwise LB estimates and their estimated variances. Details will be presented in Härkänen, Tapanainen, Sares-Jäske, Männistö, Kaartinen and Paalanen (2025) "Novel pooling method for nonlinear cohort analysis and meta-analysis estimates: Predicting health outcomes based on climate-friendly diets" (under revision) <https://journals.lww.com/epidem/pages/default.aspx>.

This package provides a suite of convenience functions for generating US state and county thematic maps using datasets from the MazamaSpatialUtils package.

Advanced methods for a valuable quantitative environmental risk assessment using Bayesian inference of several type of toxicological data. binary (e.g., survival, mobility), count (e.g., reproduction) and continuous (e.g., growth as length, weight). Estimation procedures can be used without a deep knowledge of their underlying probabilistic model or inference methods. Rather, they were designed to behave as well as possible without requiring a user to provide values for some obscure parameters. That said, models can also be used as a first step to tailor new models for more specific situations.

This package provides a lightweight framework for model selection and hyperparameter tuning in R. The package offers intuitive tools for grid search, cross-validation, and combined grid search with cross-validation that work seamlessly with virtually any modeling package. Designed for flexibility and ease of use, it standardizes tuning workflows while remaining fully compatible with a wide range of model interfaces and estimation functions.

This package provides a function that wraps mcparallel() and mccollect() from parallel with temporary variables and a task handler. Wrapped in this way the results of an mcparallel() call can be returned to the R session when the fork is complete without explicitly issuing a specific mccollect() to retrieve the value. Outside of top-level tasks, multiple mcparallel() jobs can be retrieved with a single call to mcparallelDoCheck().

This package contains functions for data analysis of Repeated measurement using GEE. Data may contain missing value in response and covariates. For parameter estimation through Fisher Scoring algorithm, Mean Score and Inverse Probability Weighted method combining with Multiple Imputation are used when there is missing value in covariates/response. Reference for mean score method, inverse probability weighted method is Wang et al(2007)<doi:10.1093/biostatistics/kxl024>.