Several multivariate techniques from a biplot perspective. It is the translation (with many improvements) into R of the previous package developed in Matlab'. The package contains some of the main developments of my team during the last 30 years together with some more standard techniques. Package includes: Classical Biplots, HJ-Biplot, Canonical Biplots, MANOVA Biplots, Correspondence Analysis, Canonical Correspondence Analysis, Canonical STATIS-ACT, Logistic Biplots for binary and ordinal data, Multidimensional Unfolding, External Biplots for Principal Coordinates Analysis or Multidimensional Scaling, among many others. References can be found in the help of each procedure.

The routine twosample_test() in this package runs the two-sample test using various test statistic for multivariate data. The user can also run several tests and then find a p value adjusted for simultaneous inference. The p values are found via permutation or via the parametric bootstrap. The routine twosample_power() allows the estimation of the power of the tests. The routine run.studies() allows a user to quickly study the power of a new method and how it compares to those included in the package. For details of the methods and references see the included vignettes.

Visualize confounder control in meta-analysis. metaconfoundr is an approach to evaluating bias in studies used in meta-analyses based on the causal inference framework. Study groups create a causal diagram displaying their assumptions about the scientific question. From this, they develop a list of important confounders'. Then, they evaluate whether studies controlled for these variables well. metaconfoundr is a toolkit to facilitate this process and visualize the results as heat maps, traffic light plots, and more.

Multi Calculator of different scores to measure adherence to Mediterranean Diet, to compute them in nutriepidemiological data. Additionally, a sample dataset of this kind of data is provided, and some other minor tools useful in epidemiological studies.

Generates multivariate subgaussian stable probabilities using the QRSVN algorithm as detailed in Genz and Bretz (2002) <DOI:10.1198/106186002394> but by sampling positive stable variates not chi/sqrt(nu).

Facilitate the description, transformation, exploration, and reproducibility of metabarcoding analyses. MiscMetabar is mainly built on top of the phyloseq', dada2 and targets R packages. It helps to build reproducible and robust bioinformatics pipelines in R. MiscMetabar makes ecological analysis of alpha and beta-diversity easier, more reproducible and more powerful by integrating a large number of tools. Important features are described in Taudière A. (2023) <doi:10.21105/joss.06038>.

Dichotomous responses having two categories can be analyzed with stats::glm() or lme4::glmer() using the family=binomial option. Unfortunately, polytomous responses with three or more unordered categories cannot be analyzed similarly because there is no analogous family=multinomial option. For between-subjects data, nnet::multinom() can address this need, but it cannot handle random factors and therefore cannot handle repeated measures. To address this gap, we transform nominal response data into counts for each categorical alternative. These counts are then analyzed using (mixed) Poisson regression as per Baker (1994) <doi:10.2307/2348134>. Omnibus analyses of variance can be run along with post hoc pairwise comparisons. For users wishing to analyze nominal responses from surveys or experiments, the functions in this package essentially act as though stats::glm() or lme4::glmer() provide a family=multinomial option.

Generate the optimal maximin distance, minimax distance (only for low dimensions), and maximum projection designs within the class of Latin hypercube designs efficiently for computer experiments. Generate Pareto front optimal designs for each two of the three criteria and all the three criteria within the class of Latin hypercube designs efficiently. Provide criterion computing functions. References of this package can be found in Morris, M. D. and Mitchell, T. J. (1995) <doi:10.1016/0378-3758(94)00035-T>, Lu Lu and Christine M. Anderson-CookTimothy J. Robinson (2011) <doi:10.1198/Tech.2011.10087>, Joseph, V. R., Gul, E., and Ba, S. (2015) <doi:10.1093/biomet/asv002>.

Identifies the optimal number of clusters by calculating the similarity between two clustering methods at the same number of clusters using the corrected indices of Rand and Jaccard as described in Albatineh and Niewiadomska-Bugaj (2011). The number of clusters at which the index attain its maximum more frequently is a candidate for being the optimal number of clusters.

Create an immutable container holding metadata for the purpose of better enabling programming activities and functionality of other packages within the clinical programming workflow.

This package provides a standalone package combining several stop-word lists for 65 languages with a median of 329 stop words for language and over 1,000 entries for English, Breton, Latin, Slovenian, and Ancient Greek! The user automatically gets access to all the unique stop words contained in: the StopwordISO repository; the Natural Language Toolkit for python'; the Snowball stop-word list; the R package quanteda'; the marimo repository; the Perseus project; and A. Berra's list of stop words for Ancient Greek and Latin.

Multi modality data matrices are factorized conjointly into the multiplication of a shared sub-matrix and multiple modality specific sub-matrices, group sparse constraint is applied to the shared sub-matrix to capture the homogeneous and heterogeneous information, respectively. Then the samples are classified by clustering the shared sub-matrix with kmeanspp(), a new version of kmeans() developed here to obtain concordant results. The package also provides the cluster number estimation by rotation cost. Moreover, cluster specific features could be retrieved using hypergeometric tests.

This package provides tools for analyzing metabolic pathway completeness, abundance, and transcripts using KEGG Orthology (KO) data from (meta)genomic and (meta)transcriptomic studies. Supports both completeness (presence/absence) and abundance-weighted analyses. Includes built-in KEGG reference datasets. For more details see Li et al. (2023) <doi:10.1038/s41467-023-42193-7>.

This package implements two versions of the algorithm namely: stochastic and batch. The package determines also the best number of clusters and offers to the user the best clustering scheme from different results.

Various functions for random number generation, density estimation, classification, curve fitting, and spatial data analysis.

Computationally efficient functions to provide direct likelihood-based inference for partially-observed multivariate birth-death processes. Such processes range from a simple Yule model to the complex susceptible-infectious-removed model in disease dynamics. Efficient likelihood evaluation facilitates maximum likelihood estimation and Bayesian inference.

Simultaneously estimates sparse regression coefficients and response network structure in multivariate models with missing data. Unlike traditional approaches requiring imputation, handles missingness natively through unbiased estimating equations (MCAR/MAR compatible). Employs dual L1 regularization with automated selection via cross-validation or information criteria. Includes parallel computation, warm starts, adaptive grids, publication-ready visualizations, and prediction methods. Ideal for genomics, neuroimaging, and multi-trait studies with incomplete high-dimensional outcomes. See Zeng et al. (2025) <doi:10.48550/arXiv.2507.05990>.

This package provides the mean to parse and render markdown text with grid along with facilities to define the styling of the text.

Implement multiverse style analyses (Steegen S., Tuerlinckx F, Gelman A., Vanpaemal, W., 2016) <doi:10.1177/1745691616658637> to show the robustness of statistical inference. Multiverse analysis is a philosophy of statistical reporting where paper authors report the outcomes of many different statistical analyses in order to show how fragile or robust their findings are. The multiverse package (Sarma A., Kale A., Moon M., Taback N., Chevalier F., Hullman J., Kay M., 2021) <doi:10.31219/osf.io/yfbwm> allows users to concisely and flexibly implement multiverse-style analysis, which involve declaring alternate ways of performing an analysis step, in R and R Notebooks.

This package provides a simple tool allowing users to easily and dynamically explore or document a data set using a tree structure.

The latest guidelines proposed by International Expert Consensus are used for the clinical diagnosis of Metabolic Associated Fatty Liver Disease (MAFLD). The new definition takes hepatic steatosis (determined by elastography or histology or biomarker-based fatty liver index) as a major criterion. In addition, race, gender, body mass index (BMI), waist circumference (WC), fasting plasma glucose (FPG), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDLC), homeostatic model assessment of insulin resistance (HOMAIR), high sensitive c-reactive protein (HsCRP) for the diagnosis of MAFLD. Each parameter has to be interpreted based on the proposed cut-offs, making the diagnosis slightly complex and error-prone. This package is developed by incorporating the latest international expert consensus guidelines, and it will aid in the easy and quick diagnosis of MAFLD based on FibroScan in busy healthcare settings and also for research purposes. The new definition for MAFLD as per the International Consensus Statement is described by Eslam M et al (2020). <doi:10.1016/j.jhep.2020.03.039>.

Framework for the simulation framework for the simulation of complex breeding programs and compare their economic and genetic impact. Associated publication: Pook et al. (2020) <doi:10.1534/g3.120.401193>.

Fits multiple variable mixtures of various parametric proportional hazard models using the EM-Algorithm. Proportionality restrictions can be imposed on the latent groups and/or on the variables. Several survival distributions can be specified. Missing values and censored values are allowed. Independence is assumed over the single variables.

This package implements two methods: a nonparametric risk adjustment and a data imputation method that use general population mortality tables to allow a correct analysis of time to disease recurrence. Also includes a powerful set of object oriented survival data simulation functions.