Alternative splicing produces a variety of different protein products from a given gene. VALERIE enables visualisation of alternative splicing events from high-throughput single-cell RNA-sequencing experiments. VALERIE computes percent spliced-in (PSI) values for user-specified genomic coordinates corresponding to alternative splicing events. PSI is the proportion of sequencing reads supporting the included exon/intron as defined by Shiozawa (2018) <doi:10.1038/s41467-018-06063-x>. PSI are inferred from sequencing reads data based on specialised infrastructures for representing and computing annotated genomic ranges by Lawrence (2013) <doi:10.1371/journal.pcbi.1003118>. Computed PSI for each single cell are subsequently presented in the form of a heatmap implemented using the pheatmap package by Kolde (2010) <https://CRAN.R-project.org/package=pheatmap>. Board overview of the mean PSI difference and associated p-values across different user-defined groups of single cells are presented in the form of a line graph using the ggplot2 package by Wickham (2007) <https://CRAN.R-project.org/package=ggplot2>.

Collection of functions to evaluate presence-absence models. It comprises functions to adjust discrimination statistics for the representativeness effect through case-weighting, along with functions for visualizing the outcomes. Originally outlined in: Jiménez-Valverde (2022) The uniform AUC: dealing with the representativeness effect in presence-absence models. Methods Ecol. Evol, 13, 1224-1236.

Multi-precision library that allows to store and operate with arbitrarily big integers without loss of precision. It includes a large list of tools to work with them, like: - Arithmetic and logic operators - Modular-arithmetic operators - Computer Number Theory utilities - Probabilistic primality tests - Factorization algorithms - Random generators of diferent types of integers.

This package performs clustering of quantitative variables, assuming that clusters lie in low-dimensional subspaces. Segmentation of variables, number of clusters and their dimensions are selected based on BIC. Candidate models are identified based on many runs of K-means algorithm with different random initializations of cluster centers.

This package provides a suite of analytical functionalities to process and analyze visual meteor observations from the Visual Meteor Database of the International Meteor Organization <https://www.imo.net/>.

This package provides a framework for generating virtual species distributions, a procedure increasingly used in ecology to improve species distribution models. This package integrates the existing methodological approaches with the objective of generating virtual species distributions with increased ecological realism.

Data version management on the file system for smaller projects. Manage data pipeline outputs with symbolic folder links, structured logging and reports, using R6 classes for encapsulation and data.table for speed. Directory-specific logs used as source of truth to allow portability of versioned data folders.

This package provides a dedicated viral-explainer model tool designed to empower researchers in the field of HIV research, particularly in viral load and CD4 (Cluster of Differentiation 4) lymphocytes regression modeling. Drawing inspiration from the tidymodels framework for rigorous model building of Max Kuhn and Hadley Wickham (2020) <https://www.tidymodels.org>, and the DALEXtra tool for explainability by Przemyslaw Biecek (2020) <doi:10.48550/arXiv.2009.13248>. It aims to facilitate interpretable and reproducible research in biostatistics and computational biology for the benefit of understanding HIV dynamics.

An implementation of the Likelihood ratio Test (LRT) for testing that, in a (non)linear mixed effects model, the variances of a subset of the random effects are equal to zero. There is no restriction on the subset of variances that can be tested: for example, it is possible to test that all the variances are equal to zero. Note that the implemented test is asymptotic. This package should be used on model fits from packages nlme', lmer', and saemix'. Charlotte Baey and Estelle Kuhn (2019) <doi:10.18637/jss.v107.i06>.

R Codes and Datasets for Duchateau, L. and Janssen, P. and Rowlands, G. J. (1998). Linear Mixed Models. An Introduction with applications in Veterinary Research. International Livestock Research Institute.

Visualizing of distributions of covariance matrices. The package implements the methodology described in Tokuda, T., Goodrich, B., Van Mechelen, I., Gelman, A., & Tuerlinckx, F. (2012) <https://sites.stat.columbia.edu/gelman/research/unpublished/Visualization.pdf>.

The spectral characteristics of a bivariate series (Marginal Spectra, Coherency- and Phase-Spectrum) determine whether there is a strong presence of short-, medium-, or long-term fluctuations (components of certain frequencies in the spectral representation of the series) in each one of them. These are induced by strong peaks of the marginal spectra of each series at the corresponding frequencies. The spectral characteristics also determine how strongly these short-, medium-, or long-term fluctuations of the two series are correlated between the two series. Information on this is provided by the Coherency spectrum at the corresponding frequencies. Finally, certain fluctuations of the two series may be lagged to each other. Information on this is provided by the Phase spectrum at the corresponding frequencies. The idea in this package is to define a VAR (Vector autoregression) model with desired spectral characteristics by specifying a number of polynomials, required to define the VAR. See Ioannidis(2007) <doi:10.1016/j.jspi.2005.12.013>. These are specified via their roots, instead of via their coefficients. This is an idea borrowed from the Time Series Library of R. Dahlhaus, where it is used for defining ARMA models for univariate time series. This way, one may e.g. specify a VAR inducing a strong presence of long-term fluctuations in series 1 and in series 2, which are weakly correlated, but lagged by a number of time units to each other, while short-term fluctuations in series 1 and in series 2, are strongly present only in one of the two series, while they are strongly correlated to each other between the two series. Simulation from such models allows studying the behavior of data-analysis tools, such as estimation of the spectra, under different circumstances, as e.g. peaks in the spectra, generating bias, induced by leakage.

This package creates Vertex Similarity matrix of an undirected graph based on the method stated by E. A. Leicht, Petter Holme, AND M. E. J. Newman in their paper <DOI:10.1103/PhysRevE.73.026120>.

Applies affine and similarity transformations on vector spatial data (sp objects). Transformations can be defined from control points or directly from parameters. If redundant control points are provided Least Squares is applied allowing to obtain residuals and RMSE.

RcppArmadillo implementation for the Matlab code of the Variational Mode Decomposition and Two-Dimensional Variational Mode Decomposition'. For more information, see (i) Variational Mode Decomposition by K. Dragomiretskiy and D. Zosso in IEEE Transactions on Signal Processing, vol. 62, no. 3, pp. 531-544, Feb.1, 2014, <doi:10.1109/TSP.2013.2288675>; (ii) Two-Dimensional Variational Mode Decomposition by Dragomiretskiy, K., Zosso, D. (2015), In: Tai, XC., Bae, E., Chan, T.F., Lysaker, M. (eds) Energy Minimization Methods in Computer Vision and Pattern Recognition. EMMCVPR 2015. Lecture Notes in Computer Science, vol 8932. Springer, <doi:10.1007/978-3-319-14612-6_15>.

R functions are not supposed to print text without giving the user the option to turn the printing off or on using a Boolean verbose in a construct like if(verbose) print(...)'. But this black/white approach is rather rigid, and an approach with shades of gray might be more appropriate in many circumstances.

Rule sets with validation rules may contain redundancies or contradictions. Functions for finding redundancies and problematic rules are provided, given a set a rules formulated with validate'.

Compared with the similar graph embedding method such as Laplacian Eigenmaps, Vicus can exploit more local structures of graph data. For the details of the methods, see the reference section of GitHub README.md <https://github.com/rikenbit/Vicus>.

It provides a comprehensive toolkit for calculating a suite of common vegetation indices (VIs) derived from remote sensing imagery. VIs are essential tools used to quantify vegetation characteristics, such as biomass, leaf area index (LAI) and photosynthetic activity, which are essential parameters in various ecological, agricultural, and environmental studies. Applications of this package include biomass estimation, crop monitoring, forest management, land use and land cover change analysis and climate change studies. For method details see, Deb,D.,Deb,S.,Chakraborty,D.,Singh,J.P.,Singh,A.K.,Dutta,P.and Choudhury,A.(2020)<doi:10.1080/10106049.2020.1756461>. Utilizing this R package, users can effectively extract and analyze critical information from remote sensing imagery, enhancing their comprehension of vegetation dynamics and their importance in global ecosystems. The package includes the function vegetation_indices().

This package provides fast spectral estimation of latent factors in random dot product graphs using the vsp estimator. Under mild assumptions, the vsp estimator is consistent for (degree-corrected) stochastic blockmodels, (degree-corrected) mixed-membership stochastic blockmodels, and degree-corrected overlapping stochastic blockmodels.

Extendable R6 file comparison classes, including a shiny app for combining the comparison functionality into a file comparison application. The package idea originates from pharma companies drug development processes, where statisticians and statistical programmers need to review and compare different versions of the same outputs and datasets. The package implementation itself is not tied to any specific industry and can be used in any context for easy file comparisons between different file version sets.

Deploy, execute, and analyze the results of models hosted on the ValidMind platform <https://validmind.com>. This package interfaces with the Python client library in order to allow advanced diagnostics and insight into trained models all from an R environment.

This package produces violin plots with optional nonparametric (Mann-Whitney test) and parametric (Tukey's honest significant difference) mean comparison and linear regression. This package aims to be a simple and quick visualization tool for comparing means and assessing trends of categorical factors.

This package provides a variety of tools to allow the quantification of videos of the lymphatic vasculature taken under an operating microscope. Lymphatic vessels that have been injected with a variety of blue dyes can be tracked throughout the video to determine their width over time. Code is optimised for efficient processing of multiple large video files. Functions to calculate physiologically relevant parameters and generate graphs from these values are also included.