This package implements discrete time deterministic and stochastic age-structured population dynamics models described in Erguler and others (2016) <doi:10.1371/journal.pone.0149282> and Erguler and others (2017) <doi:10.1371/journal.pone.0174293>.

Predicts antimicrobial peptides using random forests trained on the n-gram encoded peptides. The implemented algorithm can be accessed from both the command line and shiny-based GUI. The AmpGram model is too large for CRAN and it has to be downloaded separately from the repository: <https://github.com/michbur/AmpGramModel>.

Download air quality and meteorological information of Chile from the National Air Quality System (S.I.N.C.A.)<https://sinca.mma.gob.cl/> dependent on the Ministry of the Environment and the Meteorological Directorate of Chile (D.M.C.)<https://www.meteochile.gob.cl/> dependent on the Directorate General of Civil Aeronautics.

Stanford ATLAS (Advanced Temporal Search Engine) is a powerful tool that allows constructing cohorts of patients extremely quickly and efficiently. This package is designed to interface directly with an instance of ATLAS search engine and facilitates API queries and data dumps. Prerequisite is a good knowledge of the temporal language to be able to efficiently construct a query. More information available at <https://shahlab.stanford.edu/start>.

Compute the R-squared measure under the accelerated failure time (AFT) models proposed in Chan et. al. (2018) <doi:10.1080/03610918.2016.1177072>.

Fit, interpret, and compute predictions with oblique random forests. Includes support for partial dependence, variable importance, passing customized functions for variable importance and identification of linear combinations of features. Methods for the oblique random survival forest are described in Jaeger et al., (2023) <DOI:10.1080/10618600.2023.2231048>.

This package provides a powerful tool for automating the early detection of disease outbreaks in time series data. aeddo employs advanced statistical methods, including hierarchical models, in an innovative manner to effectively characterize outbreak signals. It is particularly useful for epidemiologists, public health professionals, and researchers seeking to identify and respond to disease outbreaks in a timely fashion. For a detailed reference on hierarchical models, consult Henrik Madsen and Poul Thyregod's book (2011), ISBN: 9781420091557.

This package provides a spatiotemporal model that simulates the spread of Ascochyta blight in chickpea fields based on location-specific weather conditions. This model is adapted from a model developed by Diggle et al. (2002) <doi:10.1094/PHYTO.2002.92.10.1110> for simulating the spread of anthracnose in a lupin field.

This package provides a client for AWS Translate <https://aws.amazon.com/documentation/translate>, a machine translation service that will convert a text input in one language into a text output in another language.

Examples of datasets on allometry, the study of the relationship of biological traits to body size. This package contains the datasets of morphological measurement taken from 113 maritime earwigs (Anisolabis maritima) by Matsuzawa and Konuma (2025) <doi:10.1093/biolinnean/blaf031>, and taken from 507 Helmâ s stag beetles (Geodorcus helmsi) collected by Grey et al. (2025) <doi:10.1093/biolinnean/blae024>.

Adaptive Sparse Multi-block Partial Least Square, a supervised algorithm, is an extension of the Sparse Multi-block Partial Least Square, which allows different quantiles to be used in different blocks of different partial least square components to decide the proportion of features to be retained. The best combinations of quantiles can be chosen from a set of user-defined quantiles combinations by cross-validation. By doing this, it enables us to do the feature selection for different blocks, and the selected features can then be further used to predict the outcome. For example, in biomedical applications, clinical covariates plus different types of omics data such as microbiome, metabolome, mRNA data, methylation data, copy number variation data might be predictive for patients outcome such as survival time or response to therapy. Different types of data could be put in different blocks and along with survival time to fit the model. The fitted model can then be used to predict the survival for the new samples with the corresponding clinical covariates and omics data. In addition, Adaptive Sparse Multi-block Partial Least Square Discriminant Analysis is also included, which extends Adaptive Sparse Multi-block Partial Least Square for classifying the categorical outcome.

Set of functions for analyzing Atomic Force Microscope (AFM) force-distance curves. It allows to obtain the contact and unbinding points, perform the baseline correction, estimate the Young's modulus, fit up to two exponential decay function to a stress-relaxation / creep experiment, obtain adhesion energies. These operations can be done either over a single F-d curve or over a set of F-d curves in batch mode.

This package provides tools to summarize, analyze, and visualize results from Mendelian randomization studies using summarized genetic association data. The package includes functions for generating forest plots and scatter plots at the single-nucleotide polymorphism and Mendelian randomization method levels, and for fitting multiple estimators in a unified workflow, including inverse-variance weighted estimation, Mendelian randomization Egger regression, the weighted median estimator, the robust adjusted profile score, Mendelian randomization pleiotropy residual sum and outlier, Mendelian randomization with the genotype recoding invariance property, and a Bayesian horseshoe method. Related methods are described by Burgess (2013) <doi:10.1002/gepi.21758>, Bowden (2015) <doi:10.1093/ije/dyv080>, Bowden (2016) <doi:10.1002/gepi.21965>, Zhao (2020) <doi:10.1214/19-AOS1866>, Verbanck (2018) <doi:10.1038/s41588-018-0099-7>, Dudbridge (2025) <doi:10.1371/journal.pgen.1011967>, and Grant and Burgess (2024) <doi:10.1016/j.ajhg.2023.12.002>. Related open-source software includes TwoSampleMR <https://github.com/MRCIEU/TwoSampleMR>, mr.raps <https://github.com/qingyuanzhao/mr.raps>, MR-PRESSO <https://github.com/rondolab/MR-PRESSO>, and MR-Horse <https://github.com/aj-grant/mrhorse>.

This wrapper package for mgcv makes it easier to create high-performing Generalized Additive Models (GAMs). With its central function autogam(), by entering just a dataset and the name of the outcome column as inputs, AutoGAM tries to automate the procedure of configuring a highly accurate GAM which performs at reasonably high speed, even for large datasets.

Compute approach bias scores using different scoring algorithms, compute bootstrapped and exact split-half reliability estimates, and compute confidence intervals for individual participant scores.

This package provides a graphical method for joint visualisation of Variant Set Association Test (VSAT) results and individual variant association statistics. The Archipelago method assigns genomic coordinates to variant set statistics, allowing simultaneous display of variant-level and set-level signals in a unified plot. This supports interpretation of both collective and individual variant contributions in genetic association studies using variant aggregation approaches. For more see Lawless et al. (2026) <doi:10.1002/gepi.70025>.

This package provides tools for estimating length-based indicators from length frequency data to assess fish stock status and manage fisheries sustainably. Implements methods from Cope and Punt (2009) <doi:10.1577/C08-025.1> for data-limited stock assessment and Froese (2004) <doi:10.1111/j.1467-2979.2004.00144.x> for detecting overfishing using simple indicators. Key functions include: FrequencyTable(): Calculate the frequency table from the collected and also the extract the length frequency data from the frequency table with the upper length_range. A numeric value specifying the bin width for class intervals. If not provided, the bin width is automatically calculated using Wang (2020) <doi:10.1016/j.fishres.2019.105474> formula. FreqTM(): Creates a frequency distribution table for fish length data across multiple months using a consistent length class structure. The bin width is determined by either a custom value or Wang's formula, applied uniformly across all months. The function dynamically detects and renames columns to Month and Length from the input dataframe. The maximum observed length is included as part of the last class, with the upper bound set to the smallest multiple of the bin width greater than or equal to the maximum length. Months can be converted to dates using a configurable day and year, with dates assigned sequentially in day.month.year format (e.g., 15.01.26). FishPar(): Calculates length-based indicators (LBIs) proposed by Froese (2004) <doi:10.1111/j.1467-2979.2004.00144.x> such as the percentage of mature fish (Pmat), percentage of optimal length fish (Popt), percentage of mega spawners (Pmega), and the sum of these as Pobj. This function also estimates confidence intervals for different lengths, visualizes length frequency distributions, and provides data frames containing calculated values. FishSS(): Makes decisions based on input from Cope and Punt (2009) <doi:10.1577/C08-025.1> and parameters calculated by FishPar() (e.g., Pobj, Pmat, Popt, LM_ratio) to determine stock status as target spawning biomass (TSB40) and limit spawning biomass (LSB25), and selectivity. LWR(): Fits and visualizes length-weight relationships using linear regression, with options for log-transformation and customizable plotting.

Lightweight validation tool for checking function arguments and validating data analysis scripts. This is an alternative to stopifnot() from the base package and to assert_that() from the assertthat package. It provides more informative error messages and facilitates debugging.

Flat text files provide a robust, compressible, and portable way to store tables from databases. This package provides convenient functions for exporting tables from relational database connections into compressed text files and streaming those text files back into a database without requiring the whole table to fit in working memory.

Analysis of task-related functional magnetic resonance imaging (fMRI) activity at the level of individual participants is commonly based on general linear modelling (GLM) that allows us to estimate to what extent the blood oxygenation level dependent (BOLD) signal can be explained by task response predictors specified in the GLM model. The predictors are constructed by convolving the hypothesised timecourse of neural activity with an assumed hemodynamic response function (HRF). To get valid and precise estimates of task response, it is important to construct a model of neural activity that best matches actual neuronal activity. The construction of models is most often driven by predefined assumptions on the components of brain activity and their duration based on the task design and specific aims of the study. However, our assumptions about the onset and duration of component processes might be wrong and can also differ across brain regions. This can result in inappropriate or suboptimal models, bad fitting of the model to the actual data and invalid estimations of brain activity. Here we present an approach in which theoretically driven models of task response are used to define constraints based on which the final model is derived computationally using the actual data. Specifically, we developed autohrf â a package for the R programming language that allows for data-driven estimation of HRF models. The package uses genetic algorithms to efficiently search for models that fit the underlying data well. The package uses automated parameter search to find the onset and duration of task predictors which result in the highest fitness of the resulting GLM based on the fMRI signal under predefined restrictions. We evaluate the usefulness of the autohrf package on publicly available datasets of task-related fMRI activity. Our results suggest that by using autohrf users can find better task related brain activity models in a quick and efficient manner.

This software solves an Advection Bi-Flux Diffusive Problem using the Finite Difference Method FDM. Vasconcellos, J.F.V., Marinho, G.M., Zanni, J.H., 2016, Numerical analysis of an anomalous diffusion with a bimodal flux distribution. <doi:10.1016/j.rimni.2016.05.001>. Silva, L.G., Knupp, D.C., Bevilacqua, L., Galeao, A.C.N.R., Silva Neto, A.J., 2014, Formulation and solution of an Inverse Anomalous Diffusion Problem with Stochastic Techniques. <doi:10.5902/2179460X13184>. In this version, it is possible to include a source as a function depending on space and time, that is, s(x,t).

This package provides scalable generalized linear and mixed effects models tailored for sequence count data analysis (e.g., analysis of 16S or RNA-seq data). Uses Dirichlet-multinomial sampling to quantify uncertainty in relative abundance or relative expression conditioned on observed count data. Implements scale models as a generalization of normalizations which account for uncertainty in scale (e.g., total abundances) as described in Nixon et al. (2025) <doi:10.1186/s13059-025-03609-3> and McGovern et al. (2025) <doi:10.1101/2025.08.05.668734>.

Add-on for arules to handle and mine frequent sequences. Provides interfaces to the C++ implementation of cSPADE by Mohammed J. Zaki.

An interactive document on the topic of one-way and two-way analysis of variance using rmarkdown and shiny packages. Runtime examples are provided in the package function as well as at <https://kartikeyab.shinyapps.io/ANOVAShiny/>.