Helps find meaningful patterns in complex genetic experiments. First gimap takes data from paired CRISPR (Clustered regularly interspaced short palindromic repeats) screens that has been pre-processed to counts table of paired gRNA (guide Ribonucleic Acid) reads. The input data will have cell counts for how well cells grow (or don't grow) when different genes or pairs of genes are disabled. The output of the gimap package is genetic interaction scores which are the distance between the observed CRISPR score and the expected CRISPR score. The expected CRISPR scores are what we expect for the CRISPR values to be for two unrelated genes. The further away an observed CRISPR score is from its expected score the more we suspect genetic interaction. The work in this package is based off of original research from the Alice Berger lab at Fred Hutchinson Cancer Center (2021) <doi:10.1016/j.celrep.2021.109597>.

Fits generalized linear models using the same model specification as glm in the stats package, but with a modified default fitting method that provides greater stability for models that may fail to converge using glm.

Projections are common dimensionality reduction methods, which represent high-dimensional data in a two-dimensional space. However, when restricting the output space to two dimensions, which results in a two dimensional scatter plot (projection) of the data, low dimensional similarities do not represent high dimensional distances coercively [Thrun, 2018] <DOI: 10.1007/978-3-658-20540-9>. This could lead to a misleading interpretation of the underlying structures [Thrun, 2018]. By means of the 3D topographic map the generalized Umatrix is able to depict errors of these two-dimensional scatter plots. The package is derived from the book of Thrun, M.C.: "Projection Based Clustering through Self-Organization and Swarm Intelligence" (2018) <DOI:10.1007/978-3-658-20540-9> and the main algorithm called simplified self-organizing map for dimensionality reduction methods is published in <DOI: 10.1016/j.mex.2020.101093>.

Second-order summary statistics K- and pair-correlation functions describe interactions in point pattern data. This package provides computations to estimate those statistics on inhomogeneous point processes, using the methods of in T Shaw, J Møller, R Waagepetersen, 2020 <doi:10.48550/arXiv.2004.00527>.

Methodology that combines feature selection, model tuning, and parsimonious model selection with Genetic Algorithms (GA) proposed in Martinez-de-Pison (2015) <DOI:10.1016/j.asoc.2015.06.012>. To this objective, a novel GA selection procedure is introduced based on separate cost and complexity evaluations.

This package contains methods for fitting Generalized Linear Models (GLMs) and Generalized Additive Models (GAMs). Generalized regression models are common methods for handling data for which assuming Gaussian-distributed errors is not appropriate. For instance, if the response of interest is binary, count, or proportion data, one can instead model the expectation of the response based on an appropriate data-generating distribution. This package provides methods for fitting GLMs and GAMs under Beta regression, Poisson regression, Gamma regression, and Binomial regression (currently GLM only) settings. Models are fit using local scoring algorithms described in Hastie and Tibshirani (1990) <doi:10.1214/ss/1177013604>.

DNA methylation of 5-methylcytosine (5mC) is the result of a multi-step, enzyme-dependent process. Predicting these sites in-vitro is laborious, time consuming as well as costly. This Gb5mC-Pred package is an in-silico pipeline for predicting DNA sequences containing the 5mC sites. It uses a machine learning approach which uses Stochastic Gradient Boosting approach for prediction of the sequences with 5mC sites. This package has been developed by using the concept of Navarez and Roxas (2022) <doi:10.1109/TCBB.2021.3082184>.

Estimates hazard ratios and mortality differentials for doubly-truncated data without population denominators. This method is described in Goldstein et al. (2023) <doi:10.1007/s11113-023-09785-z>.

Fit penalized multivariable linear mixed models with a single random effect to control for population structure in genetic association studies. The goal is to simultaneously fit many genetic variants at the same time, in order to select markers that are independently associated with the response. Can also handle prior annotation information, for example, rare variants, in the form of variable weights. For more information, see the website below and the accompanying paper: Bhatnagar et al., "Simultaneous SNP selection and adjustment for population structure in high dimensional prediction models", 2020, <DOI:10.1371/journal.pgen.1008766>.

This package provides a post-estimation method for categorical response models (CRM). Inputs from objects of class serp(), clm(), polr(), multinom(), mlogit(), vglm() and glm() are currently supported. Available tests include the Hosmer-Lemeshow tests for the binary, multinomial and ordinal logistic regression; the Lipsitz and the Pulkstenis-Robinson tests for the ordinal models. The proportional odds, adjacent-category, and constrained continuation-ratio models are particularly supported at ordinal level. Tests for the proportional odds assumptions in ordinal models are also possible with the Brant and the Likelihood-Ratio tests. Moreover, several summary measures of predictive strength (Pseudo R-squared), and some useful error metrics, including, the brier score, misclassification rate and logloss are also available for the binary, multinomial and ordinal models. Ugba, E. R. and Gertheiss, J. (2018) <http://www.statmod.org/workshops_archive_proceedings_2018.html>.

Computes marginal likelihood in Gaussian graphical models through a novel telescoping block decomposition of the precision matrix which allows estimation of model evidence. The top level function used to estimate marginal likelihood is called evidence(), which expects the prior name, data, and relevant prior specific parameters. This package also provides an MCMC prior sampler using the same underlying approach, implemented in prior_sampling(), which expects a prior name and prior specific parameters. Both functions also expect the number of burn-in iterations and the number of sampling iterations for the underlying MCMC sampler.

This package provides tools for working with Gustavo Niemeyer's geohash coordinate system, including API for interacting with other common R GIS libraries.

Detecting spatial associations via spatial stratified heterogeneity, accounting for spatial dependencies, interpretability, complex interactions, and robust stratification. In addition, it supports the spatial stratified heterogeneity family described in Lv et al. (2025)<doi:10.1111/tgis.70032>.

The gene-set distance analysis of omic data is implemented by generalizing distance correlations to evaluate the association of a gene set with categorical and censored event-time variables.

Access and analyze multi-band greenspace seasonality data cubes (available for 1,028 major global cities), global Normalized Difference Vegetation Index / land cover data from the European Space Agency WorldCover 10m Dataset, and Sentinel-2-l2a images. Users can download data using bounding boxes, city names, and filter by year or seasonal time window. The package also supports calculating human exposure to greenspace using a population-weighted greenspace exposure model introduced by Chen et al. (2022) <doi:10.1038/s41467-022-32258-4> based on Global Human Settlement Layer population data, and calculating a set of greenspace morphology metrics at patch and landscape levels.

Density, distribution function, quantile function and random generation for the bimodal skew symmetric normal distribution of Hassan and El-Bassiouni (2016) <doi:10.1080/03610926.2014.882950>.

Fast algorithms for robust estimation with large samples of multivariate observations. Estimation of the geometric median, robust k-Gmedian clustering, and robust PCA based on the Gmedian covariation matrix.

The multiple contrast tests for univariate were proposed by Munko, Ditzhaus, Pauly, Smaga, and Zhang (2023) <doi:10.48550/arXiv.2306.15259>. Recently, they were extended to the multivariate functional data in Munko, Ditzhaus, Pauly, and Smaga (2024) <doi:10.48550/arXiv.2406.01242>. These procedures enable us to evaluate the overall hypothesis regarding equality, as well as specific hypotheses defined by contrasts. In particular, we can perform post hoc tests to examine particular comparisons of interest. Different experimental designs are supported, e.g., one-way and multi-way analysis of variance for functional data.

This package provides methods for calculating gradient surface metrics for continuous analysis of landscape features.

Toolbox for various enrichment analysis methods and quantification of uncertainty of gene sets, Schmid et al. (2016) <doi:10.1093/bioinformatics/btw030>.

Factor analysis implementation for multiple data sources, i.e., for groups of variables. The whole data analysis pipeline is provided, including functions and recommendations for data normalization and model definition, as well as missing value prediction and model visualization. The model group factor analysis (GFA) is inferred with Gibbs sampling, and it has been presented originally by Virtanen et al. (2012), and extended in Klami et al. (2015) <DOI:10.1109/TNNLS.2014.2376974> and Bunte et al. (2016) <DOI:10.1093/bioinformatics/btw207>; for details, see the citation info.

It provides materials (i.e. serial axes objects, Andrew's plot, various glyphs for scatter plot) to visualize high dimensional data.

Enhance a mice imputation workflow with visualizations for incomplete and/or imputed data. The plotting functions produce ggplot objects which may be easily manipulated or extended. Use ggmice to inspect missing data, develop imputation models, evaluate algorithmic convergence, or compare observed versus imputed data.

Data-driven approach for arriving at person-specific time series models. The method first identifies which relations replicate across the majority of individuals to detect signal from noise. These group-level relations are then used as a foundation for starting the search for person-specific (or individual-level) relations. See Gates & Molenaar (2012) <doi:10.1016/j.neuroimage.2012.06.026>.