Estimate the proportions of the null and the reproducibility and non-reproducibility of the signal group for the input data set. The Bayes factor calculation and EM (Expectation Maximization) algorithm procedures are also included.

This package provides a data clustering package based on admixture ratios (Q matrix) of population structure. The framework is based on iterative Pruning procedure that performs data clustering by splitting a given population into subclusters until meeting the condition of stopping criteria the same as ipPCA, iNJclust, and IPCAPS frameworks. The package also provides a function to retrieve phylogeny tree that construct a neighbor-joining tree based on a similar matrix between clusters. By given multiple Q matrices with varying a number of ancestors (K), the framework define a similar value between clusters i,j as a minimum number K* that makes majority of members of two clusters are in the different clusters. This K* reflexes a minimum number of ancestors we need to splitting cluster i,j into different clusters if we assign K* clusters based on maximum admixture ratio of individuals. The publication of this package is at Chainarong Amornbunchornvej, Pongsakorn Wangkumhang, and Sissades Tongsima (2020) <doi:10.1101/2020.03.21.001206>.

Collection of R functions to do purely presence-only species distribution modeling with isolation forest (iForest) and its variations such as Extended isolation forest and SCiForest. See the details of these methods in references: Liu, F.T., Ting, K.M. and Zhou, Z.H. (2008) <doi:10.1109/ICDM.2008.17>, Hariri, S., Kind, M.C. and Brunner, R.J. (2019) <doi:10.1109/TKDE.2019.2947676>, Liu, F.T., Ting, K.M. and Zhou, Z.H. (2010) <doi:10.1007/978-3-642-15883-4_18>, Guha, S., Mishra, N., Roy, G. and Schrijvers, O. (2016) <https://proceedings.mlr.press/v48/guha16.html>, Cortes, D. (2021) <doi:10.48550/arXiv.2110.13402>. Additionally, Shapley values are used to explain model inputs and outputs. See details in references: Shapley, L.S. (1953) <doi:10.1515/9781400881970-018>, Lundberg, S.M. and Lee, S.I. (2017) <https://dm-gatech.github.io/CS8803-Fall2018-DML-Papers/shapley.pdf>, Molnar, C. (2020) <ISBN:978-0-244-76852-2>, Å trumbelj, E. and Kononenko, I. (2014) <doi:10.1007/s10115-013-0679-x>. itsdm also provides functions to diagnose variable response, analyze variable importance, draw spatial dependence of variables and examine variable contribution. As utilities, the package includes a few functions to download bioclimatic variables including WorldClim version 2.0 (see Fick, S.E. and Hijmans, R.J. (2017) <doi:10.1002/joc.5086>) and CMCC-BioClimInd (see Noce, S., Caporaso, L. and Santini, M. (2020) <doi:10.1038/s41597-020-00726-5>.

This package implements a suite of sensitivity analysis tools for instrumental variable estimates as described in Cinelli and Hazlett (2025) <doi:10.1093/biomet/asaf004>.

Boxplots adapted to the happenstance of missing observations where drop-out probabilities can be given by the practitioner or modelled using auxiliary covariates. The paper of "Zhang, Z., Chen, Z., Troendle, J. F. and Zhang, J.(2012) <doi:10.1111/j.1541-0420.2011.01712.x>", proposes estimators of marginal quantiles based on the Inverse Probability Weighting method.

Algorithms and utility functions for indoor positioning using fingerprinting techniques. These functions are designed for manipulation of RSSI (Received Signal Strength Intensity) data sets, estimation of positions,comparison of the performance of different models, and graphical visualization of data. Machine learning algorithms and methods such as k-nearest neighbors or probabilistic fingerprinting are implemented in this package to perform analysis and estimations over RSSI data sets.

The app will calculate the ICER (incremental cost-effectiveness ratio) Rawlins (2012) <doi:10.1016/B978-0-7020-4084-9.00044-6> from the mean costs and quality-adjusted life years (QALY) Torrance and Feeny (2009) <doi:10.1017/S0266462300008461> for a set of treatment options, and draw the efficiency frontier in the costs-effectiveness plane. The app automatically identifies and excludes dominated and extended-dominated options from the ICER calculation.

Computes the log likelihood for an inverse gamma stochastic volatility model using a closed form expression of the likelihood. The details of the computation of this closed form expression are given in Gonzalez and Majoni (2023) <http://rcea.org/RePEc/pdf/wp23-11.pdf> . The closed form expression is obtained for a stationary inverse gamma stochastic volatility model by marginalising out the volatility. This allows the user to obtain the maximum likelihood estimator for this non linear non Gaussian state space model. In addition, the user can obtain the estimates of the smoothed volatility using the exact smoothing distributions.

Training datasets for iC10; which implements the classifier described in the paper Genome-driven integrated classification of breast cancer validated in over 7,500 samples (Ali HR et al., Genome Biology 2014). It uses copy number and/or expression form breast cancer data, trains a pamr classifier (Tibshirani et al.) with the features available and predicts the iC10 group. Genomic annotation for the training dataset has been obtained from Mark Dunning's lluminaHumanv3.db package.

This package provides a data-driven projection-based method for estimating changepoints in high-dimensional time series. Multiple changepoints are estimated using a (wild) binary segmentation scheme.

This package implements the "Smith-Pittman" community detection algorithm for network analysis using igraph objects. This algorithm combines node degree and betweenness centrality measures to identify communities within networks, with a gradient evident in social partitioning. The package provides functions for community detection, visualization, and analysis of the resulting community structure. Methods are based on results from Smith, Pittman and Xu (2024) <doi:10.48550/arXiv.2411.01394>.

Several functions to calculate two important indexes (IBR (Integrated Biomarker Response) and IBRv2 (Integrated Biological Response version 2)), it also calculates the standardized values for enzyme activity for each index, and it has a graphing function to perform radarplots that make great data visualization for this type of data. Beliaeff, B., & Burgeot, T. (2002). <https://pubmed.ncbi.nlm.nih.gov/12069320/>. Sanchez, W., Burgeot, T., & Porcher, J.-M. (2013).<doi:10.1007/s11356-012-1359-1>. Devin, S., Burgeot, T., Giambérini, L., Minguez, L., & Pain-Devin, S. (2014). <doi:10.1007/s11356-013-2169-9>. Minato N. (2022). <https://minato.sip21c.org/msb/>.

This package provides functions to measure and test imaginary cognitive social structure (CSS) motifs, which are patterns of perceived relationships among individuals in a social network. Includes tools for calculating motif frequencies, comparing observed motifs to expected distributions, and visualizing motif structures. Implements methods described in Tanaka and Vega Yon (2023) <doi:10.1016/j.socnet.2023.11.005>.

Implementations of the weighted Kozachenko-Leonenko entropy estimator and independence tests based on this estimator, (Kozachenko and Leonenko (1987) <http://mi.mathnet.ru/eng/ppi797>). Also includes a goodness-of-fit test for a linear model which is an independence test between covariates and errors.

This package provides tools for importing, merging, and analysing data from international assessment studies (TIMSS, PIRLS, PISA, ICILS, and PIAAC).

Estimates the intraclass correlation coefficient (ICC) for count data to assess repeatability (intra-methods concordance) and concordance (between-method concordance). In the concordance setting, the ICC is equivalent to the concordance correlation coefficient estimated by variance components. The ICC is estimated using the estimates from generalized linear mixed models. The within-subjects distributions considered are: Poisson; Negative Binomial with additive and proportional extradispersion; Zero-Inflated Poisson; and Zero-Inflated Negative Binomial with additive and proportional extradispersion. The statistical methodology used to estimate the ICC with count data can be found in Carrasco (2010) <doi:10.1111/j.1541-0420.2009.01335.x>.

Fast and multi-threaded implementation of isolation forest (Liu, Ting, Zhou (2008) <doi:10.1109/ICDM.2008.17>), extended isolation forest (Hariri, Kind, Brunner (2018) <doi:10.48550/arXiv.1811.02141>), SCiForest (Liu, Ting, Zhou (2010) <doi:10.1007/978-3-642-15883-4_18>), fair-cut forest (Cortes (2021) <doi:10.48550/arXiv.2110.13402>), robust random-cut forest (Guha, Mishra, Roy, Schrijvers (2016) <http://proceedings.mlr.press/v48/guha16.html>), and customizable variations of them, for isolation-based outlier detection, clustered outlier detection, distance or similarity approximation (Cortes (2019) <doi:10.48550/arXiv.1910.12362>), isolation kernel calculation (Ting, Zhu, Zhou (2018) <doi:10.1145/3219819.3219990>), and imputation of missing values (Cortes (2019) <doi:10.48550/arXiv.1911.06646>), based on random or guided decision tree splitting, and providing different metrics for scoring anomalies based on isolation depth or density (Cortes (2021) <doi:10.48550/arXiv.2111.11639>). Provides simple heuristics for fitting the model to categorical columns and handling missing data, and offers options for varying between random and guided splits, and for using different splitting criteria.

Nicely formatted frequency tables and contingency tables (1-way, 2-way, 3-way and 4-way tables), that can easily be exported to HTML or Office documents. Designed to work with pipes.

Extract and replace elements using indices that start from zero (rather than one), as is common in mathematical notation and other programming languages.

This package produces a publication-ready table that includes all effect estimates necessary for full reporting effect modification and interaction analysis as recommended by Knol and Vanderweele (2012) [<doi:10.1093/ije/dyr218>]. It also estimates confidence interval for the trio of additive interaction measures using the delta method (see Hosmer and Lemeshow (1992), [<doi:10.1097/00001648-199209000-00012>]), variance recovery method (see Zou (2008), [<doi:10.1093/aje/kwn104>]), or percentile bootstrapping (see Assmann et al. (1996), [<doi:10.1097/00001648-199605000-00012>]).

Calculates event rates and compares means and variances of groups of interval data corrected for missed arrival observations.

Data sets, functions and scripts with examples to implement autoregressive models for irregularly observed time series. The models available in this package are the irregular autoregressive model (Eyheramendy et al.(2018) <doi:10.1093/mnras/sty2487>), the complex irregular autoregressive model (Elorrieta et al.(2019) <doi:10.1051/0004-6361/201935560>) and the bivariate irregular autoregressive model (Elorrieta et al.(2021) <doi:10.1093/mnras/stab1216>).

This package provides analysis results and trial simulation functions for the I-SPY Acute Respiratory Disease Syndrome trial based on composite ranked outcomes. The composite ranked outcome is a hierarchical outcome where trial participants are ranked first by 28 day mortality, then ventilator days, then by advanced respiratory support days. A Bayesian win probability approach is used for analysis. Trial design options include group sequential looks for safety, superiority, futility, and adjustment of randomization probabilities.

We construct the explicit form of clamped cubic interpolating spline (both uniform - knots are equidistant and non-uniform - knots are arbitrary). Using this form, we propose a linear regression model suitable for real data smoothing.