Facilitates population-level analysis of ligand-receptor (LR) interactions using large-scale single-cell transcriptomic data. Identifies significant LR pairs and quantifies their interactions through correlation-based filtering and projection score computations. Designed for large-sample single-cell studies, the package employs statistical modeling, including linear regression, to investigate LR relationships between cell types. It provides a systematic framework for understanding cell-cell communication, uncovering regulatory interactions and signaling mechanisms. Offers tools for LR pair-level, sample-level, and differential interaction analyses, with comprehensive visualization support to aid biological interpretation. The methodology is described in a manuscript currently under review and will be referenced here once published or publicly available.

This package performs smoothed (and non-smoothed) principal/independent components analysis of functional data. Various functional pre-whitening approaches are implemented as discussed in Vidal and Aguilera (2022) â Novel whitening approaches in functional settings", <doi:10.1002/sta4.516>. Further whitening representations of functional data can be derived in terms of a few principal components, providing an avenue to explore hidden structures in low dimensional settings: see Vidal, Rosso and Aguilera (2021) â Bi-smoothed functional independent component analysis for EEG artifact removalâ , <doi:10.3390/math9111243>.

Based on (but not identical to) the no-longer-maintained package phyext', provides enhancements to phylobase classes, specifically for use by package SigTree'; provides classes and methods which help users manipulate branch-annotated trees (as in SigTree'); also provides support for a few other extra features.

This package provides randomization using permutation for applications. To provide a Quality Control (QC) check, QC samples can be randomized within strata. A second function allows for the ability to â switchâ samples to meet set requirements and perform a certain amount of minimization on these switches. The functions are flexible for users by specifying strata size and number of QC samples per strata. The randomization meets the following requirements â ¢ QC sample requirements: QC samples not adjacent, QC samples from same mother must follow certain patterns. â ¢ Matched sample sets must be within a single strata, and next to each other.

This package provides a semi-parametric estimation method for the Cox model with left-truncated data using augmented information from the marginal of truncation times.

Support functions, data sets, and vignettes for the psych package. Contains several of the biggest data sets for the psych package as well as four vignettes. A few helper functions for file manipulation are included as well. For more information, see the <https://personality-project.org/r/> web page.

It provides users with functions to parse International Phonetic Alphabet (IPA) transcriptions into individual phones (tokenisation) based on default IPA symbols and optional user specified multi-character phones. The tokenised transcriptions can be used for obtaining counts of phones or for searching for words matching phonetic patterns.

Fit penalized splines mixed-effects models (a special case of additive models) for large longitudinal datasets. The package includes a psme() function that (1) relies on package mgcv for constructing population and subject smooth functions as penalized splines, (2) transforms the constructed additive model to a linear mixed-effects model, (3) exploits package lme4 for model estimation and (4) backtransforms the estimated linear mixed-effects model to the additive model for interpretation and visualization. See Pedersen et al. (2019) <doi:10.7717/peerj.6876> and Bates et al. (2015) <doi:10.18637/jss.v067.i01> for an introduction. Unlike the gamm() function in mgcv', the psme() function is fast and memory-efficient, able to handle datasets with millions of observations.

Power and sample size calculation for testing fixed effect coefficients in multilevel linear mixed effect models with one or more than one independent populations. Laird, Nan M. and Ware, James H. (1982) <doi:10.2307/2529876>.

The goal of this package is to cover the most common steps in probability of default (PD) rating model development and validation. The main procedures available are those that refer to univariate, bivariate, multivariate analysis, calibration and validation. Along with accompanied monobin and monobinShiny packages, PDtoolkit provides functions which are suitable for different data transformation and modeling tasks such as: imputations, monotonic binning of numeric risk factors, binning of categorical risk factors, weights of evidence (WoE) and information value (IV) calculations, WoE coding (replacement of risk factors modalities with WoE values), risk factor clustering, area under curve (AUC) calculation and others. Additionally, package provides set of validation functions for testing homogeneity, heterogeneity, discriminatory and predictive power of the model.

Poisson disk sampling is a method of generating blue noise sample patterns where all samples are at least a specified distance apart. Poisson samples may be generated in two or three dimensions with this package. The algorithm used is an implementation of Bridson's "Fast Poisson disk sampling in arbitrary dimensions" <doi:10.1145%2F1278780.1278807>.

This package provides functions used for analyzing count data, mostly crime counts. Includes checking difference in two Poisson counts (e-test), checking the fit for a Poisson distribution, small sample tests for counts in bins, Weighted Displacement Difference test (Wheeler and Ratcliffe, 2018) <doi:10.1186/s40163-018-0085-5>, to evaluate crime changes over time in treated/control areas. Additionally includes functions for aggregating spatial data and spatial feature engineering.

Monte Carlo based model choice for applied phylogenetics of continuous traits. Method described in Carl Boettiger, Graham Coop, Peter Ralph (2012) Is your phylogeny informative? Measuring the power of comparative methods, Evolution 66 (7) 2240-51. <doi:10.1111/j.1558-5646.2011.01574.x>.

This package provides a collection of color palettes inspired by the enormous diversity of skin colors in Neotropical poison frog species. Suitable for use with ggplot2 and base R graphics.

This package provides methods to easily extract and manipulate climate reconstructions for ecological and anthropological analyses, as described in Leonardi et al. (2023) <doi:10.1111/ecog.06481>. The package includes datasets of palaeoclimate reconstructions, present observations, and future projections from multiple climate models.

Enables the creation of object pools, which make it less computationally expensive to fetch a new object. Currently the only supported pooled objects are DBI connections.

The constructs used to study the human psychology have many definitions and corresponding instructions for eliciting and coding qualitative data pertaining to constructs content and for measuring the constructs. This plethora of definitions and instructions necessitates unequivocal reference to specific definitions and instructions in empirical and secondary research. This package implements a human- and machine-readable standard for specifying construct definitions and instructions for measurement and qualitative research based on YAML'. This standard facilitates systematic unequivocal reference to specific construct definitions and corresponding instructions in a decentralized manner (i.e. without requiring central curation; Peters (2020) <doi:10.31234/osf.io/xebhn>).

This package provides a wrapper for Paddle - The Merchant of Record for digital products API (Application Programming Interface) <https://developer.paddle.com/api-reference/overview>. Provides functions to manage and analyze products, customers, invoices and many more.

Load the Just Another Gibbs Sampling (JAGS) module pexm'. The module provides the tools to work with the Piecewise Exponential (PE) distribution in a Bayesian model with the corresponding Markov Chain Monte Carlo algorithm (Gibbs Sampling) implemented via JAGS. Details about the module implementation can be found in Mayrink et al. (2021) <doi:10.18637/jss.v100.i08>.

This package performs statistical tests to compare coefficients and residual variance across models. Also provides graphical methods for assessing heterogeneity in coefficients and residuals. Currently supports linear and generalized linear models.

This package provides functions to aid in micro and macro economic analysis and handling of price and currency data. Includes extraction of relevant inflation and exchange rate data from World Bank API, data cleaning/parsing, and standardisation. Inflation adjustment calculations as found in Principles of Macroeconomics by Gregory Mankiw et al (2014). Current and historical end of day exchange rates for 171 currencies from the European Central Bank Statistical Data Warehouse (2020).

This package provides a comprehensive framework for planning and executing analyses in R. It provides a structured approach to running the same function multiple times with different arguments, executing multiple functions on the same datasets, and creating systematic analyses across multiple strata or variables. The framework is particularly useful for applying the same analysis across multiple strata (e.g., locations, age groups), running statistical methods on multiple variables (e.g., exposures, outcomes), generating multiple tables or graphs for reports, and creating systematic surveillance analyses. Key features include efficient data management, structured analysis planning, flexible execution options, built-in debugging tools, and hash-based caching.

This package contains a dataset of words used in 15.000 randomly extracted pages from the Portuguese Wikipedia (<https://pt.wikipedia.org/>).

Run simulations to assess the impact of various designs features and the underlying biological behaviour on the outcome of a Patient Derived Xenograft (PDX) population study. This project can either be deployed to a server as a shiny app or installed locally as a package and run the app using the command populationPDXdesignApp()'.