Rank-based tests for enrichment of KOG (euKaryotic Orthologous Groups) classes with up- or down-regulated genes based on a continuous measure. The meta-analysis is based on correlation of KOG delta-ranks across datasets (delta-rank is the difference between mean rank of genes belonging to a KOG class and mean rank of all other genes). With binary measure (1 or 0 to indicate significant and non-significant genes), one-tailed Fisher's exact test for over-representation of each KOG class among significant genes will be performed.

It predicts any attribute (categorical) given a set of input numeric predictor values. Note that only numeric input predictors should be given. The k value can be chosen according to accuracies provided. The attribute to be predicted can be selected from the dropdown provided (select categorical attribute). This is because categorical attributes cannot be given as inputs here. A handsontable is also provided to enter the input predictor values.

Real-time quantitative polymerase chain reaction (qPCR) data sets by Karlen et al. (2007) <doi:10.1186/1471-2105-8-131>. Provides one single tabular tidy data set in long format, encompassing 32 dilution series, for seven PCR targets and four biological samples. The targeted amplicons are within the murine genes: Cav1, Ccn2, Eln, Fn1, Rpl27, Hspg2, and Serpine1, respectively. Dilution series: scheme 1 (Cav1, Eln, Hspg2, Serpine1): 1-fold, 10-fold, 50-fold, and 100-fold; scheme 2 (Ccn2, Rpl27, Fn1): 1-fold, 10-fold, 50-fold, 100-fold and 1000-fold. For each concentration there are five replicates, except for the 1000-fold concentration, where only two replicates were performed. Each amplification curve is 40 cycles long. Original raw data file is Additional file 2 from "Statistical significance of quantitative PCR" by Y. Karlen, A. McNair, S. Perseguers, C. Mazza, and N. Mermod (2007) <https://static-content.springer.com/esm/art%3A10.1186%2F1471-2105-8-131/MediaObjects/12859_2006_1503_MOESM2_ESM.ZIP>.

This package contains kidney care oriented functions. Current version contains functions for calculation of: - Estimated glomerular filtration rate by CKD-EPI (2021 and 2009), MDRD, CKiD, FAS, EKFC, etc. - Kidney Donor Risk Index and Kidney Donor Profile Index for kidney transplant donors. - Citation: Bikbov B. kidney.epi: Kidney-Related Functions for Clinical and Epidemiological Research. Scientific-Tools.Org, <https://Scientific-Tools.Org>. <doi:10.32614/CRAN.package.kidney.epi>.

Producing kernel estimates of the unconditional and conditional hazard function for right-censored data including methods of bandwidth selection.

To test if a tensor time series following a Tucker-decomposition factor model has a Kronecker product structure. Supplementary functions for tensor reshape and its reversal are also included.

This package implements the Known Sub-Sequence Algorithm <doi:10.1016/j.aaf.2021.12.013>, which helps to automatically identify and validate the best method for missing data imputation in a time series. Supports the comparison of multiple state-of-the-art algorithms.

This package provides tools to calculate the theoretical hydrodynamic response of an aquifer undergoing harmonic straining or pressurization, or analyze measured responses. There are two classes of models here, designed for use with confined aquifers: (1) for sealed wells, based on the model of Kitagawa et al (2011, <doi:10.1029/2010JB007794>), and (2) for open wells, based on the models of Cooper et al (1965, <doi:10.1029/JZ070i016p03915>), Hsieh et al (1987, <doi:10.1029/WR023i010p01824>), Rojstaczer (1988, <doi:10.1029/JB093iB11p13619>), Liu et al (1989, <doi:10.1029/JB094iB07p09453>), and Wang et al (2018, <doi:10.1029/2018WR022793>). Wang's solution is a special exception which allows for leakage out of the aquifer (semi-confined); it is equivalent to Hsieh's model when there is no leakage (the confined case). These models treat strain (or aquifer head) as an input to the physical system, and fluid-pressure (or water height) as the output. The applicable frequency band of these models is characteristic of seismic waves, atmospheric pressure fluctuations, and solid earth tides.

Knowledge space theory by Doignon and Falmagne (1999) <doi:10.1007/978-3-642-58625-5> is a set- and order-theoretical framework, which proposes mathematical formalisms to operationalize knowledge structures in a particular domain. The kstMatrix package provides basic functionalities to generate, handle, and manipulate knowledge structures and knowledge spaces. Opposed to the kst package, kstMatrix uses matrix representations for knowledge structures. Furthermore, kstMatrix contains several knowledge spaces developed by the research group around Cornelia Dowling through querying experts.

Detect and test for changes in covariance structures of functional data, as well as changepoint detection for multivariate data more generally. Method for detecting non-stationarity in resting state functional Magnetic Resonance Imaging (fMRI) scans as seen in Ramsay, K., & Chenouri, S. (2025) <doi:10.1080/10485252.2025.2503891> is implemented in fmri_changepoints(). Also includes depth- and rank-based implementation of the wild binary segmentation algorithm for detecting multiple changepoints in multivariate data.

The number of clusters (k) is needed to start all the partitioning clustering algorithms. An optimal value of this input argument is widely determined by using some internal validity indices. Since most of the existing internal indices suggest a k value which is computed from the clustering results after several runs of a clustering algorithm they are computationally expensive. On the contrary, the package kpeaks enables to estimate k before running any clustering algorithm. It is based on a simple novel technique using the descriptive statistics of peak counts of the features in a data set.

Implementation for kernel functional partial least squares (KFPLS) method. KFPLS method is developed for functional nonlinear models, and the method does not require strict constraints for the nonlinear structures. The crucial function of this package is KFPLS().

Provide routines for filtering and smoothing, forecasting, sampling and Bayesian analysis of Dynamic Generalized Linear Models using the methodology described in Alves et al. (2024)<doi:10.48550/arXiv.2201.05387> and dos Santos Jr. et al. (2024)<doi:10.48550/arXiv.2403.13069>.

An interactive document on the topic of K-nearest neighbour (KNN) using rmarkdown and shiny packages. Runtime examples are provided in the package function as well as at <https://kartikeyabolar.shinyapps.io/KNNShiny/>.

This package implements the kernel method of test equating as defined in von Davier, A. A., Holland, P. W. and Thayer, D. T. (2004) <doi:10.1007/b97446> and Andersson, B. and Wiberg, M. (2017) <doi:10.1007/s11336-016-9528-7> using the CB, EG, SG, NEAT CE/PSE and NEC designs, supporting Gaussian, logistic and uniform kernels and unsmoothed and pre-smoothed input data.

This package provides a new practical method to evaluate whether relationships between two sets of high-dimensional variables are different or not across two conditions. Song, H. and Wu, M.C. (2023) <arXiv:2307.15268>.

The kernelized version of principal component analysis (KPCA) has proven to be a valid nonlinear alternative for tackling the nonlinearity of biological sample spaces. However, it poses new challenges in terms of the interpretability of the original variables. kpcaIG aims to provide a tool to select the most relevant variables based on the kernel PCA representation of the data as in Briscik et al. (2023) <doi:10.1186/s12859-023-05404-y>. It also includes functions for 2D and 3D visualization of the original variables (as arrows) into the kernel principal components axes, highlighting the contribution of the most important ones.

Comparative evaluation of families and candidate variants in rare-variant association studies. The package can be used for two methodologically overlapping but distinct purposes. First, the prior to any genetic or genomic evaluation, evaluation of relative detection power of pedigrees, can direct recruitment efforts by showing which individuals not yet sampled would be the most meaningful additions to a study. Second, after sequencing and analysis, variants based on association with disease status and familial relationships of individuals, aids in variant prioritization. Methodology is described in Nugent (2025) <doi:10.1101/2025.10.06.25337426>.

This package infers relative kinase activity from phosphoproteomics data using the method described by Casado et al. (2013) <doi:10.1126/scisignal.2003573>.

This package provides a method for detecting outliers with a Kalman filter on impulsed noised outliers and prediction on cleaned data. kfino is a robust sequential algorithm allowing to filter data with a large number of outliers. This algorithm is based on simple latent linear Gaussian processes as in the Kalman Filter method and is devoted to detect impulse-noised outliers. These are data points that differ significantly from other observations. ML (Maximization Likelihood) and EM (Expectation-Maximization algorithm) algorithms were implemented in kfino'. The method is described in full details in the following arXiv e-Print: <arXiv:2208.00961>.

This package provides a wrapper for querying WISKI databases via the KiWIS REST API. WISKI is an SQL relational database used for the collection and storage of water data developed by KISTERS and KiWIS is a REST service that provides access to WISKI databases via HTTP requests (<https://www.kisters.eu/water-weather-and-environment/>). Contains a list of default databases (called hubs') and also allows users to provide their own KiWIS URL. Supports the entire query process- from metadata to specific time series values. All data is returned as tidy tibbles.

Given a set of points around a knee curve, analyzes first and second derivatives to find knee points.

Gaussian process regression with an emphasis on kernels. Quantitative and qualitative inputs are accepted. Some pre-defined kernels are available, such as radial or tensor-sum for quantitative inputs, and compound symmetry, low rank, group kernel for qualitative inputs. The user can define new kernels and composite kernels through a formula mechanism. Useful methods include parameter estimation by maximum likelihood, simulation, prediction and leave-one-out validation.

Rcpp implementation of the multivariate Kalman filter for state space models that can handle missing values and exogenous data in the observation and state equations. There is also a function to handle time varying parameters. Kim, Chang-Jin and Charles R. Nelson (1999) "State-Space Models with Regime Switching: Classical and Gibbs-Sampling Approaches with Applications" <doi:10.7551/mitpress/6444.001.0001><http://econ.korea.ac.kr/~cjkim/>.