Apply an adaptation of the SuperFastHash algorithm to any R object. Hash whole R objects or, for vectors or lists, hash R objects to obtain a set of hash values that is stored in a structure equivalent to the input. See <http://www.azillionmonkeys.com/qed/hash.html> for a description of the hash algorithm.

This package provides a fast, vectorized hashmap that is built on top of C++ std::unordered_map <https://en.cppreference.com/w/cpp/container/unordered_map.html>. The map can hold any R object as key / value as long as it is serializable and supports vectorized insertion, lookup, and deletion.

The harmonic mean p-value (HMP) test combines p-values and corrects for multiple testing while controlling the strong-sense family-wise error rate. It is more powerful than common alternatives including Bonferroni and Simes procedures when combining large proportions of all the p-values, at the cost of slightly lower power when combining small proportions of all the p-values. It is more stringent than controlling the false discovery rate, and possesses theoretical robustness to positive correlations between tests and unequal weights. It is a multi-level test in the sense that a superset of one or more significant tests is certain to be significant and conversely when the superset is non-significant, the constituent tests are certain to be non-significant. It is based on MAMML (model averaging by mean maximum likelihood), a frequentist analogue to Bayesian model averaging, and is theoretically grounded in generalized central limit theorem. For detailed examples type vignette("harmonicmeanp") after installation. Version 3.0 addresses errors in versions 1.0 and 2.0 that led function p.hmp to control the familywise error rate only in the weak sense, rather than the strong sense as intended.

An algorithm for time series analysis that leverages hidden Markov models, cluster analysis, and mixture distributions to segment data, detect patterns and predict future sequences.

Calculate and visualize Healthy Eating Index (HEI) scores from National Health and Nutrition Examination Survey 24-hour dietary recall data utilizing three methods recommended by the National Cancer Institute (2024) <https://epi.grants.cancer.gov/hei/hei-methods-and-calculations.html#:~:text=To%20use%20the%20simple%20HEI,the%20total%20scores%20across%20individuals.>. Effortlessly analyze HEI scores across different demographic groups and years.

Inference approach for jointly modeling correlated count and binary outcomes. This formulation allows simultaneous modeling of zero inflation via the Bernoulli component while providing a more accurate assessment of the Hierarchical Zero-Inflated Poisson's parsimony (Lizandra C. Fabio, Jalmar M. F. Carrasco, Victor H. Lachos and Ming-Hui Chen, Likelihood-based inference for joint modeling of correlated count and binary outcomes with extra variability and zeros, 2025, under submission).

This package provides tools to generate synthetic electronic health records including patients, encounters, vitals, labs, medications, procedures, and allergies, with optional COVID-19-focused and computed tomography (CT)-research views, and export them to comma separated values ('CSV'), SQLite', and Excel formats for researchers and developers.

This package contains ten datasets used in the chapters and exercises of Paul, Alice (2023) "Health Data Science in R" <https://alicepaul.github.io/health-data-science-using-r/>.

Allows users to create high-quality heatmaps from labelled, hierarchical data. Specifically, for data with a two-level hierarchical structure, it will produce a heatmap where each row and column represents a category at the lower level. These rows and columns are then grouped by the higher-level group each category belongs to, with the names for each category and groups shown in the margins. While other packages (e.g. dendextend') allow heatmap rows and columns to be arranged by groups only, hhmR also allows the labelling of the data at both the category and group level.

It provides functions to design historical controlled trials with survival outcome by group sequential method. The options for interim look boundaries are efficacy only, efficacy & futility or futility only. It also provides the function to monitor the trial for any unplanned look. The package is based on Jianrong Wu, Xiaoping Xiong (2016) <doi:10.1002/pst.1756> and Jianrong Wu, Yimei Li (2020) <doi:10.1080/10543406.2019.1684305>.

This package provides a collection of reweighted marginal hypothesis tests for clustered data, based on reweighting methods of Williamson, J., Datta, S., and Satten, G. (2003) <doi:10.1111/1541-0420.00005>. The tests in this collection are clustered analogs to well-known hypothesis tests in the classical setting, and are appropriate for data with cluster- and/or group-size informativeness. The syntax and output of functions are modeled after common, recognizable functions native to R. Methods used in the package refer to Gregg, M., Datta, S., and Lorenz, D. (2020) <doi:10.1177/0962280220928572>, Nevalainen, J., Oja, H., and Datta, S. (2017) <doi:10.1002/sim.7288> Dutta, S. and Datta, S. (2015) <doi:10.1111/biom.12447>, Lorenz, D., Datta, S., and Harkema, S. (2011) <doi:10.1002/sim.4368>, Datta, S. and Satten, G. (2008) <doi:10.1111/j.1541-0420.2007.00923.x>, Datta, S. and Satten, G. (2005) <doi:10.1198/016214504000001583>.

Fitting hidden Markov models using automatic differentiation and Laplace approximation, allowing for fast inference and flexible covariate effects (including random effects and smoothing splines) on model parameters. The package is described by Michelot (2025) <doi:10.18637/jss.v114.i05>.

Fits hidden Markov models with discrete non-parametric observation distributions to data sets. The observations may be univariate or bivariate. Simulates data from such models. Finds most probable underlying hidden states, the most probable sequences of such states, and the log likelihood of a collection of observations given the parameters of the model. Auxiliary predictors are accommodated in the univariate setting.

Test the significance of coefficients in high dimensional generalized linear models.

Simulate haplotypes through meioses. Allows specification of population parameters.

This package performs a homogeneity analysis (multiple correspondence analysis) and various extensions. Rank restrictions on the category quantifications can be imposed (nonlinear PCA). The categories are transformed by means of optimal scaling with options for nominal, ordinal, and numerical scale levels (for rank-1 restrictions). Variables can be grouped into sets, in order to emulate regression analysis and canonical correlation analysis.

Given a database of previous treatment/placebo estimates, their standard errors and sample sizes, the program calculates a significance criteria and power estimate that takes into account the among trial variation.

Cellular responses to perturbations are highly heterogeneous and depend largely on the initial state of cells. Connecting post-perturbation cells via cellular trajectories to untreated cells (e.g. by leveraging metabolic labeling information) enables exploitation of intercellular heterogeneity as a combined knock-down and overexpression screen to identify pathway modulators, termed Heterogeneity-seq (see Berg et al <doi:10.1101/2024.10.28.620481>). This package contains functions to generate cellular trajectories based on scSLAM-seq (single-cell, thiol-(SH)-linked alkylation of RNA for metabolic labelling sequencing) time courses, functions to identify pathway modulators and to visualize the results.

This package provides functionality to download and cache files from Hugging Face Hub <https://huggingface.co/models>. Uses the same caching structure so files can be shared between different client libraries.

This package contains data for software hotspot analysis, along with a function performing the analysis itself.

This package provides a suite of functions to ping URLs and to time HTTP requests'. Designed to work with httr'.

This package provides a procedure that fits derivative curves based on a sequence of quotient differences. In a hierarchical setting the package produces estimates of subject-specific and group-specific derivative curves. In a non-hierarchical setting the package produces a single derivative curve.

This package provides functions for specifying and fitting marginal models for contingency tables proposed by Bergsma and Rudas (2002) <doi:10.1214/aos/1015362188> here called hierarchical multinomial marginal models (hmmm) and their extensions presented by Bartolucci, Colombi and Forcina (2007) <https://www.jstor.org/stable/24307737>; multinomial Poisson homogeneous (mph) models and homogeneous linear predictor (hlp) models for contingency tables proposed by Lang (2004) <doi:10.1214/aos/1079120140> and Lang (2005) <doi:10.1198/016214504000001042>. Inequality constraints on the parameters are allowed and can be tested.

This package performs linear discriminant analysis in high dimensional problems based on reliable covariance estimators for problems with (many) more variables than observations. Includes routines for classifier training, prediction, cross-validation and variable selection.