Calculate clinical scores for hidradenitis suppurativa (HS), a dermatologic disease. The scores are typically used for evaluation of efficacy in clinical trials. The scores are not commonly used in clinical practice. The specific scores implemented are Hidradenitis Suppurativa Clinical Response (HiSCR) (Kimball, et al. (2015) <doi:10.1111/jdv.13216>), Hidradenitis Suppurativa Area and Severity Index Revised (HASI-R) (Goldfarb, et al. (2020) <doi:10.1111/bjd.19565>), hidradenitis suppurativa Physician Global Assessment (HS PGA) (Marzano, et al. (2020) <doi:10.1111/jdv.16328>), and the International Hidradenitis Suppurativa Severity Score System (IHS4) (Zouboulis, et al. (2017) <doi:10.1111/bjd.15748>).

This package provides functions to compute small area estimates based on a basic area or unit-level model. The model is fit using restricted maximum likelihood, or in a hierarchical Bayesian way. In the latter case numerical integration is used to average over the posterior density for the between-area variance. The output includes the model fit, small area estimates and corresponding mean squared errors, as well as some model selection measures. Additional functions provide means to compute aggregate estimates and mean squared errors, to minimally adjust the small area estimates to benchmarks at a higher aggregation level, and to graphically compare different sets of small area estimates.

This package provides a scalable implementation of the highly adaptive lasso algorithm, including routines for constructing sparse matrices of basis functions of the observed data, as well as a custom implementation of Lasso regression tailored to enhance efficiency when the matrix of predictors is composed exclusively of indicator functions. For ease of use and increased flexibility, the Lasso fitting routines invoke code from the glmnet package by default. The highly adaptive lasso was first formulated and described by MJ van der Laan (2017) <doi:10.1515/ijb-2015-0097>, with practical demonstrations of its performance given by Benkeser and van der Laan (2016) <doi:10.1109/DSAA.2016.93>. This implementation of the highly adaptive lasso algorithm was described by Hejazi, Coyle, and van der Laan (2020) <doi:10.21105/joss.02526>.

This package provides a set of tools to create georeferenced hillshade relief raster maps using ray-tracing and other advanced hill-shading techniques. It includes a wrapper function to create a georeferenced, ray-traced hillshade map from a digital elevation model, and other functions that can be used in a rayshader pipeline.

Implementation of selected high-dimensional statistical and econometric methods for estimation and inference. Efficient estimators and uniformly valid confidence intervals for various low-dimensional causal/ structural parameters are provided which appear in high-dimensional approximately sparse models. Including functions for fitting heteroscedastic robust Lasso regressions with non-Gaussian errors and for instrumental variable (IV) and treatment effect estimation in a high-dimensional setting. Moreover, the methods enable valid post-selection inference and rely on a theoretically grounded, data-driven choice of the penalty. Chernozhukov, Hansen, Spindler (2016) <arXiv:1603.01700>.

An implementation of the modelling and reporting features described in reference textbook and guidelines (Briggs, Andrew, et al. Decision Modelling for Health Economic Evaluation. Oxford Univ. Press, 2011; Siebert, U. et al. State-Transition Modeling. Medical Decision Making 32, 690-700 (2012).): deterministic and probabilistic sensitivity analysis, heterogeneity analysis, time dependency on state-time and model-time (semi-Markov and non-homogeneous Markov models), etc.

The holonomic gradient method (HGM, hgm) gives a way to evaluate normalization constants of unnormalized probability distributions by utilizing holonomic systems of differential or difference equations. The holonomic gradient descent (HGD, hgd) gives a method to find maximal likelihood estimates by utilizing the HGM.

This package provides a shiny interface for a free, open-source managerial accounting-like system for health care practices. This package allows health care administrators to project revenue with monthly adjustments and procedure-specific boosts up to a 3-year period. Granular data (patient-level) to aggregated data (department- or hospital-level) can all be used as valid inputs provided historical volume and revenue data is available. For more details on managerial accounting techniques, see Brewer et al. (2015, ISBN:9780078025792).

This package implements the method developed by Cao and Kosorok (2011) for the significance analysis of thousands of features in high-dimensional biological studies. It is an asymptotically valid data-driven procedure to find critical values for rejection regions controlling the k-familywise error rate, false discovery rate, and the tail probability of false discovery proportion.

Calculates a suite of hydrologic indices for daily time series data that are widely used in hydrology and stream ecology.

Identifies chromatin interaction modules by constructing a Hi-C contact network based on statistically significant interactions, followed by network clustering. The method enables comparison of module connectivity across two Hi-C datasets and is capable of detecting cell-type-specific regulatory modules. By integrating network analysis with chromatin conformation data, this approach provides insights into the spatial organization of the genome and its functional implications in gene regulation. Author: Sora Yoon (2025) <https://github.com/ysora/HiCociety>.

This code provides a method to fit the hidden compact representation model as well as to identify the causal direction on discrete data. We implement an effective solution to recover the above hidden compact representation under the likelihood framework. Please see the Causal Discovery from Discrete Data using Hidden Compact Representation from NIPS 2018 by Ruichu Cai, Jie Qiao, Kun Zhang, Zhenjie Zhang and Zhifeng Hao (2018) <https://nips.cc/Conferences/2018/Schedule?showEvent=11274> for a description of some of our methods.

This package implements hierarchical clustering methods (single linkage, complete linkage, average linkage, and centroid linkage) with stepwise printing and dendrograms for didactic purposes.

Hospital machine learning and ai data analysis workflow tools, modeling, and automations. This library provides many useful tools to review common administrative hospital data. Some of these include predicting length of stay, and readmits. The aim is to provide a simple and consistent verb framework that takes the guesswork out of everything.

Used for predicting a genotypeâ s allelic state at a specific locus/QTL/gene. This is accomplished by using both a genotype matrix and a separate file which has categorizations about loci/QTL/genes of interest for the individuals in the genotypic matrix. A training population can be created from a panel of individuals who have been previously screened for specific loci/QTL/genes, and this previous screening could be summarized into a category. Using the categorization of individuals which have been genotyped using a genome wide marker platform, a model can be trained to predict what category (haplotype) an individual belongs in based on their genetic sequence in the region associated with the locus/QTL/gene. These trained models can then be used to predict the haplotype of a locus/QTL/gene for individuals which have been genotyped with a genome wide platform yet not genotyped for the specific locus/QTL/gene. This package is based off work done by Winn et al 2021. For more specific information on this method, refer to <doi:10.1007/s00122-022-04178-w>.

This package implements marker-based estimation of heritability when observations on genetically identical replicates are available. These can be either observations on individual plants or plot-level data in a field trial. Heritability can then be estimated using a mixed model for the individual plant or plot data. For comparison, also mixed-model based estimation using genotypic means and estimation of repeatability with ANOVA are implemented. For illustration the package contains several datasets for the model species Arabidopsis thaliana.

This package provides univariate and indexed (multivariate) nonparametric smoothed kernel estimators for the future conditional hazard rate function when time-dependent covariates are present, a bandwidth selector for the estimator's implementation and pointwise and uniform confidence bands. Methods used in the package refer to Bagkavos, Isakson, Mammen, Nielsen and Proust-Lima (2025) <doi:10.1093/biomet/asaf008>.

This tool identifies hydropeaking events from raw time-series flow record, a rapid flow variation induced by the hourly-adjusted electricity market. The novelty of HEDA is to use vector angle instead of the first-order derivative to detect change points which not only largely improves the computing efficiency but also accounts for the rate of change of the flow variation. More details <doi:10.1016/j.jhydrol.2021.126392>.

The heatex package calculates heat storage in the body and the components of heat exchange (conductive, convective, radiative, and evaporative) between the body and the environment during physical activity based on the principles of partitional calorimetry. The program enables heat exchange calculations for a range of environmental conditions when wearing various clothing ensembles.

Estimating heterogeneous treatment effects with tree-based machine learning algorithms and visualizing estimated results in flexible and presentation-ready ways. For more information, see Brand, Xu, Koch, and Geraldo (2021) <doi:10.1177/0081175021993503>. Our current package first started as a fork of the causalTree package on GitHub and we greatly appreciate the authors for their extremely useful and free package.

The seed germination process starts with water uptake by the seed and ends with the protrusion of radicle and plumule under varying temperatures and soil water potential. Hydrotime is a way to describe the relationship between water potential and seed germination rates at germination percentages. One important quantity before applying hydrotime modeling of germination percentages is to consider the proportion of viable seeds that could germinate under saturated conditions. This package can be used to apply correction factors at various water potentials before estimating parameters like stress tolerance, and uniformity of the hydrotime model. Three different distributions namely, Gaussian, Logistic, and Extreme value distributions have been considered to fit the model to the seed germination time course. Details can be found in Bradford (2002) <https://www.jstor.org/stable/4046371>, and Bradford and Still(2004) <https://www.jstor.org/stable/23433495>.

Computes the expectation of the number of transmissions and receptions considering a Hop-by-Hop transport model with limited number of retransmissions per packet. It provides the theoretical results shown in Palma et. al.(2016) <DOI:10.1109/TLA.2016.7555237> and also estimated values based on Monte Carlo simulations. It is also possible to consider random data and ACK probabilities.

This package provides utility functions for, and drawing on, the data.table package. The package also collates useful miscellaneous functions extending base R not available elsewhere. The name is a portmanteau of utils and the author.

Simple and integrated tool that automatically extracts and folds all hairpin sequences from raw genome-wide data. It predicts the secondary structure of several overlapped segments, with longer length than the mean length of sequences of interest for the species under processing, ensuring that no one is lost nor inappropriately cut.