This package implements operations for Riemannian manifolds, e.g., geodesic distance, Riemannian metric, exponential and logarithm maps, etc. Also incorporates random object generator on the manifolds. See Dai, Lin, and Müller (2021) <doi:10.1111/biom.13385>.

Balancing quasi-experimental field research for effects of covariates is fundamental for drawing causal inference. Propensity Score Matching deals with this issue but current techniques are restricted to binary treatment variables. Moreover, they provide several solutions without providing a comprehensive framework on choosing the best model. The MAGMA R-package addresses these restrictions by offering nearest neighbor matching for two to four groups. It also includes the option to match data of a 2x2 design. In addition, MAGMA includes a framework for evaluating the post-matching balance. The package includes functions for the matching process and matching reporting. We provide a tutorial on MAGMA as vignette. More information on MAGMA can be found in Feuchter, M. D., Urban, J., Scherrer V., Breit, M. L., and Preckel F. (2022) <https://osf.io/p47nc/>.

This package contains several functions for statistical data analysis; e.g. for sample size and power calculations, computation of confidence intervals and tests, and generation of similarity matrices.

Generate interactive html reports that enable quick visual review of multiple related time series stored in a data frame. For static datasets, this can help to identify any temporal artefacts that may affect the validity of subsequent analyses. For live data feeds, regularly scheduled reports can help to pro-actively identify data feed problems or unexpected trends that may require action. The reports are self-contained and shareable without a web server.

Enables us to use the functions of the package magick interactively.

Projects mean squared out-of-sample error for a linear regression based upon the methodology developed in Rohlfs (2022) <doi:10.48550/arXiv.2209.01493>. It consumes as inputs the lm object from an estimated OLS regression (based on the "training sample") and a data.frame of out-of-sample cases (the "test sample") that have non-missing values for the same predictors. The test sample may or may not include data on the outcome variable; if it does, that variable is not used. The aim of the exercise is to project what what mean squared out-of-sample error can be expected given the predictor values supplied in the test sample. Output consists of a list of three elements: the projected mean squared out-of-sample error, the projected out-of-sample R-squared, and a vector of out-of-sample "hat" or "leverage" values, as defined in the paper.

The need for anonymization of individual survey responses often leads to many suppressed grid cells in a regular grid. Here we provide functionality for creating multi-resolution gridded data, respecting the confidentiality rules, such as a minimum number of units and dominance by one or more units for each grid cell. The functions also include the possibility for contextual suppression of data. For more details see Skoien et al. (2025) <doi:10.48550/arXiv.2410.17601>.

This package provides methods for calculating and testing the significance of pairwise monotonic association from and based on the work of Pimentel (2009) <doi:10.4135/9781412985291.n2>. Computation of association of vectors from one or multiple sets can be performed in parallel thanks to the packages foreach and doMC'.

This package implements methods for processing a sample of (hard) clusterings, e.g. the MCMC output of a Bayesian clustering model. Among them are methods that find a single best clustering to represent the sample, which are based on the posterior similarity matrix or a relabelling algorithm.

This package provides a complete and dedicated analytical toolbox for quality control and diagnosis based on subject-related measurements of micro-RNA (miRNA) expressions. The package consists of a set of functions that allow to train, optimize and use a Bayesian classifier that relies on multiplets of measured miRNA expressions. The package also implements the quality control tools required to preprocess input datasets. In addition, the package provides a function to carry out a statistical analysis of miRNA expressions, which can give insights to improve the classifier's performance. The method implemented in the package was first introduced in L. Ricci, V. Del Vescovo, C. Cantaloni, M. Grasso, M. Barbareschi and M. A. Denti, "Statistical analysis of a Bayesian classifier based on the expression of miRNAs", BMC Bioinformatics 16:287, 2015 <doi:10.1186/s12859-015-0715-9>. The package is thoroughly described in M. Castelluzzo, A. Perinelli, S. Detassis, M. A. Denti and L. Ricci, "MiRNA-QC-and-Diagnosis: An R package for diagnosis based on MiRNA expression", SoftwareX 12:100569, 2020 <doi:10.1016/j.softx.2020.100569>. Please cite both these works if you use the package for your analysis. DISCLAIMER: The software in this package is for general research purposes only and is thus provided WITHOUT ANY WARRANTY. It is NOT intended to form the basis of clinical decisions. Please refer to the GNU General Public License 3.0 (GPLv3) for further information.

Model fitting and simulation for Gaussian and logistic inner product MultiNeSS models for multiplex networks. The package implements a convex fitting algorithm with fully adaptive parameter tuning, including options for edge cross-validation. For more details see MacDonald et al. (2020).

Estimates models that extend the standard GLM to take misclassification into account. The models require side information from a secondary data set on the misclassification process, i.e. some sort of misclassification probabilities conditional on some common covariates. A detailed description of the algorithm can be found in Dlugosz, Mammen and Wilke (2015) <https://ftp.zew.de/pub/zew-docs/dp/dp15043.pdf>.

Implement meta-analyses for simultaneously estimating individual means with shrinkage, isotonic regression and pretests. Include our original implementation of the isotonic regression via the pool-adjacent-violators algorithm (PAVA) algorithm. For the pretest estimator, the confidence interval for individual means are provided. Methodologies were published in Taketomi et al. (2021) <doi:10.3390/axioms10040267>, Taketomi et al. (2022) <doi:10.3390/a15010026>, Taketomi et al. (2023-) (under review).

Prints a random quote from Marcus Aurelius book Meditations.

Statistical Analyses and Pooling after Multiple Imputation. A large variety of repeated statistical analysis can be performed and finally pooled. Statistical analysis that are available are, among others, Levene's test, Odds and Risk Ratios, One sample proportions, difference between proportions and linear and logistic regression models. Functions can also be used in combination with the Pipe operator. More and more statistical analyses and pooling functions will be added over time. Heymans (2007) <doi:10.1186/1471-2288-7-33>. Eekhout (2017) <doi:10.1186/s12874-017-0404-7>. Wiel (2009) <doi:10.1093/biostatistics/kxp011>. Marshall (2009) <doi:10.1186/1471-2288-9-57>. Sidi (2021) <doi:10.1080/00031305.2021.1898468>. Lott (2018) <doi:10.1080/00031305.2018.1473796>. Grund (2021) <doi:10.31234/osf.io/d459g>.

Parametric modeling of M-quantile regression coefficient functions.

Gene Expression datasets for the MM2S package. Contains normalized expression data for Human Medulloblastoma ('GSE37418') as well as Mouse Medulloblastoma models ('GSE36594'). Deena Gendoo et al. (2015) <doi:10.1016/j.ygeno.2015.05.002>.

Toolset that enriches mlr with a diverse set of preprocessing operators. Composable Preprocessing Operators ("CPO"s) are first-class R objects that can be applied to data.frames and mlr "Task"s to modify data, can be attached to mlr "Learner"s to add preprocessing to machine learning algorithms, and can be composed to form preprocessing pipelines.

This package provides tools for analyzing metabolic pathway completeness, abundance, and transcripts using KEGG Orthology (KO) data from (meta)genomic and (meta)transcriptomic studies. Supports both completeness (presence/absence) and abundance-weighted analyses. Includes built-in KEGG reference datasets. For more details see Li et al. (2023) <doi:10.1038/s41467-023-42193-7>.

The user must supply a matrix filled with similarity values. The software will search for significant differences between similarity values at different hierarchical levels. The algorithm will return a Loess-smoothed plot of the similarity values along with the inflection point, if there are any. There is the option to search for an inflection point within a specified range. The package also has a function that will return the matrix components at a specified cutoff. References: Mullner. <ArXiv:1109.2378>; Cserhati, Carter. (2020, Journal of Creation 34(3):41-50), <https://dl0.creation.com/articles/p137/c13759/j34-3_64-73.pdf>.

Partial Replacement Imputation Estimation (PRIME) can overcome problems caused by missing covariates in additive partially linear model. PRIME conducts imputation and regression simultaneously with known and unknown model structure. More details can be referred to Zishu Zhan, Xiangjie Li and Jingxiao Zhang. (2022) <arXiv:2205.14994>.

This package performs multi-omic differential network analysis by revealing differential interactions between molecular entities (genes, proteins, transcription factors, or other biomolecules) across the omic datasets provided. For each omic dataset, a differential network is constructed where links represent statistically significant differential interactions between entities. These networks are then integrated into a comprehensive visualization using distinct colors to distinguish interactions from different omic layers. This unified display allows interactive exploration of cross-omic patterns, such as differential interactions present at both transcript and protein levels. For each link, users can access differential statistical significance metrics (p values or adjusted p values, calculated via robust or traditional linear regression with interaction term) and differential regression plots. The methods implemented in this package are described in Sciacca et al. (2023) <doi:10.1093/bioinformatics/btad192>.

Offering enhanced statistical power compared to traditional hypothesis testing methods, informative hypothesis testing allows researchers to explicitly model their expectations regarding the relationships among parameters. An important software tool for this framework is restriktor'. The mmirestriktor package provides shiny web applications to implement some of the basic functionality of restriktor'. The mmirestriktor() function launches a shiny application for fitting and analyzing models with constraints. The FbarCards() function launches a card game application which can help build intuition about informative hypothesis testing. The iht_interpreter() helps interpret informative hypothesis testing results based on guidelines in Vanbrabant and Rosseel (2020) <doi:10.4324/9780429273872-14>.

Enables preparation of maps to be printed and drawn on. Modified maps can then be scanned back in, and hand-drawn marks converted to spatial objects.